3-methylcholanthrene has been researched along with Necrosis in 39 studies
Methylcholanthrene: A carcinogen that is often used in experimental cancer studies.
3-methylcholanthrene : A pentacyclic ortho- and peri-fused polycyclic arene consisting of a dihydrocyclopenta[ij]tetraphene ring system with a methyl substituent at the 3-position.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the antitumor action of arsenic trioxide in solid tumors, we carried out quantitative tumor perfusion studies, using locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c mice." | 7.70 | Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. ( Brown, SL; Griffin, RJ; Kim, JH; Lew, YS; Song, CW, 1999) |
| "To investigate the antitumor action of arsenic trioxide in solid tumors, we carried out quantitative tumor perfusion studies, using locally advanced methylcholanthrene-induced fibrosarcoma grown in BALB/c mice." | 3.70 | Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown. ( Brown, SL; Griffin, RJ; Kim, JH; Lew, YS; Song, CW, 1999) |
| " These LAAM-induced changes demonstrated dose- and time-dependence within that dosage range producing mortality." | 1.27 | L-alpha-acetylmethadol-induced tissue alterations in mice. ( Freeman, RW; Harbison, RD; James, RC, 1984) |
| "Hepatic necrosis was relatively mild, and was not observed in all animals treated with 1,1-DCE." | 1.27 | Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice. ( Forkert, PG; Racz, WJ; Stringer, V, 1986) |
| "The anti-tumor activity of partially purified tumor necrosis factor (TNF) was analysed in combination with chemotherapeutic drugs against intradermally transplanted Meth A sarcoma." | 1.27 | Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents. ( Curschellas, E; Matter, A; Müller, M; Regenass, U, 1987) |
| "Phenobarbital pretreatment provided little or no protection." | 1.26 | Iodipamide hepatotoxicity in the rat. ( Barnhart, JL; Burk, RF, 1979) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 34 (87.18) | 18.7374 |
| 1990's | 3 (7.69) | 18.2507 |
| 2000's | 2 (5.13) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Matschurat, S | 1 |
| Blum, S | 1 |
| Mitnacht-Kraus, R | 1 |
| Dijkman, HB | 1 |
| Kanal, L | 1 |
| De Waal, RM | 1 |
| Clauss, M | 1 |
| HUGGINS, C | 1 |
| DEUEL, TF | 1 |
| FUKUNISHI, R | 1 |
| O'GARA, RW | 1 |
| KELLY, MG | 1 |
| Milas, L | 1 |
| Mason, KA | 1 |
| Ariga, H | 1 |
| Hunter, N | 1 |
| Neal, R | 1 |
| Valdecanas, D | 1 |
| Krieg, AM | 1 |
| Whisnant, JK | 1 |
| Freudenberg, N | 1 |
| Joh, K | 1 |
| Westphal, O | 1 |
| Mittermayer, C | 1 |
| Freudenberg, MA | 1 |
| Galanos, C | 1 |
| James, RC | 1 |
| Freeman, RW | 1 |
| Harbison, RD | 1 |
| Buckpitt, AR | 1 |
| Warren, DL | 1 |
| Lake, BG | 1 |
| Evans, JG | 1 |
| Lew, YS | 1 |
| Brown, SL | 1 |
| Griffin, RJ | 1 |
| Song, CW | 1 |
| Kim, JH | 1 |
| Robinson, JR | 1 |
| Felton, JS | 1 |
| Levitt, RC | 1 |
| Thorgeirsson, SS | 3 |
| Nebert, DW | 1 |
| Green, S | 1 |
| Dobrjansky, A | 1 |
| Carswell, EA | 1 |
| Kassel, RL | 1 |
| Old, LJ | 1 |
| Fiore, N | 1 |
| Schwartz, MK | 1 |
| Osaka, A | 1 |
| Burk, RF | 1 |
| Barnhart, JL | 1 |
| Gershbein, LL | 1 |
| Benuck, I | 1 |
| Mgbodile, MU | 1 |
| Holscher, M | 1 |
| Neal, RA | 1 |
| Nagabhushan, M | 1 |
| Ng, YK | 1 |
| Elias, R | 1 |
| Polverini, PJ | 1 |
| Solt, DB | 1 |
| Kawai, T | 2 |
| Satomi, N | 2 |
| Sato, N | 2 |
| Sakurai, A | 2 |
| Haranaka, K | 2 |
| Goto, T | 2 |
| Suzuki, M | 2 |
| Forkert, PG | 1 |
| Stringer, V | 1 |
| Racz, WJ | 1 |
| Regenass, U | 1 |
| Müller, M | 1 |
| Curschellas, E | 1 |
| Matter, A | 1 |
| Mitsuhashi, T | 1 |
| Chanoki, Y | 1 |
| Kuwahara, H | 1 |
| Sakai, T | 1 |
| Masuda, H | 1 |
| Sugino, S | 1 |
| Wheatley, DN | 1 |
| Sims, P | 3 |
| Jellinck, PH | 3 |
| Smith, G | 2 |
| Potter, WZ | 4 |
| Davis, DC | 2 |
| Mitchell, JR | 5 |
| Jollow, DJ | 5 |
| Gillette, JR | 4 |
| Brodie, BB | 2 |
| Keysell, GR | 1 |
| Booth, J | 1 |
| Grover, PL | 1 |
| Hewer, A | 1 |
| Hashimoto, M | 1 |
| Reid, WD | 1 |
| Ilett, KF | 1 |
| Glick, JM | 1 |
| Krishna, G | 1 |
| Boquoi, E | 1 |
| Ebner, H | 1 |
| Zampaglione, N | 1 |
| Stripp, B | 1 |
| Hamrick, M | 1 |
| Diamond, L | 1 |
| McFall, R | 1 |
| Miller, J | 1 |
| Gelboin, HV | 1 |
| Dao, TL | 1 |
| King, C | 1 |
| Tominaga, T | 1 |
| Harris, C | 1 |
| Huggins, CB | 1 |
| Sugiyama, T | 1 |
| Goudy, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Maintenance Ipilimumab + Nivolumab Post Induction Chemotherapy + SBRT for First Line[NCT05088889] | Phase 1 | 10 participants (Anticipated) | Interventional | 2022-01-25 | Recruiting | ||
| Proteomic Approach Using Matrix-assisted Laser Desorption/Ionization Tandem Time-of-flight (MALDI-TOF/TOF) of Tumor Response in Rectal Carcinoma After Radiochemotherapy[NCT00855946] | 46 participants (Actual) | Observational | 2009-05-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
39 other studies available for 3-methylcholanthrene and Necrosis
| Article | Year |
|---|---|
Negative regulatory role of PI3-kinase in TNF-induced tumor necrosis.
Topics: Androstadienes; Animals; Blotting, Western; Endothelial Growth Factors; Endothelium, Vascular; Enzym | 2003 |
PROTECTION OF ADRENAL CORTEX BY HYDROCARBONS AGAINST INJURY FROM 7,12-DIMETHYLBENZ(A)ANTHRACENE.
Topics: Adrenal Cortex; Adrenal Gland Diseases; Anthracenes; Benz(a)Anthracenes; Fluorenes; Hemorrhage; Hydr | 1963 |
PULMONARY ARTERIOLITIS IN INFANT MONKEYS. PRODUCED BY SUBCUTANEOUS INJECTIONS OF POLYCYCLIC HYDROCARBONS.
Topics: Animals; Arteritis; Benz(a)Anthracenes; Benzopyrenes; Carcinogens; Haplorhini; Injections, Subcutane | 1965 |
CpG oligodeoxynucleotide enhances tumor response to radiation.
Topics: Animals; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Inbred C3H; Necrosis; Olig | 2004 |
CpG oligodeoxynucleotide enhances tumor response to radiation.
Topics: Animals; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Inbred C3H; Necrosis; Olig | 2004 |
CpG oligodeoxynucleotide enhances tumor response to radiation.
Topics: Animals; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Inbred C3H; Necrosis; Olig | 2004 |
CpG oligodeoxynucleotide enhances tumor response to radiation.
Topics: Animals; Lymphocytes, Tumor-Infiltrating; Methylcholanthrene; Mice; Mice, Inbred C3H; Necrosis; Olig | 2004 |
Haemorrhagic tumour necrosis following endotoxin administration. I. Communication: morphological investigation on endotoxin-induced necrosis of the methylcholanthrene (Meth A) tumour in the mouse.
Topics: Animals; Endotoxins; Female; Hemorrhage; Methylcholanthrene; Mice; Mice, Inbred BALB C; Microscopy, | 1984 |
L-alpha-acetylmethadol-induced tissue alterations in mice.
Topics: Alanine Transaminase; Animals; Blood Urea Nitrogen; Glutathione; Kidney; Liver; Male; Methadone; Met | 1984 |
Evidence for hepatic formation, export and covalent binding of reactive naphthalene metabolites in extrahepatic tissues in vivo.
Topics: Animals; Binding Sites; Biological Transport; Cytochrome P-450 Enzyme System; Glutathione; Kidney; L | 1983 |
Effect of pretreatment with some mixed-function oxidase enzyme inducers on the acute hepatotoxicity of coumarin in the rat.
Topics: Alanine Transaminase; Animals; Aroclors; Aspartate Aminotransferases; Coumarins; Dose-Response Relat | 1993 |
Arsenic trioxide causes selective necrosis in solid murine tumors by vascular shutdown.
Topics: Animals; Antineoplastic Agents; Arsenic Trioxide; Arsenicals; Biological Transport; Disease Models, | 1999 |
Relationship between "aromatic hydrocarbon responsiveness" and the survival times in mice treated with various drugs and environmental compounds.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Administration, Oral; Animals; Aryl Hydrocarbon Hydroxylases; Benz | 1975 |
Partial purification of a serum factor that causes necrosis of tumors.
Topics: Alpha-Globulins; Animals; BCG Vaccine; Blood Proteins; Endotoxins; Fibrosarcoma; Galactosamine; Glyc | 1976 |
Use of microwave radiation in surgery and cancer therapy.
Topics: Animals; Blood Cell Count; Hemorrhage; Hepatectomy; Methylcholanthrene; Microwaves; Necrosis; Neopla | 1978 |
Iodipamide hepatotoxicity in the rat.
Topics: Age Factors; Alanine Transaminase; Animals; Body Weight; Chemical and Drug Induced Liver Injury; Dos | 1979 |
Cortical implantation of hydrocarbons in rats and mice.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Brain Diseases; Brain Neoplasms; Carc | 1975 |
A possible protective role for reduced glutathione in aflatoxin B1 toxicity: effect of pretreatment of rats with phenobarbital and 3-methylcholanthrene on aflatoxin toxicity.
Topics: Aflatoxins; Animals; Benzphetamine; Body Weight; Chemical and Drug Induced Liver Injury; Cysteine; C | 1975 |
Acute inhibition of DNA synthesis in hamster buccal pouch epithelium exposed to indirect acting carcinogens.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Benz(a)Anthracenes; Benzo(a)pyrene; Carcinogens; Cell Div | 1990 |
Effects of tumor necrosis factor (TNF) on transplanted tumors induced by methylcholanthrene in mice. A histopathologic study.
Topics: Animals; Fibrosarcoma; Glycoproteins; Lipopolysaccharides; Methylcholanthrene; Mice; Mice, Inbred BA | 1987 |
Necrotizing activity of tumor necrosis factor: histopathological investigation using Meth A sarcoma and granulation tissue.
Topics: Animals; Capillaries; Granulation Tissue; Lipopolysaccharides; Methylcholanthrene; Mice; Necrosis; P | 1987 |
Effects of administration of metabolic inducers and inhibitors on pulmonary toxicity and covalent binding by 1,1-dichloroethylene in CD-1 mice.
Topics: Animals; Bronchi; Dichloroethylenes; Drug Interactions; Hydrocarbons, Chlorinated; Lung; Male; Methy | 1986 |
Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationshi | 1987 |
Experimental emphysematous bullae induced by methylcholanthrene and carrageenan.
Topics: Animals; Carrageenan; Cysts; Drug Synergism; Lung; Lung Diseases; Male; Methylcholanthrene; Necrosis | 1985 |
Comparison of the efficacy of pretreatment protection against adrenal necrosis induced by 7-hydroxymethyl-12-methylbenz(a)anthracene and by 7-methyl-12-methylbenz(a)anthracene in rats.
Topics: Adrenal Glands; Aminoglutethimide; Animals; Azo Compounds; Benz(a)Anthracenes; Chlorpromazine; Color | 1969 |
N-ethylmaleimide adduct of 7,12-dimethylbenzanthracene. Properties and metabolism by rat liver microsomes.
Topics: Adrenal Glands; Animals; Benz(a)Anthracenes; Carbon Isotopes; Chromatography, Thin Layer; Enzyme Ind | 1972 |
Acetaminophen-induced hepatic necrosis. 3. Cytochrome P-450-mediated covalent binding in vitro.
Topics: Acetaminophen; Animals; Caffeine; Carbon Monoxide; Carbon Radioisotopes; Chemical and Drug Induced L | 1973 |
The formation of "K-region" epoxides as hepatic microsomal metabolites of 7-methylbenz(a)anthracene and 7,12-dimethylbenz(a)anthracene and their 7-hydroxymethyl derivatives.
Topics: Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Chromatography, Gel; Chromatography, Thin Layer | 1973 |
A perspective on the role of chemically reactive metabolites of foreign compounds in toxicity. II. Alterations in the kinetics of covalent binding.
Topics: Acetaminophen; Animals; Benzene Derivatives; Chemical Phenomena; Chemistry; Cricetinae; Diffusion; E | 1974 |
Acetaminophen-induced hepatic necrosis. V. Correlation of hepatic necrosis, covalent binding and glutathione depletion in hamsters.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cricetinae; Depression, Chemical; Gl | 1974 |
Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen.
Topics: Acetaminophen; Acetylcysteine; Animals; Cricetinae; Depression, Chemical; Glutathione; Liver; Mass S | 1974 |
Metabolism and binding of aromatic hydrocarbons in the lung. Relationship to experimental bronchiolar necrosis.
Topics: Animals; Autoradiography; Bromine; Bronchial Diseases; Carbon Isotopes; Chemical and Drug Induced Li | 1973 |
[Early changes of the endometrium and histogenesis of malignant tumors in the corpus uteri of the mouse after implantation of 20-methyl cholanthrene (I)].
Topics: Adenocarcinoma; Animals; Carcinoma; Carcinoma, Squamous Cell; Endometritis; Endometrium; Female; Met | 1973 |
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cobalt; Dose-Response Relationship, | 1973 |
Role of detoxifying enzymes in bromobenzene-induced liver necrosis.
Topics: Adipose Tissue; Animals; Benzene Derivatives; Carbon Radioisotopes; Chemical and Drug Induced Liver | 1973 |
The effects of two isomeric benzoflavones on aryl hydrocarbon hydroxylase and the toxicity and carcinogenicity of polycyclic hydrocarbons.
Topics: Adenoma; Adrenal Gland Diseases; Animals; Benz(a)Anthracenes; Benzopyrenes; Benzyl Compounds; Cells, | 1972 |
Isolation, identification, and biological study of compounds derived from 3-methylcholanthrene by irradiation in dimethyl sulfoxide.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Benz(a)Anthracenes; Biotransformation; Dimethyl Sul | 1971 |
Studies on the metabolism of 7-methylbenz-[a]anthracene and 7,12-dimethylbenz[1]anthracene and its hydroxymethyl derivatives in rat liver and adrenal homogenates.
Topics: Adrenal Gland Diseases; Adrenal Glands; Alcohols; Animals; Benz(a)Anthracenes; Carboxylic Acids; Chr | 1970 |
The role of the adrenal in toxicity in rats caused by dimethylbenzanthracene.
Topics: Adrenal Glands; Adrenal Medulla; Animals; Anthracenes; Bone Marrow Diseases; Heparin; Hydrocortisone | 1968 |
Metabolism of 7-hydroxymethyl-12-methylbenz(a)anthracene-12-14C in vitro.
Topics: Adrenal Gland Diseases; Adrenal Glands; Animals; Autoradiography; Benz(a)Anthracenes; Carbon Isotope | 1969 |
Production and prevention of two distinctive kinds of destruction of adrenal cortex.
Topics: Adrenal Glands; Adrenalectomy; Animals; Benz(a)Anthracenes; Corticosterone; Heparin; Heparin Antagon | 1965 |
Protective action of polycyclic hydrocarbons against induction of adrenal necrosis by dimethylbenzanthracene.
Topics: Adrenal Gland Diseases; Animals; Anthracenes; Autoradiography; Benz(a)Anthracenes; Chemical Phenomen | 1966 |