nimodipine has been researched along with Necrosis in 9 studies
Nimodipine: A calcium channel blockader with preferential cerebrovascular activity. It has marked cerebrovascular dilating effects and lowers blood pressure.
nimodipine : A dihydropyridine that is 1,4-dihydropyridine which is substituted by methyl groups at positions 2 and 6, a (2-methoxyethoxy)carbonyl group at position 3, a m-nitrophenyl group at position 4, and an isopropoxycarbonyl group at position 5. An L-type calcium channel blocker, it acts particularly on cerebral circulation, and is used both orally and intravenously for the prevention and treatment of subarachnoid hemorrhage from ruptured intracranial aneurysm.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We conclude that the combination of nimodipine and MK-801, if begun 20 minutes after ischemia, may offer a neuroprotective effect against neuronal necrosis in transient forebrain ischemia and that protection is maximal in the major extrahippocampal brain regions." | 3.68 | Combination therapy with nimodipine and dizocilpine in a rat model of transient forebrain ischemia. ( Auer, RN; Rod, MR, 1992) |
| "Several authors have recently proposed that excessive calcium (Ca++) influx into postsynaptic cells may be the mechanism by which excitotoxins such as glutamate (Glu), N-methylaspartate (NMA) and kainic acid (KA) cause neuronal necrosis." | 3.67 | Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina. ( Labruyere, J; Olney, JW; Price, MT; Samson, L, 1985) |
| "Liver necrosis was produced in rats by administering 3 doses o a mixture o carbon tetrachloide+olive oil, 2 ml/kg, ip." | 1.29 | Protection of CCL4-induced liver damage in rats by some calcium channel blockers. ( Kaur, AH; Mathur, SK; Singh, J, 1995) |
| "Nimodipine-treated as well as parathyroidectomied animals showed significantly fewer hypertensive cerebral lesions." | 1.28 | Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine. ( Kazda, S; Lenz, P; Luckhaus, G; Stasch, JP, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (22.22) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nakamura, K | 1 |
| Hatakeyama, T | 1 |
| Furuta, S | 1 |
| Sakaki, S | 1 |
| Singh, J | 1 |
| Kaur, AH | 1 |
| Mathur, SK | 1 |
| Auer, RN | 2 |
| Anderson, LG | 1 |
| Cano-Abad, MF | 1 |
| Villarroya, M | 1 |
| García, AG | 1 |
| Gabilan, NH | 1 |
| López, MG | 1 |
| Rod, MR | 1 |
| Lenz, P | 1 |
| Luckhaus, G | 1 |
| Stasch, JP | 1 |
| Kazda, S | 1 |
| Nuglisch, J | 1 |
| Karkoutly, C | 1 |
| Mennel, HD | 1 |
| Rossberg, C | 1 |
| Krieglstein, J | 1 |
| Stark, GB | 1 |
| Dorer, A | 1 |
| Jaeger, K | 1 |
| Narayanan, K | 1 |
| Price, MT | 1 |
| Olney, JW | 1 |
| Samson, L | 1 |
| Labruyere, J | 1 |
9 other studies available for nimodipine and Necrosis
| Article | Year |
|---|---|
The role of early Ca2+ influx in the pathogenesis of delayed neuronal death after brief forebrain ischemia in gerbils.
Topics: Animals; Autoradiography; Brain; Calcium; Calcium Channel Blockers; Calcium Radioisotopes; Cell Deat | 1993 |
Protection of CCL4-induced liver damage in rats by some calcium channel blockers.
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Calcium Channel Blockers; Carbon Tetrach | 1995 |
Hypoglycaemic brain damage: effect of a dihydropyridine calcium channel antagonist in rats.
Topics: Animals; Blood Glucose; Body Temperature; Brain Damage, Chronic; Calcium Channel Blockers; Calcium C | 1996 |
Calcium entry through L-type calcium channels causes mitochondrial disruption and chromaffin cell death.
Topics: Adrenal Medulla; Animals; Apoptosis; Calcium; Calcium Channel Agonists; Calcium Channel Blockers; Ca | 2001 |
Combination therapy with nimodipine and dizocilpine in a rat model of transient forebrain ischemia.
Topics: Animals; Brain; Dizocilpine Maleate; Drug Combinations; Ischemic Attack, Transient; Male; Necrosis; | 1992 |
Therapy of diseased stroke-prone spontaneously hypertensive rats with nimodipine.
Topics: Aging; Animals; Brain; Calcium; Cerebrovascular Disorders; Creatinine; Hypertension; Kidney; Male; M | 1990 |
Protective effect of nimodipine against ischemic neuronal damage in rat hippocampus without changing postischemic cerebral blood flow.
Topics: Animals; Brain Ischemia; Cell Survival; Cerebrovascular Circulation; Hippocampus; Male; Necrosis; Ne | 1990 |
The influence of the calcium channel blocker nimodipine on flap survival.
Topics: Animals; Collateral Circulation; Female; Necrosis; Nimodipine; Rats; Rats, Inbred Strains; Surgical | 1989 |
Calcium influx accompanies but does not cause excitotoxin-induced neuronal necrosis in retina.
Topics: Animals; Arcuate Nucleus of Hypothalamus; Aspartic Acid; Calcium; Glutamates; Glutamic Acid; In Vitr | 1985 |