A 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TDX5]
EC 4.1.1.45;
Picolinate carboxylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (100.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| diflunisal | Homo sapiens (human) | IC50 | 13.5000 | 1 | 1 |
| diflunisal | Homo sapiens (human) | Ki | 2.5600 | 1 | 1 |
| dipicolinic acid | Homo sapiens (human) | IC50 | 15.2000 | 1 | 1 |
| dipicolinic acid | Homo sapiens (human) | Ki | 15.2000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| aminocarboxymuconate-semialdehyde decarboxylase activity | molecular function | Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H+ = 2-aminomuconate 6-semialdehyde + CO2. [EC:4.1.1.45, RHEA:16557] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
| hydrolase activity | molecular function | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| tryptophan catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid. [ISBN:0198547684] |
| negative regulation of quinolinate biosynthetic process | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of quinolinate biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] |
| picolinic acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of picolinic acid. [GO_REF:0000068, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:19843166] |
| regulation of 'de novo' NAD biosynthetic process from tryptophan | biological process | Any process that modulates the frequency, rate or extent of 'de novo' NAD biosynthetic process from tryptophan. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:12140278, PMID:19843166] |
| secondary metabolic process | biological process | The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients. [GOC:go_curators] |