Inositol polyphosphate-5-phosphatase A

An inositol polyphosphate-5-phosphatase A that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q14642]

EC 3.1.3.56;
43 kDa inositol polyphosphate 5-phosphatase;
Type I inositol 1,4,5-trisphosphate 5-phosphatase;
5PTase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
inositol 1,4,5-trisphosphate	Homo sapiens (human)	Ki	15.0000	1	1

This protein enables 5 target(s):

Target	Category	Definition
inositol-polyphosphate 5-phosphatase activity	molecular function	Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
PH domain binding	molecular function	Binding to a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton. [GOC:jl, Pfam:PF00169]
inositol-1,4,5-trisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + H2O = 1D-myo-inositol 1,4-bisphosphate + phosphate. [EC:3.1.3.56, RHEA:19797]
inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate. [EC:3.1.3.56, RHEA:11392]

This protein is located in 3 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]

This protein is involved in 3 target(s):

Target	Category	Definition
inositol phosphate metabolic process	biological process	The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl]
phosphatidylinositol dephosphorylation	biological process	The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]
negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway	biological process	Any process that stops, prevents or reduces the frequency, rate or extent of phospholipase C-activating G protein-coupled receptor signaling pathway. [GOC:BHF, GOC:TermGenie]