Proteins > Induced myeloid leukemia cell differentiation protein Mcl-1
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Induced myeloid leukemia cell differentiation protein Mcl-1
An induced myeloid leukemia cell differentiation protein Mcl-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q07820]
Synonyms
Bcl-2-like protein 3;
Bcl2-L-3;
Bcl-2-related protein EAT/mcl1;
mcl1/EAT
Research
Bioassay Publications (52)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (7.69) | 29.6817 |
| 2010's | 40 (76.92) | 24.3611 |
| 2020's | 8 (15.38) | 2.80 |
Compounds (36)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| coumarin | Homo sapiens (human) | IC50 | 24.3800 | 1 | 1 |
| coumarin | Homo sapiens (human) | Ki | 4.0600 | 1 | 1 |
| gossypol | Homo sapiens (human) | IC50 | 1.8192 | 5 | 5 |
| gossypol | Homo sapiens (human) | Ki | 0.6158 | 17 | 17 |
| alizarin | Homo sapiens (human) | Ki | 1.6200 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | IC50 | 1,425.0000 | 1 | 1 |
| acenaphthenequinone | Homo sapiens (human) | Ki | 57.0000 | 1 | 1 |
| scoparone | Homo sapiens (human) | IC50 | 25.1400 | 1 | 1 |
| scoparone | Homo sapiens (human) | Ki | 9.5400 | 1 | 1 |
| epigallocatechin gallate | Homo sapiens (human) | IC50 | 0.9200 | 1 | 1 |
| isoscopoletin | Homo sapiens (human) | IC50 | 51.4800 | 1 | 1 |
| isoscopoletin | Homo sapiens (human) | Ki | 15.8700 | 1 | 1 |
| indole-2-carboxylic acid | Homo sapiens (human) | Ki | 1,000.0000 | 2 | 2 |
| 1-(n-dimethyl)amino-7-naphthol | Homo sapiens (human) | IC50 | 280.0000 | 1 | 1 |
| 6-n-tridecylsalicylic acid | Homo sapiens (human) | Ki | 0.2000 | 1 | 1 |
| apogossypol | Homo sapiens (human) | IC50 | 4.6400 | 2 | 5 |
| apogossypol | Homo sapiens (human) | Ki | 3.3500 | 1 | 1 |
| umi-77 | Homo sapiens (human) | IC50 | 2.4000 | 1 | 1 |
| umi-77 | Homo sapiens (human) | Ki | 0.3720 | 5 | 5 |
| fraxetin | Homo sapiens (human) | IC50 | 32.1000 | 1 | 1 |
| fraxetin | Homo sapiens (human) | Ki | 5.5100 | 1 | 1 |
| 5,6-dehydrokawain | Homo sapiens (human) | Ki | 33.0000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 22.5900 | 1 | 1 |
| scopoletin | Homo sapiens (human) | Ki | 13.4500 | 1 | 1 |
| hymecromone | Homo sapiens (human) | IC50 | 103.7000 | 1 | 1 |
| hymecromone | Homo sapiens (human) | Ki | 22.1500 | 1 | 1 |
| daphnetin | Homo sapiens (human) | IC50 | 11.7700 | 1 | 1 |
| daphnetin | Homo sapiens (human) | Ki | 1.7500 | 1 | 1 |
| esculetin | Homo sapiens (human) | IC50 | 8.7700 | 1 | 1 |
| esculetin | Homo sapiens (human) | Ki | 1.4900 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | IC50 | 21.0400 | 1 | 1 |
| 7-hydroxycoumarin | Homo sapiens (human) | Ki | 3.8100 | 1 | 1 |
| 4-methylesculetin | Homo sapiens (human) | IC50 | 6.2800 | 1 | 1 |
| 4-methylesculetin | Homo sapiens (human) | Ki | 1.1900 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | IC50 | 11.2100 | 1 | 1 |
| 7,8-dihydroxy-4-methylcoumarin | Homo sapiens (human) | Ki | 2.1100 | 1 | 1 |
| abt-737 | Homo sapiens (human) | IC50 | 9.6454 | 7 | 11 |
| abt-737 | Homo sapiens (human) | Ki | 28.8001 | 7 | 7 |
| nutlin-3a | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide | Homo sapiens (human) | IC50 | 1.0300 | 1 | 1 |
| N-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide | Homo sapiens (human) | Ki | 0.2600 | 2 | 2 |
| marinopyrrole a | Homo sapiens (human) | IC50 | 10.7500 | 2 | 4 |
| marinopyrrole a | Homo sapiens (human) | Ki | 0.0101 | 1 | 1 |
| navitoclax | Homo sapiens (human) | IC50 | 20.0000 | 2 | 2 |
| navitoclax | Homo sapiens (human) | Ki | 0.2583 | 3 | 3 |
| ethyl 2-amino-6-(3,5-dimethoxyphenyl)-4-(2-ethoxy-2-oxoethyl)-4h-chromene-3-carboxylate | Homo sapiens (human) | Ki | 41,999.0000 | 1 | 1 |
| meiogynin a | Homo sapiens (human) | Ki | 8.4333 | 2 | 3 |
| abt-199 | Homo sapiens (human) | IC50 | 1.4009 | 2 | 5 |
| abt-199 | Homo sapiens (human) | Ki | 40.4224 | 5 | 5 |
| nvp-cgm097 | Homo sapiens (human) | IC50 | 50.0000 | 2 | 2 |
| jy-1-106 | Homo sapiens (human) | IC50 | 10.1050 | 2 | 2 |
| jy-1-106 | Homo sapiens (human) | Ki | 1.7900 | 2 | 2 |
| a-1155463 | Homo sapiens (human) | Ki | 0.4400 | 1 | 1 |
| BDA-366 | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| apogossypolone | Homo sapiens (human) | IC50 | 0.2825 | 2 | 2 |
| apogossypolone | Homo sapiens (human) | Ki | 8.4850 | 3 | 3 |
Drugs with Activation Measurements
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 47, 2021
Synthesis and structure-activity relationship of coumarins as potent Mcl-1 inhibitors for cancer treatment.Bioorganic & medicinal chemistry, , 01-01, Volume: 29, 2021
Development of Mcl-1 inhibitors for cancer therapy.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Improved binding affinities of pyrrolidine derivatives as Mcl-1 inhibitors by modifying amino acid side chains.Bioorganic & medicinal chemistry, , 01-01, Volume: 25, Issue:1, 2017
Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors.Bioorganic & medicinal chemistry letters, , 05-01, Volume: 27, Issue:9, 2017
Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 26, Issue:21, 2016
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
Bcl-2/MDM2 Dual Inhibitors Based on Universal Pyramid-Like α-Helical Mimetics.Journal of medicinal chemistry, , Apr-14, Volume: 59, Issue:7, 2016
Design, synthesis and biological evaluation of 3-aryl-rhodanine benzoic acids as anti-apoptotic protein Bcl-2 inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 25, Issue:22, 2015
Design, synthesis and preliminary biological studies of pyrrolidine derivatives as Mcl-1 inhibitors.Bioorganic & medicinal chemistry, , Dec-15, Volume: 23, Issue:24, 2015
Novel soluble myeloid cell leukemia sequence 1 (Mcl-1) inhibitor (E,E)-2-(benzylaminocarbonyl)-3-styrylacrylonitrile (4g) developed using a fragment-based approach.European journal of medicinal chemistry, , Volume: 59, 2013
Design and application of a rigid quinazolone scaffold based on two-face Bim α-helix mimicking.European journal of medicinal chemistry, , Volume: 69, 2013
Fragment-based design, synthesis, and biological evaluation of N-substituted-5-(4-isopropylthiophenol)-2-hydroxynicotinamide derivatives as novel Mcl-1 inhibitors.European journal of medicinal chemistry, , Volume: 60, 2013
3-Thiomorpholin-8-oxo-8H-acenaphtho [1,2-b] pyrrole-9-carbonitrile (S1) derivatives as pan-Bcl-2-inhibitors of Bcl-2, Bcl-xL and Mcl-1.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Toward the development of innovative bifunctional agents to induce differentiation and to promote apoptosis in leukemia: clinical candidates and perspectives.Journal of medicinal chemistry, , Oct-14, Volume: 53, Issue:19, 2010
Structure-activity relationship and molecular mechanisms of ethyl 2-amino-4-(2-ethoxy-2-oxoethyl)-6-phenyl-4h-chromene-3-carboxylate (sha 14-1) and its analogues.Journal of medicinal chemistry, , Oct-08, Volume: 52, Issue:19, 2009
Structure-based design of flavonoid compounds as a new class of small-molecule inhibitors of the anti-apoptotic Bcl-2 proteins.Journal of medicinal chemistry, , Jul-12, Volume: 50, Issue:14, 2007
Structure-based design of potent small-molecule inhibitors of anti-apoptotic Bcl-2 proteins.Journal of medicinal chemistry, , Oct-19, Volume: 49, Issue:21, 2006
Discovery of tricyclic indoles that potently inhibit Mcl-1 using fragment-based methods and structure-based design.Journal of medicinal chemistry, , May-14, Volume: 58, Issue:9, 2015
Discovery of potent myeloid cell leukemia 1 (Mcl-1) inhibitors using fragment-based methods and structure-based design.Journal of medicinal chemistry, , Jan-10, Volume: 56, Issue:1, 2013
Synthesis and evaluation of a UMI-77-based fluorescent probe for selective detecting Mcl-1 protein and imaging in living cancer cells.Bioorganic & medicinal chemistry, , 01-01, Volume: 29, 2021
Design, synthesis and preliminary bioactivity studies of indomethacin derivatives as Bcl-2/Mcl-1 dual inhibitors.Bioorganic & medicinal chemistry, , 07-01, Volume: 27, Issue:13, 2019
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
3-Substituted-N-(4-hydroxynaphthalen-1-yl)arylsulfonamides as a novel class of selective Mcl-1 inhibitors: structure-based design, synthesis, SAR, and biological evaluation.Journal of medicinal chemistry, , May-22, Volume: 57, Issue:10, 2014
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
(+)- and (-)-Ecarlottones, Uncommon Chalconoids from Fissistigma latifolium with Pro-Apoptotic Activity.Journal of natural products, , 12-22, Volume: 80, Issue:12, 2017
Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.Journal of natural products, , Apr-22, Volume: 79, Issue:4, 2016
Design, synthesis, and activity evaluation of selective inhibitors of anti-apoptotic Bcl-2 proteins: The effects on the selectivity of the P1 pockets in the active sites.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 26, Issue:21, 2016
Biased and unbiased strategies to identify biologically active small molecules.Bioorganic & medicinal chemistry, , Aug-15, Volume: 22, Issue:16, 2014
Endiandric acid analogues from Beilschmiedia ferruginea as dual inhibitors of Bcl-xL/Bak and Mcl-1/Bid interactions.Journal of natural products, , Jun-27, Volume: 77, Issue:6, 2014
Structure-guided design of a selective BCL-X(L) inhibitor.Nature chemical biology, , Volume: 9, Issue:6, 2013
Structure-based design of potent Bcl-2/Bcl-xL inhibitors with strong in vivo antitumor activity.Journal of medicinal chemistry, , Jul-12, Volume: 55, Issue:13, 2012
Design, synthesis, and activity evaluation of broad-spectrum small-molecule inhibitors of anti-apoptotic Bcl-2 family proteins: characteristics of broad-spectrum protein binding and its effects on anti-tumor activity.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 22, Issue:1, 2012
Lipophilic Isosteres of a π-π Stacking Interaction: New Inhibitors of the Bcl-2-Bak Protein-Protein Interaction.ACS medicinal chemistry letters, , Jul-12, Volume: 3, Issue:7, 2012
Design of Bcl-2 and Bcl-xL inhibitors with subnanomolar binding affinities based upon a new scaffold.Journal of medicinal chemistry, , May-24, Volume: 55, Issue:10, 2012
Structure-activity relationship of selected polyphenol derivatives as inhibitors of Bax/Bcl-xL interaction.European journal of medicinal chemistry, , Volume: 51, 2012
Quinazoline sulfonamides as dual binders of the proteins B-cell lymphoma 2 and B-cell lymphoma extra long with potent proapoptotic cell-based activity.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Development of Mcl-1 inhibitors for cancer therapy.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Design, synthesis and evaluation of marinopyrrole derivatives as selective inhibitors of Mcl-1 binding to pro-apoptotic Bim and dual Mcl-1/Bcl-xL inhibitors.European journal of medicinal chemistry, , Jan-27, Volume: 90, 2015
[no title available]ACS medicinal chemistry letters, , Jun-10, Volume: 12, Issue:6, 2021
Discovery and optimization of covalent Bcl-xL antagonists.Bioorganic & medicinal chemistry letters, , 12-01, Volume: 29, Issue:23, 2019
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.Journal of medicinal chemistry, , Dec-12, Volume: 56, Issue:23, 2013
Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.Journal of natural products, , Apr-22, Volume: 79, Issue:4, 2016
Pro-apoptotic meiogynin A derivatives that target Bcl-xL and Mcl-1.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 24, Issue:21, 2014
Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells.European journal of medicinal chemistry, , Jun-05, Volume: 236, 2022
Design, synthesis and biological evaluation of dual Bcl-2/Mcl-1 inhibitors bearing 2-(1H-indol-4-yl)benzoic acid scaffold.Bioorganic & medicinal chemistry letters, , 09-01, Volume: 47, 2021
Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents.European journal of medicinal chemistry, , Feb-25, Volume: 146, 2018
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.ACS chemical biology, , 02-17, Volume: 12, Issue:2, 2017
Gossypol with Hydrophobic Linear Esters Exhibits Enhanced Antitumor Activity as an Inhibitor of Antiapoptotic Proteins.ACS medicinal chemistry letters, , Dec-08, Volume: 7, Issue:12, 2016
Development of Mcl-1 inhibitors for cancer therapy.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules.Journal of medicinal chemistry, , 02-09, Volume: 60, Issue:3, 2017
Development of Mcl-1 inhibitors for cancer therapy.European journal of medicinal chemistry, , Jan-15, Volume: 210, 2021
The chemical biology of apoptosis: Revisited after 17 years.European journal of medicinal chemistry, , Sep-01, Volume: 177, 2019
Synthesis and biological evaluation of Apogossypolone derivatives as pan-active inhibitors of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins.Journal of medicinal chemistry, , Nov-25, Volume: 53, Issue:22, 2010
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein transmembrane transporter activity | molecular function | Enables the transfer of a protein from one side of a membrane to the other. [GOC:jl] |
| protein heterodimerization activity | molecular function | Binding to a nonidentical protein to form a heterodimer. [GOC:ai] |
| BH3 domain binding | molecular function | Binding to a BH3 protein domain, present in Bcl-2 family members. The BH3 domain is a potent death domain and has an important role in protein-protein interactions and in cell death. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409, Prosite:PS01259] |
| channel activity | molecular function | Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules. [GOC:mtg_transport, ISBN:0815340729] |
| BH domain binding | molecular function | Binding to a Bcl-2 homology (BH) protein domain. Bcl-2-related proteins share homology in one to four conserved regions designated the Bcl-2 homology (BH) domains BH1, BH2, BH3 and BH4. These domains contribute at multiple levels to the function of these proteins in cell death and survival. Anti-apoptotic members of the Bcl-2 family have four BH domains (BH1-BH4). Pro-apoptotic members have fewer BH domains. [PMID:11048732, PMID:12133724, PMID:9020082, PMID:9704409] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| mitochondrial outer membrane | cellular component | The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope. [GOC:ai] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| Bcl-2 family protein complex | cellular component | A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed. [GOC:so, PMID:14634621] |
Involved In
This protein is involved in 14 target(s):
| Target | Category | Definition |
|---|
| cell fate determination | biological process | The cellular developmental process involved in cell fate commitment that occurs after cell fate specification, in which a cell is irreversibly committed to a cellular developmental fate which is heritable on cell division. [ISBN:0878932437] |
| negative regulation of autophagy | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm. [GOC:dph, GOC:tb] |
| cellular homeostasis | biological process | Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172] |
| positive regulation of apoptotic process | biological process | Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| negative regulation of apoptotic process | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis] |
| protein transmembrane transport | biological process | The process in which a protein is transported across a membrane. [GOC:mah, GOC:vw] |
| extrinsic apoptotic signaling pathway in absence of ligand | biological process | The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered. [GOC:mtg_apoptosis, PMID:15044679, PMID:20816705] |
| positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | biological process | Any process that activates or increases the frequency, rate or extent of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie] |
| negative regulation of anoikis | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of anoikis. [GOC:obol] |
| negative regulation of extrinsic apoptotic signaling pathway in absence of ligand | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of extrinsic apoptotic signaling pathway in absence of ligand. [GOC:mtg_apoptosis] |
| activation of cysteine-type endopeptidase activity involved in apoptotic process | biological process | Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process. [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] |
| mitochondrial fusion | biological process | Merging of two or more mitochondria within a cell to form a single compartment. [PMID:11038192, PMID:12052774] |
| release of cytochrome c from mitochondria | biological process | The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation. [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] |
| intrinsic apoptotic signaling pathway in response to DNA damage | biological process | The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered. [GOC:go_curators, GOC:mtg_apoptosis] |