Proteins > Solute carrier family 22 member 8
Page last updated: 2024-08-07 18:46:47
Solute carrier family 22 member 8
An organic anion transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCC7]
Synonyms
Organic anion transporter 3;
hOAT3
Research
Bioassay Publications (23)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (65.22) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
Compounds (50)
Drugs with Inhibition Measurements
Drugs with Other Measurements
Is the monkey an appropriate animal model to examine drug-drug interactions involving renal clearance? Effect of probenecid on the renal elimination of H2 receptor antagonists.The Journal of pharmacology and experimental therapeutics, , Volume: 316, Issue:3, 2006
Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A).European journal of pharmacology, , Oct-25, Volume: 503, Issue:1-3, 2004
Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.Journal of pharmacological sciences, , Volume: 94, Issue:2, 2004
Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney.Molecular pharmacology, , Volume: 59, Issue:5, 2001
Pharmacological urate-lowering approaches in chronic kidney disease.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Interactions of human- and rat-organic anion transporters with pravastatin and cimetidine.Journal of pharmacological sciences, , Volume: 94, Issue:2, 2004
Characterization of methotrexate transport and its drug interactions with human organic anion transporters.The Journal of pharmacology and experimental therapeutics, , Volume: 302, Issue:2, 2002
Characterization of organic anion transport inhibitors using cells stably expressing human organic anion transporters.European journal of pharmacology, , May-11, Volume: 419, Issue:2-3, 2001
Characterization of ochratoxin A transport by human organic anion transporters.Life sciences, , Sep-21, Volume: 69, Issue:18, 2001
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|
| solute:inorganic anion antiporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah] |
| organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai] |
| prostaglandin transmembrane transporter activity | molecular function | Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai] |
| xenobiotic transmembrane transporter activity | molecular function | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| inorganic anion transport | biological process | The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc] |
| prostaglandin transport | biological process | The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| xenobiotic transport | biological process | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |