Proteins > DNA topoisomerase 4 subunit A
Page last updated: 2024-08-07 12:57:34
DNA topoisomerase 4 subunit A
[no definition available]
Synonyms
EC 5.6.2.2;
Topoisomerase IV subunit A
Research
Bioassay Publications (15)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (20.00) | 29.6817 |
| 2010's | 6 (40.00) | 24.3611 |
| 2020's | 6 (40.00) | 2.80 |
Compounds (6)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ciprofloxacin | Staphylococcus aureus | CC50 | 0.4000 | 1 | 1 |
| gatifloxacin | Staphylococcus aureus | CC50 | 0.2000 | 1 | 1 |
Solid-phase synthesis and biological evaluation of piperazine-based novel bacterial topoisomerase inhibitors.Bioorganic & medicinal chemistry letters, , 02-01, Volume: 57, 2022
1,3-Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Expanding Structural Diversity and the Antibacterial Spectrum.ACS medicinal chemistry letters, , Jun-09, Volume: 13, Issue:6, 2022
Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects.European journal of medicinal chemistry, , Jan-15, Volume: 228, 2022
Optimization of TopoIV Potency, ADMET Properties, and hERG Inhibition of 5-Amino-1,3-dioxane-Linked Novel Bacterial Topoisomerase Inhibitors: Identification of a Lead with Journal of medicinal chemistry, , 10-28, Volume: 64, Issue:20, 2021
Dioxane-Linked Amide Derivatives as Novel Bacterial Topoisomerase Inhibitors against Gram-Positive ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
Virtual Screening Approach and Investigation of Structure-Activity Relationships To Discover Novel Bacterial Topoisomerase Inhibitors Targeting Gram-Positive and Gram-Negative Pathogens.Journal of medicinal chemistry, , 08-22, Volume: 62, Issue:16, 2019
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Design, synthesis, and characterization of novel tetrahydropyran-based bacterial topoisomerase inhibitors with potent anti-gram-positive activity.Journal of medicinal chemistry, , Sep-26, Volume: 56, Issue:18, 2013
Isothiazolopyridones: synthesis, structure, and biological activity of a new class of antibacterial agents.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Development of a Dual-Acting Antibacterial Agent (TNP-2092) for the Treatment of Persistent Bacterial Infections.Journal of medicinal chemistry, , 07-28, Volume: 59, Issue:14, 2016
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Biological evaluation of isothiazoloquinolones containing aromatic heterocycles at the 7-position: In vitro activity of a series of potent antibacterial agents that are effective against methicillin-resistant Staphylococcus aureus.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Isothiazoloquinolones containing functionalized aromatic hydrocarbons at the 7-position: synthesis and in vitro activity of a series of potent antibacterial agents with diminished cytotoxicity in human cells.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 16, Issue:5, 2006
Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors.ACS medicinal chemistry letters, , Dec-10, Volume: 11, Issue:12, 2020
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
New MedChemComm, , Jun-01, Volume: 10, Issue:6, 2019
Discovery of 4,5,6,7-Tetrahydrobenzo[1,2-d]thiazoles as Novel DNA Gyrase Inhibitors Targeting the ATP-Binding Site.Journal of medicinal chemistry, , Jul-23, Volume: 58, Issue:14, 2015