Page last updated: 2024-08-07 15:40:47
Prostaglandin G/H synthase 1
A prostaglandin G/H synthase 1 that is encoded in the genome of sheep. [OMA:P05979, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-1;
COX-1;
Prostaglandin H2 synthase 1;
PGH synthase 1;
PGHS-1;
PHS 1;
Prostaglandin-endoperoxide synthase 1
Research
Bioassay Publications (243)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 9 (3.70) | 18.2507 |
| 2000's | 62 (25.51) | 29.6817 |
| 2010's | 156 (64.20) | 24.3611 |
| 2020's | 16 (6.58) | 2.80 |
Compounds (121)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| 2-(6-methoxy-2-naphthalenyl)propanoic acid | Ovis aries (sheep) | IC50 | 0.1800 | 1 | 1 |
| acetaminophen | Ovis aries (sheep) | IC50 | 372.0000 | 1 | 1 |
| ampyrone | Ovis aries (sheep) | IC50 | 34.0000 | 2 | 2 |
| n'-(3-aminopropyl)homospermidine | Ovis aries (sheep) | IC50 | 17.0000 | 1 | 1 |
| aspirin | Ovis aries (sheep) | IC50 | 1,813.8445 | 37 | 40 |
| bml 190 | Ovis aries (sheep) | IC50 | 66.0000 | 1 | 1 |
| carprofen | Ovis aries (sheep) | IC50 | 16.1667 | 3 | 3 |
| celecoxib | Ovis aries (sheep) | IC50 | 27.8937 | 141 | 155 |
| cyproheptadine | Ovis aries (sheep) | Ki | 0.0016 | 1 | 1 |
| desipramine | Ovis aries (sheep) | Ki | 0.1600 | 1 | 1 |
| diclofenac | Ovis aries (sheep) | IC50 | 3.4011 | 16 | 16 |
| dup 697 | Ovis aries (sheep) | IC50 | 1.9279 | 4 | 4 |
| fenbufen | Ovis aries (sheep) | IC50 | 3.9000 | 1 | 1 |
| fenoprofen | Ovis aries (sheep) | IC50 | 2.7300 | 1 | 1 |
| flufenamic acid | Ovis aries (sheep) | IC50 | 14.0000 | 1 | 1 |
| flurbiprofen | Ovis aries (sheep) | IC50 | 0.1682 | 4 | 4 |
| flurbiprofen | Ovis aries (sheep) | Ki | 1.0000 | 1 | 1 |
| ibuprofen | Ovis aries (sheep) | IC50 | 8.9585 | 37 | 40 |
| ibuprofen | Ovis aries (sheep) | Ki | 9.0000 | 1 | 1 |
| imipramine | Ovis aries (sheep) | Ki | 0.1600 | 1 | 1 |
| indomethacin | Ovis aries (sheep) | IC50 | 0.9926 | 74 | 91 |
| indomethacin | Ovis aries (sheep) | Ki | 7.9000 | 1 | 1 |
| ketoprofen | Ovis aries (sheep) | IC50 | 1.1942 | 4 | 4 |
| meclofenamic acid | Ovis aries (sheep) | IC50 | 0.0675 | 2 | 4 |
| mesalamine | Ovis aries (sheep) | IC50 | 7.7300 | 1 | 1 |
| metiazinic acid | Ovis aries (sheep) | IC50 | 6.2300 | 1 | 1 |
| mofezolac | Ovis aries (sheep) | IC50 | 0.0076 | 4 | 4 |
| lm 4108 | Ovis aries (sheep) | IC50 | 33.0800 | 2 | 4 |
| nimesulide | Ovis aries (sheep) | IC50 | 53.1000 | 2 | 2 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | Ovis aries (sheep) | IC50 | 120.3333 | 11 | 12 |
| phenylbutazone | Ovis aries (sheep) | IC50 | 384.0000 | 1 | 2 |
| rofecoxib | Ovis aries (sheep) | IC50 | 162.5556 | 25 | 27 |
| sb 216995 | Ovis aries (sheep) | IC50 | 51.0000 | 1 | 1 |
| sk&f 86002 | Ovis aries (sheep) | IC50 | 5.4000 | 1 | 1 |
| thalidomide | Ovis aries (sheep) | IC50 | 0.3700 | 1 | 1 |
| pirinixic acid | Ovis aries (sheep) | IC50 | 0.0100 | 1 | 1 |
| phenidone | Ovis aries (sheep) | IC50 | 94.0000 | 1 | 1 |
| chrysophanic acid | Ovis aries (sheep) | IC50 | 46.2100 | 1 | 1 |
| osthol | Ovis aries (sheep) | IC50 | 52.5000 | 1 | 1 |
| olivetol | Ovis aries (sheep) | IC50 | 13.6300 | 1 | 1 |
| oleanolic acid | Ovis aries (sheep) | IC50 | 42.0000 | 1 | 1 |
| podophyllotoxin | Ovis aries (sheep) | IC50 | 18.0000 | 2 | 3 |
| indomethacin ethyl ester | Ovis aries (sheep) | IC50 | 66.0000 | 1 | 1 |
| dexibuprofen | Ovis aries (sheep) | IC50 | 8.3817 | 6 | 6 |
| staurosporine | Ovis aries (sheep) | IC50 | 0.0560 | 1 | 1 |
| mifepristone | Ovis aries (sheep) | IC50 | 0.0003 | 1 | 1 |
| tepoxalin | Ovis aries (sheep) | IC50 | 2.8500 | 1 | 1 |
| zileuton | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 1 |
| ursolic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| n-phenylphthalimide | Ovis aries (sheep) | IC50 | 0.0010 | 1 | 1 |
| n-demethylantipyrine | Ovis aries (sheep) | IC50 | 67.5000 | 1 | 2 |
| masoprocol | Ovis aries (sheep) | IC50 | 6.7500 | 1 | 2 |
| epicatechin | Ovis aries (sheep) | IC50 | 18.5000 | 1 | 1 |
| 2,6-dimethylphenylphthalimide | Ovis aries (sheep) | IC50 | 0.0010 | 1 | 1 |
| arjunolic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| maslinic acid | Ovis aries (sheep) | IC50 | 42.0000 | 1 | 1 |
| adipostatin a | Ovis aries (sheep) | IC50 | 5.6100 | 1 | 1 |
| primin | Ovis aries (sheep) | IC50 | 18.9200 | 1 | 1 |
| nepodin | Ovis aries (sheep) | IC50 | 27.4300 | 1 | 1 |
| icrf 193 | Ovis aries (sheep) | IC50 | 13.9000 | 1 | 1 |
| sc 58125 | Ovis aries (sheep) | IC50 | 20.0000 | 1 | 1 |
| asiatic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| valdecoxib | Ovis aries (sheep) | IC50 | 128.6000 | 2 | 2 |
| kadsurenone | Ovis aries (sheep) | IC50 | 25.6000 | 1 | 1 |
| mk 0663 | Ovis aries (sheep) | IC50 | 30.0000 | 1 | 1 |
| ml-3000 | Ovis aries (sheep) | IC50 | 0.1850 | 2 | 2 |
| enkephalin-leu, des-tyr(1)- | Ovis aries (sheep) | IC50 | 10.0000 | 1 | 1 |
| n-(3,4,5-trichlorophenyl)succinimide | Ovis aries (sheep) | IC50 | 100.0000 | 1 | 1 |
| naproxen | Ovis aries (sheep) | IC50 | 15.8821 | 9 | 10 |
| didesipramine | Ovis aries (sheep) | Ki | 0.3970 | 1 | 1 |
| boswellic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| erlotinib | Ovis aries (sheep) | IC50 | 10.0000 | 1 | 1 |
| 1-methyl-6-methoxy-dihydro-beta-carboline | Ovis aries (sheep) | IC50 | 4.0000 | 1 | 1 |
| resveratrol | Ovis aries (sheep) | IC50 | 2.0250 | 4 | 4 |
| boswellic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| propolin c | Ovis aries (sheep) | IC50 | 1.8000 | 1 | 1 |
| caffeic acid | Ovis aries (sheep) | IC50 | 3.0000 | 1 | 1 |
| curcumin | Ovis aries (sheep) | IC50 | 63.8350 | 1 | 2 |
| urb 597 | Ovis aries (sheep) | IC50 | 100.0000 | 1 | 1 |
| sulindac | Ovis aries (sheep) | IC50 | 16.0000 | 1 | 1 |
| l 663536 | Ovis aries (sheep) | IC50 | 5.3367 | 3 | 3 |
| sc 560 | Ovis aries (sheep) | IC50 | 0.0279 | 8 | 8 |
| diclofenac sodium | Ovis aries (sheep) | IC50 | 2.6367 | 9 | 9 |
| luteolin | Ovis aries (sheep) | IC50 | 3.2000 | 1 | 1 |
| baicalein | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 1 |
| chrysin | Ovis aries (sheep) | IC50 | 39.3000 | 1 | 1 |
| morusin | Ovis aries (sheep) | IC50 | 100.0000 | 1 | 1 |
| Licarin A | Ovis aries (sheep) | IC50 | 312.0000 | 1 | 1 |
| onapristone | Ovis aries (sheep) | IC50 | 0.0028 | 2 | 2 |
| sulindac sulfide | Ovis aries (sheep) | IC50 | 0.0500 | 1 | 1 |
| 3,4',5-trimethoxystilbene | Ovis aries (sheep) | IC50 | 1.2280 | 1 | 1 |
| 4',7,8-trihydroxyisoflavone | Ovis aries (sheep) | IC50 | 150.0000 | 1 | 2 |
| mimulone | Ovis aries (sheep) | IC50 | 3.7000 | 1 | 1 |
| bwa 4c | Ovis aries (sheep) | IC50 | 0.0100 | 1 | 1 |
| acuminatin | Ovis aries (sheep) | IC50 | 223.0000 | 1 | 1 |
| licarin b | Ovis aries (sheep) | IC50 | 289.0000 | 1 | 1 |
| ci 987 | Ovis aries (sheep) | IC50 | 42.0000 | 1 | 1 |
| corosolic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| 4-(5-(4-fluorophenyl)-3-(trifluoromethyl)-1h-pyrazol-1-yl)benzenesulfonamide | Ovis aries (sheep) | IC50 | 25.7040 | 1 | 1 |
| 11-keto-boswellic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| sc 236 | Ovis aries (sheep) | IC50 | 17.7828 | 1 | 1 |
| sb 210313 | Ovis aries (sheep) | IC50 | 100.0000 | 1 | 1 |
| 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole | Ovis aries (sheep) | IC50 | 26.6667 | 3 | 3 |
| 9-(aminomethyl)-9,10-dihydroanthracene | Ovis aries (sheep) | Ki | 0.0200 | 1 | 1 |
| dysinosin a | Ovis aries (sheep) | Ki | 0.4520 | 1 | 1 |
| acetyl-11-ketoboswellic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| barettin | Ovis aries (sheep) | Ki | 10.0000 | 1 | 1 |
| 3-o-acetyl-beta-boswellic acid | Ovis aries (sheep) | IC50 | 40.0000 | 1 | 1 |
| boeravinone e | Ovis aries (sheep) | IC50 | 23.9000 | 1 | 1 |
| 11-deoxy glycyrrhetinic acid | Ovis aries (sheep) | IC50 | 42.0000 | 1 | 1 |
| roburic acid | Ovis aries (sheep) | IC50 | 10.0000 | 2 | 2 |
| boeravinone b | Ovis aries (sheep) | IC50 | 25.0000 | 1 | 1 |
| beta-Elemonic acid | Ovis aries (sheep) | IC50 | 10.0000 | 1 | 1 |
| ys 121 | Ovis aries (sheep) | IC50 | 0.0100 | 1 | 1 |
| 4'-geranyloxyferulic acid | Ovis aries (sheep) | IC50 | 54.2000 | 1 | 1 |
| cinerin c | Ovis aries (sheep) | IC50 | 28.3000 | 1 | 1 |
| N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide | Ovis aries (sheep) | IC50 | 100.0000 | 1 | 1 |
| cinerin a | Ovis aries (sheep) | IC50 | 165.0000 | 1 | 1 |
| piroxicam | Ovis aries (sheep) | IC50 | 21.0000 | 1 | 2 |
Drugs with Activation Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| indomethacin | Ovis aries (sheep) | Kinact | 3.9000 | 1 | 1 |
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Human disorders associated with inflammation and the evolving role of natural products to overcome.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.Journal of natural products, , 09-22, Volume: 80, Issue:9, 2017
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.Bioorganic chemistry, , Volume: 63, 2015
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.ACS medicinal chemistry letters, , Oct-08, Volume: 6, Issue:10, 2015
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.Chemical biology & drug design, , Volume: 86, Issue:1, 2015
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2.Journal of natural products, , Nov-29, Volume: 73, Issue:11, 2010
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 20, Issue:4, 2010
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:3, 2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 15, Issue:18, 2007
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.Journal of natural products, , Volume: 68, Issue:1, 2005
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.Journal of medicinal chemistry, , Nov-19, Volume: 41, Issue:24, 1998
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.Journal of medicinal chemistry, , Oct-25, Volume: 55, Issue:20, 2012
SAR studies of acidic dual γ-secretase/PPARγ modulators.Bioorganic & medicinal chemistry, , Sep-15, Volume: 19, Issue:18, 2011
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Synthetic methodology-enabled discovery of a tunable indole template for COX-1 inhibition and anti-cancer activity.Bioorganic & medicinal chemistry, , 03-01, Volume: 57, 2022
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents Journal of medicinal chemistry, , 07-08, Volume: 64, Issue:13, 2021
Development of Fluorescence Imaging Probes for Labeling COX-1 in Live Ovarian Cancer Cells.ACS medicinal chemistry letters, , May-13, Volume: 12, Issue:5, 2021
Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.Bioorganic & medicinal chemistry, , 02-15, Volume: 32, 2021
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.European journal of medicinal chemistry, , Nov-15, Volume: 224, 2021
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Discovery of pyrazole N-aryl sulfonate: A novel and highly potent cyclooxygenase-2 (COX-2) selective inhibitors.Bioorganic & medicinal chemistry, , 09-15, Volume: 46, 2021
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.Bioorganic & medicinal chemistry, , 01-15, Volume: 28, Issue:2, 2020
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
[no title available]Bioorganic & medicinal chemistry letters, , 06-01, Volume: 30, Issue:11, 2020
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.European journal of medicinal chemistry, , Jun-01, Volume: 171, 2019
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
[no title available]European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
[no title available]Journal of medicinal chemistry, , 07-11, Volume: 62, Issue:13, 2019
[no title available]European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Synthesis, in vitro and in vivo biological evaluation, COX-1/2 inhibition and molecular docking study of indole-N-acylhydrazone derivatives.Bioorganic & medicinal chemistry, , 11-01, Volume: 26, Issue:20, 2018
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Design, synthesis, anti-inflammatory activity and molecular docking of potential novel antipyrine and pyrazolone analogs as cyclooxygenase enzyme (COX) inhibitors.Bioorganic & medicinal chemistry letters, , 03-01, Volume: 28, Issue:5, 2018
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Synthesis, in vitro and in silico evaluation of novel trans-stilbene analogues as potential COX-2 inhibitors.Bioorganic & medicinal chemistry, , 01-01, Volume: 26, Issue:1, 2018
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.Bioorganic & medicinal chemistry, , 02-15, Volume: 26, Issue:4, 2018
Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.Bioorganic chemistry, , Volume: 72, 2017
In vivo anti-inflammatory activity and docking study of newly synthesized benzimidazole derivatives bearing oxadiazole and morpholine rings.Bioorganic chemistry, , Volume: 70, 2017
[no title available]Bioorganic chemistry, , Volume: 70, 2017
[no title available]European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
[no title available]Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.Bioorganic & medicinal chemistry, , 08-15, Volume: 25, Issue:16, 2017
Novel 2-phenyl-4,5,6,7-tetrahydro[b]benzothiophene analogues as selective COX-2 inhibitors: Design, synthesis, anti-inflammatory evaluation, and molecular docking studies.Bioorganic & medicinal chemistry letters, , 04-15, Volume: 27, Issue:8, 2017
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
[no title available]Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids.Bioorganic & medicinal chemistry letters, , 09-15, Volume: 27, Issue:18, 2017
[no title available]Bioorganic chemistry, , Volume: 72, 2017
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.Bioorganic chemistry, , Volume: 72, 2017
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.Bioorganic chemistry, , Volume: 69, 2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Design and synthesis of [(125)I]Pyricoxib: A novel (125)I-labeled cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 26, Issue:6, 2016
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Structure-activity relationship of novel series of 1,5-disubstituted tetrazoles as cyclooxygenase-2 inhibitors: Design, synthesis, bioassay screening and molecular docking studies.Bioorganic & medicinal chemistry letters, , 10-01, Volume: 26, Issue:19, 2016
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.Journal of medicinal chemistry, , 04-28, Volume: 59, Issue:8, 2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.Bioorganic & medicinal chemistry, , May-01, Volume: 24, Issue:9, 2016
Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.European journal of medicinal chemistry, , Jun-10, Volume: 115, 2016
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Design, synthesis and biological screening of new 4-thiazolidinone derivatives with promising COX-2 selectivity, anti-inflammatory activity and gastric safety profile.Bioorganic chemistry, , Volume: 64, 2016
1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.Bioorganic chemistry, , Volume: 63, 2015
Five new phorbol esters with cytotoxic and selective anti-inflammatory activities from Croton tiglium.Bioorganic & medicinal chemistry letters, , May-01, Volume: 25, Issue:9, 2015
Novel (pyrazolyl)benzenesulfonamides with a nitric oxide-releasing moiety as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 25, Issue:16, 2015
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Dicarabrol, a new dimeric sesquiterpene from Carpesium abrotanoides L.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 25, Issue:19, 2015
Compounds from the insect Blaps japanensis with COX-1 and COX-2 inhibitory activities.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 25, Issue:12, 2015
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of novel triarylpyrazoline derivatives as selective COX-2 inhibitors.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 25, Issue:24, 2015
Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents.Chemical biology & drug design, , Volume: 84, Issue:4, 2014
Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study.Chemical biology & drug design, , Volume: 84, Issue:4, 2014
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 22, Issue:7, 2014
Celecoxib analogs bearing benzofuran moiety as cyclooxygenase-2 inhibitors: design, synthesis and evaluation as potential anti-inflammatory agents.European journal of medicinal chemistry, , Apr-09, Volume: 76, 2014
Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.European journal of medicinal chemistry, , Oct-30, Volume: 86, 2014
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.ACS medicinal chemistry letters, , Sep-11, Volume: 5, Issue:9, 2014
2-(2-Arylphenyl)benzoxazole As a Novel Anti-Inflammatory Scaffold: Synthesis and Biological Evaluation.ACS medicinal chemistry letters, , May-08, Volume: 5, Issue:5, 2014
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 22, Issue:2, 2014
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
1,4-Diaryl-substituted triazoles as cyclooxygenase-2 inhibitors: Synthesis, biological evaluation and molecular modeling studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 21, Issue:14, 2013
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Radiosynthesis of a ¹⁸F-labeled 2,3-diarylsubstituted indole via McMurry coupling for functional characterization of cyclooxygenase-2 (COX-2) in vitro and in vivo.Bioorganic & medicinal chemistry, , Jun-01, Volume: 20, Issue:11, 2012
Synthesis and evaluation of fluorobenzoylated di- and tripeptides as inhibitors of cyclooxygenase-2 (COX-2).Bioorganic & medicinal chemistry, , Apr-01, Volume: 20, Issue:7, 2012
Fragment-based design, docking, synthesis, biological evaluation and structure-activity relationships of 2-benzo/benzisothiazolimino-5-aryliden-4-thiazolidinones as cycloxygenase/lipoxygenase inhibitors.European journal of medicinal chemistry, , Volume: 47, Issue:1, 2012
Novel 5-substituted 1H-tetrazoles as cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 22, Issue:21, 2012
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.Bioorganic & medicinal chemistry, , May-15, Volume: 20, Issue:10, 2012
Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:6, 2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Synthesis and evaluation of 1,5-diaryl-substituted tetrazoles as novel selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 21, Issue:6, 2011
[I]-Celecoxib Analogues as SPECT Tracers of Cyclooxygenase-2 in Inflammation.ACS medicinal chemistry letters, , Feb-10, Volume: 2, Issue:2, 2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 20, Issue:4, 2010
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Triaryl (Z)-olefins suitable for radiolabeling with carbon-11 or fluorine-18 radionuclides for positron emission tomography imaging of cyclooxygenase-2 expression in pathological disease.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 20, Issue:17, 2010
Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.European journal of medicinal chemistry, , Volume: 44, Issue:9, 2009
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 17, Issue:15, 2009
Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 18, Issue:4, 2008
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
'Bridged' stilbene derivatives as selective cyclooxygenase-1 inhibitors.Bioorganic & medicinal chemistry, , Sep-15, Volume: 15, Issue:18, 2007
Design, synthesis, and biological evaluation of substituted 2-alkylthio-1,5-diarylimidazoles as selective COX-2 inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 15, Issue:5, 2007
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and rofecoxib as selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 14, Issue:19, 2004
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-29, Volume: 47, Issue:16, 2004
Polar substitutions in the benzenesulfonamide ring of celecoxib afford a potent 1,5-diarylpyrazole class of COX-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jan-19, Volume: 14, Issue:2, 2004
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Inhibitory mode of 1,5-diarylpyrazole derivatives against cyclooxygenase-2 and cyclooxygenase-1: molecular docking and 3D QSAR analyses.Journal of medicinal chemistry, , Oct-24, Volume: 45, Issue:22, 2002
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents Journal of medicinal chemistry, , 07-08, Volume: 64, Issue:13, 2021
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.Bioorganic & medicinal chemistry, , 01-15, Volume: 28, Issue:2, 2020
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.Bioorganic & medicinal chemistry, , 08-15, Volume: 25, Issue:16, 2017
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
Rational Design of Small Peptides for Optimal Inhibition of Cyclooxygenase-2: Development of a Highly Effective Anti-Inflammatory Agent.Journal of medicinal chemistry, , 04-28, Volume: 59, Issue:8, 2016
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.ACS medicinal chemistry letters, , Sep-11, Volume: 5, Issue:9, 2014
Design and synthesis of novel 2-phenyl-5-(1,3-diphenyl-1H-pyrazol-4-yl)-1,3,4-oxadiazoles as selective COX-2 inhibitors with potent anti-inflammatory activity.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.The Journal of biological chemistry, , Jun-01, Volume: 282, Issue:22, 2007
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Novel 1,3,4-oxadiazole/oxime hybrids: Synthesis, docking studies and investigation of anti-inflammatory, ulcerogenic liability and analgesic activities.Bioorganic chemistry, , Volume: 69, 2016
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
Structure-based design of COX-2 selectivity into flurbiprofen.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Potent multitarget FAAH-COX inhibitors: Design and structure-activity relationship studies.European journal of medicinal chemistry, , Feb-15, Volume: 109, 2016
In silico search for multi-target anti-inflammatories in Chinese herbs and formulas.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004
Structure-based design of COX-2 selectivity into flurbiprofen.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Synthesis, Inhibitory Activity, and ACS medicinal chemistry letters, , Apr-08, Volume: 12, Issue:4, 2021
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.Journal of natural products, , 07-26, Volume: 82, Issue:7, 2019
Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Synthesis, biological evaluation and docking study of a new series of di-substituted benzoxazole derivatives as selective COX-2 inhibitors and anti-inflammatory agents.Bioorganic & medicinal chemistry, , 02-15, Volume: 26, Issue:4, 2018
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.Journal of natural products, , 09-22, Volume: 80, Issue:9, 2017
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
Synthesis, cyclooxygenase inhibition, anti-inflammatory evaluation and ulcerogenic liability of new 1,3,5-triarylpyrazoline and 1,5-diarylpyrazole derivatives as selective COX-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 26, Issue:2, 2016
1-(4-Methane(amino)sulfonylphenyl)-3-(4-substituted-phenyl)-5-(4-trifluoromethylphenyl)-1H-2-pyrazolines/pyrazoles as potential anti-inflammatory agents.Bioorganic chemistry, , Volume: 63, 2015
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.ACS medicinal chemistry letters, , Oct-08, Volume: 6, Issue:10, 2015
Enzymatic Studies of Isoflavonoids as Selective and Potent Inhibitors of Human Leukocyte 5-Lipo-Oxygenase.Chemical biology & drug design, , Volume: 86, Issue:1, 2015
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.ACS medicinal chemistry letters, , Sep-11, Volume: 5, Issue:9, 2014
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Identification and characterization of carprofen as a multitarget fatty acid amide hydrolase/cyclooxygenase inhibitor.Journal of medicinal chemistry, , Oct-25, Volume: 55, Issue:20, 2012
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.Journal of medicinal chemistry, , Mar-10, Volume: 54, Issue:5, 2011
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
SAR studies of acidic dual γ-secretase/PPARγ modulators.Bioorganic & medicinal chemistry, , Sep-15, Volume: 19, Issue:18, 2011
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 20, Issue:3, 2010
Celecoxib prodrugs possessing a diazen-1-ium-1,2-diolate nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 20, Issue:15, 2010
Synthesis and biological evaluation of N-difluoromethyl-1,2-dihydropyrid-2-one acetic acid regioisomers: dual inhibitors of cyclooxygenases and 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 20, Issue:7, 2010
Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 20, Issue:4, 2010
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-carboxymethylphenyl)-1-(4-methanesulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its aminosulfonyl analog: Synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 15, Issue:7, 2005
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
Manipulation of kinetic profiles in 2-aryl propionic acid cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Synthetic methodology-enabled discovery of a tunable indole template for COX-1 inhibition and anti-cancer activity.Bioorganic & medicinal chemistry, , 03-01, Volume: 57, 2022
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents Journal of medicinal chemistry, , 07-08, Volume: 64, Issue:13, 2021
Synthesis and computational studies of novel fused pyrimidinones as a promising scaffold with analgesic, anti-inflammatory and COX inhibitory potential.European journal of medicinal chemistry, , Nov-15, Volume: 224, 2021
Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats.Bioorganic & medicinal chemistry, , 01-15, Volume: 28, Issue:2, 2020
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
Shooting three inflammatory targets with a single bullet: Novel multi-targeting anti-inflammatory glitazones.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Bioisosteres of Indomethacin as Inhibitors of Aldo-Keto Reductase 1C3.ACS medicinal chemistry letters, , Apr-11, Volume: 10, Issue:4, 2019
[no title available]European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
[no title available]Journal of medicinal chemistry, , 07-11, Volume: 62, Issue:13, 2019
Novel click modifiable thioquinazolinones as anti-inflammatory agents: Design, synthesis, biological evaluation and docking study.European journal of medicinal chemistry, , Jan-20, Volume: 144, 2018
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Tailoring the Substitution Pattern on 1,3,5-Triazine for Targeting Cyclooxygenase-2: Discovery and Structure-Activity Relationship of Triazine-4-Aminophenylmorpholin-3-one Hybrids that Reverse Algesia and Inflammation in Swiss Albino Mice.Journal of medicinal chemistry, , 09-13, Volume: 61, Issue:17, 2018
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
[no title available]Bioorganic & medicinal chemistry, , 10-15, Volume: 25, Issue:20, 2017
Synthesis, anti-inflammatory, cyclooxygenases inhibitions assays and histopathological study of poly-substituted 1,3,5-triazines: Confirmation of regiospecific pyrazole cyclization by HMBC.European journal of medicinal chemistry, , Feb-15, Volume: 127, 2017
[no title available]Bioorganic & medicinal chemistry, , 01-15, Volume: 25, Issue:2, 2017
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.Bioorganic chemistry, , Volume: 69, 2016
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.ACS chemical biology, , 11-18, Volume: 11, Issue:11, 2016
1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and β-amyloid aggregation inhibitors: biological evaluation and in silico study.Chemical biology & drug design, , Volume: 85, Issue:4, 2015
Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents.Chemical biology & drug design, , Volume: 85, Issue:6, 2015
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Indole based peptidomimetics as anti-inflammatory and anti-hyperalgesic agents: Dual inhibition of 5-LOX and COX-2 enzymes.European journal of medicinal chemistry, , Jun-05, Volume: 97, 2015
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.ACS medicinal chemistry letters, , Oct-08, Volume: 6, Issue:10, 2015
Effects of novel diarylpentanoid analogues of curcumin on secretory phospholipase A2 , cyclooxygenases, lipo-oxygenase, and microsomal prostaglandin E synthase-1.Chemical biology & drug design, , Volume: 83, Issue:6, 2014
Pharmacological evaluation and docking studies of α,β-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A₂, cyclooxygenases, lipoxygenase and proinflammatory cytokines.Bioorganic & medicinal chemistry, , Aug-01, Volume: 22, Issue:15, 2014
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.European journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Rational design, synthesis and evaluation of chromone-indole and chromone-pyrazole based conjugates: identification of a lead for anti-inflammatory drug.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 24, Issue:19, 2014
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
Rationally designed hybrid molecules with appreciable COX-2 inhibitory and anti-nociceptive activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
The 2'-Trifluoromethyl Analogue of Indomethacin Is a Potent and Selective COX-2 Inhibitor.ACS medicinal chemistry letters, , May-09, Volume: 4, Issue:5, 2013
Development of potent and selective indomethacin analogues for the inhibition of AKR1C3 (Type 5 17β-hydroxysteroid dehydrogenase/prostaglandin F synthase) in castrate-resistant prostate cancer.Journal of medicinal chemistry, , Mar-28, Volume: 56, Issue:6, 2013
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.European journal of medicinal chemistry, , Volume: 65, 2013
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.Journal of medicinal chemistry, , Sep-27, Volume: 55, Issue:18, 2012
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.European journal of medicinal chemistry, , Volume: 57, 2012
N-1 and C-3 substituted indole Schiff bases as selective COX-2 inhibitors: synthesis and biological evaluation.Bioorganic & medicinal chemistry letters, , Mar-15, Volume: 22, Issue:6, 2012
Nitric oxide release is not required to decrease the ulcerogenic profile of nonsteroidal anti-inflammatory drugs.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Synthesis and pharmacological evaluation of N-substituted 2-(2-oxo-2H-chromen-4-yloxy)propanamide as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 22, Issue:21, 2012
Ethanesulfohydroxamic acid ester prodrugs of nonsteroidal anti-inflammatory drugs (NSAIDs): synthesis, nitric oxide and nitroxyl release, cyclooxygenase inhibition, anti-inflammatory, and ulcerogenicity index studies.Journal of medicinal chemistry, , Mar-10, Volume: 54, Issue:5, 2011
SAR studies of acidic dual γ-secretase/PPARγ modulators.Bioorganic & medicinal chemistry, , Sep-15, Volume: 19, Issue:18, 2011
Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Podophyllotoxin analogues active versus Trypanosoma brucei.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 18, Issue:17, 2010
Design, synthesis, and biological evaluation of a novel class of gamma-secretase modulators with PPARgamma activity.Journal of medicinal chemistry, , Jun-24, Volume: 53, Issue:12, 2010
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:5, 2009
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Molecular determinants for the selective inhibition of cyclooxygenase-2 by lumiracoxib.The Journal of biological chemistry, , Jun-01, Volume: 282, Issue:22, 2007
Structural basis of enantioselective inhibition of cyclooxygenase-1 by S-alpha-substituted indomethacin ethanolamides.The Journal of biological chemistry, , Sep-21, Volume: 282, Issue:38, 2007
Nitrogen-containing phorbol esters from Croton ciliatoglandulifer and their effects on cyclooxygenases-1 and -2.Journal of natural products, , Volume: 69, Issue:6, 2006
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Lanostane triterpenoids and triterpene glycosides from the fruit body of Fomitopsis pinicola and their inhibitory activity against COX-1 and COX-2.Journal of natural products, , Volume: 68, Issue:1, 2005
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
Methanesulfonamide group at position-4 of the C-5-phenyl ring of 1,5-diarylpyrazole affords a potent class of cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
Synthesis and cyclooxygenase-2 inhibiting property of 1,5-diarylpyrazoles with substituted benzenesulfonamide moiety as pharmacophore: Preparation of sodium salt for injectable formulation.Journal of medicinal chemistry, , Sep-11, Volume: 46, Issue:19, 2003
Enantiospecific, selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , May-06, Volume: 12, Issue:9, 2002
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-27, Volume: 43, Issue:15, 2000
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Antiinflammatory 4,5-diarylpyrroles. 2. Activity as a function of cyclooxygenase-2 inhibition.Journal of medicinal chemistry, , Sep-29, Volume: 38, Issue:20, 1995
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Synthesis and Evaluation of Novel Erlotinib-NSAID Conjugates as More Comprehensive Anticancer Agents.ACS medicinal chemistry letters, , Oct-08, Volume: 6, Issue:10, 2015
Propyphenazone-based analogues as prodrugs and selective cyclooxygenase-2 inhibitors.ACS medicinal chemistry letters, , Sep-11, Volume: 5, Issue:9, 2014
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
An attempt to chemically state the cross-talk between monomers of COX homodimers by double/hybrid inhibitors mofezolac-spacer-mofezolac and mofezolac-spacer-arachidonic acid.European journal of medicinal chemistry, , Jan-01, Volume: 209, 2021
Translational impact of novel widely pharmacological characterized mofezolac-derived COX-1 inhibitors combined with bortezomib on human multiple myeloma cell lines viability.European journal of medicinal chemistry, , Feb-15, Volume: 164, 2019
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Biochemically based design of cyclooxygenase-2 (COX-2) inhibitors: facile conversion of nonsteroidal antiinflammatory drugs to potent and highly selective COX-2 inhibitors.Proceedings of the National Academy of Sciences of the United States of America, , Jan-18, Volume: 97, Issue:2, 2000
Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-27, Volume: 43, Issue:15, 2000
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Synthesis, structure determination, and biological evaluation of phenylsulfonyl hydrazide derivatives as potential anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , 11-01, Volume: 26, Issue:21, 2016
1,2-Diaryl-2-hydroxyiminoethanones as dual COX-1 and β-amyloid aggregation inhibitors: biological evaluation and in silico study.Chemical biology & drug design, , Volume: 85, Issue:4, 2015
Novel thiazolo[3,2-b]-1,2,4-triazoles derived from naproxen with analgesic/anti-inflammatory properties: Synthesis, biological evaluation and molecular modeling studies.Bioorganic & medicinal chemistry, , May-15, Volume: 23, Issue:10, 2015
Synthesis, biological evaluation, and docking analysis of a novel family of 1-methyl-1H-pyrrole-2,5-diones as highly potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-15, Volume: 24, Issue:8, 2014
1-(4-Methoxyphenyl)-5-(3,4,5-trimethoxyphenyl)-1H-1,2,4-triazole-3-carboxamides: synthesis, molecular modeling, evaluation of their anti-inflammatory activity and ulcerogenicity.European journal of medicinal chemistry, , Apr-22, Volume: 77, 2014
Molecular modeling, synthesis and screening of some new 4-thiazolidinone derivatives with promising selective COX-2 inhibitory activity.European journal of medicinal chemistry, , Volume: 57, 2012
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Amide derivatives of meclofenamic acid as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Feb-25, Volume: 12, Issue:4, 2002
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Structure-based design of COX-2 selectivity into flurbiprofen.Bioorganic & medicinal chemistry letters, , Feb-08, Volume: 9, Issue:3, 1999
Hydroxytriazole derivatives as potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors discovered by bioisosteric scaffold hopping approach.European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
Structure-activity relationship of celecoxib and rofecoxib for the membrane permeabilizing activity.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
Design of Fluorine-Containing 3,4-Diarylfuran-2(5H)-ones as Selective COX-1 Inhibitors.ACS medicinal chemistry letters, , Nov-13, Volume: 5, Issue:11, 2014
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
A diazen-1-ium-1,2-diolated nitric oxide donor ester prodrug of 3-(4-hydroxymethylphenyl)-4-(4-methanesulfonylphenyl)-5H-furan-2-one: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jul-01, Volume: 21, Issue:13, 2011
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 18, Issue:17, 2010
Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:5, 2009
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Synthesis and biological evaluation of methanesulfonamide analogues of rofecoxib: Replacement of methanesulfonyl by methanesulfonamido decreases cyclooxygenase-2 selectivity.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases.Bioorganic & medicinal chemistry letters, , Nov-01, Volume: 15, Issue:21, 2005
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 14, Issue:19, 2004
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-29, Volume: 47, Issue:16, 2004
Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-06, Volume: 46, Issue:23, 2003
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors.ACS chemical biology, , 11-18, Volume: 11, Issue:11, 2016
Podophyllotoxin analogues active versus Trypanosoma brucei.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 20, Issue:5, 2010
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.European journal of medicinal chemistry, , Oct-15, Volume: 204, 2020
Methyl-monofluorination of ibuprofen selectively increases its inhibitory activity toward cyclooxygenase-1 leading to enhanced analgesic activity and reduced gastric damage in vivo.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 21, Issue:12, 2011
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.Journal of medicinal chemistry, , Apr-08, Volume: 42, Issue:7, 1999
Novel valdecoxib derivatives by ruthenium(ii)-promoted 1,3-dipolar cycloaddition of nitrile oxides with alkynes - synthesis and COX-2 inhibition activity.MedChemComm, , Mar-01, Volume: 9, Issue:3, 2018
New celecoxib derivatives as anti-inflammatory agents.Journal of medicinal chemistry, , Jan-10, Volume: 51, Issue:1, 2008
Design, Synthesis, and Activity Evaluation of Stereoconfigured Tartarate Derivatives as Potential Anti-inflammatory Agents Journal of medicinal chemistry, , 07-08, Volume: 64, Issue:13, 2021
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity.Bioorganic & medicinal chemistry, , 08-15, Volume: 25, Issue:16, 2017
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Lipid Peroxidation and Cyclooxygenase Enzyme Inhibitory Compounds from Prangos haussknechtii.Journal of natural products, , 09-22, Volume: 80, Issue:9, 2017
Discovery of (R)-2-(6-Methoxynaphthalen-2-yl)butanoic Acid as a Potent and Selective Aldo-keto Reductase 1C3 Inhibitor.Journal of medicinal chemistry, , 08-25, Volume: 59, Issue:16, 2016
Hybrid fluorescent conjugates of COX-2 inhibitors: search for a COX-2 isozyme imaging cancer biomarker.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 23, Issue:1, 2013
Synthesis and biological evaluation of some 5-arylidene-2-(1,3-thiazol-2-ylimino)-1,3-thiazolidin-4-ones as dual anti-inflammatory/antimicrobial agents.Bioorganic & medicinal chemistry, , Jan-15, Volume: 21, Issue:2, 2013
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Design of balanced COX inhibitors based on anti-inflammatory and/or COX-2 inhibitory ascidian metabolites.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
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Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.European journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Synthesis and biological evaluation of isoxazolo[4,5-d]pyridazin-4-(5H)-one analogues as potent anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-01, Volume: 20, Issue:9, 2012
[no title available]European journal of medicinal chemistry, , Jul-05, Volume: 219, 2021
Novel class of benzimidazole-thiazole hybrids: The privileged scaffolds of potent anti-inflammatory activity with dual inhibition of cyclooxygenase and 15-lipoxygenase enzymes.Bioorganic & medicinal chemistry, , 04-01, Volume: 28, Issue:7, 2020
Expanding the anticancer potential of 1,2,3-triazoles via simultaneously targeting Cyclooxygenase-2, 15-lipoxygenase and tumor-associated carbonic anhydrases.European journal of medicinal chemistry, , Aug-15, Volume: 200, 2020
New oxadiazoles with selective-COX-2 and EGFR dual inhibitory activity: Design, synthesis, cytotoxicity evaluation and in silico studies.European journal of medicinal chemistry, , Dec-01, Volume: 183, 2019
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Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.Bioorganic & medicinal chemistry, , May-15, Volume: 20, Issue:10, 2012
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