Page last updated: 2024-08-07 16:47:50
Methionine aminopeptidase 2
A methionine aminopeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50579]
Synonyms
MAP 2;
MetAP 2;
EC 3.4.11.18;
Initiation factor 2-associated 67 kDa glycoprotein;
p67;
p67eIF2;
Peptidase M
Research
Bioassay Publications (14)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (42.86) | 29.6817 |
| 2010's | 8 (57.14) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (15)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| oxyquinoline | Homo sapiens (human) | IC50 | 2.9667 | 3 | 3 |
| cloxyquin | Homo sapiens (human) | IC50 | 0.6625 | 2 | 2 |
| ebselen | Homo sapiens (human) | IC50 | 2.4300 | 1 | 1 |
| thiabendazole | Homo sapiens (human) | IC50 | 44.7000 | 1 | 1 |
| 8-hydroxyquinoline-5-sulfonic acid | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| dimoxyline | Homo sapiens (human) | IC50 | 34.8000 | 1 | 1 |
| 8-hydroxy-2-methylquinoline | Homo sapiens (human) | IC50 | 8.5150 | 2 | 2 |
| nitroxoline | Homo sapiens (human) | IC50 | 0.0550 | 2 | 2 |
| 2-(2'-pyridyl)benzimidazole | Homo sapiens (human) | IC50 | 13.3000 | 1 | 1 |
| bis(2-(n-phenylcarboxamido)phenyl)diselenide | Homo sapiens (human) | IC50 | 0.2300 | 1 | 1 |
| 8-(4-benzenesulfonylamino)quinoline | Homo sapiens (human) | IC50 | 39.8000 | 1 | 1 |
| o-(chloroacetylcarbamoyl)fumagillol | Homo sapiens (human) | IC50 | 0.5930 | 4 | 4 |
| o-(chloroacetylcarbamoyl)fumagillol | Homo sapiens (human) | Ki | 0.0010 | 2 | 2 |
| pyridine-2-carboxylic acid thiazol-2-ylamide | Homo sapiens (human) | IC50 | 25.8000 | 1 | 1 |
| fumagillin | Homo sapiens (human) | IC50 | 0.0082 | 4 | 4 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ppi 2458 | Homo sapiens (human) | EC50 | 0.0001 | 1 | 1 |
Enables
This protein enables 7 target(s):
| Target | Category | Definition |
|---|---|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| aminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE, PMID:24157837] |
| initiator methionyl aminopeptidase activity | molecular function | Catalysis of the release of N-terminal initiator methionine from peptides. [EC:3.4.11.18] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| metalloexopeptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| metalloaminopeptidase activity | molecular function | Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [https://www.ebi.ac.uk/merops/about/glossary.shtml#AMINOPEPTIDASE] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein processing | biological process | Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein. [GOC:curators, GOC:jl, GOC:jsg] |
| peptidyl-methionine modification | biological process | The modification of peptidyl-methionine. [GOC:go_curators] |
| N-terminal protein amino acid modification | biological process | The alteration of the N-terminal amino acid residue in a protein. [GOC:mah] |