Proteins > Solute carrier family 15 member 1
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Solute carrier family 15 member 1
A solute carrier family 15 member 1 that is encoded in the genome of rat. [OMA:P51574, PRO:DNx]
Synonyms
Intestinal H(+)/peptide cotransporter;
Oligopeptide transporter, small intestine isoform;
Peptide transporter 1;
Proton-coupled dipeptide cotransporter
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (66.67) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 1 (11.11) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (38)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aminolevulinic acid | Rattus norvegicus (Norway rat) | Ki | 2,200.0000 | 1 | 1 |
| glyburide | Rattus norvegicus (Norway rat) | Ki | 25.0000 | 1 | 1 |
| ampicillin | Rattus norvegicus (Norway rat) | Ki | 47,800.0000 | 1 | 1 |
| glycyl-glycyl-glycine | Rattus norvegicus (Norway rat) | Ki | 1,300.0000 | 1 | 1 |
| glycylglycine | Rattus norvegicus (Norway rat) | Ki | 860.0000 | 1 | 1 |
| cyclacillin | Rattus norvegicus (Norway rat) | Ki | 168.0000 | 1 | 1 |
| cephalexin | Rattus norvegicus (Norway rat) | Ki | 4,500.0000 | 1 | 1 |
| amoxicillin | Rattus norvegicus (Norway rat) | Ki | 13,000.0000 | 1 | 1 |
| cephradine | Rattus norvegicus (Norway rat) | Ki | 8,540.0000 | 1 | 1 |
| captopril | Rattus norvegicus (Norway rat) | Ki | 8,700.0000 | 1 | 1 |
| cefadroxil anhydrous | Rattus norvegicus (Norway rat) | Ki | 2,170.0000 | 1 | 1 |
| omega-aminocaprylic acid | Rattus norvegicus (Norway rat) | Ki | 4,400.0000 | 1 | 1 |
| ubenimex | Rattus norvegicus (Norway rat) | Ki | 1,500.0000 | 1 | 1 |
| tamiflu | Rattus norvegicus (Norway rat) | IC50 | 18,300.0000 | 1 | 1 |
| glycyltryptophan | Rattus norvegicus (Norway rat) | Ki | 1,400.0000 | 1 | 1 |
| glycyltyrosine | Rattus norvegicus (Norway rat) | Ki | 210.0000 | 1 | 1 |
| glycylleucine | Rattus norvegicus (Norway rat) | Ki | 110.0000 | 1 | 1 |
| glycyl-l-phenylalanine | Rattus norvegicus (Norway rat) | Ki | 170.0000 | 1 | 1 |
| glycyl-leucyl-tyrosine | Rattus norvegicus (Norway rat) | Ki | 190.0000 | 1 | 1 |
| glycylaspartic acid | Rattus norvegicus (Norway rat) | Ki | 300.0000 | 1 | 1 |
| beta-aspartylglycine | Rattus norvegicus (Norway rat) | Ki | 50,000.0000 | 1 | 1 |
| lysyllysine | Rattus norvegicus (Norway rat) | Ki | 8,000.0000 | 1 | 1 |
| alanine-4-nitroanilide | Rattus norvegicus (Norway rat) | Ki | 61.0000 | 1 | 1 |
| aspartylglycine | Rattus norvegicus (Norway rat) | Ki | 830.0000 | 1 | 1 |
| carnosine | Rattus norvegicus (Norway rat) | Ki | 8,000.0000 | 1 | 1 |
| aspartyl-aspartic acid | Rattus norvegicus (Norway rat) | Ki | 990.0000 | 1 | 1 |
| glycyllysine | Rattus norvegicus (Norway rat) | Ki | 2,200.0000 | 1 | 1 |
| 7432 s | Rattus norvegicus (Norway rat) | Ki | 597.0000 | 1 | 1 |
| nateglinide | Rattus norvegicus (Norway rat) | IC50 | 160.0000 | 1 | 1 |
| cefixime | Rattus norvegicus (Norway rat) | Ki | 6,920.0000 | 1 | 1 |
| enalapril | Rattus norvegicus (Norway rat) | Ki | 4,300.0000 | 1 | 1 |
| prolylglycine | Rattus norvegicus (Norway rat) | Ki | 13,000.0000 | 1 | 1 |
| cefdinir | Rattus norvegicus (Norway rat) | Ki | 11,900.0000 | 1 | 1 |
| phenylalanylglycine | Rattus norvegicus (Norway rat) | Ki | 220.0000 | 1 | 1 |
| lysylglycine | Rattus norvegicus (Norway rat) | Ki | 910.0000 | 1 | 1 |
| glycylhistidine | Rattus norvegicus (Norway rat) | Ki | 1,400.0000 | 1 | 1 |
| valacyclovir | Rattus norvegicus (Norway rat) | Ki | 2,600.0000 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cephradine | Rattus norvegicus (Norway rat) | Km | 10,300.0000 | 2 | 2 |
| glycylsarcosine | Rattus norvegicus (Norway rat) | Km | 1,080.0000 | 3 | 3 |
| 7432 s | Rattus norvegicus (Norway rat) | Km | 1,200.0000 | 2 | 2 |
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.The American journal of physiology, , Volume: 273, Issue:5, 1997
Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics.The Journal of pharmacology and experimental therapeutics, , Volume: 281, Issue:3, 1997
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.The Journal of pharmacology and experimental therapeutics, , Volume: 275, Issue:3, 1995
Species-dependent uptake of glycylsarcosine but not oseltamivir in Pichia pastoris expressing the rat, mouse, and human intestinal peptide transporter PEPT1.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:7, 2012
Recognition of L-amino acid ester compounds by rat peptide transporters PEPT1 and PEPT2.The Journal of pharmacology and experimental therapeutics, , Volume: 291, Issue:2, 1999
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.The American journal of physiology, , Volume: 273, Issue:5, 1997
Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells.The American journal of physiology, , Volume: 273, Issue:5, 1997
Characterization of stably transfected kidney epithelial cell line expressing rat H+/peptide cotransporter PEPT1: localization of PEPT1 and transport of beta-lactam antibiotics.The Journal of pharmacology and experimental therapeutics, , Volume: 281, Issue:3, 1997
Cloning and characterization of a rat H+/peptide cotransporter mediating absorption of beta-lactam antibiotics in the intestine and kidney.The Journal of pharmacology and experimental therapeutics, , Volume: 275, Issue:3, 1995