Page last updated: 2024-10-30

metformin and Necrosis

metformin has been researched along with Necrosis in 25 studies

Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Metformin-induced lactic acidosis with acute kidney injury is rare but well known."8.31Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023)
"Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)."8.02Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021)
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."7.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
" In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)."7.78Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012)
"Metformin was demonstrated to evoke metabolic stress and induce cancer cell death."5.48Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3). ( Bryś, M; Forma, E; Marczak, A; Rogalska, A; Śliwińska, A, 2018)
"Metformin-induced lactic acidosis with acute kidney injury is rare but well known."4.31Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023)
"Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)."4.02Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021)
"Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro."3.91Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019)
" In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)."3.78Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012)
"Obesity is a major health problem threatening humanity in medical, social and psychological dimensions."1.56Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats. ( Doganyigit, Z; Kaymak, E; Okan, A; Silici, S; Soylu, M; Yakan, B, 2020)
"Metformin was demonstrated to evoke metabolic stress and induce cancer cell death."1.48Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3). ( Bryś, M; Forma, E; Marczak, A; Rogalska, A; Śliwińska, A, 2018)
"Metformin treatment inhibited proliferation of cancer cells in the optimal concentration of 10 mM under hypoxia condition, while it showed no effects on non-cancerous cell viability."1.42The Induction of Metformin Inhibitory Effects on Tumor Cell Growth in Hypoxic Condition. ( Hosseinpour Feizi, MA; Kardar, GA; Safaralizadeh, R; Safari, Z; Seyedzadeh, MH; Valinezad Orang, A; Zare, A, 2015)
"Metformin does not inhibit NF-κB activation."1.39Metformin protects rat hepatocytes against bile acid-induced apoptosis. ( Buist-Homan, M; Conde de la Rosa, L; Faber, KN; Moshage, H; Woudenberg-Vrenken, TE, 2013)

Research

Studies (25)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (8.00)18.2507
2000's1 (4.00)29.6817
2010's15 (60.00)24.3611
2020's7 (28.00)2.80

Authors

AuthorsStudies
Roca, FJ1
Whitworth, LJ1
Prag, HA1
Murphy, MP1
Ramakrishnan, L1
Ariga, M1
Hagita, J1
Soda, M1
Oida, Y1
Teramachi, H1
Kitaichi, K1
Geng, Y1
Hernández Villanueva, A1
Oun, A1
Buist-Homan, M2
Blokzijl, H1
Faber, KN2
Dolga, A1
Moshage, H2
Huijink, TM1
Venema, LH1
Posma, RA1
de Vries, NJ1
Westerkamp, AC1
Ottens, PJ1
Touw, DJ1
Nijsten, MW1
Leuvenink, HGD1
Doganyigit, Z1
Yakan, B1
Soylu, M1
Kaymak, E1
Okan, A1
Silici, S1
Skemiene, K1
Rekuviene, E1
Jekabsone, A1
Cizas, P1
Morkuniene, R1
Borutaite, V1
Pateliya, B1
Burade, V1
Goswami, S1
Rogalska, A1
Forma, E1
Bryś, M1
Śliwińska, A1
Marczak, A1
Malekpour-Dehkordi, Z1
Teimourian, S1
Nourbakhsh, M1
Naghiaee, Y1
Sharifi, R1
Mohiti-Ardakani, J1
Soraya, H1
Khorrami, A1
Garjani, A2
Maleki-Dizaji, N1
Woudenberg-Vrenken, TE1
Conde de la Rosa, L1
Marini, C1
Salani, B1
Massollo, M1
Amaro, A1
Esposito, AI1
Orengo, AM1
Capitanio, S1
Emionite, L1
Riondato, M1
Bottoni, G1
Massara, C1
Boccardo, S1
Fabbi, M1
Campi, C1
Ravera, S1
Angelini, G1
Morbelli, S1
Cilli, M1
Cordera, R1
Truini, M1
Maggi, D1
Pfeffer, U1
Sambuceti, G1
Babcook, MA1
Sramkoski, RM1
Fujioka, H1
Daneshgari, F1
Almasan, A1
Shukla, S1
Nanavaty, RR1
Gupta, S1
Cheng, L1
Meng, XB1
Lu, S1
Wang, TT1
Liu, Y1
Sun, GB1
Sun, XB1
Langone, F1
Cannata, S1
Fuoco, C1
Lettieri Barbato, D1
Testa, S1
Nardozza, AP1
Ciriolo, MR1
Castagnoli, L1
Gargioli, C1
Cesareni, G1
Heidari, R1
Niknahad, H1
Jamshidzadeh, A1
Azarpira, N1
Bazyari, M1
Najibi, A1
Liberati-Čizmek, AM1
Kruljac, I1
Bakula, M1
Safari, Z1
Safaralizadeh, R1
Seyedzadeh, MH1
Valinezad Orang, A1
Zare, A1
Hosseinpour Feizi, MA1
Kardar, GA1
Pennanen, P1
Syvälä, H1
Bläuer, M1
Savinainen, K1
Ylikomi, T1
Tammela, TLJ1
Murtola, TJ1
Du, K1
Ramachandran, A1
Weemhoff, JL1
Chavan, H1
Xie, Y1
Krishnamurthy, P1
Jaeschke, H1
Solano, ME1
Sander, V1
Wald, MR1
Motta, AB1
Fonseca, EA1
de Oliveira, MA1
Lobato, Nde S1
Akamine, EH1
Colquhoun, A1
de Carvalho, MH1
Zyngier, SB1
Fortes, ZB1
Brännmark, C1
Nyman, E1
Fagerholm, S1
Bergenholm, L1
Ekstrand, EM1
Cedersund, G1
Strålfors, P1
Strunin, L1
Davies, JM1
Schneider, M1

Other Studies

25 other studies available for metformin and Necrosis

ArticleYear
Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport.
    Science (New York, N.Y.), 2022, 06-24, Volume: 376, Issue:6600

    Topics: Animals; Citric Acid Cycle; Electron Transport; Electron Transport Complex I; Humans; Macrophages; M

2022
Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.
    Journal of medical case reports, 2023, Sep-16, Volume: 17, Issue:1

    Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Kidney Tubular

2023
Protective effect of metformin against palmitate-induced hepatic cell death.
    Biochimica et biophysica acta. Molecular basis of disease, 2020, 03-01, Volume: 1866, Issue:3

    Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolis

2020
Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model.
    Clinical and translational science, 2021, Volume: 14, Issue:1

    Topics: Animals; Female; Kidney; Kidney Transplantation; Male; Metformin; Models, Animal; Necrosis; Nephrect

2021
Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats.
    Bratislavske lekarske listy, 2020, Volume: 121, Issue:7

    Topics: Animals; Female; Ghrelin; Hypoglycemic Agents; Leptin; Metformin; Necrosis; Obesity; Propolis; Rats;

2020
Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury.
    Biomolecules, 2020, 10-01, Volume: 10, Issue:10

    Topics: Animals; Brain; Brain Injuries; Electron Transport Complex I; Humans; Male; Metformin; Mitochondria;

2020
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo.
    European journal of pharmacology, 2021, Jan-15, Volume: 891

    Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Cell Line, Tumor; Cell Prolifer

2021
Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3).
    International journal of molecular sciences, 2018, Sep-13, Volume: 19, Issue:9

    Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hyperglycemia; Metformin; Necrosis;

2018
Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction.
    Life sciences, 2019, Sep-15, Volume: 233

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Collagen Type IV; Extracellular

2019
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.
    Pharmacological reports : PR, 2012, Volume: 64, Issue:6

    Topics: Administration, Oral; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Dose-R

2012
Metformin protects rat hepatocytes against bile acid-induced apoptosis.
    PloS one, 2013, Volume: 8, Issue:8

    Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bile Acids and Salts; Caspase 3; Cell Membrane; D

2013
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
    Cell cycle (Georgetown, Tex.), 2013, Nov-15, Volume: 12, Issue:22

    Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Glucose; Heterografts; Hexokinase; Metformin; Mice

2013
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.
    Cell death & disease, 2014, Nov-20, Volume: 5

    Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Chloroquine; Drug Combinations; G

2014
Evaluation of hypoglycemic efficacy of tangningtongluo formula, a traditional Chinese Miao medicine, in two rodent animal models.
    Journal of diabetes research, 2014, Volume: 2014

    Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diabeti

2014
Metformin protects skeletal muscle from cardiotoxin induced degeneration.
    PloS one, 2014, Volume: 9, Issue:12

    Topics: Animals; Calcium; Caloric Restriction; Cell Line; Membrane Transport Proteins; Metformin; Mice; Mice

2014
Carbonyl traps as potential protective agents against methimazole-induced liver injury.
    Journal of biochemical and molecular toxicology, 2015, Volume: 29, Issue:4

    Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and

2015
A 65-year-old female with poorly controlled type 2 diabetes mellitus.
    The Netherlands journal of medicine, 2015, Volume: 73, Issue:10

    Topics: Aged; Atrophy; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents;

2015
The Induction of Metformin Inhibitory Effects on Tumor Cell Growth in Hypoxic Condition.
    Iranian journal of allergy, asthma, and immunology, 2015, Volume: 14, Issue:6

    Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Proliferation; HEK293 Cells; Humans; Matrix Met

2015
The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines.
    European journal of pharmacology, 2016, Oct-05, Volume: 788

    Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Prolife

2016
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
    Toxicological sciences : an official journal of the Society of Toxicology, 2016, Volume: 154, Issue:2

    Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect

2016
Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes.
    Clinical and experimental immunology, 2008, Volume: 153, Issue:2

    Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dehydroepiandr

2008
Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.
    Life sciences, 2011, May-09, Volume: 88, Issue:19-20

    Topics: Animals; Carcinoma 256, Walker; Male; Metformin; Necrosis; Obesity; Random Allocation; Rats; Rats, W

2011
Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.
    The Journal of biological chemistry, 2013, Apr-05, Volume: 288, Issue:14

    Topics: Adipocytes; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Transporter Type 4; Humans; Insulin;

2013
Hepatic necrosis after cardiac surgery.
    Anaesthesia and intensive care, 1995, Volume: 23, Issue:6

    Topics: Acidosis, Lactic; Anesthetics, Inhalation; Cardiac Surgical Procedures; Diabetes Mellitus; Enflurane

1995
Fatal hepatic necrosis following cardiac surgery and enflurane anaesthesia.
    Anaesthesia and intensive care, 1996, Volume: 24, Issue:2

    Topics: Acidosis, Lactic; Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiac Surgical Procedures; Chem

1996