Page last updated: 2024-08-07 18:46:47
Solute carrier family 22 member 8
An organic anion transporter 3 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCC7]
Synonyms
Organic anion transporter 3;
hOAT3
Research
Bioassay Publications (23)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 15 (65.22) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 1 (4.35) | 2.80 |
Compounds (50)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| salicylic acid | Homo sapiens (human) | Ki | 1,020.0000 | 1 | 1 |
| octanoic acid | Homo sapiens (human) | Ki | 8.6000 | 1 | 1 |
| hippuric acid | Homo sapiens (human) | Ki | 31.0000 | 1 | 1 |
| uric acid | Homo sapiens (human) | Ki | 275.0000 | 1 | 1 |
| p-aminohippuric acid | Homo sapiens (human) | Ki | 19.6000 | 1 | 1 |
| cimetidine | Homo sapiens (human) | IC50 | 92.4000 | 1 | 1 |
| cimetidine | Homo sapiens (human) | Ki | 53.0000 | 1 | 1 |
| ibuprofen | Homo sapiens (human) | Ki | 1,170.0000 | 1 | 1 |
| indomethacin | Homo sapiens (human) | Ki | 5.9500 | 1 | 1 |
| ketoprofen | Homo sapiens (human) | Ki | 1,160.0000 | 1 | 1 |
| phenylbutazone | Homo sapiens (human) | Ki | 34.7000 | 1 | 1 |
| probenecid | Homo sapiens (human) | IC50 | 6.9650 | 2 | 2 |
| probenecid | Homo sapiens (human) | Ki | 14.4033 | 3 | 3 |
| cephaloridine | Homo sapiens (human) | Ki | 2.4600 | 1 | 1 |
| penicillin g | Homo sapiens (human) | Ki | 97.6000 | 1 | 1 |
| cephalothin | Homo sapiens (human) | Ki | 0.0400 | 1 | 1 |
| indican | Homo sapiens (human) | Ki | 168.8500 | 2 | 2 |
| 2,2-dimethylbutyric acid | Homo sapiens (human) | IC50 | 3,511.0000 | 1 | 1 |
| indoxyl acetate | Homo sapiens (human) | Ki | 491.0000 | 1 | 1 |
| cefazolin | Homo sapiens (human) | Ki | 0.5500 | 1 | 1 |
| cefoperazone | Homo sapiens (human) | Ki | 1.8900 | 1 | 1 |
| cefadroxil anhydrous | Homo sapiens (human) | Ki | 8.6200 | 2 | 2 |
| cefaclor anhydrous | Homo sapiens (human) | IC50 | 120.0000 | 1 | 1 |
| pravastatin | Homo sapiens (human) | IC50 | 13.7000 | 1 | 1 |
| rolofylline | Homo sapiens (human) | Ki | 3.7000 | 1 | 1 |
| betamipron | Homo sapiens (human) | IC50 | 9.9200 | 1 | 1 |
| betamipron | Homo sapiens (human) | Ki | 48.3000 | 1 | 1 |
| juncusol | Homo sapiens (human) | IC50 | 6.5000 | 1 | 1 |
| effusol | Homo sapiens (human) | IC50 | 22.7000 | 1 | 1 |
| ym 872 | Homo sapiens (human) | IC50 | 6.6000 | 1 | 1 |
| cefamandole | Homo sapiens (human) | Ki | 0.0460 | 1 | 1 |
| fosbretabulin | Homo sapiens (human) | IC50 | 16.3900 | 1 | 1 |
| ceftriaxone | Homo sapiens (human) | Ki | 4.3900 | 1 | 1 |
| famotidine | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| cefotaxime | Homo sapiens (human) | Ki | 0.2900 | 1 | 1 |
| cilastatin | Homo sapiens (human) | IC50 | 249.0000 | 1 | 1 |
| cilastatin | Homo sapiens (human) | Ki | 231.0000 | 1 | 1 |
| linagliptin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| piroxicam | Homo sapiens (human) | Ki | 602.4400 | 2 | 2 |
| citrinin | Homo sapiens (human) | Ki | 15.4000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| p-aminohippuric acid | Homo sapiens (human) | Km | 87.2000 | 1 | 1 |
| cimetidine | Homo sapiens (human) | Km | 103.2000 | 2 | 2 |
| ranitidine | Homo sapiens (human) | Km | 234.0000 | 1 | 1 |
| indican | Homo sapiens (human) | Km | 263.0000 | 1 | 1 |
| zidovudine | Homo sapiens (human) | Km | 145.1000 | 1 | 1 |
| adefovir | Homo sapiens (human) | Km | 1,220.0000 | 1 | 1 |
| 3-carboxy-4-methyl-5-propyl-2-furanpropionic acid | Homo sapiens (human) | Km | 27.0000 | 1 | 1 |
| methotrexate | Homo sapiens (human) | Km | 16.0000 | 2 | 2 |
| ochratoxin a | Homo sapiens (human) | Km | 0.7500 | 1 | 1 |
| tenofovir | Homo sapiens (human) | Km | 770.0000 | 1 | 1 |
| estrone sulfate | Homo sapiens (human) | Km | 10.0500 | 2 | 2 |
| dinoprostone | Homo sapiens (human) | Km | 0.3450 | 1 | 1 |
| dinoprost | Homo sapiens (human) | Km | 1.0920 | 1 | 1 |
| famotidine | Homo sapiens (human) | Km | 124.0000 | 1 | 1 |
| gs-9148 | Homo sapiens (human) | Km | 1,216.0000 | 1 | 1 |
| tetracycline | Homo sapiens (human) | Km | 566.2000 | 1 | 1 |
| acyclovir | Homo sapiens (human) | Km | 772.0000 | 1 | 1 |
| valacyclovir | Homo sapiens (human) | Km | 57.9000 | 1 | 1 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| solute:inorganic anion antiporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion(out) + solute(in) = inorganic anion (in) + solute(out). [GOC:mah] |
| organic anion transmembrane transporter activity | molecular function | Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage. [GOC:ai] |
| prostaglandin transmembrane transporter activity | molecular function | Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities. [GOC:ai] |
| xenobiotic transmembrane transporter activity | molecular function | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
Located In
This protein is located in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| monoatomic ion transport | biological process | The directed movement of a monoatomic ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:ai] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| inorganic anion transport | biological process | The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage. [GOC:krc] |
| prostaglandin transport | biological process | The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:krc] |
| xenobiotic transport | biological process | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |