metformin has been researched along with Necrosis in 25 studies
Metformin: A biguanide hypoglycemic agent used in the treatment of non-insulin-dependent diabetes mellitus not responding to dietary modification. Metformin improves glycemic control by improving insulin sensitivity and decreasing intestinal absorption of glucose. (From Martindale, The Extra Pharmacopoeia, 30th ed, p289)
metformin : A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 8.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| "Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)." | 8.02 | Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021) |
| "Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro." | 7.91 | Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 7.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "Metformin was demonstrated to evoke metabolic stress and induce cancer cell death." | 5.48 | Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3). ( Bryś, M; Forma, E; Marczak, A; Rogalska, A; Śliwińska, A, 2018) |
| "Metformin-induced lactic acidosis with acute kidney injury is rare but well known." | 4.31 | Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report. ( Ariga, M; Hagita, J; Kitaichi, K; Oida, Y; Soda, M; Teramachi, H, 2023) |
| "Metformin may act renoprotective prior to kidney transplantation by reducing ischemia-reperfusion injury (IRI)." | 4.02 | Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model. ( de Vries, NJ; Huijink, TM; Leuvenink, HGD; Nijsten, MW; Ottens, PJ; Posma, RA; Touw, DJ; Venema, LH; Westerkamp, AC, 2021) |
| "Metformin with reduction of ECM component as collagen VI, MMP2 and MMP9, integrin/ERK pathway, necrosis markers as RIPK1, RIPK3 and MLKL, and apoptosis markers including DAP, DAPK1, DAPK3 and SIVA effects on fibrosis in insulin resistant and hypertrophied adipocytes in vitro." | 3.91 | Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction. ( Malekpour-Dehkordi, Z; Mohiti-Ardakani, J; Naghiaee, Y; Nourbakhsh, M; Sharifi, R; Teimourian, S, 2019) |
| " In the present study, we evaluated the effects of metformin on cardiac function, hemodynamic parameters, and histopathological changes in isoproterenol-induced myocardial infarction (MI)." | 3.78 | Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats. ( Garjani, A; Khorrami, A; Maleki-Dizaji, N; Soraya, H, 2012) |
| "Obesity is a major health problem threatening humanity in medical, social and psychological dimensions." | 1.56 | Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats. ( Doganyigit, Z; Kaymak, E; Okan, A; Silici, S; Soylu, M; Yakan, B, 2020) |
| "Metformin was demonstrated to evoke metabolic stress and induce cancer cell death." | 1.48 | Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3). ( Bryś, M; Forma, E; Marczak, A; Rogalska, A; Śliwińska, A, 2018) |
| "Metformin treatment inhibited proliferation of cancer cells in the optimal concentration of 10 mM under hypoxia condition, while it showed no effects on non-cancerous cell viability." | 1.42 | The Induction of Metformin Inhibitory Effects on Tumor Cell Growth in Hypoxic Condition. ( Hosseinpour Feizi, MA; Kardar, GA; Safaralizadeh, R; Safari, Z; Seyedzadeh, MH; Valinezad Orang, A; Zare, A, 2015) |
| "Metformin does not inhibit NF-κB activation." | 1.39 | Metformin protects rat hepatocytes against bile acid-induced apoptosis. ( Buist-Homan, M; Conde de la Rosa, L; Faber, KN; Moshage, H; Woudenberg-Vrenken, TE, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (8.00) | 18.2507 |
| 2000's | 1 (4.00) | 29.6817 |
| 2010's | 15 (60.00) | 24.3611 |
| 2020's | 7 (28.00) | 2.80 |
| Authors | Studies |
|---|---|
| Roca, FJ | 1 |
| Whitworth, LJ | 1 |
| Prag, HA | 1 |
| Murphy, MP | 1 |
| Ramakrishnan, L | 1 |
| Ariga, M | 1 |
| Hagita, J | 1 |
| Soda, M | 1 |
| Oida, Y | 1 |
| Teramachi, H | 1 |
| Kitaichi, K | 1 |
| Geng, Y | 1 |
| Hernández Villanueva, A | 1 |
| Oun, A | 1 |
| Buist-Homan, M | 2 |
| Blokzijl, H | 1 |
| Faber, KN | 2 |
| Dolga, A | 1 |
| Moshage, H | 2 |
| Huijink, TM | 1 |
| Venema, LH | 1 |
| Posma, RA | 1 |
| de Vries, NJ | 1 |
| Westerkamp, AC | 1 |
| Ottens, PJ | 1 |
| Touw, DJ | 1 |
| Nijsten, MW | 1 |
| Leuvenink, HGD | 1 |
| Doganyigit, Z | 1 |
| Yakan, B | 1 |
| Soylu, M | 1 |
| Kaymak, E | 1 |
| Okan, A | 1 |
| Silici, S | 1 |
| Skemiene, K | 1 |
| Rekuviene, E | 1 |
| Jekabsone, A | 1 |
| Cizas, P | 1 |
| Morkuniene, R | 1 |
| Borutaite, V | 1 |
| Pateliya, B | 1 |
| Burade, V | 1 |
| Goswami, S | 1 |
| Rogalska, A | 1 |
| Forma, E | 1 |
| Bryś, M | 1 |
| Śliwińska, A | 1 |
| Marczak, A | 1 |
| Malekpour-Dehkordi, Z | 1 |
| Teimourian, S | 1 |
| Nourbakhsh, M | 1 |
| Naghiaee, Y | 1 |
| Sharifi, R | 1 |
| Mohiti-Ardakani, J | 1 |
| Soraya, H | 1 |
| Khorrami, A | 1 |
| Garjani, A | 2 |
| Maleki-Dizaji, N | 1 |
| Woudenberg-Vrenken, TE | 1 |
| Conde de la Rosa, L | 1 |
| Marini, C | 1 |
| Salani, B | 1 |
| Massollo, M | 1 |
| Amaro, A | 1 |
| Esposito, AI | 1 |
| Orengo, AM | 1 |
| Capitanio, S | 1 |
| Emionite, L | 1 |
| Riondato, M | 1 |
| Bottoni, G | 1 |
| Massara, C | 1 |
| Boccardo, S | 1 |
| Fabbi, M | 1 |
| Campi, C | 1 |
| Ravera, S | 1 |
| Angelini, G | 1 |
| Morbelli, S | 1 |
| Cilli, M | 1 |
| Cordera, R | 1 |
| Truini, M | 1 |
| Maggi, D | 1 |
| Pfeffer, U | 1 |
| Sambuceti, G | 1 |
| Babcook, MA | 1 |
| Sramkoski, RM | 1 |
| Fujioka, H | 1 |
| Daneshgari, F | 1 |
| Almasan, A | 1 |
| Shukla, S | 1 |
| Nanavaty, RR | 1 |
| Gupta, S | 1 |
| Cheng, L | 1 |
| Meng, XB | 1 |
| Lu, S | 1 |
| Wang, TT | 1 |
| Liu, Y | 1 |
| Sun, GB | 1 |
| Sun, XB | 1 |
| Langone, F | 1 |
| Cannata, S | 1 |
| Fuoco, C | 1 |
| Lettieri Barbato, D | 1 |
| Testa, S | 1 |
| Nardozza, AP | 1 |
| Ciriolo, MR | 1 |
| Castagnoli, L | 1 |
| Gargioli, C | 1 |
| Cesareni, G | 1 |
| Heidari, R | 1 |
| Niknahad, H | 1 |
| Jamshidzadeh, A | 1 |
| Azarpira, N | 1 |
| Bazyari, M | 1 |
| Najibi, A | 1 |
| Liberati-Čizmek, AM | 1 |
| Kruljac, I | 1 |
| Bakula, M | 1 |
| Safari, Z | 1 |
| Safaralizadeh, R | 1 |
| Seyedzadeh, MH | 1 |
| Valinezad Orang, A | 1 |
| Zare, A | 1 |
| Hosseinpour Feizi, MA | 1 |
| Kardar, GA | 1 |
| Pennanen, P | 1 |
| Syvälä, H | 1 |
| Bläuer, M | 1 |
| Savinainen, K | 1 |
| Ylikomi, T | 1 |
| Tammela, TLJ | 1 |
| Murtola, TJ | 1 |
| Du, K | 1 |
| Ramachandran, A | 1 |
| Weemhoff, JL | 1 |
| Chavan, H | 1 |
| Xie, Y | 1 |
| Krishnamurthy, P | 1 |
| Jaeschke, H | 1 |
| Solano, ME | 1 |
| Sander, V | 1 |
| Wald, MR | 1 |
| Motta, AB | 1 |
| Fonseca, EA | 1 |
| de Oliveira, MA | 1 |
| Lobato, Nde S | 1 |
| Akamine, EH | 1 |
| Colquhoun, A | 1 |
| de Carvalho, MH | 1 |
| Zyngier, SB | 1 |
| Fortes, ZB | 1 |
| Brännmark, C | 1 |
| Nyman, E | 1 |
| Fagerholm, S | 1 |
| Bergenholm, L | 1 |
| Ekstrand, EM | 1 |
| Cedersund, G | 1 |
| Strålfors, P | 1 |
| Strunin, L | 1 |
| Davies, JM | 1 |
| Schneider, M | 1 |
25 other studies available for metformin and Necrosis
| Article | Year |
|---|---|
Tumor necrosis factor induces pathogenic mitochondrial ROS in tuberculosis through reverse electron transport.
Topics: Animals; Citric Acid Cycle; Electron Transport; Electron Transport Complex I; Humans; Macrophages; M | 2022 |
Daily dose of metformin caused acute kidney injury with lactic acidosis: a case report.
Topics: Acidosis, Lactic; Acute Kidney Injury; Creatinine; Diabetes Mellitus, Type 2; Humans; Kidney Tubular | 2023 |
Protective effect of metformin against palmitate-induced hepatic cell death.
Topics: Animals; Apoptosis; Cell Death; Cell Line, Tumor; Hep G2 Cells; Hepatocytes; Humans; Lipid Metabolis | 2020 |
Metformin Preconditioning and Postconditioning to Reduce Ischemia Reperfusion Injury in an Isolated Ex Vivo Rat and Porcine Kidney Normothermic Machine Perfusion Model.
Topics: Animals; Female; Kidney; Kidney Transplantation; Male; Metformin; Models, Animal; Necrosis; Nephrect | 2021 |
Histological, immunohistochemical and biochemical effects of bee bread on stomach tissue of obese rats.
Topics: Animals; Female; Ghrelin; Hypoglycemic Agents; Leptin; Metformin; Necrosis; Obesity; Propolis; Rats; | 2020 |
Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury.
Topics: Animals; Brain; Brain Injuries; Electron Transport Complex I; Humans; Male; Metformin; Mitochondria; | 2020 |
Combining naringenin and metformin with doxorubicin enhances anticancer activity against triple-negative breast cancer in vitro and in vivo.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Biomarkers; Cell Line, Tumor; Cell Prolifer | 2021 |
Hyperglycemia-Associated Dysregulation of O-GlcNAcylation and HIF1A Reduces Anticancer Action of Metformin in Ovarian Cancer Cells (SKOV-3).
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; Female; Humans; Hyperglycemia; Metformin; Necrosis; | 2018 |
Metformin reduces fibrosis factors in insulin resistant and hypertrophied adipocyte via integrin/ERK, collagen VI, apoptosis, and necrosis reduction.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Apoptosis; Cell Differentiation; Collagen Type IV; Extracellular | 2019 |
Acute treatment with metformin improves cardiac function following isoproterenol induced myocardial infarction in rats.
Topics: Administration, Oral; Animals; Arterial Pressure; Cardiotonic Agents; Disease Models, Animal; Dose-R | 2012 |
Metformin protects rat hepatocytes against bile acid-induced apoptosis.
Topics: AMP-Activated Protein Kinases; Animals; Apoptosis; Bile Acids and Salts; Caspase 3; Cell Membrane; D | 2013 |
Direct inhibition of hexokinase activity by metformin at least partially impairs glucose metabolism and tumor growth in experimental breast cancer.
Topics: Animals; Antineoplastic Agents; Cell Line, Tumor; Glucose; Heterografts; Hexokinase; Metformin; Mice | 2013 |
Combination simvastatin and metformin induces G1-phase cell cycle arrest and Ripk1- and Ripk3-dependent necrosis in C4-2B osseous metastatic castration-resistant prostate cancer cells.
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Cell Line, Tumor; Chloroquine; Drug Combinations; G | 2014 |
Evaluation of hypoglycemic efficacy of tangningtongluo formula, a traditional Chinese Miao medicine, in two rodent animal models.
Topics: Animals; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetic Nephropathies; Diabeti | 2014 |
Metformin protects skeletal muscle from cardiotoxin induced degeneration.
Topics: Animals; Calcium; Caloric Restriction; Cell Line; Membrane Transport Proteins; Metformin; Mice; Mice | 2014 |
Carbonyl traps as potential protective agents against methimazole-induced liver injury.
Topics: Acetylcysteine; Alanine Transaminase; Animals; Aspartate Aminotransferases; Carnosine; Chemical and | 2015 |
A 65-year-old female with poorly controlled type 2 diabetes mellitus.
Topics: Aged; Atrophy; Diabetes Mellitus, Type 2; Female; Glycated Hemoglobin; Humans; Hypoglycemic Agents; | 2015 |
The Induction of Metformin Inhibitory Effects on Tumor Cell Growth in Hypoxic Condition.
Topics: Antineoplastic Agents; Apoptosis; Cell Hypoxia; Cell Proliferation; HEK293 Cells; Humans; Matrix Met | 2015 |
The effects of metformin and simvastatin on the growth of LNCaP and RWPE-1 prostate epithelial cell lines.
Topics: Adenosine Triphosphate; Apoptosis; Autophagy; Cell Count; Cell Cycle; Cell Line, Tumor; Cell Prolife | 2016 |
Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Topics: Acetaminophen; Animals; Antioxidants; Cell Line; Chemical and Drug Induced Liver Injury; Cytoprotect | 2016 |
Dehydroepiandrosterone and metformin regulate proliferation of murine T lymphocytes.
Topics: Animals; Antioxidants; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Dehydroepiandr | 2008 |
Metformin reduces the stimulatory effect of obesity on in vivo Walker-256 tumor development and increases the area of tumor necrosis.
Topics: Animals; Carcinoma 256, Walker; Male; Metformin; Necrosis; Obesity; Random Allocation; Rats; Rats, W | 2011 |
Insulin signaling in type 2 diabetes: experimental and modeling analyses reveal mechanisms of insulin resistance in human adipocytes.
Topics: Adipocytes; Diabetes Mellitus, Type 2; Female; Glucose; Glucose Transporter Type 4; Humans; Insulin; | 2013 |
Hepatic necrosis after cardiac surgery.
Topics: Acidosis, Lactic; Anesthetics, Inhalation; Cardiac Surgical Procedures; Diabetes Mellitus; Enflurane | 1995 |
Fatal hepatic necrosis following cardiac surgery and enflurane anaesthesia.
Topics: Acidosis, Lactic; Anesthesia, Inhalation; Anesthetics, Inhalation; Cardiac Surgical Procedures; Chem | 1996 |