Page last updated: 2024-08-07 13:30:34
Induced myeloid leukemia cell differentiation protein Mcl-1
An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07820]
Synonyms
Bcl-2-like protein 3;
Bcl2-L-3;
Bcl-2-related protein EAT/mcl1;
mcl1/EAT
Research
Bioassay Publications (52)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (7.69) | 29.6817 |
| 2010's | 40 (76.92) | 24.3611 |
| 2020's | 8 (15.38) | 2.80 |
Compounds (36)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| coumarin | Homo sapiens (human) | IC50 | 24.3800 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 4.0600 | 1 | 1 |
| gossypol | Homo sapiens (human) | IC50 | 1.8192 | 5 | 5 |
| gossypol | Homo sapiens (human) | Ki | 0.6158 | 17 | 17 |
| alizarin | Homo sapiens (human) | Ki | 1.6200 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | IC50 | 1,425.0000 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 57.0000 | 1 | 1 |
| scoparone | Homo sapiens (human) | IC50 | 25.1400 | 1 | 1 |
| scoparone | Homo sapiens (human) | Ki | 9.5400 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 0.9200 | 1 | 1 |
| isoscopoletin | Homo sapiens (human) | IC50 | 51.4800 | 1 | 1 |
| isoscopoletin | Homo sapiens (human) | Ki | 15.8700 | 1 | 1 |
| indole-2-carboxylic acid | Homo sapiens (human) | Ki | 1,000.0000 | 2 | 2 |
| 1-(n-dimethyl)amino-7-naphthol | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| 6-n-tridecylsalicylic acid | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| apogossypol | Homo sapiens (human) | IC50 | 4.6400 | 2 | 5 |
| apogossypol | Homo sapiens (human) | Ki | 3.3500 | 1 | 1 |
| umi-77 | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| umi-77 | Homo sapiens (human) | Ki | 0.3720 | 5 | 5 |
| fraxetin | Homo sapiens (human) | IC50 | 32.1000 | 1 | 1 |
| fraxetin | Homo sapiens (human) | Ki | 5.5100 | 1 | 1 |
| 5,6-dehydrokawain | Homo sapiens (human) | Ki | 33.0000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 22.5900 | 1 | 1 |
| scopoletin | Homo sapiens (human) | Ki | 13.4500 | 1 | 1 |
| hymecromone | Homo sapiens (human) | IC50 | 103.7000 | 1 | 1 |
| hymecromone | Homo sapiens (human) | Ki | 22.1500 | 1 | 1 |
| daphnetin | Homo sapiens (human) | IC50 | 11.7700 | 1 | 1 |
| daphnetin | Homo sapiens (human) | Ki | 1.7500 | 1 | 1 |
| esculetin | Homo sapiens (human) | IC50 | 8.7700 | 1 | 1 |
| esculetin | Homo sapiens (human) | Ki | 1.4900 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | IC50 | 21.0400 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | Ki | 3.8100 | 1 | 1 |
| 4-methylesculetin | Homo sapiens (human) | IC50 | 6.2800 | 1 | 1 |
| 4-methylesculetin | Homo sapiens (human) | Ki | 1.1900 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | IC50 | 11.2100 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 2.1100 | 1 | 1 |
| abt-737 | Homo sapiens (human) | IC50 | 9.6454 | 7 | 11 |
| abt-737 | Homo sapiens (human) | Ki | 28.8001 | 7 | 7 |
| nutlin-3a | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide | Homo sapiens (human) | IC50 | 1.0300 | 1 | 1 |
| N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide | Homo sapiens (human) | Ki | 0.2600 | 2 | 2 |
| marinopyrrole a | Homo sapiens (human) | IC50 | 10.7500 | 2 | 4 |
| marinopyrrole a | Homo sapiens (human) | Ki | 0.0101 | 1 | 1 |
| navitoclax | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| navitoclax | Homo sapiens (human) | Ki | 0.2583 | 3 | 3 |
| ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate | Homo sapiens (human) | Ki | 41,999.0000 | 1 | 1 |
| meiogynin a | Homo sapiens (human) | Ki | 8.4333 | 2 | 3 |
| abt-199 | Homo sapiens (human) | IC50 | 1.4009 | 2 | 5 |
| abt-199 | Homo sapiens (human) | Ki | 40.4224 | 5 | 5 |
| nvp-cgm097 | Homo sapiens (human) | IC50 | 50.0000 | 2 | 2 |
| jy-1-106 | Homo sapiens (human) | IC50 | 10.1050 | 2 | 2 |
| jy-1-106 | Homo sapiens (human) | Ki | 1.7900 | 2 | 2 |
| a-1155463 | Homo sapiens (human) | Ki | 0.4400 | 1 | 1 |
| BDA-366 | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| apogossypolone | Homo sapiens (human) | IC50 | 0.2825 | 2 | 2 |
| apogossypolone | Homo sapiens (human) | Ki | 8.4850 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| gossypol | Homo sapiens (human) | Kd | 2.5636 | 3 | 4 |
| acenaphthenequinone | Homo sapiens (human) | Kd | 324.1420 | 1 | 2 |
| 2-cyanoacetamide | Homo sapiens (human) | Kd | 342.3365 | 2 | 3 |
| thiamorpholine | Homo sapiens (human) | Kd | 1,000.0000 | 1 | 1 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein transmembrane transporter activity | molecular function | Enables the transfer of a protein from one side of a membrane to the other. [GOC:jl] |
| protein heterodimerization activity | molecular function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
| BH3 domain binding | molecular function | Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] |
| channel activity | molecular function | Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. [GOC:mtg_transport, ISBN:0815340729] |
| BH domain binding | molecular function | Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| Bcl-2 family protein complex | cellular component | A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|---|---|
| cell fate determination | biological process | The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division. [ISBN:0878932437] |
| negative regulation of autophagy | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb] |
| cellular homeostasis | biological process | Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| protein transmembrane transport | biological process | The process in which a protein is transported across a membrane. [GOC:mah, GOC:vw] |
| extrinsic apoptotic signaling pathway in absence of ligand | biological process | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] |
| positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| negative regulation of anoikis | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. [GOC:obol] |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |
| mitochondrial fusion | biological process | Merging of two or more mitochondria within a cell to form a single compartment. [PMID:11038192, PMID:12052774] |
| release of cytochrome c from mitochondria | biological process | The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] |
| intrinsic apoptotic signaling pathway in response to DNA damage | biological process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis] |