Compounds > n-nitratopivaloyl-s-(n'-acetylalanyl)-cysteine ethyl ester
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n-nitratopivaloyl-s-(n'-acetylalanyl)-cysteine ethyl ester

Description

N-nitratopivaloyl-S-(N'-acetylalanyl)-cysteine ethyl ester: a cysteine-containing NO donor in myocardial ischemia-reperfusion [MeSH]

Cross-References

ID SourceID
PubMed CID5487460
MeSH IDM0206917

Synonyms (8)

Synonym
n-nitratopivaloyl-s-(n'-acetylalanyl)-cysteine ethyl ester
139146-66-0
l-cysteine, n-(2,2-dimethyl-3-(nitrooxy)-1-oxopropyl)-, ethyl ester, ester with n-acetyl-l-alanine
spm-5185
spm 5185
DTXSID80160934
(2s)-2-acetamidopropanoic acid;[3-[[(2r)-1-ethenoxy-3-sulfanylidenepropan-2-yl]amino]-2,2-dimethyl-3-oxopropyl] nitrate
n-nitratopivaloyl-s-(n/'-acetylalanyl)-cysteine ethyl ester

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's16 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (12.50%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other14 (87.50%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
nitrates
1
monovalent inorganic anion;
nitrogen oxoanion;
reactive nitrogen species		1995199529.0low001000
molsidomine
2
ethyl ester;
morpholines;
oxadiazole;
zwitterion		antioxidant;
apoptosis inhibitor;
cardioprotective agent;
nitric oxide donor;
vasodilator agent		1995199728.0low002000
nitroglycerin
3
nitroglycerolexplosive;
muscle relaxant;
nitric oxide donor;
prodrug;
tocolytic agent;
vasodilator agent;
xenobiotic		1995199628.7medium003000
linsidomine
1
morpholines1995199529.0low001000
phenylephrine
1
phenols;
phenylethanolamines;
secondary amino compound		alpha-adrenergic agonist;
cardiotonic drug;
mydriatic agent;
nasal decongestant;
protective agent;
sympathomimetic agent;
vasoconstrictor agent		1997199727.0low001000
arginine
3
arginine;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		biomarker;
Escherichia coli metabolite;
micronutrient;
mouse metabolite;
nutraceutical		1995199728.3medium003000
isosorbide dinitrate
1
glucitol derivative;
nitrate ester		nitric oxide donor;
vasodilator agent		1995199529.0low001000
acetylcysteine
1
acetylcysteine;
L-cysteine derivative;
N-acetyl-L-amino acid		antidote to paracetamol poisoning;
antiinfective agent;
antioxidant;
antiviral drug;
ferroptosis inhibitor;
geroprotector;
human metabolite;
mucolytic;
radical scavenger;
vulnerary		1995199529.0low001000
ng-nitroarginine methyl ester
2
alpha-amino acid ester;
L-arginine derivative;
methyl ester;
N-nitro compound		EC 1.14.13.39 (nitric oxide synthase) inhibitor1995199728.0low002000
n-(3-nitratopivaloyl)cysteine ethyl ester
1
1995199529.0high001000
cysteine
2
cysteiniumfundamental metabolite1992199530.5low002000
mocetinostat
3
aminopyrimidine;
benzamides;
pyridines;
secondary amino compound;
secondary carboxamide;
substituted aniline		antineoplastic agent;
apoptosis inducer;
autophagy inducer;
cardioprotective agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
hepatotoxic agent		1993199530.3medium003000
sodium nitrite
1
inorganic sodium salt;
nitrite salt		antidote to cyanide poisoning;
antihypertensive agent;
antimicrobial food preservative;
food antioxidant;
poison		1993199331.0low001000
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Cardiovascular Diseases0
1
1993199331.0low001000
Carotid Arteriopathies, Traumatic0
1
1994199430.0low001000
Coronary Disease0
1
1992199232.0low001000
Coronary Heart Disease0
1
1992199232.0low001000
Elevated Cholesterol0
1
1997199727.0low001000
Heart Disease, Ischemic0
2
1993199530.0low002000
Hypercholesterolemia0
1
1997199727.0low001000
Injuries0
1
1994199430.0low001000
Injury, Myocardial Reperfusion0
8
1992199529.9high008000
Left Ventricular Dysfunction0
1
1995199529.0low001000
Muscle Contraction0
1
1997199727.0low001000
Muscle Relaxation0
2
1995199529.0low002000
Myocardial Ischemia0
2
1993199530.0low002000
Necrosis0
2
1992199331.5low002000
Sensitivity and Specificity0
1
1995199529.0low001000
Ventricular Dysfunction, Left0
1
1995199529.0low001000
Wounds and Injuries0
1
1994199430.0low001000

Dosage (1)

ArticleYear
Novel organic nitrates are potent dilators of large coronary arteries with reduced development of tolerance during long-term infusion in dogs: role of the sulfhydryl moiety.
Journal of cardiovascular pharmacology, , Volume: 23, Issue:5		1994