Page last updated: 2024-12-07

s-(1,1,2,2-tetrafluoroethyl)cysteine

Description

S-(1,1,2,2-tetrafluoroethyl)cysteine: toxic to human proximal tubular cells [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID105059
SCHEMBL ID4294107
MeSH IDM0176740

Synonyms (8)

Synonym
s-(1,1,2,2-tetrafluoroethyl)cysteine
s-(1,1,2,2-tetrafluoroethyl)-l-cysteine
l-cysteine, s-(1,1,2,2-tetrafluoroethyl)-
ccris 5243
tfe-cys
94840-66-1
SCHEMBL4294107
DTXSID20915283

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" DCVC was consistently found to be more toxic than DCVG, but the inclusion of gamma-glutamyltransferase (0."( Renal cysteine conjugate beta-lyase-mediated toxicity studied with primary cultures of human proximal tubular cells.
Chen, JC; Jones, TW; Stevens, JL; Trifillis, AL, 1990
)
0.28
" DCVG was toxic to HPT cells, but the onset of toxicity was delayed compared with the corresponding cysteine conjugate."( Renal cysteine conjugate C-S lyase mediated toxicity of halogenated alkenes in primary cultures of human and rat proximal tubular cells.
Hawksworth, GM; Lock, EA; McGoldrick, TA; Rodilla, V, 2003
)
0.32
" Previous workers showed that the reactive-sulphur-containing fragment released from S -(1,1,2,2-tetrafluoroethyl)-L-cysteine and S -(1,2-dichlorovinyl)-L-cysteine is toxic by acting as a thioacylating agent - particularly of lysine residues in nearby proteins."( L-alanine-glyoxylate aminotransferase II of rat kidney and liver mitochondria possesses cysteine S-conjugate beta-lyase activity: a contributing factor to the nephrotoxicity/hepatotoxicity of halogenated alkenes?
Cooper, AJ; Jeitner, TM; Krasnikov, BF; Okuno, E, 2003
)
0.32

Dosage Studied

ExcerptRelevanceReference
" Dose-response studies in the Fischer 344 rat indicate that five proteins with apparent molecular masses of 99, 84, 66, 52, and 48 kDa are predominantly adducted in vivo after nephrotoxic doses of TFEC (> 10 mg/kg, intraperitoneally)."( Mitochondrial HSP60 (P1 protein) and a HSP70-like protein (mortalin) are major targets for modification during S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-induced nephrotoxicity.
Bruschi, SA; Crabb, JW; Gupta, RS; Stevens, JL; West, KA, 1993
)
0.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (30)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's18 (60.00)18.2507
2000's12 (40.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.71

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.71 (24.57)
Research Supply Index3.56 (2.92)
Research Growth Index4.27 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.71)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.94%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other33 (97.06%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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