carbocyanines

Description

Carbocyanines: Compounds that contain three methine groups. They are frequently used as cationic dyes used for differential staining of biological materials. [MeSH]

pinacyanol iodide : no description available [CHeBI]

Cross-References

ID Source	ID
PubMed CID	5709754
CHEMBL ID	2361697
SCHEMBL ID	58012
MeSH ID	M0003347

Synonyms (19)

Synonym
g 1700
1-ethyl-2-(3-(1-ethyl-2(1h)-quinolylidene)propenyl)quinolinium iodide
nsc 403532
quinolinium, 1-ethyl-2-(3-(1-ethyl-2(1h)-quinolylidene)propenyl)-, iodide
1-ethyl-2-(3-(1-ethyl-2(1h)-quinolylidene)prop-1-enyl)quinolinium iodide
eastman kodak 622
einecs 210-099-4
unii-94623a1122
carbocyanines
94623a1122 ,
quinolinium, 1-ethyl-2-(3-(1-ethyl-2(1h)-quinolinylidene)-1-propen-1-yl)-, iodide (1:1)
nk-3
SCHEMBL58012
AKOS024302141
CHEMBL2361697
1-ethyl-2-((1e,3z)-3-(1-ethylquinolin-2(1h)-ylidene)prop-1-en-1-yl)quinolin-1-ium iodide
Q27123307
AS-81192
quinolinium, 1-ethyl-2-[3-(1-ethyl-2(1h)-quinolinylidene)-1-propen-1-yl]-, iodide (1:1)

Roles (1)

Role	Description
fluorochrome	A fluorescent dye used to stain biological specimens.

Drug Classes (2)

Class	Description
cyanine dye	Cyanine dyes are synthetic dyes with the general formula R2N[CH=CH]nCH=N(+)R2 <-> R2N(+)=CH[CH=CH]nNR2 (n is a small number) in which the nitrogen and part of the conjugated chain usually form part of a heterocyclic system, such as imidazole, pyridine, pyrrole, quinoline and thiazole.
organic iodide salt

Research

Studies (5,093)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	265 (5.20)	18.7374
1990's	909 (17.85)	18.2507
2000's	1600 (31.42)	29.6817
2010's	1970 (38.68)	24.3611
2020's	349 (6.85)	2.80

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	4 (0.08%)	5.53%
Reviews	72 (1.36%)	6.00%
Case Studies	4 (0.08%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5,207 (98.49%)	84.16%

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	pre-1990	2000's	2010's	post-2020
indocyanine green	0	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye		0	0		low	0	0	0	0
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine	0	cyanine dye; indolium ion	fluorochrome	0	0		low	0	0	0	0
3,3'-diethyloxacarbocyanine	0	1,3-benzoxazoles; benzoxazolium ion; cyanine dye	fluorochrome	0	0		low	0	0	0	0
quinaldine blue	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
3,3'-dipentyl-2,2'-oxacarbocyanine	0	benzoxazolium ion; cyanine dye	fluorochrome	0	0		low	0	0	0	0
3,3'-diethylthiacarbocyanine iodide	0	benzothiazoles; cyanine dye	fluorochrome	0	0		low	0	0	0	0
2-(dimethylaminostyryl)-1-ethylpyridinium	0	cyanine dye; organic iodide salt		0	0		low	0	0	0	0
stains-all	0	cyanine dye; organic bromide salt	fluorochrome	0	0		low	0	0	0	0
1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidine)quinolinium, tetraiodide	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
thiazole orange	0	cyanine dye	fluorochrome	0	0		low	0	0	0	0
1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
yo-pro 1	0	cyanine dye; organic iodide salt; quaternary ammonium salt	fluorochrome	0	0		low	0	0	0	0
indocyanine green	18	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye		1979	2021	15.5	low	1	7	9	1
picogreen	0	benzothiazoles; cyanine dye; quinolines; tertiary amine	fluorescent dye	0	0		low	0	0	0	0
3,3'-diethylthiacarbocyanine iodide	0	benzothiazoles; cyanine dye	fluorochrome	0	0		low	0	0	0	0
yoyo-3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
to-pro-3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
bobo 3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
to-pro-1	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
sybr green i	0	benzothiazolium ion; cyanine dye; quinolines; tertiary amine	fluorescent dye	0	0		low	0	0	0	0
dimethylphenylpiperazinium iodide	0	N-arylpiperazine; organic iodide salt; piperazinium salt; quaternary ammonium salt	nicotinic acetylcholine receptor agonist	0	0		low	0	0	0	0
pralidoxime iodide	0	organic iodide salt; pyridinium salt	cholinergic drug; cholinesterase reactivator	0	0		low	0	0	0	0
propidium iodide	0	organic iodide salt		0	0		low	0	0	0	0
2-(4-(dimethylamino)styryl)-1-methylpyridinium	0	organic iodide salt; pyridinium salt; tertiary amine	fluorochrome	0	0		low	0	0	0	0
dithiazanine iodide	0	benzothiazoles; organic iodide salt	anthelminthic drug; fluorochrome	0	0		low	0	0	0	0
4-(4-diethylaminostyryl)-n-methylpyridinium	0	organic iodide salt; pyridinium salt	fluorochrome	0	0		low	0	0	0	0
nk 5	0	organic iodide salt; quinolines	fluorochrome	0	0		low	0	0	0	0
pralidoxime iodide	0	organic iodide salt; pyridinium salt	cholinergic drug; cholinesterase reactivator	0	0		low	0	0	0	0

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	pre-1990	1990's	2000's	2010's
hoe 33342	0	bibenzimidazole; N-methylpiperazine	fluorochrome	0	0		low	0	0	0	0
aurintricarboxylic acid	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist	2005	2005	19.0	low	0	0	1	0
bisbenzimidazole	9	bibenzimidazole; N-methylpiperazine	anthelminthic drug; fluorochrome	1997	2015	19.8	low	0	3	5	1
dapi	0	indoles	fluorochrome	0	0		low	0	0	0	0
ethidium	14	phenanthridines	fluorochrome; intercalator	1995	2011	18.5	low	0	1	12	1
monodansylcadaverine	0	aminonaphthalene; primary amino compound; sulfonamide; tertiary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor; fluorochrome; protective agent	0	0		low	0	0	0	0
propidium	39	phenanthridines; quaternary ammonium ion	fluorochrome; intercalator	1992	2016	18.7	low	0	9	19	11
methylene blue	5	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer	1983	2011	25.2	low	1	1	2	1
rhodamine b	0	organic chloride salt; xanthene dye	fluorescent probe; fluorochrome; histological dye	0	0		low	0	0	0	0
uvitex swn	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
evans blue	0	organic sodium salt	fluorochrome; histological dye; sodium channel blocker; teratogenic agent	0	0		low	0	0	0	0
biphenylacetylene	0	arylacetylene; benzenes	fluorochrome	0	0		low	0	0	0	0
dithiazanine	1	benzothiazoles; benzothiazolium ion	anthelminthic drug; fluorochrome	2015	2015	9.0	low	0	0	0	1
herniarin	0	coumarins	fluorochrome	0	0		low	0	0	0	0
eosine yellowish-(ys)	2	organic sodium salt; organobromine compound	fluorochrome; histological dye	2000	2005	21.5	low	0	1	1	0
malachite green	0	organic chloride salt	antibacterial agent; antifungal drug; carcinogenic agent; environmental contaminant; fluorochrome; histological dye; teratogenic agent	0	0		low	0	0	0	0
brilliant green	0	organic hydrogensulfate salt	antibacterial agent; antiseptic drug; environmental contaminant; fluorochrome; histological dye; poison	0	0		low	0	0	0	0
cascade blue	0	aminonaphthalene	fluorochrome	0	0		low	0	0	0	0
9,10-diphenylanthracene	0	anthracenes	fluorochrome; photosensitizing agent	0	0		low	0	0	0	0
popop	0	1,3-oxazoles	fluorochrome	0	0		low	0	0	0	0
basic blue k	0	iminium salt; organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
fast green fcf	0	organic sodium salt	fluorochrome; food colouring; histological dye	0	0		low	0	0	0	0
thioflavin t	0	organic chloride salt	fluorochrome; geroprotector; histological dye	0	0		low	0	0	0	0
ethyl violet	0	organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
benzophenoneidum	0	hydrochloride	fluorochrome; histological dye	0	0		low	0	0	0	0
victoria blue b	0	iminium salt; organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
4-chloro-7-nitrobenzofurazan	11	benzoxadiazole; C-nitro compound; organochlorine compound	EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.6.1.3 (adenosinetriphosphatase) inhibitor; fluorescent probe; fluorochrome	1992	2018	21.9	low	0	6	3	2
pyranine	0	organic sodium salt	fluorochrome	0	0		low	0	0	0	0
scarlet red	0	azobenzenes; bis(azo) compound; naphthols	carcinogenic agent; fluorochrome; histological dye	0	0		low	0	0	0	0
sudan iii	0	azobenzenes; bis(azo) compound; naphthols	carcinogenic agent; fluorochrome; histological dye	0	0		low	0	0	0	0
acridine orange	15	aminoacridines; aromatic amine; tertiary amino compound	fluorochrome; histological dye	1981	2016	24.1	low	3	5	4	3
2',7'-dichlorofluorescein	0	2-benzofurans	fluorochrome	0	0		low	0	0	0	0
fluorexon	0	xanthene dye	fluorochrome	0	0		low	0	0	0	0
nile red	0	aromatic amine; cyclic ketone; organic heterotetracyclic compound; tertiary amino compound	fluorochrome; histological dye	0	0		low	0	0	0	0
rhodamine 123	0	organic chloride salt; xanthene dye	fluorochrome	0	0		low	0	0	0	0
tris(2,2'-bipyridine)ruthenium(II)	0	ruthenium coordination entity	fluorochrome	0	0		low	0	0	0	0
phenosafranine	0	organic chloride salt	fluorochrome; histological dye; photosensitizing agent	0	0		low	0	0	0	0
perylenediimide	0	dicarboximide; organic heteropolycyclic compound	fluorochrome	0	0		low	0	0	0	0
coumarin 153	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
coumarin 314	0	7-aminocoumarins; ethyl ester	fluorochrome	0	0		low	0	0	0	0
gallein	0	2-benzofurans; gamma-lactone; organic heteropentacyclic compound; oxaspiro compound; polyphenol; xanthene dye	fluorochrome; G-protein-coupled receptor antagonist; histological dye	0	0		low	0	0	0	0
c.i. direct red 80	0	organic sodium salt	fluorochrome; histological dye	0	0		low	0	0	0	0
methylene green	0	organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
9,10-bis(phenylethynyl)anthracene	0	anthracenes; arylacetylene; benzenes	fluorochrome	0	0		low	0	0	0	0
oxazine 1	0	organic cation; phenoxazine	fluorochrome	0	0		low	0	0	0	0
7-amino-4-methylcoumarin	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
coumarin 480	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
coumarin 6	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
7-amino-4-trifluoromethylcoumarin	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
fluo-3	0	xanthene dye	fluorochrome	0	0		low	0	0	0	0
indo-1	0	indoles	fluorochrome	0	0		low	0	0	0	0
coumarin 343	0	7-aminocoumarins	fluorochrome	0	0		low	0	0	0	0
monobromobimane	0	organobromine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0
monochlorobimane	0	organochlorine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0
sulforhodamine 101	0	organic heteroheptacyclic compound	fluorochrome	0	0		low	0	0	0	0
5-chloromethylfluorescein diacetate	0	acetate ester	fluorochrome	0	0		low	0	0	0	0
4-carboxyfluorescein	0	monocarboxylic acid	fluorochrome	0	0		low	0	0	0	0
sodium-binding benzofuran isophthalate	0	1-benzofurans; aromatic ether; crown compound; tetracarboxylic acid	fluorochrome	0	0		low	0	0	0	0
3-(4-carboxybenzoyl)-2-quinolinecarboxaldehyde	0	benzoic acids; quinolines	fluorochrome	0	0		low	0	0	0	0
dibromobimane	0	organobromine compound; pyrazolopyrazole	fluorochrome	0	0		low	0	0	0	0
7-nitrobenzoxadiazole-6-aminohexanoic acid	0	benzoxadiazole; C-nitro compound; epsilon-amino acid; secondary amino compound	fluorochrome	0	0		low	0	0	0	0
victoria blue 4r	0	iminium salt; organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
hydromethylthionine	0	aromatic amine; phenothiazines; tertiary amino compound	bacterial xenobiotic metabolite; fluorochrome; mouse metabolite; rat metabolite	0	0		low	0	0	0	0
magnesium green	0	organic potassium salt	fluorochrome	0	0		low	0	0	0	0
7-methoxycoumarin-4-acetic acid	0	monocarboxylic acid	fluorochrome	0	0		low	0	0	0	0
calcein am	0	2-benzofurans; acetate ester; gamma-lactone; organic heteropentacyclic compound; oxaspiro compound; xanthene dye	fluorochrome	0	0		low	0	0	0	0
texas red	0	organic heteroheptacyclic compound	fluorochrome	0	0		low	0	0	0	0
zn(ii)-phthalocyanine	0	metallophthalocyanine; zinc tetrapyrrole	fluorochrome	0	0		low	0	0	0	0
DND-167 dye	0	morpholines	fluorochrome	0	0		low	0	0	0	0
safranine t	0	organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
ponceau s	0	organic sodium salt; organosulfonate salt	fluorochrome; histological dye	0	0		low	0	0	0	0
5-carboxytetramethylrhodamine	0	xanthenes	fluorochrome	0	0		low	0	0	0	0
primuline	0	organic sodium salt; organosulfonate salt	fluorochrome; histological dye	0	0		low	0	0	0	0
rose bengal(2-)	0	monocarboxylic acid anion; xanthene dye	fluorochrome	0	0		low	0	0	0	0
rhodamine 123	34	organic cation; xanthene dye	fluorochrome	1986	2020	21.4	low	1	15	8	10
oregon green 488 carboxylic acid	0	xanthene dye	epitope; fluorochrome	0	0		low	0	0	0	0
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine	0	cyanine dye; indolium ion	fluorochrome	0	0		low	0	0	0	0
diphenylhexatriene	5	alkatriene	fluorochrome	1997	2015	16.2	low	0	1	1	3
3,3'-diethyloxacarbocyanine	0	1,3-benzoxazoles; benzoxazolium ion; cyanine dye	fluorochrome	0	0		low	0	0	0	0
2-(4-(dimethylamino)styryl)-1-methylpyridinium	0	organic iodide salt; pyridinium salt; tertiary amine	fluorochrome	0	0		low	0	0	0	0
quinaldine blue	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
3,3'-dipentyl-2,2'-oxacarbocyanine	0	benzoxazolium ion; cyanine dye	fluorochrome	0	0		low	0	0	0	0
dithiazanine iodide	0	benzothiazoles; organic iodide salt	anthelminthic drug; fluorochrome	0	0		low	0	0	0	0
3,3'-dioctadecylindocarbocyanine	0	Cy5 dye; indolium ion	fluorochrome	0	0		low	0	0	0	0
4-(4-diethylaminostyryl)-n-methylpyridinium	0	organic iodide salt; pyridinium salt	fluorochrome	0	0		low	0	0	0	0
3,3'-diethylthiacarbocyanine iodide	0	benzothiazoles; cyanine dye	fluorochrome	0	0		low	0	0	0	0
4-(4-dihexadecylaminostyryl)-n-methylpyridium	0	pyridinium ion; tertiary amine	fluorochrome	0	0		low	0	0	0	0
stains-all	0	cyanine dye; organic bromide salt	fluorochrome	0	0		low	0	0	0	0
1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidine)quinolinium, tetraiodide	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
thiazole orange	0	cyanine dye	fluorochrome	0	0		low	0	0	0	0
1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
yo-pro 1	0	cyanine dye; organic iodide salt; quaternary ammonium salt	fluorochrome	0	0		low	0	0	0	0
fm1 43	0	organic bromide salt; pyridinium salt; quaternary ammonium salt; tertiary amine	fluorochrome	0	0		low	0	0	0	0
Alexa Fluor 555	0	xanthenes	fluorochrome	0	0		low	0	0	0	0
oregon green 514	0	xanthene dye	fluorochrome	0	0		low	0	0	0	0
lissamine rhodamine b	0	organic sodium salt	fluorescent probe; fluorochrome; histological dye	0	0		low	0	0	0	0
rhodamine 123	0	organic chloride salt; xanthene dye	fluorochrome	0	0		low	0	0	0	0
epicocconone	0	organic heterotricyclic compound	fluorochrome	0	0		low	0	0	0	0
succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide	0	7-aminocoumarins; tetrapeptide	fluorochrome	0	0		low	0	0	0	0
tris(4,7-diphenyl-1,10-phenanthroline)ruthenium (ii)	0	ruthenium coordination entity	fluorochrome	0	0		low	0	0	0	0
new fuchsin	0	hydrochloride	fluorochrome; histological dye	0	0		low	0	0	0	0
calcium orange	0	xanthene dye	fluorochrome	0	0		low	0	0	0	0
calcium crimson	0	ammonium betaine; sulfonamide	fluorochrome	0	0		low	0	0	0	0
3,3'-diethylthiacarbocyanine iodide	0	benzothiazoles; cyanine dye	fluorochrome	0	0		low	0	0	0	0
nk 5	0	organic iodide salt; quinolines	fluorochrome	0	0		low	0	0	0	0
lucifer yellow	0	organic lithium salt	fluorochrome	0	0		low	0	0	0	0
nuclear fast red	0	organic sodium salt	fluorochrome; histological dye	0	0		low	0	0	0	0
alcian yellow	0	iminium salt; organic chloride salt	fluorochrome; histological dye	0	0		low	0	0	0	0
yoyo-3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
alexa fluor 546	0	organic heteropentacyclic compound	fluorochrome	0	0		low	0	0	0	0
acridine yellow	0	aminoacridines; hydrochloride	fluorochrome	0	0		low	0	0	0	0
mitotracker orange	0	organic chloride salt	fluorochrome	0	0		low	0	0	0	0
to-pro-3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
bobo 3	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
to-pro-1	0	cyanine dye; organic iodide salt	fluorochrome	0	0		low	0	0	0	0
clomipramine	0	quaternary ammonium salt	fluorochrome	0	0		low	0	0	0	0
pacific blue succinimidyl ester	0	hydroxycoumarin; N-hydroxysuccinimide ester; organofluorine compound	fluorochrome	0	0		low	0	0	0	0
2-(5'-chloro-2'-phosphoryloxyphenyl)-6-chloro-4-(3h)-quinazolinone	0	aryl phosphate; monochlorobenzenes; quinazolines	fluorochrome	0	0		low	0	0	0	0
dy-676	0	organic sodium salt	fluorochrome	0	0		low	0	0	0	0

Substance	Classes	Roles	Relationship Strength
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine	cyanine dye; indolium ion	fluorochrome	low
3,3'-diethyloxacarbocyanine	1,3-benzoxazoles; benzoxazolium ion; cyanine dye	fluorochrome	low
2-(4-(dimethylamino)styryl)-1-methylpyridinium	organic iodide salt; pyridinium salt; tertiary amine	fluorochrome	low
quinaldine blue	cyanine dye; organic iodide salt	fluorochrome	low
3,3'-dipentyl-2,2'-oxacarbocyanine	benzoxazolium ion; cyanine dye	fluorochrome	low
dithiazanine iodide	benzothiazoles; organic iodide salt	anthelminthic drug; fluorochrome	low
4-(4-diethylaminostyryl)-n-methylpyridinium	organic iodide salt; pyridinium salt	fluorochrome	low
3,3'-diethylthiacarbocyanine iodide	benzothiazoles; cyanine dye	fluorochrome	low
stains-all	cyanine dye; organic bromide salt	fluorochrome	low
1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidine)quinolinium, tetraiodide	cyanine dye; organic iodide salt	fluorochrome	low
thiazole orange	cyanine dye	fluorochrome	low
1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium	cyanine dye; organic iodide salt	fluorochrome	low
yo-pro 1	cyanine dye; organic iodide salt; quaternary ammonium salt	fluorochrome	low
3,3'-diethylthiacarbocyanine iodide	benzothiazoles; cyanine dye	fluorochrome	low
nk 5	organic iodide salt; quinolines	fluorochrome	low
yoyo-3	cyanine dye; organic iodide salt	fluorochrome	low
to-pro-3	cyanine dye; organic iodide salt	fluorochrome	low
bobo 3	cyanine dye; organic iodide salt	fluorochrome	low
to-pro-1	cyanine dye; organic iodide salt	fluorochrome	low

Substance	Studies	Classes	Roles	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
2-keto-4-methylvalerate	1	2-oxo monocarboxylic acid; branched-chain keto acid	algal metabolite; human metabolite	2018	2018	6.0	low	0	0	0	0	1	0
protocatechuic acid	1	catechols; dihydroxybenzoic acid	antineoplastic agent; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.14.11.2 (procollagen-proline dioxygenase) inhibitor; human xenobiotic metabolite; plant metabolite	2008	2008	16.0	low	0	0	0	1	0	0
gamma-aminobutyric acid	19	amino acid zwitterion; gamma-amino acid; monocarboxylic acid	human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule	1991	2018	21.7	low	0	0	8	8	3	0
aminolevulinic acid	1	4-oxo monocarboxylic acid; amino acid zwitterion; delta-amino acid	antineoplastic agent; dermatologic drug; Escherichia coli metabolite; human metabolite; mouse metabolite; photosensitizing agent; plant metabolite; prodrug; Saccharomyces cerevisiae metabolite	2014	2014	10.0	low	0	0	0	0	1	0
ethylene glycol	2	ethanediol; glycol	metabolite; mouse metabolite; solvent; toxin	2006	2006	18.0	low	0	0	0	2	0	0
acetic acid	3	monocarboxylic acid	antimicrobial food preservative; Daphnia magna metabolite; food acidity regulator; protic solvent	2005	2013	15.7	low	0	0	0	2	1	0
acetamide	1	acetamides; carboximidic acid; monocarboxylic acid amide; N-acylammonia		2007	2007	17.0	low	0	0	0	1	0	0
acetone	2	ketone body; methyl ketone; propanones; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; human metabolite; polar aprotic solvent	2009	2012	13.5	low	0	0	0	1	1	0
adenine	9	6-aminopurines; purine nucleobase	Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2001	2022	11.8	low	0	0	0	4	4	1
ammonium hydroxide	2	azane; gas molecular entity; mononuclear parent hydride	EC 3.5.1.4 (amidase) inhibitor; metabolite; mouse metabolite; neurotoxin; NMR chemical shift reference compound; nucleophilic reagent; refrigerant	2001	2021	13.0	low	0	0	0	1	0	1
quinacrine	1	acridines; aromatic ether; organochlorine compound; tertiary amino compound	antimalarial; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor	1978	1978	46.0	low	0	1	0	0	0	0
beta-alanine	2	amino acid zwitterion; beta-amino acid	agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter	2008	2009	15.5	low	0	0	0	2	0	0
benzoic acid	2	benzoic acids	algal metabolite; antimicrobial food preservative; drug allergen; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 3.1.1.3 (triacylglycerol lipase) inhibitor; human xenobiotic metabolite; plant metabolite	2002	2015	15.5	low	0	0	0	1	1	0
betaine	3	amino-acid betaine; glycine derivative	fundamental metabolite	2001	2019	15.0	low	0	0	0	2	1	0
bromide	1	halide anion; monoatomic bromine		2003	2003	21.0	low	0	0	0	1	0	0
1-butanol	1	alkyl alcohol; primary alcohol; short-chain primary fatty alcohol	human metabolite; mouse metabolite; protic solvent	2013	2013	11.0	low	0	0	0	0	1	0
cadaverine	4	alkane-alpha,omega-diamine	Daphnia magna metabolite; Escherichia coli metabolite; mouse metabolite; plant metabolite	2001	2017	17.5	low	0	0	0	3	1	0
carbamates	1	amino-acid anion		2021	2021	3.0	low	0	0	0	0	0	1
carbon monoxide	2	carbon oxide; gas molecular entity; one-carbon compound	biomarker; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; human metabolite; ligand; metabolite; mitochondrial respiratory-chain inhibitor; mouse metabolite; neurotoxin; neurotransmitter; P450 inhibitor; probe; signalling molecule; vasodilator agent	2002	2022	12.0	low	0	0	0	1	0	1
aminooxyacetic acid	1	amino acid; hydroxylamines; monocarboxylic acid	anticonvulsant; EC 2.6.1.19 (4-aminobutyrate--2-oxoglutarate transaminase) inhibitor; EC 4.2.1.22 (cystathionine beta-synthase) inhibitor; nootropic agent	2013	2013	11.0	low	0	0	0	0	1	0
carnitine	1	amino-acid betaine	human metabolite; mouse metabolite	2005	2005	19.0	low	0	0	0	1	0	0
catechol	1	catechols	allelochemical; genotoxin; plant metabolite	2010	2010	14.0	low	0	0	0	1	0	0
methane	8	alkane; gas molecular entity; mononuclear parent hydride; one-carbon compound	bacterial metabolite; fossil fuel; greenhouse gas	2007	2018	11.8	low	0	0	0	2	6	0
choline	6	cholines	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter; nutrient; plant metabolite; Saccharomyces cerevisiae metabolite	1976	2020	35.5	low	0	3	2	0	1	0
citric acid, anhydrous	1	tricarboxylic acid	antimicrobial agent; chelator; food acidity regulator; fundamental metabolite	2015	2015	9.0	low	0	0	0	0	1	0
chlorine	13	halide anion; monoatomic chlorine	cofactor; Escherichia coli metabolite; human metabolite	1981	2023	28.2	low	0	8	1	1	2	1
hydrochloric acid	1	chlorine molecular entity; gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite	1979	1979	45.0	low	0	1	0	0	0	0
coumarin	5	coumarins	fluorescent dye; human metabolite; plant metabolite	2012	2020	9.2	low	0	0	0	0	5	0
gallic acid	1	trihydroxybenzoic acid	antineoplastic agent; antioxidant; apoptosis inducer; astringent; cyclooxygenase 2 inhibitor; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; geroprotector; human xenobiotic metabolite; plant metabolite	2009	2009	15.0	low	0	0	0	1	0	0
hydrogen sulfide	10	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent	2009	2019	9.9	low	0	0	0	1	9	0
malic acid	3	2-hydroxydicarboxylic acid; C4-dicarboxylic acid	food acidity regulator; fundamental metabolite	1982	2006	28.0	low	0	1	1	1	0	0
hydrogen selenide	1	mononuclear parent hydride; selenium hydride	Escherichia coli metabolite; mouse metabolite	2017	2017	7.0	low	0	0	0	0	1	0
aminocaproic acid	1	amino acid zwitterion; epsilon-amino acid; omega-amino fatty acid	antifibrinolytic drug; hematologic agent; metabolite	2012	2012	12.0	low	0	0	0	0	1	0
cytosine	7	aminopyrimidine; pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2001	2010	18.9	low	0	0	0	7	0	0
lactic acid	21	2-hydroxy monocarboxylic acid	algal metabolite; Daphnia magna metabolite	1982	2019	16.7	low	0	3	2	6	10	0
diacetyl	1	alpha-diketone	Escherichia coli metabolite; Saccharomyces cerevisiae metabolite	1999	1999	25.0	low	0	0	1	0	0	0
dimethyl sulfoxide	10	sulfoxide; volatile organic compound	alkylating agent; antidote; Escherichia coli metabolite; geroprotector; MRI contrast agent; non-narcotic analgesic; polar aprotic solvent; radical scavenger	1987	2019	21.2	low	0	2	1	5	2	0
formaldehyde	9	aldehyde; one-carbon compound	allergen; carcinogenic agent; disinfectant; EC 3.5.1.4 (amidase) inhibitor; environmental contaminant; Escherichia coli metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1991	2020	17.8	low	0	0	3	2	4	0
formamide	4	carboximidic acid; formamides; monocarboxylic acid amide; one-carbon compound	solvent	2002	2011	19.0	low	0	0	0	3	1	0
glycine	4	alpha-amino acid; amino acid zwitterion; proteinogenic amino acid; serine family amino acid	EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor; fundamental metabolite; hepatoprotective agent; micronutrient; neurotransmitter; NMDA receptor agonist; nutraceutical	2004	2016	16.8	low	0	0	0	3	1	0
glycerol	14	alditol; triol	algal metabolite; detergent; Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; solvent	1995	2021	10.3	low	0	0	1	2	10	1
hydrogen carbonate	1	carbon oxoanion	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1987	1987	37.0	low	0	1	0	0	0	0
histamine	6	aralkylamino compound; imidazoles	human metabolite; mouse metabolite; neurotransmitter	1983	2000	29.0	low	0	1	5	0	0	0
hydrogen	5	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite	1986	2014	17.4	low	0	1	0	1	3	0
hydrogen	3	elemental hydrogen; elemental molecule; gas molecular entity	antioxidant; electron donor; food packaging gas; fuel; human metabolite	1986	2014	21.3	low	0	1	0	1	1	0
imidazole	2	imidazole		2011	2013	12.0	low	0	0	0	0	2	0
iodine	1	diatomic iodine	nutrient	2014	2014	10.0	low	0	0	0	0	1	0
2-keto-3-deoxyoctonate	2			2003	2017	14.0	low	0	0	0	1	1	0
dihydroxyphenylalanine	1	hydroxyphenylalanine; non-proteinogenic alpha-amino acid; tyrosine derivative	human metabolite	1993	1993	31.0	low	0	0	1	0	0	0
thioctic acid	1	dithiolanes; heterocyclic fatty acid; thia fatty acid	fundamental metabolite; geroprotector	2019	2019	5.0	low	0	0	0	0	1	0
methanol	13	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite	2000	2015	16.2	low	0	0	1	8	4	0
inositol	1	cyclitol; hexol		2012	2012	12.0	low	0	0	0	0	1	0
melatonin	5	acetamides; tryptamines	anticonvulsant; central nervous system depressant; geroprotector; hormone; human metabolite; immunological adjuvant; mouse metabolite; radical scavenger	2002	2021	11.4	low	0	0	0	1	3	1
nickel	4	metal allergen; nickel group element atom	epitope; micronutrient	2013	2020	8.2	low	0	0	0	0	4	0
niacinamide	2	pyridine alkaloid; pyridinecarboxamide; vitamin B3	anti-inflammatory agent; antioxidant; cofactor; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; Escherichia coli metabolite; geroprotector; human urinary metabolite; metabolite; mouse metabolite; neuroprotective agent; Saccharomyces cerevisiae metabolite; Sir2 inhibitor	2000	2020	14.0	low	0	0	1	0	1	0
nitrates	3	monovalent inorganic anion; nitrogen oxoanion; reactive nitrogen species		1985	2020	22.3	low	0	1	1	0	1	0
nitroxyl	1	nitrogen oxoacid		2009	2009	15.0	low	0	0	0	1	0	0
hydroxide ion	1	oxygen hydride	mouse metabolite	2020	2020	4.0	low	0	0	0	0	1	0
palmitic acid	2	long-chain fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; EC 1.1.1.189 (prostaglandin-E2 9-reductase) inhibitor; plant metabolite	1999	2019	15.0	low	0	0	1	0	1	0
pentachlorophenol	1	aromatic fungicide; chlorophenol; organochlorine pesticide; pentachlorobenzenes	human xenobiotic metabolite	2003	2003	21.0	low	0	0	0	1	0	0
phenanthrene	1	ortho-fused polycyclic arene; ortho-fused tricyclic hydrocarbon; phenanthrenes	environmental contaminant; mouse metabolite	2019	2019	5.0	low	0	0	0	0	1	0
phenol	3	phenols	antiseptic drug; disinfectant; human xenobiotic metabolite; mouse metabolite	2004	2014	15.0	low	0	0	0	2	1	0
phosphorylcholine	4	phosphocholines	allergen; epitope; hapten; human metabolite; mouse metabolite	1993	2019	13.0	low	0	0	1	0	3	0
phosphorylethanolamine	1	phosphoethanolamine; primary amino compound	algal metabolite; human metabolite; mouse metabolite	1996	1996	28.0	low	0	0	1	0	0	0
porphobilinogen	1	aralkylamino compound; dicarboxylic acid; pyrroles	Escherichia coli metabolite; metabolite; mouse metabolite	2017	2017	7.0	low	0	0	0	0	1	0
1-propanol	1	propan-1-ols; short-chain primary fatty alcohol	metabolite; protic solvent	2007	2007	17.0	low	0	0	0	1	0	0
propionic acid	1	saturated fatty acid; short-chain fatty acid	antifungal drug	2004	2004	20.0	low	0	0	0	1	0	0
purine	2	purine		2005	2018	12.5	low	0	0	0	1	1	0
pyridoxal phosphate	1	methylpyridines; monohydroxypyridine; pyridinecarbaldehyde; vitamin B6 phosphate	coenzyme; cofactor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2003	2003	21.0	low	0	0	0	1	0	0
pyruvic acid	3	2-oxo monocarboxylic acid	cofactor; fundamental metabolite	1985	2003	27.3	low	0	1	0	2	0	0
dithionite	1	sulfur oxide; sulfur oxoanion		2008	2008	16.0	low	0	0	0	1	0	0
sarcosine	2	N-alkylglycine zwitterion; N-alkylglycine; N-methyl-amino acid; N-methylglycines	Escherichia coli metabolite; glycine receptor agonist; glycine transporter 1 inhibitor; human metabolite; mouse metabolite	1983	2020	22.5	low	0	1	0	0	1	0
sulfites	4	divalent inorganic anion; sulfur oxide; sulfur oxoanion		2002	2023	9.8	low	0	0	0	1	2	1
spermine	1	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent	2010	2010	14.0	low	0	0	0	1	0	0
succinic acid	4	alpha,omega-dicarboxylic acid; C4-dicarboxylic acid	anti-ulcer drug; fundamental metabolite; micronutrient; nutraceutical; radiation protective agent	1982	2005	35.5	low	0	3	0	1	0	0
sulfur dioxide	4	sulfur oxide	Escherichia coli metabolite; food bleaching agent; refrigerant	2016	2022	4.2	low	0	0	0	0	2	2
thymine	3	pyrimidine nucleobase; pyrimidone	Escherichia coli metabolite; human metabolite; mouse metabolite	2005	2014	13.7	low	0	0	0	1	2	0
toluene	3	methylbenzene; toluenes; volatile organic compound	cholinergic antagonist; fuel additive; neurotoxin; non-polar solvent	1947	2006	38.3	low	0	1	0	2	0	0
uracil	1	pyrimidine nucleobase; pyrimidone	allergen; Daphnia magna metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; prodrug; Saccharomyces cerevisiae metabolite	2018	2018	6.0	low	0	0	0	0	1	0
urea	7	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1989	2019	18.3	low	0	1	0	5	1	0
2-amino-5-phosphonovalerate	10	non-proteinogenic alpha-amino acid	NMDA receptor antagonist	1999	2015	18.7	low	0	0	1	7	2	0
2-amino-5-phosphonovalerate	5	non-proteinogenic alpha-amino acid	NMDA receptor antagonist	2001	2015	18.4	low	0	0	0	4	1	0
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid	1			1995	1995	29.0	low	0	0	1	0	0	0
ibotenic acid	3	non-proteinogenic alpha-amino acid	neurotoxin	1994	2013	22.0	low	0	0	2	0	1	0
1,2-dioctanoylglycerol	1			1990	1990	34.0	low	0	0	1	0	0	0
1,3-dipropyl-8-cyclopentylxanthine	1	oxopurine	adenosine A1 receptor antagonist; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor	2005	2005	19.0	low	0	0	0	1	0	0
pk 11195	4	aromatic amide; isoquinolines; monocarboxylic acid amide; monochlorobenzenes	antineoplastic agent	2003	2019	15.8	low	0	0	0	3	1	0
1-anilino-8-naphthalenesulfonate	4	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe	1982	2009	32.8	low	0	2	1	1	0	0
1-anilino-8-naphthalenesulfonate	1	aminonaphthalene; naphthalenesulfonic acid	fluorescent probe	2009	2009	15.0	low	0	0	0	1	0	0
2,2'-dipyridyl	1	bipyridine	chelator; ferroptosis inhibitor	2002	2002	22.0	low	0	0	0	1	0	0
2,4-dinitrophenol	1	dinitrophenol	allergen; antiseptic drug; bacterial xenobiotic metabolite; geroprotector; oxidative phosphorylation inhibitor	1987	1987	37.0	low	0	1	0	0	0	0
mercaptoethanol	4	alkanethiol; primary alcohol	geroprotector	2003	2020	13.5	low	0	0	0	2	2	0
4-aminopyridine	3	aminopyridine; aromatic amine	avicide; orphan drug; potassium channel blocker	1999	2009	20.0	low	0	0	1	2	0	0
5-dimethylamiloride	1			2001	2001	23.0	low	0	0	0	1	0	0
5-hydroxydecanoate	2	medium-chain fatty acid		2005	2009	17.0	low	0	0	0	2	0	0
2,2'-azobis(2-amidinopropane)	1	monoazo compound		1999	1999	25.0	low	0	0	1	0	0	0
acetaminophen	4	acetamides; phenols	antipyretic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor; cyclooxygenase 3 inhibitor; environmental contaminant; ferroptosis inducer; geroprotector; hepatotoxic agent; human blood serum metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	2003	2020	13.8	low	0	0	0	2	2	0
albendazole	1	aryl sulfide; benzimidazoles; benzimidazolylcarbamate fungicide; carbamate ester	anthelminthic drug; microtubule-destabilising agent; tubulin modulator	2016	2016	8.0	low	0	0	0	0	1	0
altretamine	1	triamino-1,3,5-triazine		2010	2010	14.0	low	0	0	0	1	0	0
amantadine	1	adamantanes; primary aliphatic amine	analgesic; antiparkinson drug; antiviral drug; dopaminergic agent; NMDA receptor antagonist; non-narcotic analgesic	2018	2018	6.0	low	0	0	0	0	1	0
theophylline	1	dimethylxanthine	adenosine receptor antagonist; anti-asthmatic drug; anti-inflammatory agent; bronchodilator agent; drug metabolite; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; fungal metabolite; human blood serum metabolite; immunomodulator; muscle relaxant; vasodilator agent	1991	1991	33.0	low	0	0	1	0	0	0
aurintricarboxylic acid	1	monohydroxybenzoic acid; quinomethanes; tricarboxylic acid	fluorochrome; histological dye; insulin-like growth factor receptor 1 antagonist	2005	2005	19.0	low	0	0	0	1	0	0
azobenzene	3	azobenzenes		2010	2020	8.0	low	0	0	0	1	2	0
bay-k-8644	2	(trifluoromethyl)benzenes; C-nitro compound; dihydropyridine; methyl ester		1986	1989	36.5	low	0	2	0	0	0	0
2,5-di-tert-butylhydroquinone	1	hydroquinones		2009	2009	15.0	low	0	0	0	1	0	0
bisbenzimidazole	9	bibenzimidazole; N-methylpiperazine	anthelminthic drug; fluorochrome	1997	2015	19.8	low	0	0	3	5	1	0
bisindolylmaleimide i	1			2007	2007	17.0	low	0	0	0	1	0	0
bumetanide	1	amino acid; benzoic acids; sulfonamide	diuretic; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor	1988	1988	36.0	low	0	1	0	0	0	0
busulfan	1	methanesulfonate ester	alkylating agent; antineoplastic agent; carcinogenic agent; insect sterilant; teratogenic agent	2005	2005	19.0	low	0	0	0	1	0	0
caffeine	1	purine alkaloid; trimethylxanthine	adenosine A2A receptor antagonist; adenosine receptor antagonist; adjuvant; central nervous system stimulant; diuretic; EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 3.1.4.* (phosphoric diester hydrolase) inhibitor; environmental contaminant; food additive; fungal metabolite; geroprotector; human blood serum metabolite; mouse metabolite; mutagen; plant metabolite; psychotropic drug; ryanodine receptor agonist; xenobiotic	2010	2010	14.0	low	0	0	0	1	0	0
verapamil	11	aromatic ether; nitrile; polyether; tertiary amino compound		1984	2018	25.7	low	0	4	2	3	2	0
carbazilquinone	1	organic molecular entity		2016	2016	8.0	low	0	0	0	0	1	0
carbonyl cyanide m-chlorophenyl hydrazone	24	hydrazone; monochlorobenzenes; nitrile	antibacterial agent; geroprotector; ionophore	1981	2020	22.4	low	0	3	7	10	4	0
celecoxib	1	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug	2018	2018	6.0	low	0	0	0	0	1	0
cetyltrimethylammonium ion	5	quaternary ammonium ion		2000	2011	19.0	low	0	0	1	3	1	0
cgp 37157	3	benzothiazepine		1996	1999	26.7	low	0	0	3	0	0	0
chlorambucil	1	aromatic amine; monocarboxylic acid; nitrogen mustard; organochlorine compound; tertiary amino compound	alkylating agent; antineoplastic agent; carcinogenic agent; drug allergen; immunosuppressive agent	2019	2019	5.0	low	0	0	0	0	1	0
chloroquine	4	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug	1997	2017	12.2	low	0	0	1	0	3	0
chlorpromazine	2	organochlorine compound; phenothiazines; tertiary amine	anticoronaviral agent; antiemetic; dopaminergic antagonist; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; phenothiazine antipsychotic drug	1988	2000	30.0	low	0	1	1	0	0	0
ciprofloxacin	1	aminoquinoline; cyclopropanes; fluoroquinolone antibiotic; N-arylpiperazine; quinolinemonocarboxylic acid; quinolone antibiotic; quinolone; zwitterion	antibacterial drug; antiinfective agent; antimicrobial agent; DNA synthesis inhibitor; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; environmental contaminant; topoisomerase IV inhibitor; xenobiotic	2009	2009	15.0	low	0	0	0	1	0	0
cisapride	1	benzamides		2004	2004	20.0	low	0	0	0	1	0	0
clonazepam	3	1,4-benzodiazepinone; monochlorobenzenes	anticonvulsant; anxiolytic drug; GABA modulator	1996	1999	26.7	low	0	0	3	0	0	0
clonidine	1	clonidine; imidazoline		2004	2004	20.0	low	0	0	0	1	0	0
cyclofenil	2	organic molecular entity		2008	2010	15.0	low	0	0	0	2	0	0
dapi	25	indoles	fluorochrome	1998	2017	17.0	low	0	0	2	17	6	0
2,3-dimethoxy-5-methyl-6-decyl-1,4-benzoquinone	1	1,4-benzoquinones	cofactor	1994	1994	30.0	low	0	0	1	0	0	0
deferoxamine	1	acyclic desferrioxamine	bacterial metabolite; ferroptosis inhibitor; iron chelator; siderophore	2015	2015	9.0	low	0	0	0	0	1	0
amphetamine	1	primary amine		2013	2013	11.0	low	0	0	0	0	1	0
diazoxide	2	benzothiadiazine; organochlorine compound; sulfone	antihypertensive agent; beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; diuretic; K-ATP channel agonist; sodium channel blocker; sympathomimetic agent; vasodilator agent	2005	2009	17.0	low	0	0	0	2	0	0
dibucaine	1	aromatic ether; monocarboxylic acid amide; tertiary amino compound	topical anaesthetic	1997	1997	27.0	low	0	0	1	0	0	0
diclofenac	1	amino acid; aromatic amine; dichlorobenzene; monocarboxylic acid; secondary amino compound	antipyretic; drug allergen; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; non-narcotic analgesic; non-steroidal anti-inflammatory drug; xenobiotic	2006	2006	18.0	low	0	0	0	1	0	0
pentetic acid	8	pentacarboxylic acid	copper chelator	2005	2017	12.6	low	0	0	0	3	5	0
dimaprit	1	imidothiocarbamic ester		1983	1983	41.0	low	0	1	0	0	0	0
stallimycin	1			2002	2002	22.0	low	0	0	0	1	0	0
n(6),n(6)-dimethyladenine	1	tertiary amine		2018	2018	6.0	low	0	0	0	0	1	0
ebselen	1	benzoselenazole	anti-inflammatory drug; antibacterial agent; anticoronaviral agent; antifungal agent; antineoplastic agent; antioxidant; apoptosis inducer; EC 1.13.11.33 (arachidonate 15-lipoxygenase) inhibitor; EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 2.5.1.7 (UDP-N-acetylglucosamine 1-carboxyvinyltransferase) inhibitor; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; EC 3.1.3.25 (inositol-phosphate phosphatase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; EC 3.5.4.1 (cytosine deaminase) inhibitor; EC 5.1.3.2 (UDP-glucose 4-epimerase) inhibitor; enzyme mimic; ferroptosis inhibitor; genotoxin; hepatoprotective agent; neuroprotective agent; radical scavenger	2001	2001	23.0	low	0	0	0	1	0	0
econazole	1	dichlorobenzene; ether; imidazoles; monochlorobenzenes		1994	1994	30.0	low	0	0	1	0	0	0
9-(2-hydroxy-3-nonyl)adenine	1			2005	2005	19.0	low	0	0	0	1	0	0
erythrosine	92			1983	2022	19.9	low	0	5	32	28	24	3
etanidazole	3	C-nitro compound; imidazoles; monocarboxylic acid amide	alkylating agent; antineoplastic agent; prodrug; radiosensitizing agent	2000	2004	22.3	low	0	0	1	2	0	0
ethoxzolamide	1	aromatic ether; benzothiazoles; sulfonamide	antiglaucoma drug; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor	1993	1993	31.0	low	0	0	1	0	0	0
ethylenediamine	2	alkane-alpha,omega-diamine	GABA agonist	2013	2018	8.5	low	0	0	0	0	2	0
carbonyl cyanide p-trifluoromethoxyphenylhydrazone	29	aromatic ether; hydrazone; nitrile; organofluorine compound	ATP synthase inhibitor; geroprotector; ionophore	1978	2010	26.6	low	0	8	6	15	0	0
fenofibrate	1	aromatic ether; chlorobenzophenone; isopropyl ester; monochlorobenzenes	antilipemic drug; environmental contaminant; geroprotector; xenobiotic	2017	2017	7.0	low	0	0	0	0	1	0
flucytosine	1	aminopyrimidine; nucleoside analogue; organofluorine compound; pyrimidine antifungal drug; pyrimidone	prodrug	2009	2009	15.0	low	0	0	0	1	0	0
fluorouracil	3	nucleobase analogue; organofluorine compound	antimetabolite; antineoplastic agent; environmental contaminant; immunosuppressive agent; radiosensitizing agent; xenobiotic	2009	2013	13.3	low	0	0	0	2	1	0
vanoxerine	1	ether; N-alkylpiperazine; organofluorine compound; tertiary amino compound	dopamine uptake inhibitor	2003	2003	21.0	low	0	0	0	1	0	0
guanidinoethylmercaptosuccinic acid	1			2012	2012	12.0	low	0	0	0	0	1	0
gentamicin	1			2020	2020	4.0	low	0	0	0	0	1	0
glutaral	2	dialdehyde	cross-linking reagent; disinfectant; fixative	2005	2013	15.0	low	0	0	0	1	1	0
glyburide	1	monochlorobenzenes; N-sulfonylurea	anti-arrhythmia drug; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 3.6.3.49 (channel-conductance-controlling ATPase) inhibitor; hypoglycemic agent	2009	2009	15.0	low	0	0	0	1	0	0
gossypol	1			2019	2019	5.0	low	0	0	0	0	1	0
guanidine	2	carboxamidine; guanidines; one-carbon compound		2004	2011	16.5	low	0	0	0	1	1	0
haloperidol	1	aromatic ketone; hydroxypiperidine; monochlorobenzenes; organofluorine compound; tertiary alcohol	antidyskinesia agent; antiemetic; dopaminergic antagonist; first generation antipsychotic; serotonergic antagonist	1999	1999	25.0	low	0	0	1	0	0	0
ethidium	14	phenanthridines	fluorochrome; intercalator	1995	2011	18.5	low	0	0	1	12	1	0
hydralazine	1	azaarene; hydrazines; ortho-fused heteroarene; phthalazines	antihypertensive agent; vasodilator agent	2001	2001	23.0	low	0	0	0	1	0	0
hydroxyurea	4	one-carbon compound; ureas	antimetabolite; antimitotic; antineoplastic agent; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; genotoxin; immunomodulator; radical scavenger; teratogenic agent	1989	2010	24.8	low	0	1	1	2	0	0
hypericin	2			2005	2008	17.5	low	0	0	0	2	0	0
lidocaine	2	benzenes; monocarboxylic acid amide; tertiary amino compound	anti-arrhythmia drug; drug allergen; environmental contaminant; local anaesthetic; xenobiotic	2000	2014	17.0	low	0	0	1	0	1	0
indomethacin	1	aromatic ether; indole-3-acetic acids; monochlorobenzenes; N-acylindole	analgesic; drug metabolite; EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor; environmental contaminant; gout suppressant; non-steroidal anti-inflammatory drug; xenobiotic metabolite; xenobiotic	2021	2021	3.0	low	0	0	0	0	0	1
iodoacetamide	3			2003	2010	16.7	low	0	0	0	3	0	0
isoniazid	2	carbohydrazide	antitubercular agent; drug allergen	2019	2020	4.5	low	0	0	0	0	2	0
isoniazid	3	carbohydrazide	antitubercular agent; drug allergen	2019	2020	4.7	low	0	0	0	0	3	0
2-propanol	1	secondary alcohol; secondary fatty alcohol	protic solvent	2017	2017	7.0	low	0	0	0	0	1	0
2-propanol	2	secondary alcohol; secondary fatty alcohol	protic solvent	1978	2017	26.5	low	0	1	0	0	1	0
isoproterenol	4	catechols; secondary alcohol; secondary amino compound	beta-adrenergic agonist; bronchodilator agent; cardiotonic drug; sympathomimetic agent	1997	2013	16.8	low	0	0	1	1	2	0
isradipine	2	benzoxadiazole; dihydropyridine; isopropyl ester; methyl ester		1989	1995	32.0	low	0	1	1	0	0	0
staurosporine aglycone	1			2006	2006	18.0	low	0	0	0	1	0	0
kynurenic acid	1	monohydroxyquinoline; quinolinemonocarboxylic acid	G-protein-coupled receptor agonist; human metabolite; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist; Saccharomyces cerevisiae metabolite	2015	2015	9.0	low	0	0	0	0	1	0
qx-314	1	monocarboxylic acid amide	local anaesthetic	2000	2000	24.0	low	0	0	1	0	0	0
lomerizine	1	diarylmethane		2009	2009	15.0	low	0	0	0	1	0	0
losartan	2	biphenylyltetrazole; imidazoles	angiotensin receptor antagonist; anti-arrhythmia drug; antihypertensive agent; endothelin receptor antagonist	1993	2009	23.0	low	0	0	1	1	0	0
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one	3	chromones; morpholines; organochlorine compound	autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector	2008	2013	14.3	low	0	0	0	2	1	0
memantine	2	adamantanes; primary aliphatic amine	antidepressant; antiparkinson drug; dopaminergic agent; neuroprotective agent; NMDA receptor antagonist	1999	2010	19.5	low	0	0	1	1	0	0
vitamin k 3	2	1,4-naphthoquinones; vitamin K	angiogenesis inhibitor; antineoplastic agent; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; human urinary metabolite; nutraceutical	2004	2008	18.0	low	0	0	0	2	0	0
metformin	2	guanidines	environmental contaminant; geroprotector; hypoglycemic agent; xenobiotic	2012	2016	10.0	low	0	0	0	0	2	0
nocodazole	5	aromatic ketone; benzimidazoles; carbamate ester; thiophenes	antimitotic; antineoplastic agent; microtubule-destabilising agent; tubulin modulator	1989	2010	27.2	low	0	1	3	1	0	0
methyl methanesulfonate	1	methanesulfonate ester	alkylating agent; apoptosis inducer; carcinogenic agent; genotoxin; mutagen	2003	2003	21.0	low	0	0	0	1	0	0
metronidazole	1	C-nitro compound; imidazoles; primary alcohol	antiamoebic agent; antibacterial drug; antimicrobial agent; antiparasitic agent; antitrichomonal drug; environmental contaminant; prodrug; radiosensitizing agent; xenobiotic	2013	2013	11.0	low	0	0	0	0	1	0
miconazole	2	dichlorobenzene; ether; imidazoles		1994	1998	28.0	low	0	0	2	0	0	0
mitoxantrone	1	dihydroxyanthraquinone	analgesic; antineoplastic agent	2012	2012	12.0	low	0	0	0	0	1	0
molsidomine	3	ethyl ester; morpholines; oxadiazole; zwitterion	antioxidant; apoptosis inhibitor; cardioprotective agent; nitric oxide donor; vasodilator agent	2010	2018	9.7	low	0	0	0	1	2	0
monodansylcadaverine	2	aminonaphthalene; primary amino compound; sulfonamide; tertiary amino compound	EC 2.3.2.13 (protein-glutamine gamma-glutamyltransferase) inhibitor; fluorochrome; protective agent	2001	2004	21.5	low	0	0	0	2	0	0
entinostat	1	benzamides; carbamate ester; primary amino compound; pyridines; substituted aniline	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2017	2017	7.0	low	0	0	0	0	1	0
ethylmaleimide	4	maleimides	anticoronaviral agent; EC 1.3.1.8 [acyl-CoA dehydrogenase (NADP(+))] inhibitor; EC 2.1.1.122 [(S)-tetrahydroprotoberberine N-methyltransferase] inhibitor; EC 2.7.1.1 (hexokinase) inhibitor	1981	1995	33.5	low	0	1	3	0	0	0
clorgyline	3	aromatic ether; dichlorobenzene; terminal acetylenic compound; tertiary amino compound	antidepressant; EC 1.4.3.4 (monoamine oxidase) inhibitor	2001	2009	20.0	low	0	0	0	3	0	0
fenamic acid	1	aminobenzoic acid; secondary amino compound	membrane transport modulator	1989	1989	35.0	low	0	1	0	0	0	0
activins	1			2013	2013	11.0	low	0	0	0	0	1	0
nevirapine	1	cyclopropanes; dipyridodiazepine	antiviral drug; HIV-1 reverse transcriptase inhibitor	2008	2008	16.0	low	0	0	0	1	0	0
nicardipine	1	benzenes; C-nitro compound; diester; dihydropyridine; methyl ester; tertiary amino compound		2000	2000	24.0	low	0	0	1	0	0	0
nifedipine	2	C-nitro compound; dihydropyridine; methyl ester	calcium channel blocker; human metabolite; tocolytic agent; vasodilator agent	1986	2001	30.5	low	0	1	0	1	0	0
nimesulide	1	aromatic ether; C-nitro compound; sulfonamide	cyclooxygenase 2 inhibitor; non-steroidal anti-inflammatory drug	2012	2012	12.0	low	0	0	0	0	1	0
nimodipine	1	2-methoxyethyl ester; C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; isopropyl ester	antihypertensive agent; calcium channel blocker; cardiovascular drug; vasodilator agent	2013	2013	11.0	low	0	0	0	0	1	0
nitrendipine	2	C-nitro compound; dicarboxylic acids and O-substituted derivatives; diester; dihydropyridine; ethyl ester; methyl ester	antihypertensive agent; calcium channel blocker; geroprotector; vasodilator agent	1989	1995	32.0	low	0	1	1	0	0	0
ns 1619	1	(trifluoromethyl)benzenes; benzimidazoles; phenols	potassium channel opener	2005	2005	19.0	low	0	0	0	1	0	0
omeprazole	1	aromatic ether; benzimidazoles; pyridines; sulfoxide		2001	2001	23.0	low	0	0	0	1	0	0
oxidopamine	3	benzenetriol; catecholamine; primary amino compound	drug metabolite; human metabolite; neurotoxin	1995	2009	23.7	low	0	0	2	1	0	0
oxotremorine	1	N-alkylpyrrolidine		2006	2006	18.0	low	0	0	0	1	0	0
patulin	1	furopyran; gamma-lactone; lactol	antimicrobial agent; Aspergillus metabolite; carcinogenic agent; mutagen; mycotoxin; Penicillium metabolite	2015	2015	9.0	low	0	0	0	0	1	0
pentamidine	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic	1997	1997	27.0	low	0	0	1	0	0	0
pentobarbital	2	barbiturates	GABAA receptor agonist	1997	2017	17.0	low	0	0	1	0	1	0
oxophenylarsine	2	arsine oxides	antineoplastic agent; apoptosis inducer; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor	2000	2005	21.5	low	0	0	1	1	0	0
o-phthalaldehyde	1	benzaldehydes; dialdehyde	epitope	2008	2008	16.0	low	0	0	0	1	0	0
pifithrin	1	aromatic ketone		2004	2004	20.0	low	0	0	0	1	0	0
pioglitazone	1	aromatic ether; pyridines; thiazolidinediones	antidepressant; cardioprotective agent; EC 2.7.1.33 (pantothenate kinase) inhibitor; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; geroprotector; hypoglycemic agent; insulin-sensitizing drug; PPARgamma agonist; xenobiotic	2016	2016	8.0	low	0	0	0	0	1	0
piperazine	2	azacycloalkane; piperazines; saturated organic heteromonocyclic parent	anthelminthic drug	2015	2016	8.5	low	0	0	0	0	2	0
pirenzepine	3	pyridobenzodiazepine	anti-ulcer drug; antispasmodic drug; muscarinic antagonist	2003	2010	17.0	low	0	0	0	3	0	0
potassium chloride	12	inorganic chloride; inorganic potassium salt; potassium salt	fertilizer	1976	2004	29.8	low	0	2	8	2	0	0
potassium iodide	1	potassium salt	expectorant; radical scavenger	1997	1997	27.0	low	0	0	1	0	0	0
ag 1879	1	aromatic amine; monochlorobenzenes; pyrazolopyrimidine	beta-adrenergic antagonist; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; geroprotector	2004	2004	20.0	low	0	0	0	1	0	0
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid	1	arenesulfonic acid; azobenzenes; methylpyridines; monohydroxypyridine; organic phosphate; pyridinecarbaldehyde	purinergic receptor P2X antagonist	2003	2003	21.0	low	0	0	0	1	0	0
probenecid	1	benzoic acids; sulfonamide	uricosuric drug	2002	2002	22.0	low	0	0	0	1	0	0
probucol	1	dithioketal; polyphenol	anti-inflammatory drug; anticholesteremic drug; antilipemic drug; antioxidant; cardiovascular drug	2004	2004	20.0	low	0	0	0	1	0	0
propidium	39	phenanthridines; quaternary ammonium ion	fluorochrome; intercalator	1992	2016	18.7	low	0	0	9	19	11	0
propranolol	1	naphthalenes; propanolamine; secondary amine	anti-arrhythmia drug; antihypertensive agent; anxiolytic drug; beta-adrenergic antagonist; environmental contaminant; human blood serum metabolite; vasodilator agent; xenobiotic	1978	1978	46.0	low	0	1	0	0	0	0
propyl gallate	1	trihydroxybenzoic acid		2008	2008	16.0	low	0	0	0	1	0	0
protoporphyrin ix	1			2014	2014	10.0	low	0	0	0	0	1	0
resorcinol	1	benzenediol; phenolic donor; resorcinols	erythropoietin inhibitor; sensitiser	2003	2003	21.0	low	0	0	0	1	0	0
ro 31-8220	1	imidothiocarbamic ester; indoles; maleimides	EC 2.7.11.13 (protein kinase C) inhibitor	2007	2007	17.0	low	0	0	0	1	0	0
linsidomine	3	morpholines		2010	2018	9.7	low	0	0	0	1	2	0
sodium fluoride	1	fluoride salt	mutagen	2000	2000	24.0	low	0	0	1	0	0	0
spiperone	1	aromatic ketone; azaspiro compound; organofluorine compound; piperidines; tertiary amino compound	alpha-adrenergic antagonist; antipsychotic agent; dopaminergic antagonist; psychotropic drug; serotonergic antagonist	2021	2021	3.0	low	0	0	0	0	0	1
stearic acid	3	long-chain fatty acid; saturated fatty acid; straight-chain saturated fatty acid	algal metabolite; Daphnia magna metabolite; human metabolite; plant metabolite	2004	2019	11.0	low	0	0	0	1	2	0
vorinostat	1	dicarboxylic acid diamide; hydroxamic acid	antineoplastic agent; apoptosis inducer; EC 3.5.1.98 (histone deacetylase) inhibitor	2021	2021	3.0	low	0	0	0	0	0	1
sulfobromophthalein	3	2-benzofurans; organobromine compound; organosulfonic acid; phenols	dye	1981	2019	19.0	low	0	1	0	0	2	0
sumatriptan	1	sulfonamide; tryptamines	serotonergic agonist; vasoconstrictor agent	2012	2012	12.0	low	0	0	0	0	1	0
telenzepine	3	benzodiazepine		2003	2010	17.0	low	0	0	0	3	0	0
temozolomide	3	imidazotetrazine; monocarboxylic acid amide; triazene derivative	alkylating agent; antineoplastic agent; prodrug	2021	2022	2.7	low	0	0	0	0	0	3
tetracaine	1	benzoate ester; tertiary amino compound	local anaesthetic	2000	2000	24.0	low	0	0	1	0	0	0
tetraethylammonium	3	quaternary ammonium ion		1986	1997	33.3	low	0	2	1	0	0	0
theobromine	1	dimethylxanthine	adenosine receptor antagonist; bronchodilator agent; food component; human blood serum metabolite; mouse metabolite; plant metabolite; vasodilator agent	2005	2005	19.0	low	0	0	0	1	0	0
tilorone	1	aromatic ether; diether; fluoren-9-ones; tertiary amino compound	anti-inflammatory agent; antineoplastic agent; antiviral agent; interferon inducer; nicotinic acetylcholine receptor agonist	2012	2012	12.0	low	0	0	0	0	1	0
tiopronin	1	N-acyl-amino acid		2007	2007	17.0	low	0	0	0	1	0	0
tranexamic acid	1	amino acid		1997	1997	27.0	low	0	0	1	0	0	0
triclosan	1	aromatic ether; dichlorobenzene; monochlorobenzenes; phenols	antibacterial agent; antimalarial; drug allergen; EC 1.3.1.9 [enoyl-[acyl-carrier-protein] reductase (NADH)] inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; fungicide; persistent organic pollutant; xenobiotic	2013	2013	11.0	low	0	0	0	0	1	0
trifluoperazine	1	N-alkylpiperazine; N-methylpiperazine; organofluorine compound; phenothiazines	antiemetic; calmodulin antagonist; dopaminergic antagonist; EC 1.8.1.12 (trypanothione-disulfide reductase) inhibitor; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; phenothiazine antipsychotic drug	1997	1997	27.0	low	0	0	1	0	0	0
trimethoprim	3	aminopyrimidine; methoxybenzenes	antibacterial drug; diuretic; drug allergen; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; environmental contaminant; xenobiotic	2012	2016	10.0	low	0	0	0	0	3	0
troglitazone	1	chromanes; thiazolidinone	anticoagulant; anticonvulsant; antineoplastic agent; antioxidant; EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; hypoglycemic agent; platelet aggregation inhibitor; vasodilator agent	2016	2016	8.0	low	0	0	0	0	1	0
troxipide	1	benzamides		2021	2021	3.0	low	0	0	0	0	0	1
tyramine	6	monoamine molecular messenger; primary amino compound; tyramines	EC 3.1.1.8 (cholinesterase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; neurotransmitter	1996	2021	16.7	low	0	0	3	0	2	1
urethane	1	carbamate ester	fungal metabolite; mutagen	2017	2017	7.0	low	0	0	0	0	1	0
usnic acid	1	benzofurans		2010	2010	14.0	low	0	0	0	1	0	0
w 7	1			2010	2010	14.0	low	0	0	0	1	0	0
8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine	1			2005	2005	19.0	low	0	0	0	1	0	0
zinc chloride	1	inorganic chloride; zinc molecular entity	astringent; disinfectant; EC 5.3.3.5 (cholestenol Delta-isomerase) inhibitor; Lewis acid	2018	2018	6.0	low	0	0	0	0	1	0
mitomycin	2	mitomycin	alkylating agent; antineoplastic agent	1989	2010	24.5	low	0	1	0	1	0	0
corticosterone	2	11beta-hydroxy steroid; 20-oxo steroid; 21-hydroxy steroid; 3-oxo-Delta(4) steroid; C21-steroid; glucocorticoid; primary alpha-hydroxy ketone	human metabolite; mouse metabolite	2005	2008	17.5	low	0	0	0	2	0	0
thymidine	10	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; metabolite; mouse metabolite	1994	2013	21.3	low	0	0	4	4	2	0
hydroxyproline	2	4-hydroxyproline; L-alpha-amino acid zwitterion	human metabolite; mouse metabolite; plant metabolite	2001	2019	14.0	low	0	0	0	1	1	0
thyroxine	1	2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine zwitterion; thyroxine	antithyroid drug; human metabolite; mouse metabolite; thyroid hormone	2020	2020	4.0	low	0	0	0	0	1	0
carbachol	3	ammonium salt; carbamate ester	cardiotonic drug; miotic; muscarinic agonist; nicotinic acetylcholine receptor agonist; non-narcotic analgesic	1988	2005	27.3	low	0	1	1	1	0	0
spironolactone	2	3-oxo-Delta(4) steroid; oxaspiro compound; steroid lactone; thioester	aldosterone antagonist; antihypertensive agent; diuretic; environmental contaminant; xenobiotic	2009	2019	10.0	low	0	0	0	1	1	0
estrone	2	17-oxo steroid; 3-hydroxy steroid; phenolic steroid; phenols	antineoplastic agent; bone density conservation agent; estrogen; human metabolite; mouse metabolite	2005	2015	14.0	low	0	0	0	1	1	0
2-acetylaminofluorene	1	2-acetamidofluorenes	antimitotic; carcinogenic agent; epitope; mutagen	2008	2008	16.0	low	0	0	0	1	0	0
penicillin g	2	penicillin allergen; penicillin	antibacterial drug; drug allergen; epitope	1993	2002	26.5	low	0	0	1	1	0	0
idoxuridine	1	organoiodine compound; pyrimidine 2'-deoxyribonucleoside	antiviral drug; DNA synthesis inhibitor	1998	1998	26.0	low	0	0	1	0	0	0
pentylenetetrazole	1	organic heterobicyclic compound; organonitrogen heterocyclic compound		2010	2010	14.0	low	0	0	0	1	0	0
carbon tetrachloride	2	chlorocarbon; chloromethanes	hepatotoxic agent; refrigerant	1994	2013	20.5	low	0	0	1	0	1	0
alanine	4	alanine zwitterion; alanine; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid	EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor; fundamental metabolite	2005	2015	12.8	low	0	0	0	1	3	0
serine	1	L-alpha-amino acid; proteinogenic amino acid; serine family amino acid; serine zwitterion; serine	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2009	2009	15.0	low	0	0	0	1	0	0
chloramphenicol	3	C-nitro compound; carboxamide; diol; organochlorine compound	antibacterial drug; antimicrobial agent; Escherichia coli metabolite; geroprotector; Mycoplasma genitalium metabolite; protein synthesis inhibitor	1997	2020	16.7	low	0	0	1	1	1	0
aspartic acid	3	aspartate family amino acid; aspartic acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; mouse metabolite; neurotransmitter	2000	2006	22.0	low	0	0	2	1	0	0
glutamine	2	amino acid zwitterion; glutamine family amino acid; glutamine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	EC 1.14.13.39 (nitric oxide synthase) inhibitor; Escherichia coli metabolite; human metabolite; metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2016	2018	7.0	low	0	0	0	0	2	0
lysine	26	aspartate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; lysine; organic molecular entity; proteinogenic amino acid	algal metabolite; anticonvulsant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	1996	2020	18.1	low	0	0	9	9	8	0
cyanides	6	pseudohalide anion	EC 1.9.3.1 (cytochrome c oxidase) inhibitor	1981	2021	16.3	low	0	1	1	0	3	1
chlorobutanol	1	tertiary alcohol		2015	2015	9.0	low	0	0	0	0	1	0
sucrose	5	glycosyl glycoside	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; osmolyte; Saccharomyces cerevisiae metabolite; sweetening agent	1993	2011	20.4	low	0	0	2	2	1	0
ethinyl estradiol	3	17-hydroxy steroid; 3-hydroxy steroid; terminal acetylenic compound	xenoestrogen	2010	2016	10.3	low	0	0	0	1	2	0
apomorphine	1	aporphine alkaloid	alpha-adrenergic drug; antidyskinesia agent; antiparkinson drug; dopamine agonist; emetic; serotonergic drug	2010	2010	14.0	low	0	0	0	1	0	0
adenosine diphosphate	13	adenosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	fundamental metabolite; human metabolite	1985	2016	22.0	low	0	1	5	4	3	0
uridine	2	uridines	drug metabolite; fundamental metabolite; human metabolite	2001	2009	19.0	low	0	0	0	2	0	0
bromodeoxyuridine	41	pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent	1995	2021	19.5	low	0	0	10	26	4	1
galactose	5	D-galactose; galactopyranose	Escherichia coli metabolite; mouse metabolite	2006	2013	14.6	low	0	0	0	3	2	0
carbostyril	1	monohydroxyquinoline; quinolone	bacterial xenobiotic metabolite	2004	2004	20.0	low	0	0	0	1	0	0
levodopa	1	amino acid zwitterion; dopa; L-tyrosine derivative; non-proteinogenic L-alpha-amino acid	allelochemical; antidyskinesia agent; antiparkinson drug; dopaminergic agent; hapten; human metabolite; mouse metabolite; neurotoxin; plant growth retardant; plant metabolite; prodrug	1997	1997	27.0	low	0	0	1	0	0	0
edetic acid	7	ethylenediamine derivative; polyamino carboxylic acid; tetracarboxylic acid	anticoagulant; antidote; chelator; copper chelator; geroprotector	1989	2020	20.6	low	0	1	2	3	1	0
p-dimethylaminoazobenzene	2	azobenzenes		1993	2005	25.0	low	0	0	1	1	0	0
tyrosine	3	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; proteinogenic amino acid; tyrosine	EC 1.3.1.43 (arogenate dehydrogenase) inhibitor; fundamental metabolite; micronutrient; nutraceutical	1994	2018	19.0	low	0	0	1	1	1	0
cysteamine	1	amine; thiol	geroprotector; human metabolite; mouse metabolite; radiation protective agent	2015	2015	9.0	low	0	0	0	0	1	0
adenosine monophosphate	2	adenosine 5'-phosphate; purine ribonucleoside 5'-monophosphate	adenosine A1 receptor agonist; cofactor; EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.11 (fructose-bisphosphatase) inhibitor; fundamental metabolite; micronutrient; nutraceutical	1982	2002	32.0	low	0	1	0	1	0	0
methicillin	1	penicillin allergen; penicillin	antibacterial drug	2017	2017	7.0	low	0	0	0	0	1	0
methylene blue	5	organic chloride salt	acid-base indicator; antidepressant; antimalarial; antimicrobial agent; antioxidant; cardioprotective agent; EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.1.1.8 (cholinesterase) inhibitor; EC 4.6.1.2 (guanylate cyclase) inhibitor; fluorochrome; histological dye; neuroprotective agent; physical tracer	1983	2011	25.2	low	0	1	1	2	1	0
4-toluenesulfonic acid	1	arenesulfonic acid; toluenes		1947	1947	77.0	low	0	1	0	0	0	0
leucine	2	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite	1990	2006	26.0	low	0	0	1	1	0	0
aniline	1	anilines; primary arylamine		2007	2007	17.0	low	0	0	0	1	0	0
uridine triphosphate	3	pyrimidine ribonucleoside 5'-triphosphate; uridine 5'-phosphate	Escherichia coli metabolite; mouse metabolite	1996	2019	18.0	low	0	0	1	1	1	0
lactose	2	lactose		2013	2018	8.5	low	0	0	0	0	2	0
methionine	6	aspartate family amino acid; L-alpha-amino acid; methionine zwitterion; methionine; proteinogenic amino acid	antidote to paracetamol poisoning; human metabolite; micronutrient; mouse metabolite; nutraceutical	1980	2017	16.7	low	0	1	0	1	4	0
1,2-dipalmitoylphosphatidylcholine	9			1987	2020	23.7	low	0	1	5	1	2	0
phenylalanine	5	amino acid zwitterion; erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid; phenylalanine; proteinogenic amino acid	algal metabolite; EC 3.1.3.1 (alkaline phosphatase) inhibitor; Escherichia coli metabolite; human xenobiotic metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	1982	2019	14.8	low	0	1	0	0	4	0
colchicine	3	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen	1994	2008	21.0	low	0	0	1	2	0	0
oxacillin	1	penicillin	antibacterial agent; antibacterial drug	1993	1993	31.0	low	0	0	1	0	0	0
cycloheximide	8	antibiotic fungicide; cyclic ketone; dicarboximide; piperidine antibiotic; piperidones; secondary alcohol	anticoronaviral agent; bacterial metabolite; ferroptosis inhibitor; neuroprotective agent; protein synthesis inhibitor	1989	2017	23.4	low	0	1	4	1	2	0
egtazic acid	9	diether; tertiary amino compound; tetracarboxylic acid	chelator	1976	2016	28.7	low	0	4	1	1	3	0
chloroform	2	chloromethanes; one-carbon compound	carcinogenic agent; central nervous system drug; inhalation anaesthetic; non-polar solvent; refrigerant	2007	2008	16.5	low	0	0	0	2	0	0
dimethylformamide	1	formamides; volatile organic compound	geroprotector; hepatotoxic agent; polar aprotic solvent	2004	2004	20.0	low	0	0	0	1	0	0
mannitol	3	mannitol	allergen; antiglaucoma drug; compatible osmolytes; Escherichia coli metabolite; food anticaking agent; food bulking agent; food humectant; food stabiliser; food thickening agent; hapten; metabolite; osmotic diuretic; sweetening agent	2001	2018	16.3	low	0	0	0	2	1	0
cytarabine	4	beta-D-arabinoside; monosaccharide derivative; pyrimidine nucleoside	antimetabolite; antineoplastic agent; antiviral agent; immunosuppressive agent	1986	2013	23.8	low	0	1	1	1	1	0
dithionitrobenzoic acid	3	nitrobenzoic acid; organic disulfide	indicator	1988	2020	20.7	low	0	1	0	1	1	0
trifluridine	1	nucleoside analogue; organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; EC 2.1.1.45 (thymidylate synthase) inhibitor	2021	2021	3.0	low	0	0	0	0	0	1
asparagine	1	amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	2010	2010	14.0	low	0	0	0	1	0	0
histidine	9	amino acid zwitterion; histidine; L-alpha-amino acid; polar amino acid zwitterion; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2004	2017	12.4	low	0	0	0	4	5	0
n-pentanol	1	pentanol; short-chain primary fatty alcohol	human metabolite; plant metabolite	1991	1991	33.0	low	0	0	1	0	0	0
valine	6	L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; pyruvate family amino acid; valine	algal metabolite; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	1990	2015	21.5	low	0	0	2	3	1	0
tryptophan	3	erythrose 4-phosphate/phosphoenolpyruvate family amino acid; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid; tryptophan zwitterion; tryptophan	antidepressant; Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite	2012	2020	9.3	low	0	0	0	0	3	0
isoleucine	1	aspartate family amino acid; isoleucine; L-alpha-amino acid zwitterion; L-alpha-amino acid; proteinogenic amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite	1990	1990	34.0	low	0	0	1	0	0	0
arginine	7	arginine; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	biomarker; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical	2003	2022	12.0	low	0	0	0	2	4	1
acetylene	1	alkyne; gas molecular entity; terminal acetylenic compound		2007	2007	17.0	low	0	0	0	1	0	0
boranes	1	boranes; mononuclear parent hydride		2013	2013	11.0	low	0	0	0	0	1	0
acetonitrile	2	aliphatic nitrile; volatile organic compound	EC 3.5.1.4 (amidase) inhibitor; NMR chemical shift reference compound; polar aprotic solvent	2012	2013	11.5	low	0	0	0	0	2	0
propylene oxide	1	epoxide		1999	1999	25.0	low	0	0	1	0	0	0
tert-butylhydroperoxide	4	alkyl hydroperoxide	antibacterial agent; oxidising agent	1999	2019	14.0	low	0	0	1	1	2	0
trichloroacetic acid	1	monocarboxylic acid; organochlorine compound	carcinogenic agent; metabolite; mouse metabolite	2009	2009	15.0	low	0	0	0	1	0	0
phencyclidine	1	benzenes; piperidines	anaesthetic; neurotoxin; NMDA receptor antagonist; psychotropic drug	1986	1986	38.0	low	0	1	0	0	0	0
tromethamine	1	primary amino compound; triol	buffer	1983	1983	41.0	low	0	1	0	0	0	0
isoprene	1	alkadiene; hemiterpene; volatile organic compound	plant metabolite	2015	2015	9.0	low	0	0	0	0	1	0
trichloroethylene	1	chloroethenes	inhalation anaesthetic; mouse metabolite	2022	2022	2.0	low	0	0	0	0	0	1
acrylic acid	3	alpha,beta-unsaturated monocarboxylic acid	metabolite	2015	2019	7.0	low	0	0	0	0	3	0
bisphenol a	1	bisphenol	endocrine disruptor; environmental contaminant; xenobiotic; xenoestrogen	2007	2007	17.0	low	0	0	0	1	0	0
ovex	1	arenesulfonic acid		2014	2014	10.0	medium	0	0	0	0	1	0
taurocholic acid	1	amino sulfonic acid; bile acid taurine conjugate	human metabolite	2019	2019	5.0	low	0	0	0	0	1	0
rhodamine b	10	organic chloride salt; xanthene dye	fluorescent probe; fluorochrome; histological dye	1993	2018	15.1	low	0	0	1	4	5	0
rotenone	17	organic heteropentacyclic compound; rotenones	antineoplastic agent; metabolite; mitochondrial NADH:ubiquinone reductase inhibitor; phytogenic insecticide; piscicide; toxin	1979	2016	24.5	low	0	4	4	7	2	0
carbazole	5	carbazole		2011	2016	10.4	low	0	0	0	0	5	0
2,4-dinitrobenzenesulfonic acid	1	arenesulfonic acid; C-nitro compound		2013	2013	11.0	low	0	0	0	0	1	0
salicylaldehyde	1	hydroxybenzaldehyde	nematicide; plant metabolite	2020	2020	4.0	low	0	0	0	0	1	0
1-naphthylphenylamine	4	naphthalenes		1983	2021	25.0	low	0	2	0	1	0	1
aminacrine	2	aminoacridines; primary amino compound	acid-base indicator; antiinfective agent; antiseptic drug; fluorescent dye; MALDI matrix material; mutagen	1985	2002	30.5	low	0	1	0	1	0	0
quinoxalines	2	mancude organic heterobicyclic parent; naphthyridine; ortho-fused heteroarene		1997	2006	22.5	low	0	0	1	1	0	0
quinoline	2	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinolines		2017	2022	4.5	low	0	0	0	0	1	1
2-naphthylamine	2	naphthylamine	carcinogenic agent	2014	2018	8.0	low	0	0	0	0	2	0
3,3'-diaminobenzidine	3	biphenyls; substituted aniline	histological dye	1996	2002	25.3	low	0	0	2	1	0	0
tolonium chloride	8			1983	2018	23.4	low	0	1	3	3	1	0
xanthenes	38	xanthene		1983	2021	15.6	low	0	2	4	14	17	1
phenothiazine	1	phenothiazine	ferroptosis inhibitor; plant metabolite; radical scavenger	2013	2013	11.0	low	0	0	0	0	1	0
benzothiazole	4	benzothiazoles	environmental contaminant; plant metabolite; xenobiotic	2014	2020	7.0	low	0	0	0	0	4	0
1,2-diaminobenzene	1	phenylenediamine	hydrogen donor	2005	2005	19.0	low	0	0	0	1	0	0
furaldehyde	1	aldehyde; furans	Maillard reaction product; metabolite	2020	2020	4.0	low	0	0	0	0	1	0
trehalose	1	trehalose	Escherichia coli metabolite; geroprotector; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2007	2007	17.0	low	0	0	0	1	0	0
styrene	2	styrenes; vinylarene; volatile organic compound	mouse metabolite; mutagen; plant metabolite	2014	2015	9.5	low	0	0	0	0	2	0
benzyl chloride	1	benzyl chlorides		2019	2019	5.0	low	0	0	0	0	1	0
caprolactam	1	caprolactams	human blood serum metabolite	2019	2019	5.0	low	0	0	0	0	1	0
acrolein	1	enal	herbicide; human xenobiotic metabolite; toxin	2016	2016	8.0	low	0	0	0	0	1	0
allyl alcohol	1	primary allylic alcohol; propenol	antibacterial agent; fungicide; herbicide; insecticide; plant metabolite	2003	2003	21.0	low	0	0	0	1	0	0
glyoxal	1	dialdehyde	agrochemical; allergen; pesticide; plant growth regulator	2002	2002	22.0	low	0	0	0	1	0	0
cyanuric chloride	1	chloro-1,3,5-triazine; organochlorine compound	cross-linking reagent	2015	2015	9.0	low	0	0	0	0	1	0
thiophenol	2	aryl thiol		2020	2021	3.5	low	0	0	0	0	1	1
pyrroles	13	pyrrole; secondary amine		2008	2021	12.0	low	0	0	0	6	6	1
tetrahydrofuran	1	cyclic ether; oxolanes; saturated organic heteromonocyclic parent; volatile organic compound	polar aprotic solvent	2007	2007	17.0	low	0	0	0	1	0	0
furan	1	furans; mancude organic heteromonocyclic parent; monocyclic heteroarene	carcinogenic agent; hepatotoxic agent; Maillard reaction product	2013	2013	11.0	low	0	0	0	0	1	0
thiophenes	3	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent	2004	2015	15.0	low	0	0	0	2	1	0
n,n,n',n'-tetramethylethylenediamine	1	ethylenediamine derivative	catalyst; chelator	1985	1985	39.0	low	0	1	0	0	0	0
cyclohexane	1	cycloalkane; volatile organic compound	non-polar solvent	2012	2012	12.0	low	0	0	0	0	1	0
cyclohexene	1	cycloalkene		2005	2005	19.0	low	0	0	0	1	0	0
1-hexanol	1	hexanol; primary alcohol	alarm pheromone; antibacterial agent; fragrance; plant metabolite	2006	2006	18.0	low	0	0	0	1	0	0
undecanoic acid	1	medium-chain fatty acid; straight-chain saturated fatty acid	antifungal agent; human metabolite	2008	2008	16.0	low	0	0	0	1	0	0
glycofurol	1	poly(ethylene glycol)		2018	2018	6.0	low	0	0	0	0	1	0
behenic acid	1	long-chain fatty acid; straight-chain saturated fatty acid	plant metabolite	2019	2019	5.0	low	0	0	0	0	1	0
trinitrotoluene	1	trinitrotoluene	explosive	2003	2003	21.0	low	0	0	0	1	0	0
pyrazolanthrone	1	anthrapyrazole; aromatic ketone; cyclic ketone	antineoplastic agent; c-Jun N-terminal kinase inhibitor; geroprotector	2012	2012	12.0	low	0	0	0	0	1	0
1-naphthylamine	4	naphthylamine	human xenobiotic metabolite	1983	2021	25.0	low	0	2	0	1	0	1
2-naphthol	3	naphthol	antinematodal drug; genotoxin; human urinary metabolite; human xenobiotic metabolite; mouse metabolite; radical scavenger	2016	2017	7.3	low	0	0	0	0	3	0
nitrilotriacetic acid	3	NTA; tricarboxylic acid	carcinogenic agent; nephrotoxic agent	2008	2010	15.0	low	0	0	0	3	0	0
n-butyl acrylate	1	acrylate ester		2017	2017	7.0	low	0	0	0	0	1	0
n-heptane	1	alkane; volatile organic compound	non-polar solvent; plant metabolite	2014	2014	10.0	low	0	0	0	0	1	0
sodium cyanide	1	cyanide salt; one-carbon compound; sodium salt	EC 1.15.1.1 (superoxide dismutase) inhibitor	2003	2003	21.0	low	0	0	0	1	0	0
tetraphenylborate	2			1980	1993	37.5	low	0	1	1	0	0	0
pregnenolone	2	20-oxo steroid; 3beta-hydroxy-Delta(5)-steroid; C21-steroid	human metabolite; mouse metabolite	1991	2015	21.0	low	0	0	1	0	1	0
potassium cyanide	1	cyanide salt; one-carbon compound; potassium salt	EC 1.15.1.1 (superoxide dismutase) inhibitor; EC 1.9.3.1 (cytochrome c oxidase) inhibitor; neurotoxin	2000	2000	24.0	low	0	0	1	0	0	0
catechin	3	catechin	antioxidant; plant metabolite	2004	2019	13.0	low	0	0	0	2	1	0
perylene	8	ortho- and peri-fused polycyclic arene; perylenes		2002	2022	11.4	low	0	0	0	3	4	1
quinazolines	1	azaarene; mancude organic heterobicyclic parent; ortho-fused heteroarene; quinazolines		2016	2016	8.0	low	0	0	0	0	1	0
acridines	3	acridines; mancude organic heterotricyclic parent; polycyclic heteroarene	genotoxin	1978	2012	24.0	low	0	1	0	1	1	0
indazoles	1	indazole		2020	2020	4.0	low	0	0	0	0	1	0
benzoxazoles	13	1,3-benzoxazoles; mancude organic heterobicyclic parent		1975	2016	20.9	low	0	2	2	5	4	0
adamantane	2	adamantanes; polycyclic alkane		2014	2015	9.5	low	0	0	0	0	2	0
cyclopentane	3	cycloalkane; cyclopentanes; volatile organic compound	non-polar solvent	1994	2005	25.0	low	0	0	2	1	0	0
isoxazoles	9	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1979	2015	27.3	low	0	3	3	1	2	0
oxazoles	8	1,3-oxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1985	2021	18.6	low	0	2	1	1	3	1
thiazoles	48	1,3-thiazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene		1975	2018	22.2	low	0	8	6	25	9	0
pyrimidine	1	diazine; pyrimidines	Daphnia magna metabolite	2008	2008	16.0	low	0	0	0	1	0	0
pyrazines	4	diazine; pyrazines	Daphnia magna metabolite	2009	2021	8.8	low	0	0	0	1	2	1
nitroblue tetrazolium	1	organic cation		1996	1996	28.0	low	0	0	1	0	0	0
triphenyltetrazolium	2	organic cation		2010	2011	13.5	low	0	0	0	1	1	0
muscarine	1	monosaccharide		2005	2005	19.0	low	0	0	0	1	0	0
hydrazine	21	azane; hydrazines	EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor	2001	2022	13.3	low	0	0	0	11	9	1
monocrotaline	1	pyrrolizidine alkaloid		2013	2013	11.0	low	0	0	0	0	1	0
perflexane	2	fluoroalkane; fluorocarbon; volatile organic compound	non-polar solvent; radioopaque medium	2017	2019	6.0	low	0	0	0	0	2	0
methysergide	1	ergoline alkaloid		2011	2011	13.0	low	0	0	0	0	1	0
cuprizone	1	organonitrogen compound; organooxygen compound		2011	2011	13.0	low	0	0	0	0	1	0
perflubron	1	haloalkane; organobromine compound; perfluorinated compound	blood substitute; radioopaque medium	2017	2017	7.0	low	0	0	0	0	1	0
2-aminopurine	4	2-aminopurines; nucleobase analogue	antimetabolite	2001	2018	16.0	low	0	0	0	3	1	0
limestone	1	calcium salt; carbonate salt; inorganic calcium salt; one-carbon compound	antacid; fertilizer; food colouring; food firming agent	2019	2019	5.0	low	0	0	0	0	1	0
glycocholic acid	1	bile acid glycine conjugate	human metabolite	2020	2020	4.0	low	0	0	0	0	1	0
bicuculline	5	benzylisoquinoline alkaloid; isoquinoline alkaloid; isoquinolines	agrochemical; central nervous system stimulant; GABA-gated chloride channel antagonist; GABAA receptor antagonist; neurotoxin	1997	2004	21.6	low	0	0	1	4	0	0
kainic acid	6	dicarboxylic acid; L-proline derivative; non-proteinogenic L-alpha-amino acid; pyrrolidinecarboxylic acid	antinematodal drug; excitatory amino acid agonist	1988	2001	29.8	low	0	1	4	1	0	0
thymoquinone	1	1,4-benzoquinones	adjuvant; anti-inflammatory agent; antidepressant; antineoplastic agent; antioxidant; cardioprotective agent; plant metabolite	2012	2012	12.0	low	0	0	0	0	1	0
methyl red	2			2011	2012	12.5	low	0	0	0	0	2	0
indoline	1	indoles		2014	2014	10.0	low	0	0	0	0	1	0
sodium carbonate	1	carbonate salt; organic sodium salt		2011	2011	13.0	low	0	0	0	0	1	0
carvacrol	1	botanical anti-fungal agent; p-menthane monoterpenoid; phenols	agrochemical; antimicrobial agent; flavouring agent; TRPA1 channel agonist; volatile oil component	2016	2016	8.0	low	0	0	0	0	1	0
caprolactone	1	epsilon-lactone		2015	2015	9.0	low	0	0	0	0	1	0
thiazolidines	6	thiazolidine		1999	2013	18.5	low	0	0	2	2	2	0
echothiophate iodide	1	iodide salt; quaternary ammonium salt	antiglaucoma drug; EC 3.1.1.8 (cholinesterase) inhibitor; miotic	1995	1995	29.0	low	0	0	1	0	0	0
dithiazanine	1	benzothiazoles; benzothiazolium ion	anthelminthic drug; fluorochrome	2015	2015	9.0	low	0	0	0	0	1	0
hematoxylin	2	organic heterotetracyclic compound; oxacycle; polyphenol; tertiary alcohol	histological dye; plant metabolite	2000	2005	21.5	low	0	0	1	1	0	0
luminol	1			2003	2003	21.0	low	0	0	0	1	0	0
copper gluconate	1	organic molecular entity		1981	1981	43.0	low	0	1	0	0	0	0
azomycin	4	C-nitro compound; imidazoles	antitubercular agent	2012	2021	9.5	low	0	0	0	0	3	1
tropolone	1	alpha-hydroxy ketone; cyclic ketone; enol	bacterial metabolite; fungicide; toxin	2019	2019	5.0	low	0	0	0	0	1	0
methoxyhydroxyphenylglycol	1	methoxybenzenes; phenols		2005	2005	19.0	low	0	0	0	1	0	0
dicyclohexylcarbodiimide	1	carbodiimide	ATP synthase inhibitor; cross-linking reagent; peptide coupling reagent	2001	2001	23.0	low	0	0	0	1	0	0
uranyl acetate	1			2014	2014	10.0	low	0	0	0	0	1	0
maleimide	7	dicarboximide; maleimides	EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	1998	2019	14.6	low	0	0	1	3	3	0
malondialdehyde	5	dialdehyde	biomarker	1989	2014	17.8	low	0	1	0	3	1	0
cadmium acetate	1			2021	2021	3.0	low	0	0	0	0	0	1
trinitrobenzenesulfonic acid	2	arenesulfonic acid; C-nitro compound	epitope; explosive; reagent	1985	2013	25.0	low	0	1	0	0	1	0
eosine yellowish-(ys)	2	organic sodium salt; organobromine compound	fluorochrome; histological dye	2000	2005	21.5	low	0	0	1	1	0	0
gentian violet	2	organic chloride salt	anthelminthic drug; antibacterial agent; antifungal agent; antiseptic drug; histological dye	2006	2011	15.5	low	0	0	0	1	1	0
resazurin	3	phenoxazine		2003	2014	16.3	low	0	0	0	2	1	0
hematoporphyrin	1			2015	2015	9.0	low	0	0	0	0	1	0
neutral red	1	hydrochloride	acid-base indicator; dye; two-colour indicator	1996	1996	28.0	low	0	0	1	0	0	0
4-chloromercuribenzenesulfonate	1	arenesulfonic acid; arylmercury compound		1990	1990	34.0	low	0	0	1	0	0	0
glycyl-glycyl-glycine	1	tripeptide zwitterion; tripeptide		2009	2009	15.0	low	0	0	0	1	0	0
malachite green	2	organic chloride salt	antibacterial agent; antifungal drug; carcinogenic agent; environmental contaminant; fluorochrome; histological dye; teratogenic agent	2016	2018	7.0	low	0	0	0	0	2	0
congo red	2	bis(azo) compound		2003	2007	19.0	low	0	0	0	2	0	0
docusate	2	diester; organosulfonic acid		2011	2012	12.5	low	0	0	0	0	2	0
acetylcysteine	6	acetylcysteine; L-cysteine derivative; N-acetyl-L-amino acid	antidote to paracetamol poisoning; antiinfective agent; antioxidant; antiviral drug; ferroptosis inhibitor; geroprotector; human metabolite; mucolytic; radical scavenger; vulnerary	1995	2015	19.5	low	0	0	1	4	1	0
ethyl pyruvate	1	oxo carboxylic acid		2015	2015	9.0	low	0	0	0	0	1	0
amyl acetate	1	acetate ester	metabolite	1991	1991	33.0	low	0	0	1	0	0	0
1-octyne	1			2013	2013	11.0	low	0	0	0	0	1	0
c.i. 42510	7			1980	2018	26.6	low	0	3	1	1	2	0
triphenyltin chloride	1	chlorine molecular entity; organotin compound	antifungal agrochemical; immunosuppressive agent	1991	1991	33.0	low	0	0	1	0	0	0
erythromycin	1	cyclic ketone; erythromycin		2021	2021	3.0	low	0	0	0	0	0	1
2-piperidone	1	delta-lactam; piperidones	EC 1.2.1.88 (L-glutamate gamma-semialdehyde dehydrogenase) inhibitor	2002	2002	22.0	low	0	0	0	1	0	0
perfluoropentane	1	fluoroalkane; fluorocarbon	radioopaque medium; ultrasound contrast agent	2018	2018	6.0	low	0	0	0	0	1	0
diethyl chlorophosphate	1			2017	2017	7.0	low	0	0	0	0	1	0
amaranth dye	1			2007	2007	17.0	low	0	0	0	1	0	0
deoxycytidine	6	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2008	2019	9.5	low	0	0	0	1	5	0
deoxyuridine	5	pyrimidine 2'-deoxyribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1998	2019	12.8	low	0	0	1	1	3	0
2,6-dichloroindophenol	1	dichlorobenzene; quinone imine		2002	2002	22.0	low	0	0	0	1	0	0
rhodamine 6g	10			1985	2016	17.3	low	0	1	1	4	4	0
pyrrole-2-carboxaldehyde	1	1,3-thiazole-2-carbaldehyde; pyrroles		2008	2008	16.0	low	0	0	0	1	0	0
ethambutol	1	ethanolamines; ethylenediamine derivative	antitubercular agent; environmental contaminant; xenobiotic	1999	1999	25.0	low	0	0	1	0	0	0
3,3',4',5-tetrachlorosalicylanilide	1	dichlorobenzene; salicylanilides	drug allergen	1981	1981	43.0	low	0	1	0	0	0	0
carmine	1			2005	2005	19.0	low	0	0	0	1	0	0
durapatite	2			2012	2013	11.5	low	0	0	0	0	2	0
cadmium sulfide	1	cadmium molecular entity		2019	2019	5.0	low	0	0	0	0	1	0
sodium hydroxide	2	alkali metal hydroxide		2003	2008	18.5	low	0	0	0	2	0	0
molybdenum trioxide	1	molybdenum oxide		2019	2019	5.0	low	0	0	0	0	1	0
zinc oxide	5	zinc molecular entity		2011	2019	10.4	low	0	0	0	0	5	0
arsenic trioxide	1			2012	2012	12.0	low	0	0	0	0	1	0
vancomycin	1	glycopeptide	antibacterial drug; antimicrobial agent; bacterial metabolite	2017	2017	7.0	low	0	0	0	0	1	0
d-alpha tocopherol	5	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite	1994	2003	25.4	low	0	0	3	2	0	0
selenomethionine	1	selenoamino acid; selenomethionines	plant metabolite	2019	2019	5.0	low	0	0	0	0	1	0
digoxigenin	5	12beta-hydroxy steroid; 14beta-hydroxy steroid; 3beta-hydroxy steroid; 3beta-sterol	hapten; plant metabolite	2008	2018	11.6	low	0	0	0	2	3	0
stearylamine	1	primary aliphatic amine	film-forming compound	2019	2019	5.0	low	0	0	0	0	1	0
2'-deoxyadenosine triphosphate	1	2'-deoxyadenosine 5'-phosphate; purine 2'-deoxyribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite	2020	2020	4.0	low	0	0	0	0	1	0
dronabinol	1	benzochromene; diterpenoid; phytocannabinoid; polyketide	cannabinoid receptor agonist; epitope; hallucinogen; metabolite; non-narcotic analgesic	2003	2003	21.0	low	0	0	0	1	0	0
amiloride	2	aromatic amine; guanidines; organochlorine compound; pyrazines	diuretic; sodium channel blocker	1985	2001	31.0	low	0	1	0	1	0	0
n-isopropylacrylamide	1			2012	2012	12.0	low	0	0	0	0	1	0
fluorescein	36	2-benzofurans; gamma-lactone; organic heteropentacyclic compound; oxaspiro compound; polyphenol; xanthene dye	fluorescent dye; radioopaque medium	1983	2020	19.0	low	0	2	7	18	9	0
nile blue	2			1980	2003	32.5	low	0	1	0	1	0	0
thioflavin t	8	organic chloride salt	fluorochrome; geroprotector; histological dye	1998	2020	13.9	low	0	0	1	3	4	0
fucose	6	fucopyranose; L-fucose	Escherichia coli metabolite; mouse metabolite	1982	2021	19.5	low	0	2	0	0	3	1
glyphosphine	1	glycine derivative; phosphonic acids; tertiary amino compound	plant growth retardant	2005	2005	19.0	medium	0	0	0	1	0	0
sulfur hexafluoride	1	sulfur coordination entity	greenhouse gas; NMR chemical shift reference compound; ultrasound contrast agent	2004	2004	20.0	low	0	0	0	1	0	0
fluorescein-5-isothiocyanate	82	fluorescein isothiocyanate		1987	2022	17.8	low	1	1	25	27	26	3
sabinene	1	thujene	plant metabolite	2006	2006	18.0	low	0	0	0	1	0	0
2-(2-hydroxyphenyl)benzothiazole	2	benzothiazoles; phenols	geroprotector	2016	2019	6.5	low	0	0	0	0	2	0
mannose	2	D-aldohexose; D-mannose; mannopyranose	metabolite	2016	2020	6.0	low	0	0	0	0	2	0
dithiothreitol	3	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent	2002	2018	13.0	low	0	0	0	1	2	0
carbonates	2	carbon oxoanion		2011	2013	12.0	low	0	0	0	0	2	0
l 451167	1			1996	1996	28.0	low	0	0	1	0	0	0
acetylthiocholine	1			2019	2019	5.0	low	0	0	0	0	1	0
buthionine sulfoximine	2	diastereoisomeric mixture; homocysteines; non-proteinogenic alpha-amino acid; sulfoximide	EC 6.3.2.2 (glutamate--cysteine ligase) inhibitor; ferroptosis inducer	2008	2010	15.0	low	0	0	0	2	0	0
4-aminobenzhydrazide	1			2015	2015	9.0	low	0	0	0	0	1	0
4-(4-dimethylaminophenylazo)benzoic acid	1			2005	2005	19.0	low	0	0	0	1	0	0
n-methylaspartate	7	amino dicarboxylic acid; D-alpha-amino acid; D-aspartic acid derivative; secondary amino compound	neurotransmitter agent	1999	2015	21.0	low	0	0	1	5	1	0
enbucrilate	3	alpha,beta-unsaturated monocarboxylic acid; nitrile		2011	2017	10.0	low	0	0	0	0	3	0
hepes	1	HEPES; organosulfonic acid		2002	2002	22.0	low	0	0	0	1	0	0
dysprosium	1	f-block element atom; lanthanoid atom		2017	2017	7.0	low	0	0	0	0	1	0
iridium	4	cobalt group element atom; platinum group metal atom		2012	2019	9.0	low	0	0	0	0	4	0
lanthanum	4	f-block element atom; lanthanoid atom; scandium group element atom		1989	2006	26.0	low	0	1	2	1	0	0
manganese	2	elemental manganese; manganese group element atom	Escherichia coli metabolite; micronutrient	2010	2013	12.5	low	0	0	0	1	1	0
mercury	13	elemental mercury; zinc group element atom	neurotoxin	2008	2022	10.2	low	0	0	0	2	10	1
molybdenum	1	chromium group element atom	micronutrient	2019	2019	5.0	low	0	0	0	0	1	0
neodymium	1	f-block element atom; lanthanoid atom		2015	2015	9.0	low	0	0	0	0	1	0
palladium	2	metal allergen; nickel group element atom; platinum group metal atom		2013	2014	10.5	low	0	0	0	0	2	0
platinum	4	elemental platinum; nickel group element atom; platinum group metal atom		2003	2020	9.0	low	0	0	0	1	3	0
rhodium	2	cobalt group element atom		2017	2020	5.5	low	0	0	0	0	2	0
ruthenium	8	iron group element atom; platinum group metal atom		2000	2020	15.0	low	0	0	1	3	4	0
silver	52	copper group element atom; elemental silver	Escherichia coli metabolite	1990	2022	13.8	low	0	0	3	20	28	1
technetium	5	manganese group element atom		2009	2017	12.0	low	0	0	0	3	2	0
terbium	7	f-block element atom; lanthanoid atom		1988	2020	13.0	low	0	1	0	2	4	0
titanium	2	titanium group element atom		2012	2018	9.0	low	0	0	0	0	2	0
tungsten	3	chromium group element atom	micronutrient	2002	2019	14.7	low	0	0	0	2	1	0
argon	1	monoatomic argon; noble gas atom; p-block element atom	food packaging gas; neuroprotective agent	1994	1994	30.0	low	0	0	1	0	0	0
cadmium	4	cadmium molecular entity; zinc group element atom		1999	2021	16.2	low	0	0	2	0	1	1
cerium	2	f-block element atom; lanthanoid atom		2006	2019	11.5	low	0	0	0	1	1	0
chromium	1	chromium group element atom; metal allergen	micronutrient	2012	2012	12.0	low	0	0	0	0	1	0
europium	12	f-block element atom; lanthanoid atom		1998	2019	14.2	low	0	0	1	4	7	0
gadolinium	14	f-block element atom; lanthanoid atom		2004	2021	9.6	low	0	0	0	2	11	1
gold	102	copper group element atom; elemental gold		1998	2022	9.5	low	0	0	2	18	78	4
helium	1	monoatomic helium; noble gas atom; s-block element atom	food packaging gas	2013	2013	11.0	low	0	0	0	0	1	0
uranium	1	actinoid atom; f-block element atom; monoatomic uranium		2016	2016	8.0	low	0	0	0	0	1	0
xenon	1	monoatomic xenon; noble gas atom; p-block element atom		2004	2004	20.0	low	0	0	0	1	0	0
yttrium	2	d-block element atom; rare earth metal atom; scandium group element atom		2017	2020	5.5	low	0	0	0	0	2	0
zirconium	1	titanium group element atom		2021	2021	3.0	low	0	0	0	0	0	1
mercuric chloride	1	mercury coordination entity	sensitiser	2004	2004	20.0	low	0	0	0	1	0	0
acetylglucosamine	1	N-acetyl-D-glucosamine	epitope	2017	2017	7.0	low	0	0	0	0	1	0
sodium nitrate	1	inorganic nitrate salt; inorganic sodium salt	fertilizer; NMR chemical shift reference compound	2020	2020	4.0	low	0	0	0	0	1	0
hypochlorous acid	7	chlorine oxoacid; reactive oxygen species	EC 2.5.1.18 (glutathione transferase) inhibitor; EC 3.1.1.7 (acetylcholinesterase) inhibitor; human metabolite	2012	2023	8.4	low	0	0	0	0	6	1
camptothecin	7	delta-lactone; pyranoindolizinoquinoline; quinoline alkaloid; tertiary alcohol	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor; genotoxin; plant metabolite	2002	2018	10.7	low	0	0	0	1	6	0
ferric chloride	1	iron coordination entity	astringent; Lewis acid	2010	2010	14.0	low	0	0	0	1	0	0
isopentenyladenosine	1	N-ribosyl-N(6)-isopentenyladenine; nucleoside analogue	antineoplastic agent; plant growth regulator; plant metabolite	2018	2018	6.0	low	0	0	0	0	1	0
zinc sulfate	1	metal sulfate; zinc molecular entity	fertilizer	2006	2006	18.0	low	0	0	0	1	0	0
tricalcium phosphate	2	calcium phosphate		2009	2014	12.5	low	0	0	0	1	1	0
ferrous chloride	1	iron coordination entity		2009	2009	15.0	low	0	0	0	1	0	0
copper sulfate	2	metal sulfate	emetic; fertilizer; sensitiser	2003	2004	20.5	low	0	0	0	2	0	0
silver nitrate	1	inorganic nitrate salt; silver salt	astringent	1981	1981	43.0	low	0	1	0	0	0	0
potassium sulfate	1	inorganic potassium salt; potassium salt		2006	2006	18.0	low	0	0	0	1	0	0
deuterium	2	dihydrogen		1993	2010	22.5	low	0	0	1	1	0	0
fluorine	5	diatomic fluorine; gas molecular entity	NMR chemical shift reference compound	2003	2017	15.2	low	0	0	0	3	2	0
chlorine	1	diatomic chlorine; gas molecular entity	bleaching agent	2010	2010	14.0	low	0	0	0	1	0	0
deuterium oxide	1	deuterated compound; water	NMR solvent	2003	2003	21.0	low	0	0	0	1	0	0
ozone	6	elemental molecule; gas molecular entity; reactive oxygen species; triatomic oxygen	antiseptic drug; disinfectant; electrophilic reagent; greenhouse gas; mutagen; oxidising agent; tracer	2003	2017	13.5	low	0	0	0	3	3	0
4-chloro-7-nitrobenzofurazan	11	benzoxadiazole; C-nitro compound; organochlorine compound	EC 1.4.3.4 (monoamine oxidase) inhibitor; EC 3.6.1.3 (adenosinetriphosphatase) inhibitor; fluorescent probe; fluorochrome	1992	2018	21.9	low	0	0	6	3	2	0
trolamine salicylate	4			1988	2015	16.5	low	0	1	0	0	3	0
clodronic acid	1	1,1-bis(phosphonic acid); one-carbon compound; organochlorine compound	antineoplastic agent; bone density conservation agent	2020	2020	4.0	low	0	0	0	0	1	0
ammonium chloride	3	ammonium salt; inorganic chloride	ferroptosis inhibitor	1997	2020	18.0	low	0	0	1	1	1	0
titanium dioxide	1	titanium oxides	food colouring	2012	2012	12.0	low	0	0	0	0	1	0
diacerein	1	anthraquinone		2020	2020	4.0	low	0	0	0	0	1	0
tetradecanoylphorbol acetate	18	acetate ester; diester; phorbol ester; tertiary alpha-hydroxy ketone; tetradecanoate ester	antineoplastic agent; apoptosis inducer; carcinogenic agent; mitogen; plant metabolite; protein kinase C agonist; reactive oxygen species generator	1980	2018	29.3	low	0	7	5	4	2	0
fluorides	6	halide anion; monoatomic fluorine		1979	2021	12.5	low	0	1	0	0	4	1
stannic oxide	2	tin oxide		2011	2014	11.5	low	0	0	0	0	2	0
cresyl violet	3			2000	2013	19.3	low	0	0	1	1	1	0
molybdenum dioxide	1			2019	2019	5.0	low	0	0	0	0	1	0
oryzalin	1	aromatic amine; C-nitro compound; sulfonamide; tertiary amino compound	agrochemical; antimitotic; herbicide	2000	2000	24.0	low	0	0	1	0	0	0
1-deoxynojirimycin	1	2-(hydroxymethyl)piperidine-3,4,5-triol; piperidine alkaloid	anti-HIV agent; anti-obesity agent; bacterial metabolite; EC 3.2.1.20 (alpha-glucosidase) inhibitor; hepatoprotective agent; hypoglycemic agent; plant metabolite	2004	2004	20.0	low	0	0	0	1	0	0
iodine	5	halide anion; monoatomic iodine	human metabolite	1996	2020	16.8	low	0	0	1	2	2	0
osmium tetroxide	1	osmium coordination entity	fixative; histological dye; oxidising agent; poison	1997	1997	27.0	low	0	0	1	0	0	0
daunorubicin	6	aminoglycoside antibiotic; anthracycline; p-quinones; tetracenequinones	antineoplastic agent; bacterial metabolite	2000	2023	17.0	low	0	0	1	4	0	1
phosphotyrosine	3	L-tyrosine derivative; non-proteinogenic L-alpha-amino acid; O(4)-phosphotyrosine	Escherichia coli metabolite; immunogen	1994	2004	24.7	low	0	0	2	1	0	0
phenyl acetate	5	benzenes; phenyl acetates		1979	2021	17.0	low	0	1	0	2	1	1
phenoxyethanol	1	aromatic ether; glycol ether; primary alcohol	antiinfective agent; central nervous system depressant	2004	2004	20.0	low	0	0	0	1	0	0
dimethylacetamide	1	acetamides; monocarboxylic acid amide	human metabolite	2002	2002	22.0	low	0	0	0	1	0	0
pregnanolone	1	3-hydroxy-5beta-pregnan-20-one; 3alpha-hydroxy steroid	human metabolite; intravenous anaesthetic; sedative	2002	2002	22.0	low	0	0	0	1	0	0
1,4-diaminoanthraquinone	1			2003	2003	21.0	low	0	0	0	1	0	0
pyrene	5	ortho- and peri-fused polycyclic arene	fluorescent probe; persistent organic pollutant	2012	2020	6.4	low	0	0	0	0	5	0
dihydro-beta-erythroidine	1	delta-lactone; organic heterotetracyclic compound; tertiary amino compound	nicotinic antagonist	2007	2007	17.0	low	0	0	0	1	0	0
8-bromo cyclic adenosine monophosphate	1	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; organobromine compound	antidepressant; protein kinase agonist	2005	2005	19.0	low	0	0	0	1	0	0
transferrin	14			1994	2019	12.8	low	0	0	3	1	10	0
alkenes	6			1979	2018	16.7	low	0	1	0	2	3	0
glutamic acid	23	glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical	1988	2019	19.0	low	0	1	5	13	4	0
azoxymethane	2			2012	2016	10.0	low	0	0	0	0	2	0
torpedo	1			2003	2003	21.0	low	0	0	0	1	0	0
sodium azide	4	inorganic sodium salt	antibacterial agent; explosive; mitochondrial respiratory-chain inhibitor; mutagen	2000	2014	15.8	low	0	0	1	2	1	0
azides	37	pseudohalide anion	mitochondrial respiratory-chain inhibitor	1993	2023	9.6	low	0	0	3	2	30	2
adenosine diphosphate ribose	1	ADP-sugar	Escherichia coli metabolite; mouse metabolite	1995	1995	29.0	low	0	0	1	0	0	0
nigericin	6	polycyclic ether	antibacterial agent; antimicrobial agent; bacterial metabolite; potassium ionophore	1977	2000	37.3	low	0	4	2	0	0	0
acetylgalactosamine	1	N-acetyl-D-hexosamine; N-acetylgalactosamine	Escherichia coli metabolite; human metabolite; mouse metabolite	1996	1996	28.0	low	0	0	1	0	0	0
paclitaxel	21	taxane diterpenoid; tetracyclic diterpenoid	antineoplastic agent; human metabolite; metabolite; microtubule-stabilising agent	1989	2021	13.2	low	0	1	3	4	11	2
etoposide	3	beta-D-glucoside; furonaphthodioxole; organic heterotetracyclic compound	antineoplastic agent; DNA synthesis inhibitor	2000	2017	16.0	low	0	0	1	1	1	0
substance p	19	peptide	neurokinin-1 receptor agonist; neurotransmitter; vasodilator agent	1991	2007	25.1	low	0	0	12	7	0	0
rhodamine wt	1			1983	1983	41.0	low	0	1	0	0	0	0
phorbol 12,13-dibutyrate	1	butyrate ester; phorbol ester; tertiary alpha-hydroxy ketone		1992	1992	32.0	low	0	0	1	0	0	0
n-(2-hydroxypropyl)methacrylamide	3			2013	2016	9.3	low	0	0	0	0	3	0
1-methyl-4-phenylpyridinium	4	pyridinium ion	apoptosis inducer; herbicide; human xenobiotic metabolite; neurotoxin	2003	2016	17.0	low	0	0	0	3	1	0
ng-nitroarginine methyl ester	2	alpha-amino acid ester; L-arginine derivative; methyl ester; N-nitro compound	EC 1.14.13.39 (nitric oxide synthase) inhibitor	2000	2005	21.5	low	0	0	1	1	0	0
quisqualic acid	1	non-proteinogenic alpha-amino acid		1988	1988	36.0	low	0	1	0	0	0	0
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	6	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor	2001	2016	14.8	low	0	0	0	3	3	0
epirubicin	2	aminoglycoside; anthracycline antibiotic; anthracycline; deoxy hexoside; monosaccharide derivative; p-quinones; primary alpha-hydroxy ketone; tertiary alpha-hydroxy ketone	antimicrobial agent; antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor	2015	2016	8.5	low	0	0	0	0	2	0
enkephalin, methionine	1			1994	1994	30.0	low	0	0	1	0	0	0
idarubicin	1	anthracycline antibiotic; deoxy hexoside; monosaccharide derivative		2002	2002	22.0	low	0	0	0	1	0	0
laurocapram	1			2015	2015	9.0	low	0	0	0	0	1	0
captopril	1	alkanethiol; L-proline derivative; N-acylpyrrolidine; pyrrolidinemonocarboxylic acid	antihypertensive agent; EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor	2009	2009	15.0	low	0	0	0	1	0	0
mezlocillin	1			1999	1999	25.0	low	0	0	1	0	0	0
colforsin	1	acetate ester; cyclic ketone; labdane diterpenoid; organic heterotricyclic compound; tertiary alpha-hydroxy ketone; triol	adenylate cyclase agonist; anti-HIV agent; antihypertensive agent; plant metabolite; platelet aggregation inhibitor; protein kinase A agonist	2005	2005	19.0	low	0	0	0	1	0	0
fomesafen	2	aromatic ether; C-nitro compound; monochlorobenzenes; N-sulfonylcarboxamide; organofluorine compound; phenols	agrochemical; EC 1.3.3.4 (protoporphyrinogen oxidase) inhibitor; herbicide	1997	2000	25.5	low	0	0	2	0	0	0
fenoxycarb	3	aromatic ether; carbamate ester	environmental contaminant; insecticide; juvenile hormone mimic; xenobiotic	2012	2020	8.7	low	0	0	0	0	3	0
miglustat	1	piperidines; tertiary amino compound	anti-HIV agent; EC 2.4.1.80 (ceramide glucosyltransferase) inhibitor	2004	2004	20.0	low	0	0	0	1	0	0
lovastatin	5	delta-lactone; fatty acid ester; hexahydronaphthalenes; polyketide; statin (naturally occurring)	anticholesteremic drug; antineoplastic agent; Aspergillus metabolite; prodrug	1993	2007	26.6	low	0	0	4	1	0	0
simvastatin	2	delta-lactone; fatty acid ester; hexahydronaphthalenes; statin (semi-synthetic)	EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitor; EC 3.4.24.83 (anthrax lethal factor endopeptidase) inhibitor; ferroptosis inducer; geroprotector; prodrug	1995	1995	29.0	low	0	0	2	0	0	0
fura-2	9			1991	2004	25.6	low	0	0	6	3	0	0
topotecan	1	pyranoindolizinoquinoline	antineoplastic agent; EC 5.99.1.2 (DNA topoisomerase) inhibitor	2012	2012	12.0	low	0	0	0	0	1	0
gemcitabine	6	organofluorine compound; pyrimidine 2'-deoxyribonucleoside	antimetabolite; antineoplastic agent; antiviral drug; DNA synthesis inhibitor; EC 1.17.4.1 (ribonucleoside-diphosphate reductase) inhibitor; environmental contaminant; immunosuppressive agent; photosensitizing agent; prodrug; radiosensitizing agent; xenobiotic	2008	2019	9.5	low	0	0	0	1	5	0
temoporfin	1			2010	2010	14.0	low	0	0	0	1	0	0
atorvastatin	2	aromatic amide; dihydroxy monocarboxylic acid; monofluorobenzenes; pyrroles; statin (synthetic)	environmental contaminant; xenobiotic	2008	2008	16.0	low	0	0	0	2	0	0
irinotecan	1	carbamate ester; delta-lactone; N-acylpiperidine; pyranoindolizinoquinoline; ring assembly; tertiary alcohol; tertiary amino compound	antineoplastic agent; apoptosis inducer; EC 5.99.1.2 (DNA topoisomerase) inhibitor; prodrug	2016	2016	8.0	low	0	0	0	0	1	0
ibandronic acid	1			2008	2008	16.0	low	0	0	0	1	0	0
adenosine	6	adenosines; purines D-ribonucleoside	analgesic; anti-arrhythmia drug; fundamental metabolite; human metabolite; vasodilator agent	1999	2020	12.2	low	0	0	1	1	4	0
sudan black b	1	azobenzenes; bis(azo) compound; perimidines	histological dye	2012	2012	12.0	low	0	0	0	0	1	0
coomassie brilliant blue r	1			1980	1980	44.0	low	0	1	0	0	0	0
pyranine	2	organic sodium salt	fluorochrome	1983	2000	32.5	low	0	1	1	0	0	0
vanadates	4	trivalent inorganic anion; vanadium oxoanion	EC 3.1.3.1 (alkaline phosphatase) inhibitor; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.1.3.48 (protein-tyrosine-phosphatase) inhibitor	2001	2019	13.2	low	0	0	0	2	2	0
cathinone	1	2-aminopropiophenone; monoamine alkaloid	central nervous system stimulant; psychotropic drug	2020	2020	4.0	low	0	0	0	0	1	0
acridine orange	15	aminoacridines; aromatic amine; tertiary amino compound	fluorochrome; histological dye	1981	2016	24.1	low	0	3	5	4	3	0
benzylaminopurine	1	6-aminopurines	cytokinin; plant metabolite	2009	2009	15.0	low	0	0	0	1	0	0
isothiocyanic acid	2	hydracid; one-carbon compound		1989	2006	26.5	low	0	1	0	1	0	0
carbogen	1			2000	2000	24.0	low	0	0	1	0	0	0
trazodone hydrochloride	5	hydrochloride	adrenergic antagonist; antidepressant; H1-receptor antagonist; sedative; serotonin uptake inhibitor	2008	2020	11.4	low	0	0	0	3	2	0
aluminum phosphate	1			2008	2008	16.0	low	0	0	0	1	0	0
glucose, (beta-d)-isomer	5	D-glucopyranose	epitope; mouse metabolite	1981	2008	28.0	low	0	2	0	3	0	0
2',7'-dichlorofluorescein	1	2-benzofurans	fluorochrome	2001	2001	23.0	low	0	0	0	1	0	0
8-amino-1,3,6-naphthalenetrisulfonic acid	1			2000	2000	24.0	low	0	0	1	0	0	0
thiazolyl blue	9	organic bromide salt	colorimetric reagent; dye	1997	2015	18.6	low	0	0	2	5	2	0
guanidine thiocyanate	1			2012	2012	12.0	low	0	0	0	0	1	0
diacetylfluorescein	3			1992	2011	20.0	low	0	0	1	1	1	0
epigallocatechin gallate	2	flavans; gallate ester; polyphenol	antineoplastic agent; antioxidant; apoptosis inducer; geroprotector; Hsp90 inhibitor; neuroprotective agent; plant metabolite	2004	2019	12.5	low	0	0	0	1	1	0
deoxyuridine triphosphate	6	deoxyuridine phosphate; pyrimidine 2'-deoxyribonucleoside 5'-triphosphate	Arabidopsis thaliana metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite	1994	2018	20.0	low	0	0	2	3	1	0
cholesteryl sulfate	1	steroid sulfate	human metabolite	2015	2015	9.0	low	0	0	0	0	1	0
fluorexon	12	xanthene dye	fluorochrome	1995	2015	17.0	low	0	0	3	5	4	0
2'-deoxycytidine 5'-triphosphate	4	2'-deoxycytidine phosphate; pyrimidine 2'-deoxyribonucleoside 5'-triphosphate	Escherichia coli metabolite; human metabolite; mouse metabolite	2002	2013	17.8	low	0	0	0	3	1	0
2,2'-dipyridyl disulfide	1	organic disulfide; pyridines	oxidising agent	2002	2002	22.0	low	0	0	0	1	0	0
25-hydroxycholesterol	1	25-hydroxy steroid; oxysterol	human metabolite	1993	1993	31.0	low	0	0	1	0	0	0
chlorin	1			2020	2020	4.0	low	0	0	0	0	1	0
1,2-dipalmitoyl-3-phosphatidylethanolamine	1			2006	2006	18.0	low	0	0	0	1	0	0
1,2-distearoyllecithin	3			1993	2000	28.3	low	0	0	3	0	0	0
5-bromo-4-chloro-3-indolyl beta-galactoside	1	beta-D-galactoside; D-aldohexose derivative; indolyl carbohydrate; organobromine compound; organochlorine compound	chromogenic compound	2003	2003	21.0	low	0	0	0	1	0	0
nile red	7	aromatic amine; cyclic ketone; organic heterotetracyclic compound; tertiary amino compound	fluorochrome; histological dye	1992	2018	14.4	low	0	0	1	2	4	0
metaperiodate	1	iodine oxoacid		2020	2020	4.0	low	0	0	0	0	1	0
lissamine rhodamine b	1			2014	2014	10.0	low	0	0	0	0	1	0
octadecyl rhodamine b chloride	5			1994	2010	25.2	low	0	0	4	1	0	0
surfactin peptide	1			2019	2019	5.0	low	0	0	0	0	1	0
4-nitrobenzylthioinosine	1	purine nucleoside		2005	2005	19.0	low	0	0	0	1	0	0
5-chloro-2'-deoxyuridine	1			1998	1998	26.0	low	0	0	1	0	0	0
cephalosporin c	1	cephalosporin	fungal metabolite	2005	2005	19.0	low	0	0	0	1	0	0
tetraiodothyroacetic acid	1	2-halophenol; aromatic ether; iodophenol; monocarboxylic acid	apoptosis inducer; human metabolite; thyroid hormone	2020	2020	4.0	low	0	0	0	0	1	0
phenosafranine	1	organic chloride salt	fluorochrome; histological dye; photosensitizing agent	1998	1998	26.0	low	0	0	1	0	0	0
omega-aminocaprylic acid	1	medium-chain fatty acid; omega-amino fatty acid	human metabolite	2009	2009	15.0	low	0	0	0	1	0	0
silver bromide	1			2003	2003	21.0	low	0	0	0	1	0	0
perylenediimide	1	dicarboximide; organic heteropolycyclic compound	fluorochrome	2017	2017	7.0	low	0	0	0	0	1	0
naphthalimides	1			2019	2019	5.0	low	0	0	0	0	1	0
Diphenolic acid	1	bisphenol		2015	2015	9.0	medium	0	0	0	0	1	0
bromosuccinimide	1	dicarboximide; organobromine compound; pyrrolidinone	reagent	2013	2013	11.0	low	0	0	0	0	1	0
1,7-phenanthroline	2	phenanthroline		2006	2017	12.5	low	0	0	0	1	1	0
4-aminoquinoline	1			2011	2011	13.0	low	0	0	0	0	1	0
fluorodeoxyglucose f18	2	2-deoxy-2-((18)F)fluoro-D-glucose; 2-deoxy-2-fluoro-aldehydo-D-glucose		2012	2012	12.0	low	0	0	0	0	2	0
4-nitrobenzyl alcohol	2	benzyl alcohols; C-nitro compound	xenobiotic metabolite	2009	2011	14.0	medium	0	0	0	1	1	0
resorufin	1	phenoxazine		2011	2011	13.0	low	0	0	0	0	1	0
n-methylmaleimide	1			2014	2014	10.0	low	0	0	0	0	1	0
bindarit	1			2020	2020	4.0	low	0	0	0	0	1	0
nobiletin	1	methoxyflavone	antineoplastic agent; plant metabolite	2006	2006	18.0	low	0	0	0	1	0	0
2,2'-dipicolylamine	2			2014	2019	7.5	low	0	0	0	0	2	0
oxazolidin-2-one	1	carbamate ester; oxazolidinone	metabolite	2012	2012	12.0	low	0	0	0	0	1	0
ceric oxide	1	cerium molecular entity; metal oxide		2019	2019	5.0	low	0	0	0	0	1	0
triphenylmethylphosphonium	5			1980	1983	41.8	low	0	5	0	0	0	0
janus green b	1	organic chloride salt	dye	2010	2010	14.0	low	0	0	0	1	0	0
6-carboxyfluorescein	10	monocarboxylic acid		1991	2019	17.6	low	0	0	3	3	4	0
5-aminofluorescein	1	primary amino compound		2021	2021	3.0	low	0	0	0	0	0	1
perfluoroundecanoic acid	1	fluoroalkanoic acid	environmental contaminant; xenobiotic	2017	2017	7.0	low	0	0	0	0	1	0
2',7'-dichlorodihydrofluorescein diacetate	1			2010	2010	14.0	low	0	0	0	1	0	0
rosiglitazone	1	aminopyridine; thiazolidinediones	EC 6.2.1.3 (long-chain-fatty-acid--CoA ligase) inhibitor; ferroptosis inhibitor; insulin-sensitizing drug	2007	2007	17.0	low	0	0	0	1	0	0
n-hydroxysuccinimide	1			2004	2004	20.0	low	0	0	0	1	0	0
2-(4-toluidino)-6-naphthalenesulfonic acid	1			1983	1983	41.0	low	0	1	0	0	0	0
biocytin	15	azabicycloalkane; L-alpha-amino acid zwitterion; L-lysine derivative; monocarboxylic acid amide; non-proteinogenic L-alpha-amino acid; thiabicycloalkane; ureas	mouse metabolite	1996	2018	22.6	low	0	0	9	5	1	0
ketorolac tromethamine	1	organoammonium salt	analgesic; cyclooxygenase 1 inhibitor; cyclooxygenase 2 inhibitor	2015	2015	9.0	low	0	0	0	0	1	0
clarithromycin	1	macrolide antibiotic	antibacterial drug; environmental contaminant; protein synthesis inhibitor; xenobiotic	2004	2004	20.0	low	0	0	0	1	0	0
cyprodinil	1	aminopyrimidine; anilinopyrimidine fungicide; cyclopropanes; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic	2012	2012	12.0	low	0	0	0	0	1	0
fludioxonil	1	benzodioxoles; nitrile; organofluorine compound; pyrroles	androgen antagonist; antifungal agrochemical; estrogen receptor agonist	2012	2012	12.0	low	0	0	0	0	1	0
we 201	1			2017	2017	7.0	low	0	0	0	0	1	0
acetyl methyl tetramethyl tetralin	1	tetralins		2011	2011	13.0	low	0	0	0	0	1	0
nicotine	1	3-(1-methylpyrrolidin-2-yl)pyridine	anxiolytic drug; biomarker; immunomodulator; mitogen; neurotoxin; nicotinic acetylcholine receptor agonist; peripheral nervous system drug; phytogenic insecticide; plant metabolite; psychotropic drug; teratogenic agent; xenobiotic	1985	1985	39.0	low	0	1	0	0	0	0
fibrinogen	3	iditol	fungal metabolite	2002	2017	16.0	low	0	0	0	2	1	0
oxazine 1	2	organic cation; phenoxazine	fluorochrome	1980	2011	28.5	medium	0	1	0	0	1	0
7-ketocholesterol	1	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; 7-oxo steroid; cholestanoid	neuroprotective agent	2004	2004	20.0	low	0	0	0	1	0	0
cadmium telluride	3			2007	2019	10.0	low	0	0	0	1	2	0
3,4-dihydroxyphenylglycol	1	catechols; tetrol	metabolite; mouse metabolite	2005	2005	19.0	low	0	0	0	1	0	0
homocysteine	3	amino acid zwitterion; homocysteine; serine family amino acid	fundamental metabolite; mouse metabolite	2000	2018	13.7	low	0	0	1	0	2	0
alpha,beta-methyleneadenosine 5'-triphosphate	1	nucleoside triphosphate analogue		2005	2005	19.0	low	0	0	0	1	0	0
8-((4-chlorophenyl)thio)cyclic-3',5'-amp	1	3',5'-cyclic purine nucleotide; adenyl ribonucleotide; aryl sulfide; organochlorine compound	protein kinase agonist	2003	2003	21.0	low	0	0	0	1	0	0
pyrimethanil	1	aminopyrimidine; anilinopyrimidine fungicide; secondary amino compound	antifungal agrochemical; aryl hydrocarbon receptor agonist; environmental contaminant; xenobiotic	2012	2012	12.0	low	0	0	0	0	1	0
n(6)-(delta(2)-isopentenyl)adenine	1	6-isopentenylaminopurine	cytokinin	2018	2018	6.0	low	0	0	0	0	1	0
3-aminobenzeneboronic acid	1			2019	2019	5.0	low	0	0	0	0	1	0
firefly luciferin	2	1,3-thiazolemonocarboxylic acid; benzothiazoles; imidothioate	luciferin	2012	2013	11.5	low	0	0	0	0	2	0
firefly luciferin	1	1,3-thiazolemonocarboxylic acid; benzothiazoles; imidothioate	luciferin	2013	2013	11.0	low	0	0	0	0	1	0
alanyltyrosine	1	dipeptide	metabolite	2012	2012	12.0	low	0	0	0	0	1	0
glycidyl nitrate	1			2005	2005	19.0	low	0	0	0	1	0	0
glycylsarcosine	2	dipeptide zwitterion; dipeptide		1985	2013	25.0	low	0	1	0	0	1	0
viridin	1			2009	2009	15.0	low	0	0	0	1	0	0
glucuronic acid	5	D-glucuronic acid	algal metabolite	2010	2016	10.6	low	0	0	0	1	4	0
n-succinimidyl-3-(4-hydroxyphenyl)propionate	1			1997	1997	27.0	low	0	0	1	0	0	0
3,7-dimethyl-1-propargylxanthine	1			2005	2005	19.0	low	0	0	0	1	0	0
coumarin 6	2	7-aminocoumarins	fluorochrome	2013	2018	8.5	low	0	0	0	0	2	0
methyl mannoside, (alpha-d)-isomer	1	alpha-D-mannoside; methyl mannoside		1984	1984	40.0	low	0	1	0	0	0	0
n-methyladenosine	1	methyladenosine		2020	2020	4.0	low	0	0	0	0	1	0
1,2-distearoylphosphatidylethanolamine	2	phosphatidylethanolamine zwitterion; phosphatidylethanolamine	human metabolite	2014	2019	7.5	low	0	0	0	0	2	0
cobalt	5	cobalt group element atom; metal allergen	micronutrient	1991	2019	15.4	low	0	0	1	2	2	0
hydrogen sulfite	2	sulfur oxoanion	human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2016	2016	8.0	low	0	0	0	0	2	0
1,2-bis(2-aminophenoxy)ethane-n,n,n',n'-tetraacetic acid	2	polyamino carboxylic acid; tetracarboxylic acid	chelator	1994	2016	19.0	low	0	0	1	0	1	0
yttrium radioisotopes	2			2007	2009	16.0	low	0	0	0	2	0	0
enkephalin, d-penicillamine (2,5)-	1	heterodetic cyclic peptide	delta-opioid receptor agonist	2004	2004	20.0	low	0	0	0	1	0	0
u 73122	1	aromatic ether; aza-steroid; maleimides	EC 3.1.4.11 (phosphoinositide phospholipase C) inhibitor	2004	2004	20.0	low	0	0	0	1	0	0
arginyl-glycyl-aspartic acid	17	oligopeptide		2004	2019	12.9	low	0	0	0	8	9	0
quin2	1			1987	1987	37.0	low	0	1	0	0	0	0
bicuculline methiodide	1			2004	2004	20.0	low	0	0	0	1	0	0
u 74006f	1	corticosteroid hormone		1996	1996	28.0	low	0	0	1	0	0	0
diacetyldichlorofluorescein	4			1985	2015	19.8	low	0	1	0	1	2	0
fluo-3	3	xanthene dye	fluorochrome	1991	2011	21.0	low	0	0	1	1	1	0
laurdan	2			2014	2018	8.0	low	0	0	0	0	2	0
paxilline	3	diterpene alkaloid; enone; organic heterohexacyclic compound; terpenoid indole alkaloid; tertiary alcohol	anticonvulsant; Aspergillus metabolite; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor; genotoxin; geroprotector; mycotoxin; Penicillium metabolite; potassium channel blocker	2005	2017	13.0	low	0	0	0	1	2	0
paxilline	2	diterpene alkaloid; enone; organic heterohexacyclic compound; terpenoid indole alkaloid; tertiary alcohol	anticonvulsant; Aspergillus metabolite; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor; genotoxin; geroprotector; mycotoxin; Penicillium metabolite; potassium channel blocker	2011	2017	10.0	low	0	0	0	0	2	0
artesunic acid	2			2014	2014	10.0	low	0	0	0	0	2	0
dihydrorhodamine 123	1			2015	2015	9.0	low	0	0	0	0	1	0
indo-1	3	indoles	fluorochrome	1989	2001	28.7	low	0	1	1	1	0	0
fura-2-am	3			2000	2004	21.7	low	0	0	1	2	0	0
quin2-acetoxymethyl ester	2			1984	1988	38.0	low	0	2	0	0	0	0
u 69593	1	monocarboxylic acid amide; N-alkylpyrrolidine; organic heterobicyclic compound; oxaspiro compound	anti-inflammatory agent; diuretic; kappa-opioid receptor agonist	2004	2004	20.0	low	0	0	0	1	0	0
valylvaline	1	dipeptide	Mycoplasma genitalium metabolite	2013	2013	11.0	low	0	0	0	0	1	0
fluorocitrate	1	carbonyl compound		2013	2013	11.0	low	0	0	0	0	1	0
3-((3-cholamidopropyl)dimethylammonium)-1-propanesulfonate	2	1,1-diunsubstituted alkanesulfonate		1993	2003	26.0	low	0	0	1	1	0	0
dimyristoylphosphatidylglycerol	1			2009	2009	15.0	low	0	0	0	1	0	0
arginyl-glycyl-aspartyl-serine	1			2016	2016	8.0	low	0	0	0	0	1	0
phorbol-12-myristate	1			2015	2015	9.0	low	0	0	0	0	1	0
parinaric acid	3	octadecatetraenoic acid		1996	2008	21.3	low	0	0	1	2	0	0
1-hexadecyl-2-acetyl-glycero-3-phosphocholine	1	2-acetyl-1-alkyl-sn-glycero-3-phosphocholine	antihypertensive agent; beta-adrenergic antagonist; bronchoconstrictor agent; hematologic agent; vasodilator agent	1985	1985	39.0	low	0	1	0	0	0	0
deoxyglucose	9			1981	2014	23.7	low	0	2	1	3	3	0
coumarin 343	1	7-aminocoumarins	fluorochrome	2014	2014	10.0	low	0	0	0	0	1	0
monobromobimane	1	organobromine compound; pyrazolopyrazole	fluorochrome	2004	2004	20.0	low	0	0	0	1	0	0
10-n-nonylacridinium orange	6			1996	2013	20.5	low	0	0	2	3	1	0
phenylalanyl-prolyl-arginine-chloromethyl ketone	1			1999	1999	25.0	low	0	0	1	0	0	0
3beta-(n-(n',n'-dimethylaminoethane)carbamoyl)cholesterol	1			2003	2003	21.0	low	0	0	0	1	0	0
chymosin	2			1986	2023	19.5	low	0	1	0	0	0	1
caprylates	1	fatty acid anion 8:0; straight-chain saturated fatty acid anion	human metabolite; Saccharomyces cerevisiae metabolite	2009	2009	15.0	low	0	0	0	1	0	0
tris(2-carboxyethyl)phosphine	4	phosphine derivative; tricarboxylic acid	reducing agent	2002	2017	14.8	low	0	0	0	2	2	0
pramipexole	1	benzothiazoles; diamine	antidyskinesia agent; antiparkinson drug; dopamine agonist; radical scavenger	2004	2004	20.0	low	0	0	0	1	0	0
1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid	8	azamacrocycle	chelator; copper chelator	2009	2018	11.6	low	0	0	0	4	4	0
brl 44408	1			2008	2008	16.0	low	0	0	0	1	0	0
ym 022	1			2005	2005	19.0	low	0	0	0	1	0	0
gadolinium 1,4,7,10-tetraazacyclododecane-n,n',n'',n'''-tetraacetate	3			2012	2014	11.0	low	0	0	0	0	3	0
dimyristoylmethylphosphatidic acid	1			1989	1989	35.0	low	0	1	0	0	0	0
5-chloromethylfluorescein diacetate	1	acetate ester	fluorochrome	1994	1994	30.0	low	0	0	1	0	0	0
terrylene	1	ortho- and peri-fused polycyclic arene		2011	2011	13.0	low	0	0	0	0	1	0
cyclopropene	1	cycloalkene; cyclopropenes		2017	2017	7.0	low	0	0	0	0	1	0
peroxynitrous acid	11	nitrogen oxoacid		2003	2020	10.1	low	0	0	0	3	8	0
perchlorate	1	chlorine oxoanion; monovalent inorganic anion		2010	2010	14.0	low	0	0	0	1	0	0
fullerene c60	1	fullerene	geroprotector	2011	2011	13.0	low	0	0	0	0	1	0
imatinib mesylate	1	methanesulfonate salt	anticoronaviral agent; antineoplastic agent; apoptosis inducer; tyrosine kinase inhibitor	2013	2013	11.0	low	0	0	0	0	1	0
rhod-2	3			2005	2015	15.7	low	0	0	0	2	1	0
4-carboxyfluorescein	3	monocarboxylic acid	fluorochrome	2016	2022	4.7	low	0	0	0	0	2	1
p(3)-1-(2-nitro)phenylethyladenosine 5'-triphosphate	1			1996	1996	28.0	low	0	0	1	0	0	0
5,5'-bis(8-(phenylamino)-1-naphthalenesulfonate)	1			2011	2011	13.0	low	0	0	0	0	1	0
cyclic adp-ribose	1	cyclic purine nucleotide; nucleotide-sugar	metabolite; ryanodine receptor agonist	1995	1995	29.0	low	0	0	1	0	0	0
n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)phosphatidylethanolamine	2			2003	2018	13.5	low	0	0	0	1	1	0
f-chemotactic peptide	1			2001	2001	23.0	low	0	0	0	1	0	0
sodium-binding benzofuran isophthalate	1	1-benzofurans; aromatic ether; crown compound; tetracarboxylic acid	fluorochrome	2000	2000	24.0	low	0	0	1	0	0	0
1-((3,5-dichloro)-2,6-dihydroxy-4-methoxyphenyl)-1-hexanone	2	dichlorobenzene; differentiation-inducing factor; monomethoxybenzene; resorcinols	eukaryotic metabolite; signalling molecule	1996	2001	25.5	low	0	0	1	1	0	0
1,9-dimethylmethylene blue	1			1983	1983	41.0	low	0	1	0	0	0	0
dodecyloctaethyleneglycol monoether	1	hydroxypolyether		2006	2006	18.0	low	0	0	0	1	0	0
5-((4,6-dichloro-1,3,5-triazin-2-yl)amino)fluorescein	2			1996	2000	26.0	low	0	0	2	0	0	0
6-methoxy-n-(3-sulfopropyl)quinolinium	1			2013	2013	11.0	low	0	0	0	0	1	0
vadimezan	1	monocarboxylic acid; xanthones	antineoplastic agent	2008	2008	16.0	low	0	0	0	1	0	0
dehydroalanine	1	2,3-dehydroamino acid; alpha,beta-unsaturated monocarboxylic acid; amino acid zwitterion; enamine; non-proteinogenic alpha-amino acid	alkylating agent; human metabolite; mouse metabolite	2015	2015	9.0	low	0	0	0	0	1	0
1,4,7-triazacyclononane-n,n',n''-triacetic acid	1			2020	2020	4.0	low	0	0	0	0	1	0
solutol hs 15	1	aliphatic alcohol		2012	2012	12.0	low	0	0	0	0	1	0
n-(4-aminophenethyl)spiroperidol	1	aromatic ketone		2021	2021	3.0	low	0	0	0	0	0	1
glycerophosphoinositol 4,5-bisphosphate	2			2018	2018	6.0	low	0	0	0	0	2	0
t-butyloxycarbonyl-methionyl-leucyl-phenylalanine	1			1990	1990	34.0	low	0	0	1	0	0	0
2-methylellipticinium	1			1984	1984	40.0	low	0	1	0	0	0	0
(hexadecanoyl)aminofluorescein	1			1998	1998	26.0	low	0	0	1	0	0	0
phenylalanyl-phenylalanyl-arginine chloromethyl ketone	1			2015	2015	9.0	low	0	0	0	0	1	0
methotrexate	6	dicarboxylic acid; monocarboxylic acid amide; pteridines	abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent	1988	2021	13.2	low	0	1	0	1	3	1
n-4-nitrobenzo-2-oxa-1,3-diazoledipalmitoyl phosphatidylethanolamine	1			1992	1992	32.0	medium	0	0	1	0	0	0
6-anilino-1-naphthalenesulfonic acid	1			1983	1983	41.0	low	0	1	0	0	0	0
n-butyl beta-carboline-3-carboxylate	1	beta-carbolines		2005	2005	19.0	low	0	0	0	1	0	0
dihydroethidium	6			1995	2011	18.2	low	0	0	1	4	1	0
1-myristoyl-2-palmitoyl-sn-glycero-3-phosphocholine	1	1-acyl-2-hexadecanoyl-sn-glycero-3-phosphocholine; phosphatidylcholine 30:0; tetradecanoate ester	mouse metabolite	2013	2013	11.0	low	0	0	0	0	1	0
bis-benzimidazole	1			2004	2004	20.0	low	0	0	0	1	0	0
1,2-(palmitoyl-nbd-aminocaproyl)phosphatidylethanolamine	1			2008	2008	16.0	low	0	0	0	1	0	0
pak 104p	1			1996	1996	28.0	low	0	0	1	0	0	0
2-(9-anthroyloxy)stearic acid	1			1990	1990	34.0	medium	0	0	1	0	0	0
omega-n-methylarginine	2	amino acid zwitterion; arginine derivative; guanidines; L-arginine derivative; non-proteinogenic L-alpha-amino acid		2003	2015	15.0	low	0	0	0	1	1	0
zinquin	1			2004	2004	20.0	low	0	0	0	1	0	0
5-carboxyfluorescein diacetate	1			2018	2018	6.0	low	0	0	0	0	1	0
castasterone	2	22-hydroxy steroid; 23-hydroxy steroid; 2alpha-hydroxy steroid; 3alpha-hydroxy steroid; 6-oxo steroid; brassinosteroid	plant growth stimulator	2012	2017	9.5	low	0	0	0	0	2	0
carbapenems	1			2017	2017	7.0	low	0	0	0	0	1	0
triiodothyronine	1	tetrahydrothiophenes; thiolactone	human metabolite	2000	2000	24.0	low	0	0	1	0	0	0
iodoacetamidoerythrosin	1			1994	1994	30.0	medium	0	0	1	0	0	0
proline	2	amino acid zwitterion; glutamine family amino acid; L-alpha-amino acid; proline; proteinogenic amino acid	algal metabolite; compatible osmolytes; Escherichia coli metabolite; micronutrient; mouse metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	1985	1992	35.5	low	0	1	1	0	0	0
n-nbd-1,2-dilauroylphosphatidylethanolamine	1			2000	2000	24.0	medium	0	0	1	0	0	0
5-(n-dodecanoyl)aminofluorescein	1			1998	1998	26.0	low	0	0	1	0	0	0
docetaxel anhydrous	5	secondary alpha-hydroxy ketone; tetracyclic diterpenoid	antimalarial; antineoplastic agent; photosensitizing agent	2012	2020	8.2	low	0	0	0	0	5	0
2-(1-hexyloxyethyl)-2-devinyl pyropheophorbide-a	2			2007	2018	11.5	low	0	0	0	1	1	0
tariquidar	1	benzamides		2018	2018	6.0	low	0	0	0	0	1	0
6-carboxyfluorescein diacetate	1			2018	2018	6.0	low	0	0	0	0	1	0
cariporide	1			2001	2001	23.0	low	0	0	0	1	0	0
tyrosinamide	1	amino acid amide; L-tyrosine derivative		2018	2018	6.0	low	0	0	0	0	1	0
mn(iii) 5,10,15,20-tetrakis(n-methylpyridinium-2-yl)porphyrin	1			2012	2012	12.0	low	0	0	0	0	1	0
hydroxyl radical	3	oxygen hydride; oxygen radical; reactive oxygen species		2007	2019	10.0	low	0	0	0	1	2	0
n-(2-(1-maleimidyl)ethyl)-7-(diethylamino)coumarin-3-carboxamide	1			2005	2005	19.0	low	0	0	0	1	0	0
singlet oxygen	18	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient	2004	2021	8.6	low	0	0	0	2	14	2
cyc 202	3	2,6-diaminopurines	antiviral drug; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	2003	2010	18.0	low	0	0	0	3	0	0
carbodiimides	1	carbodiimide		2005	2005	19.0	low	0	0	0	1	0	0
leonurine	1	trihydroxybenzoic acid		2009	2009	15.0	low	0	0	0	1	0	0
phenylarsonous acid	1	arsonous acids		2011	2011	13.0	low	0	0	0	0	1	0
8-aminohexylamino camp	7			2006	2011	16.0	medium	0	0	0	6	1	0
bactenecin	1			1999	1999	25.0	low	0	0	1	0	0	0
n-(2-amino-3-(4-isothiocyanatophenyl)propyl)cyclohexane-1,2-diamine-n,n',n',n'',n''-pentaacetic acid	1			2007	2007	17.0	low	0	0	0	1	0	0
edba	1	alpha-amino acid		1999	1999	25.0	medium	0	0	1	0	0	0
tetraphenylphosphonium	8	heteroorganic entity; phosphorus molecular entity; polyatomic cation		1981	1996	37.1	low	0	5	3	0	0	0
technetium tc 99m pentetate	2			2014	2015	9.5	low	0	0	0	0	2	0
anacardic acid	1	hydroxy monocarboxylic acid; hydroxybenzoic acid	anti-inflammatory agent; antibacterial agent; anticoronaviral agent; apoptosis inducer; EC 2.3.1.48 (histone acetyltransferase) inhibitor; EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor; neuroprotective agent; plant metabolite	2002	2002	22.0	low	0	0	0	1	0	0
biotin	81	biotins; vitamin B7	coenzyme; cofactor; Escherichia coli metabolite; fundamental metabolite; human metabolite; mouse metabolite; nutraceutical; prosthetic group; Saccharomyces cerevisiae metabolite	1980	2020	15.9	low	0	1	17	26	37	0
angiotensin ii	4	amino acid zwitterion; angiotensin II	human metabolite	1993	2013	24.0	low	0	0	3	0	1	0
atropine	3			1997	2008	21.3	low	0	0	1	2	0	0
sb 203580	1	imidazoles; monofluorobenzenes; pyridines; sulfoxide	EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; geroprotector; Hsp90 inhibitor; neuroprotective agent	2009	2009	15.0	low	0	0	0	1	0	0
sb 216763	2	indoles; maleimides		2013	2013	11.0	low	0	0	0	0	2	0
erlotinib hydrochloride	2	hydrochloride; terminal acetylenic compound	antineoplastic agent; protein kinase inhibitor	2016	2018	7.0	low	0	0	0	0	2	0
cilengitide	1	oligopeptide		2005	2005	19.0	low	0	0	0	1	0	0
organophosphonates	2	divalent inorganic anion; phosphite ion		2005	2006	18.5	low	0	0	0	2	0	0
aflatoxin b1	2	aflatoxin; aromatic ether; aromatic ketone	carcinogenic agent; human metabolite	2014	2019	7.5	low	0	0	0	0	2	0
maltotriose	1	maltotriose trisaccharide	human metabolite	2020	2020	4.0	low	0	0	0	0	1	0
ferrocobalt	1			2015	2015	9.0	medium	0	0	0	0	1	0
1-palmitoyl-2-(1'-pyreneoctanoyl)glycero-3-phosphochine	1			1996	1996	28.0	low	0	0	1	0	0	0
2-(4-morpholinoanilino)-6-cyclohexylaminopurine	1	morpholines; purines; secondary amino compound; tertiary amino compound	adenosine A3 receptor antagonist; antineoplastic agent; Aurora kinase inhibitor; cell dedifferentiation agent	2012	2012	12.0	low	0	0	0	0	1	0
cholic acid	1	12alpha-hydroxy steroid; 3alpha-hydroxy steroid; 7alpha-hydroxy steroid; bile acid; C24-steroid; trihydroxy-5beta-cholanic acid	human metabolite; mouse metabolite	2019	2019	5.0	low	0	0	0	0	1	0
deoxycholic acid	5	bile acid; C24-steroid; dihydroxy-5beta-cholanic acid	human blood serum metabolite	1999	2019	13.6	low	0	0	1	2	2	0
3-nitrotyrosine	1	2-nitrophenols; C-nitro compound; nitrotyrosine; non-proteinogenic alpha-amino acid		2003	2003	21.0	low	0	0	0	1	0	0
5-hydroxymethylfurfural	1	arenecarbaldehyde; furans; primary alcohol	indicator; Maillard reaction product	2020	2020	4.0	low	0	0	0	0	1	0
pheophorbide a	1			2012	2012	12.0	low	0	0	0	0	1	0
anisomycin	1	monohydroxypyrrolidine; organonitrogen heterocyclic antibiotic	anticoronaviral agent; antimicrobial agent; antineoplastic agent; antiparasitic agent; bacterial metabolite; DNA synthesis inhibitor; protein synthesis inhibitor	2017	2017	7.0	low	0	0	0	0	1	0
benzofurans	6			1999	2019	15.7	low	0	0	2	2	2	0
wortmannin	3	acetate ester; cyclic ketone; delta-lactone; organic heteropentacyclic compound	anticoronaviral agent; antineoplastic agent; autophagy inhibitor; EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor; geroprotector; Penicillium metabolite; radiosensitizing agent	2002	2010	18.0	low	0	0	0	3	0	0
lariciresinol	1	aromatic ether; lignan; oxolanes; phenols; primary alcohol	antifungal agent; plant metabolite	2011	2011	13.0	low	0	0	0	0	1	0
2-(2-nitro-1h-imidazol-1-yl)-n-(2,2,3,3,3-pentafluoropropyl)acetamide	3			2000	2004	22.3	low	0	0	1	2	0	0
calcein am	8	2-benzofurans; acetate ester; gamma-lactone; organic heteropentacyclic compound; oxaspiro compound; xanthene dye	fluorochrome	1996	2013	19.6	low	0	0	2	4	2	0
dihydropyridines	2			1989	2022	18.5	low	0	1	0	0	0	1
leupeptins	3			2001	2015	17.3	low	0	0	0	2	1	0
lithium chloride	3	inorganic chloride; lithium salt	antimanic drug; geroprotector	1999	2004	22.3	low	0	0	1	2	0	0
n-acetylneuraminic acid	5	N-acetylneuraminic acids	antioxidant; bacterial metabolite; EC 3.2.1.18 (exo-alpha-sialidase) inhibitor; human metabolite; mouse metabolite	1994	2021	11.2	low	0	0	1	0	3	1
fibrin	5	peptide		1998	2015	15.0	low	0	0	1	1	3	0
bradykinin	4	oligopeptide	human blood serum metabolite; vasodilator agent	1996	2008	24.0	low	0	0	3	1	0	0
glucosamine	4	D-glucosamine	Escherichia coli metabolite; geroprotector; mouse metabolite	2005	2018	14.0	low	0	0	0	2	2	0
elastin	1	oligopeptide		2022	2022	2.0	low	0	0	0	0	0	1
mevalonic acid	3	3,5-dihydroxy-3-methylpentanoic acid		1995	1997	28.3	low	0	0	3	0	0	0
formiminoglutamic acid	1	dicarboxylic acid; L-glutamic acid derivative		1993	1993	31.0	low	0	0	1	0	0	0
naringenin	1	(2S)-flavan-4-one; naringenin	expectorant; plant metabolite	2004	2004	20.0	low	0	0	0	1	0	0
oxytocin	1	heterodetic cyclic peptide; peptide hormone	oxytocic; vasodilator agent	1995	1995	29.0	low	0	0	1	0	0	0
inositol 1,4,5-trisphosphate	2	myo-inositol trisphosphate	mouse metabolite	1995	1999	27.0	low	0	0	2	0	0	0
ouabain	11	11alpha-hydroxy steroid; 14beta-hydroxy steroid; 5beta-hydroxy steroid; alpha-L-rhamnoside; cardenolide glycoside; steroid hormone	anti-arrhythmia drug; cardiotonic drug; EC 2.3.3.1 [citrate (Si)-synthase] inhibitor; EC 3.1.3.41 (4-nitrophenylphosphatase) inhibitor; EC 3.6.3.10 (H(+)/K(+)-exchanging ATPase) inhibitor; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; ion transport inhibitor; plant metabolite	1978	2005	32.7	low	0	6	1	4	0	0
puromycin	1	puromycins	antiinfective agent; antimicrobial agent; antineoplastic agent; EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor; EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor; nucleoside antibiotic; protein synthesis inhibitor	2007	2007	17.0	low	0	0	0	1	0	0
mannuronic acid	1	D-mannonic acid		2009	2009	15.0	low	0	0	0	1	0	0
n-formylmethionine	2	L-methionine derivative; N-formyl amino acid; proteinogenic amino acid	metabolite	1980	1980	44.0	low	0	2	0	0	0	0
inositol 3-phosphate	2			1996	2007	22.5	low	0	0	1	1	0	0
adenosine 5'-o-(3-thiotriphosphate)	1	nucleoside triphosphate analogue		2011	2011	13.0	low	0	0	0	0	1	0
strychnine	2	monoterpenoid indole alkaloid; organic heteroheptacyclic compound	avicide; cholinergic antagonist; glycine receptor antagonist; neurotransmitter agent; rodenticide	1997	2003	24.0	low	0	0	1	1	0	0
quinidine	1	cinchona alkaloid	alpha-adrenergic antagonist; anti-arrhythmia drug; antimalarial; drug allergen; EC 1.14.13.181 (13-deoxydaunorubicin hydroxylase) inhibitor; EC 3.6.3.44 (xenobiotic-transporting ATPase) inhibitor; muscarinic antagonist; P450 inhibitor; potassium channel blocker; sodium channel blocker	2013	2013	11.0	low	0	0	0	0	1	0
monensin	3	cyclic hemiketal; monocarboxylic acid; polyether antibiotic; spiroketal	antifungal agent; coccidiostat; ionophore	1997	2003	24.7	low	0	0	2	1	0	0
pentazocine	1	benzazocine		2017	2017	7.0	low	0	0	0	0	1	0
mometasone furoate	1	11beta-hydroxy steroid; 2-furoate ester; 20-oxo steroid; 3-oxo-Delta(1),Delta(4)-steroid; organochlorine compound; steroid ester	anti-allergic agent; anti-inflammatory drug	2008	2008	16.0	low	0	0	0	1	0	0
phalloidine	10	homodetic cyclic peptide		1993	2021	16.4	low	0	0	1	6	2	1
ryanodine	3			1995	2001	27.0	low	0	0	2	1	0	0
ochratoxin a	4	isochromanes; monocarboxylic acid amide; N-acyl-L-phenylalanine; organochlorine compound; phenylalanine derivative	Aspergillus metabolite; calcium channel blocker; carcinogenic agent; mycotoxin; nephrotoxin; Penicillium metabolite; teratogenic agent	2018	2020	5.0	low	0	0	0	0	4	0
cyclopamine	2	piperidines	glioma-associated oncogene inhibitor	2004	2005	19.5	low	0	0	0	2	0	0
lignans	1			2011	2011	13.0	low	0	0	0	0	1	0
acetylleucyl-leucyl-norleucinal	1	aldehyde; tripeptide	cysteine protease inhibitor	2001	2001	23.0	low	0	0	0	1	0	0
bq 123	1	cyclic peptide		2012	2012	12.0	low	0	0	0	0	1	0
n-formylmethionine leucyl-phenylalanine	17	tripeptide		1980	2018	34.3	low	0	10	6	0	1	0
phenylalanine arginine beta-naphthylamide	1	peptide		2013	2013	11.0	low	0	0	0	0	1	0
sodium arsenite	1	arsenic molecular entity; inorganic sodium salt	antibacterial agent; antifungal agent; antineoplastic agent; carcinogenic agent; herbicide; insecticide; rodenticide	2008	2008	16.0	low	0	0	0	1	0	0
metrizamide	1	amino sugar		1991	1991	33.0	low	0	0	1	0	0	0
betadex	8	cyclodextrin		2002	2019	13.6	low	0	0	0	4	4	0
ergosterol	3	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	fungal metabolite; Saccharomyces cerevisiae metabolite	2004	2007	19.0	low	0	0	0	3	0	0
trichostatin a	2	antibiotic antifungal agent; hydroxamic acid; trichostatin	bacterial metabolite; EC 3.5.1.98 (histone deacetylase) inhibitor; geroprotector	2006	2019	11.5	low	0	0	0	1	1	0
tretinoin	1	retinoic acid; vitamin A	anti-inflammatory agent; antineoplastic agent; antioxidant; AP-1 antagonist; human metabolite; keratolytic drug; retinoic acid receptor agonist; retinoid X receptor agonist; signalling molecule	1998	1998	26.0	low	0	0	1	0	0	0
arachidonic acid	3	icosa-5,8,11,14-tetraenoic acid; long-chain fatty acid; omega-6 fatty acid	Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; human metabolite; mouse metabolite	2004	2011	17.0	low	0	0	0	2	1	0
alpha-cyclodextrin	1	cyclodextrin		2018	2018	6.0	low	0	0	0	0	1	0
fumaric acid	1	butenedioic acid	food acidity regulator; fundamental metabolite; geroprotector	2000	2000	24.0	low	0	0	1	0	0	0
farnesol	1	farnesol	plant metabolite	2017	2017	7.0	low	0	0	0	0	1	0
resveratrol	3	resveratrol	antioxidant; phytoalexin; plant metabolite; quorum sensing inhibitor; radical scavenger	2008	2015	13.7	low	0	0	0	2	1	0
retinol	1	retinol; vitamin A	human metabolite; mouse metabolite; plant metabolite	2003	2003	21.0	low	0	0	0	1	0	0
1,2-dilauroylphosphatidylcholine	2	1,2-diacyl-sn-glycero-3-phosphocholine(1+)		2000	2004	22.0	low	0	0	1	1	0	0
latrunculin a	2	cyclic hemiketal; macrolide; oxabicycloalkane; thiazolidinone	actin polymerisation inhibitor; metabolite; toxin	2005	2013	15.0	low	0	0	0	1	1	0
cyanoginosin lr	1	microcystin	bacterial metabolite; EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor; environmental contaminant; xenobiotic	2014	2014	10.0	low	0	0	0	0	1	0
oleic acid	2	octadec-9-enoic acid	antioxidant; Daphnia galeata metabolite; EC 3.1.1.1 (carboxylesterase) inhibitor; Escherichia coli metabolite; mouse metabolite; plant metabolite; solvent	1997	2011	20.0	low	0	0	1	0	1	0
tacrolimus	1	macrolide lactam	bacterial metabolite; immunosuppressive agent	2009	2009	15.0	low	0	0	0	1	0	0
pectins	2	D-galactopyranuronic acid		1976	1991	40.5	low	0	1	1	0	0	0
1,5-dihydro-fad	1	flavin adenine dinucleotide	Escherichia coli metabolite; mouse metabolite	2018	2018	6.0	low	0	0	0	0	1	0
cocaine	4	benzoate ester; methyl ester; tertiary amino compound; tropane alkaloid	adrenergic uptake inhibitor; central nervous system stimulant; dopamine uptake inhibitor; environmental contaminant; local anaesthetic; mouse metabolite; plant metabolite; serotonin uptake inhibitor; sodium channel blocker; sympathomimetic agent; vasoconstrictor agent; xenobiotic	2002	2018	12.5	low	0	0	0	2	2	0
thapsigargin	4	butyrate ester; organic heterotricyclic compound; sesquiterpene lactone	calcium channel blocker; EC 3.6.3.8 (Ca(2+)-transporting ATPase) inhibitor	1995	2015	18.8	low	0	0	1	2	1	0
cgs 27023a	1			2009	2009	15.0	low	0	0	0	1	0	0
mycophenolic acid	1	2-benzofurans; gamma-lactone; monocarboxylic acid; phenols	anticoronaviral agent; antimicrobial agent; antineoplastic agent; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; environmental contaminant; immunosuppressive agent; mycotoxin; Penicillium metabolite; xenobiotic	2008	2008	16.0	low	0	0	0	1	0	0
lycopene	1	acyclic carotene	antioxidant; plant metabolite	2004	2004	20.0	low	0	0	0	1	0	0
prostaglandin d2	1	prostaglandins D	human metabolite; mouse metabolite	2013	2013	11.0	low	0	0	0	0	1	0
benzene-1,3,5-tricarboxamide	1			2016	2016	8.0	low	0	0	0	0	1	0
h 89	2	N-[2-(4-bromocinnamylamino)ethyl]isoquinoline-5-sulfonamide		2011	2015	11.0	low	0	0	0	0	2	0
texas red	12	organic heteroheptacyclic compound	fluorochrome	1997	2020	14.2	low	0	0	2	4	6	0
dactinomycin	8	actinomycin	mutagen	1992	2017	20.1	low	0	0	1	6	1	0
aphidicolin	2	tetracyclic diterpenoid	antimicrobial agent; antimitotic; antineoplastic agent; antiviral drug; apoptosis inducer; Aspergillus metabolite; DNA synthesis inhibitor; EC 2.7.7.7 (DNA-directed DNA polymerase) inhibitor; fungal metabolite	2005	2010	16.5	low	0	0	0	2	0	0
enkephalin, leucine	6	pentapeptide; peptide zwitterion	analgesic; delta-opioid receptor agonist; human metabolite; mu-opioid receptor agonist; neurotransmitter; rat metabolite	1993	2000	27.8	low	0	0	6	0	0	0
benzyloxycarbonylleucyl-leucyl-leucine aldehyde	2	amino aldehyde; carbamate ester; tripeptide	proteasome inhibitor	2004	2015	14.5	low	0	0	0	1	1	0
5-ethynyl-2'-deoxyuridine	1			2019	2019	5.0	low	0	0	0	0	1	0
8-prenylnaringenin	1	(2S)-flavan-4-one; 4'-hydroxyflavanones; trihydroxyflavanone	plant metabolite; platelet aggregation inhibitor	2004	2004	20.0	low	0	0	0	1	0	0
riboflavin	2	flavin; vitamin B2	anti-inflammatory agent; antioxidant; cofactor; Escherichia coli metabolite; food colouring; fundamental metabolite; human urinary metabolite; mouse metabolite; photosensitizing agent; plant metabolite	2020	2020	4.0	low	0	0	0	0	2	0
sodium thiocyanate	1	organic sodium salt		1991	1991	33.0	low	0	0	1	0	0	0
forsterite	1			2012	2012	12.0	low	0	0	0	0	1	0
oxazolidine	1	oxazolidine		2021	2021	3.0	low	0	0	0	0	0	1
bromochloroacetic acid	7	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound		1996	2017	21.1	low	0	0	5	0	2	0
carbenoxolone sodium	1	triterpenoid		1995	1995	29.0	low	0	0	1	0	0	0
cinnamaldehyde	1	3-phenylprop-2-enal; cinnamaldehydes	antifungal agent; EC 4.3.1.24 (phenylalanine ammonia-lyase) inhibitor; flavouring agent; hypoglycemic agent; plant metabolite; sensitiser; vasodilator agent	2016	2016	8.0	low	0	0	0	0	1	0
isomethyleugenol	2	isomethyleugenol		2008	2019	10.5	low	0	0	0	1	1	0
retinaldehyde	1	retinal; vitamin A	gap junctional intercellular communication inhibitor; human metabolite; mouse metabolite	2002	2002	22.0	low	0	0	0	1	0	0
stilbenes	8	stilbene		1981	2020	13.2	low	0	1	0	2	5	0
flavin-adenine dinucleotide	2	flavin adenine dinucleotide; vitamin B2	cofactor; Escherichia coli metabolite; human metabolite; mouse metabolite; prosthetic group	2014	2018	8.0	low	0	0	0	0	2	0
lypressin	1	cyclic peptide		1989	1989	35.0	low	0	1	0	0	0	0
arginine vasopressin	2	vasopressin	cardiovascular drug; hematologic agent; mitogen	1993	2008	23.5	low	0	0	1	1	0	0
dodecylphosphocholine	1	phosphocholines	detergent	2018	2018	6.0	low	0	0	0	0	1	0
7-diethylaminocoumarin-3-carboxylic acid	1			2010	2010	14.0	low	0	0	0	1	0	0
sesquiterpenes	2			2008	2008	16.0	low	0	0	0	2	0	0
mercaptopurine	1	aryl thiol; purines; thiocarbonyl compound	anticoronaviral agent; antimetabolite; antineoplastic agent	2012	2012	12.0	low	0	0	0	0	1	0
thioinosine	1			2005	2005	19.0	low	0	0	0	1	0	0
flunarizine	1	diarylmethane		1999	1999	25.0	low	0	0	1	0	0	0
curcumin	3	aromatic ether; beta-diketone; diarylheptanoid; enone; polyphenol	anti-inflammatory agent; antifungal agent; antineoplastic agent; biological pigment; contraceptive drug; dye; EC 1.1.1.205 (IMP dehydrogenase) inhibitor; EC 1.1.1.21 (aldehyde reductase) inhibitor; EC 1.1.1.25 (shikimate dehydrogenase) inhibitor; EC 1.6.5.2 [NAD(P)H dehydrogenase (quinone)] inhibitor; EC 1.8.1.9 (thioredoxin reductase) inhibitor; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor; EC 3.5.1.98 (histone deacetylase) inhibitor; flavouring agent; food colouring; geroprotector; hepatoprotective agent; immunomodulator; iron chelator; ligand; lipoxygenase inhibitor; metabolite; neuroprotective agent; nutraceutical; radical scavenger	2008	2018	10.7	low	0	0	0	1	2	0
rhodanine	1	thiazolidinone		1999	1999	25.0	low	0	0	1	0	0	0
sj 172550	1			2018	2018	6.0	medium	0	0	0	0	1	0
capsaicin	10	capsaicinoid	non-narcotic analgesic; TRPV1 agonist; voltage-gated sodium channel blocker	1997	2017	17.6	low	0	0	2	5	3	0
threoninol	2			2012	2015	10.5	low	0	0	0	0	2	0
thioguanine anhydrous	1	2-aminopurines	anticoronaviral agent; antimetabolite; antineoplastic agent	2012	2012	12.0	low	0	0	0	0	1	0
thiobarbituric acid	2	barbiturates	allergen; reagent	2003	2003	21.0	low	0	0	0	2	0	0
2-thiopyridine	1	aryl thiol; pyridines	allergen; fluorescence quencher	2018	2018	6.0	low	0	0	0	0	1	0
thiourea	1	one-carbon compound; thioureas; ureas	antioxidant; chromophore	1983	1983	41.0	low	0	1	0	0	0	0
safranine t	3	organic chloride salt	fluorochrome; histological dye	1985	2012	23.3	low	0	1	0	1	1	0
D-fructopyranose	1	cyclic hemiketal; D-fructose; fructopyranose	sweetening agent	2005	2005	19.0	low	0	0	0	1	0	0
tempo	3	aminoxyls; piperidines	catalyst; ferroptosis inhibitor; radical scavenger	2001	2020	14.0	low	0	0	0	2	1	0
ferric ferrocyanide	2			2009	2011	14.0	low	0	0	0	1	1	0
succimer	2	dicarboxylic acid; dithiol; sulfur-containing carboxylic acid	chelator	2016	2016	8.0	low	0	0	0	0	2	0
digoxin	3	cardenolide glycoside; steroid saponin	anti-arrhythmia drug; cardiotonic drug; EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor; epitope	1999	2019	12.0	low	0	0	1	0	2	0
n-hydroxy-n'-(4-butyl-2-methylphenyl)formamidine	1	toluenes		2011	2011	13.0	low	0	0	0	0	1	0
capsazepine	1	benzazepine; catechols; monochlorobenzenes; thioureas	capsaicin receptor antagonist	2001	2001	23.0	low	0	0	0	1	0	0
fumonisin b1	1	diester; fumonisin; primary amino compound; triol	carcinogenic agent; metabolite	2020	2020	4.0	low	0	0	0	0	1	0
tamoxifen	2	stilbenoid; tertiary amino compound	angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator	2000	2012	18.0	low	0	0	1	0	1	0
hydroxypropyl-gamma-cyclodextrin	1			2014	2014	10.0	low	0	0	0	0	1	0
1-butyl-3-methylimidazolium hexafluorophosphate	1			2008	2008	16.0	low	0	0	0	1	0	0
nadp	2			1999	2018	15.5	low	0	0	1	0	1	0
7-amino-4-chloromethylcoumarin	1			2009	2009	15.0	low	0	0	0	1	0	0
5-carboxytetramethylrhodamine succinimidyl ester	13			2003	2019	11.8	low	0	0	0	4	9	0
5-carboxytetramethylrhodamine	1	xanthenes	fluorochrome	2002	2002	22.0	low	0	0	0	1	0	0
6-carboxytetramethylrhodamine	1			2018	2018	6.0	low	0	0	0	0	1	0
krn 7000	1	glycophytoceramide; N-acyl-beta-D-galactosylphytosphingosine	allergen; antigen; antineoplastic agent; epitope; immunological adjuvant	2015	2015	9.0	low	0	0	0	0	1	0
valinomycin	54	cyclodepsipeptide; macrocycle	antimicrobial agent; antiviral agent; bacterial metabolite; potassium ionophore	1976	2017	35.3	low	0	31	16	5	2	0
estrone sulfate	2	17-oxo steroid; steroid sulfate	human metabolite; mouse metabolite	2005	2015	14.0	low	0	0	0	1	1	0
u 0126	2	aryl sulfide; dinitrile; enamine; substituted aniline	antineoplastic agent; antioxidant; apoptosis inducer; EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor; osteogenesis regulator; vasoconstrictor agent	2009	2013	13.0	low	0	0	0	1	1	0
glycylproline	1	dipeptide zwitterion; dipeptide	metabolite	1985	1985	39.0	low	0	1	0	0	0	0
3,7,11,15-tetramethyl-1,2,3-hexadecanetriol	1	triol		2018	2018	6.0	low	0	0	0	0	1	0
lithium	3	alkali metal atom		2002	2020	15.7	low	0	0	0	2	1	0
nitrogen dioxide	1	nitrogen oxide		2013	2013	11.0	low	0	0	0	0	1	0
dermatan sulfate	1	amino disaccharide; glycosylgalactose derivative; iduronic acids; oligosaccharide sulfate		2005	2005	19.0	low	0	0	0	1	0	0
quinine	4	cinchona alkaloid	antimalarial; muscle relaxant; non-narcotic analgesic	1980	1989	38.0	low	0	4	0	0	0	0
1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester	2			2001	2014	16.5	low	0	0	0	1	1	0
iodonaphthylazide	3			1997	2002	25.0	low	0	0	2	1	0	0
photobiotin	1			2005	2005	19.0	low	0	0	0	1	0	0
n,n'-4-xylylenebis(pyridinium)	1			2000	2000	24.0	low	0	0	1	0	0	0
dasatinib	2	1,3-thiazoles; aminopyrimidine; monocarboxylic acid amide; N-(2-hydroxyethyl)piperazine; N-arylpiperazine; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antineoplastic agent; tyrosine kinase inhibitor	2019	2020	4.5	low	0	0	0	0	2	0
4-azidophenylalanine	1			2018	2018	6.0	low	0	0	0	0	1	0
1,2-ditetradecylphosphatidylcholine	1			1989	1989	35.0	medium	0	1	0	0	0	0
bis(2,2'-bipyridyl)(dipyrido(3,2-alpha-2',3'-c)phenazine)ruthenium (ii)	1			2001	2001	23.0	low	0	0	0	1	0	0
calixarenes	2			2016	2018	7.0	low	0	0	0	0	2	0
silicon nitride	1			2003	2003	21.0	low	0	0	0	1	0	0
ginsenosides	2			2005	2013	15.0	low	0	0	0	1	1	0
2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline	1	naphthalenes; sulfonic acid derivative		2006	2006	18.0	low	0	0	0	1	0	0
ovalbumin	8			1994	2018	15.2	low	0	0	1	3	4	0
rink amide resin	1			2019	2019	5.0	medium	0	0	0	0	1	0
sodium dodecyl sulfate	10	organic sodium salt	detergent; protein denaturant	1976	2021	16.6	low	0	1	1	3	4	1
mtt formazan	4			2005	2009	16.5	low	0	0	0	4	0	0
6-cyano-7-nitroquinoxaline-2,3-dione	7	quinoxaline derivative		1999	2008	19.9	low	0	0	1	6	0	0
fg 9041	1	quinoxaline derivative		1997	1997	27.0	low	0	0	1	0	0	0
alpha-chymotrypsin	1			2014	2014	10.0	low	0	0	0	0	1	0
tetramethylrhodamine isothiocyanate	8			1993	2008	25.8	low	0	0	7	1	0	0
4-mercaptophenylboronic acid	1			2019	2019	5.0	low	0	0	0	0	1	0
rhodamine 123	34	organic cation; xanthene dye	fluorochrome	1986	2020	21.4	low	0	1	15	8	10	0
tolcapone	1	2-nitrophenols; benzophenones; catechols	antiparkinson drug; EC 2.1.1.6 (catechol O-methyltransferase) inhibitor	2016	2016	8.0	low	0	0	0	0	1	0
myelin basic protein	5			1992	2019	18.8	low	0	0	2	1	2	0
2-mercaptoacetate	1	monocarboxylic acid anion		2016	2016	8.0	low	0	0	0	0	1	0
diethyl maleate	1	ethyl ester; maleate ester	glutathione depleting agent	2001	2001	23.0	low	0	0	0	1	0	0
sphingosine	2	sphing-4-enine	human metabolite; mouse metabolite	2001	2004	21.5	low	0	0	0	2	0	0
quercetin	4	7-hydroxyflavonol; pentahydroxyflavone	antibacterial agent; antineoplastic agent; antioxidant; Aurora kinase inhibitor; chelator; EC 1.10.99.2 [ribosyldihydronicotinamide dehydrogenase (quinone)] inhibitor; geroprotector; phytoestrogen; plant metabolite; protein kinase inhibitor; radical scavenger	1990	2015	20.5	low	0	0	1	2	1	0
dinoprostone	4	prostaglandins E	human metabolite; mouse metabolite; oxytocic	1988	2017	22.5	low	0	1	1	1	1	0
dinoprost	1	monocarboxylic acid; prostaglandins Falpha	human metabolite; mouse metabolite	2002	2002	22.0	low	0	0	0	1	0	0
psychosine	1	glycosylsphingoid	human metabolite	2007	2007	17.0	low	0	0	0	1	0	0
vitamin k semiquinone radical	2			1993	2000	27.5	low	0	0	2	0	0	0
11-cis-retinal	1	retinal	chromophore; human metabolite; mouse metabolite	1980	1980	44.0	low	0	1	0	0	0	0
hymecromone	1	hydroxycoumarin	antineoplastic agent; hyaluronic acid synthesis inhibitor	2015	2015	9.0	low	0	0	0	0	1	0
8,11,14-eicosatrienoic acid	1	fatty acid 20:3; long-chain fatty acid	fungal metabolite; human metabolite; nutraceutical	2010	2010	14.0	low	0	0	0	1	0	0
alprostadil	3	prostaglandins E	anticoagulant; human metabolite; platelet aggregation inhibitor; vasodilator agent	1991	2002	26.0	low	0	0	1	2	0	0
genistein	2	7-hydroxyisoflavones	antineoplastic agent; EC 5.99.1.3 [DNA topoisomerase (ATP-hydrolysing)] inhibitor; geroprotector; human urinary metabolite; phytoestrogen; plant metabolite; tyrosine kinase inhibitor	1997	2002	24.5	low	0	0	1	1	0	0
amphotericin b	5	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite	1997	2013	23.0	low	0	0	4	0	1	0
bruceantin	1	triterpenoid		2004	2004	20.0	low	0	0	0	1	0	0
geranylgeraniol	1	geranylgeraniol		1995	1995	29.0	low	0	0	1	0	0	0
7-hydroxycoumarin	1	hydroxycoumarin	fluorescent probe; food component; plant metabolite	2008	2008	16.0	low	0	0	0	1	0	0
humulene	1	alpha-humulene		2003	2003	21.0	low	0	0	0	1	0	0
zearalenone	1	macrolide; resorcinols	fungal metabolite; mycoestrogen	2020	2020	4.0	low	0	0	0	0	1	0
retrorsine	1	macrolide		2008	2008	16.0	low	0	0	0	1	0	0
4'-methoxy-3',5,7-trihydroxyisoflavone	1	4'-methoxyisoflavones; 7-hydroxyisoflavones		2007	2007	17.0	low	0	0	0	1	0	0
coenzyme q10	1	ubiquinones	antioxidant; ferroptosis inhibitor; human metabolite	2003	2003	21.0	low	0	0	0	1	0	0
4-acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic acid	5	stilbenoid		1981	1993	35.4	low	0	3	2	0	0	0
1-palmitoyl-2-oleoylphosphatidylethanolamine	1	(18R,21S)-24-amino-21-hydroxy-21-oxido-15-oxo-16,20,22-trioxa-21lambdalambda(5)-phosphatetracosan-18-yl icosanoate; phosphatidylethanolamine		2017	2017	7.0	low	0	0	0	0	1	0
1-palmitoyl-2-oleoylglycero-3-phosphoglycerol	3	phosphatidylglycerol		2006	2017	13.3	low	0	0	0	2	1	0
20-hydroxy-5,8,11,14-eicosatetraenoic acid	1	HETE; hydroxy monocarboxylic acid	human metabolite; mouse metabolite	2011	2011	13.0	low	0	0	0	0	1	0
4-hydroxy-2-nonenal	1	4-hydroxynon-2-enal; 4-hydroxynonenal		2005	2005	19.0	low	0	0	0	1	0	0
1-monooleoyl-rac-glycerol	1	1-acylglycerol 18:1; monooleoylglycerol	plant metabolite	2017	2017	7.0	low	0	0	0	0	1	0
cholesteryl oleate	1	CE(18:1); cholesteryl octadec-9-enoate	mouse metabolite	2019	2019	5.0	low	0	0	0	0	1	0
phenylephrine hydrochloride	1	hydrochloride		2005	2005	19.0	low	0	0	0	1	0	0
granisetron	1	aromatic amide; indazoles		1999	1999	25.0	low	0	0	1	0	0	0
naloxone	2	morphinane alkaloid; organic heteropentacyclic compound; tertiary alcohol	antidote to opioid poisoning; central nervous system depressant; mu-opioid receptor antagonist	2004	2004	20.0	low	0	0	0	2	0	0
sirolimus	4	antibiotic antifungal drug; cyclic acetal; cyclic ketone; ether; macrolide lactam; organic heterotricyclic compound; secondary alcohol	antibacterial drug; anticoronaviral agent; antineoplastic agent; bacterial metabolite; geroprotector; immunosuppressive agent; mTOR inhibitor	2013	2019	7.2	low	0	0	0	0	4	0
brefeldin a	3	macrolide antibiotic	Penicillium metabolite	1994	2006	24.7	low	0	0	2	1	0	0
morphine	3	morphinane alkaloid; organic heteropentacyclic compound; tertiary amino compound	anaesthetic; drug allergen; environmental contaminant; geroprotector; mu-opioid receptor agonist; opioid analgesic; plant metabolite; vasodilator agent; xenobiotic	1994	2004	23.3	low	0	0	1	2	0	0
oregon green 488 carboxylic acid	2	xanthene dye	epitope; fluorochrome	2006	2017	12.5	low	0	0	0	1	1	0
cp 99994	2			1999	2001	24.0	low	0	0	1	1	0	0
iloprost	1	carbobicyclic compound; monocarboxylic acid; secondary alcohol	platelet aggregation inhibitor; vasodilator agent	2002	2002	22.0	low	0	0	0	1	0	0
lysophosphatidylcholines	4	1-O-acyl-sn-glycero-3-phosphocholine		1986	2017	20.8	low	0	1	1	0	2	0
cytochalasin b	7	cytochalasin; lactam; lactone; organic heterotricyclic compound	actin polymerisation inhibitor; metabolite; mycotoxin; platelet aggregation inhibitor	1980	2013	28.6	low	0	3	1	2	1	0
neurokinin a	4			1995	2003	25.8	low	0	0	3	1	0	0
kn 93	1	monochlorobenzenes; monomethoxybenzene; primary alcohol; sulfonamide; tertiary amino compound	EC 2.7.11.17 (Ca(2+)/calmodulin-dependent protein kinase) inhibitor; geroprotector	1998	1998	26.0	low	0	0	1	0	0	0
5,9,12-octadecatrienoic acid	1	octadecatrienoic acid		2004	2004	20.0	low	0	0	0	1	0	0
1,2-oleoylphosphatidylcholine	12	phosphatidylcholine(1+)		1993	2018	17.3	low	0	0	3	4	5	0
casein kinase ii	1			1999	1999	25.0	low	0	0	1	0	0	0
semaxinib	1	olefinic compound; oxindoles; pyrroles	angiogenesis modulating agent; antineoplastic agent; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor; vascular endothelial growth factor receptor antagonist	2011	2011	13.0	low	0	0	0	0	1	0
palbociclib	1	aminopyridine; aromatic ketone; cyclopentanes; piperidines; pyridopyrimidine; secondary amino compound; tertiary amino compound	antineoplastic agent; EC 2.7.11.22 (cyclin-dependent kinase) inhibitor	2022	2022	2.0	low	0	0	0	0	0	1
fosbretabulin	1			2015	2015	9.0	low	0	0	0	0	1	0
lead	6	carbon group element atom; elemental lead; metal atom	neurotoxin	2011	2021	8.2	low	0	0	0	0	5	1
5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolocarbocyanine	254	cyanine dye; indolium ion	fluorochrome	1991	2022	16.3	high	0	0	32	131	87	4
diamide	1	1,1'-azobis(N,N-dimethylformamide)		2005	2005	19.0	low	0	0	0	1	0	0
antimony	1	metalloid atom; pnictogen		2011	2011	13.0	low	0	0	0	0	1	0
cesium	2	alkali metal atom		1991	2020	18.5	low	0	0	1	0	1	0
barium	2	alkaline earth metal atom; elemental barium		1976	1998	37.0	low	0	1	1	0	0	0
oleylamine	1			2019	2019	5.0	low	0	0	0	0	1	0
rubidium	7	alkali metal atom		1978	1990	39.7	low	0	5	2	0	0	0
aluminum	1	boron group element atom; elemental aluminium; metal atom		2015	2015	9.0	low	0	0	0	0	1	0
arsenic	8	metalloid atom; pnictogen	micronutrient	2000	2013	15.1	low	0	0	1	2	5	0
indium	1	boron group element atom		2020	2020	4.0	low	0	0	0	0	1	0
gallium	1	boron group element atom		2004	2004	20.0	low	0	0	0	1	0	0
sulfur	2	chalcogen; nonmetal atom	macronutrient	1994	2015	19.5	low	0	0	1	0	1	0
geldanamycin	2			2006	2021	10.5	low	0	0	0	1	0	1
diphenylhexatriene	5	alkatriene	fluorochrome	1997	2015	16.2	low	0	0	1	1	3	0
ir-786	6			2003	2020	10.5	high	0	0	0	1	5	0
3,3'-diethyloxacarbocyanine	23	1,3-benzoxazoles; benzoxazolium ion; cyanine dye	fluorochrome	1993	2016	20.8	high	0	0	10	8	5	0
dimyristoylphosphatidylcholine	7	1,2-diacyl-sn-glycero-3-phosphocholine; phosphatidylcholine 28:0; tetradecanoate ester	antigen; mouse metabolite	1987	2019	26.1	low	0	3	2	1	1	0
ecdysterone	1	14alpha-hydroxy steroid; 20-hydroxy steroid; 22-hydroxy steroid; 25-hydroxy steroid; 2beta-hydroxy steroid; 3beta-sterol; ecdysteroid; phytoecdysteroid	animal metabolite; plant metabolite	1998	1998	26.0	low	0	0	1	0	0	0
fumarates	1	butenedioate; C4-dicarboxylate	human metabolite; metabolite; Saccharomyces cerevisiae metabolite	2000	2000	24.0	low	0	0	1	0	0	0
cysteine	25	cysteinium	fundamental metabolite	1996	2022	11.8	low	0	0	1	9	13	2
silicon	13	carbon group element atom; metalloid atom; nonmetal atom		2003	2021	12.4	low	0	0	0	6	6	1
phosphorus	1	monoatomic phosphorus; nonmetal atom; pnictogen	macronutrient	2010	2010	14.0	low	0	0	0	1	0	0
2-(4-(dimethylamino)styryl)-1-methylpyridinium	2	organic iodide salt; pyridinium salt; tertiary amine	fluorochrome	1998	2009	20.5	low	0	0	1	1	0	0
quinaldine blue	25	cyanine dye; organic iodide salt	fluorochrome	1952	2015	28.2	high	0	6	7	9	3	0
cyanine 863	1			1997	1997	27.0	low	0	0	1	0	0	0
1,1'-diethyl-2,2'-cyanine	2	1,1'-diethyl-2,2'-cyanine; quinolines		2007	2011	15.0	low	0	0	0	1	1	0
2,3-dehydrosilybin	1	flavonolignan		2010	2010	14.0	low	0	0	0	1	0	0
s-trans,trans-farnesylthiosalicylic acid	1	sesquiterpenoid		2017	2017	7.0	low	0	0	0	0	1	0
ici 118551	1	aromatic ether; indanes; secondary alcohol; secondary amino compound	beta-adrenergic antagonist	2015	2015	9.0	low	0	0	0	0	1	0
enkephalin, ala(2)-mephe(4)-gly(5)-	3			1993	2004	23.7	low	0	0	1	2	0	0
3,3'-dipropyl-2,2'-thiadicarbocyanine	130			1979	2021	32.2	high	0	73	32	13	10	2
3,3'-dipropyloxadicarbocyanine	32			1977	2013	32.0	high	0	7	23	1	1	0
3,3'-dipentyl-2,2'-oxacarbocyanine	31	benzoxazolium ion; cyanine dye	fluorochrome	1978	2015	32.1	high	0	16	10	3	2	0
3,3'-diheptyloxycarbocyanine	9			1981	2003	30.9	high	0	3	4	2	0	0
cyanine dye 1	22			1985	2020	11.0	high	0	1	0	2	19	0
n-acetylsphingosine	1	N-acylsphingosine		2004	2004	20.0	low	0	0	0	1	0	0
bafilomycin a	1			2022	2022	2.0	low	0	0	0	0	0	1
3,3'-dihexyl-2,2'-oxacarbocyanine	133			1982	2022	23.9	high	0	14	57	47	14	1
1,1',3,3,3',3'-hexamethylindotricarbocyanine	7			1987	2017	22.4	high	0	1	2	2	2	0
3,3'-dioctadecylindocarbocyanine	655	Cy5 dye; indolium ion	fluorochrome	1979	2021	25.8	high	2	22	446	125	61	1
4-(4-diethylaminostyryl)-n-methylpyridinium	4	organic iodide salt; pyridinium salt	fluorochrome	1990	2008	26.2	medium	0	0	3	1	0	0
true blue	1			2009	2009	15.0	low	0	0	0	1	0	0
cefotaxime	1	1,3-thiazoles; cephalosporin; oxime O-ether	antibacterial drug; drug allergen	2002	2002	22.0	low	0	0	0	1	0	0
4-(4-dihexadecylaminostyryl)-n-methylpyridium	13	pyridinium ion; tertiary amine	fluorochrome	1993	2007	25.5	high	0	0	9	4	0	0
1,2-dielaidoylphosphatidylethanolamine	2			2010	2011	13.5	low	0	0	0	1	1	0
ammonium sulfate	1	ammonium salt; inorganic sulfate salt	fertilizer	2020	2020	4.0	low	0	0	0	0	1	0
bisabolol	1			2019	2019	5.0	low	0	0	0	0	1	0
c.i. fluorescent brightening agent 28	2			1998	2006	22.0	low	0	0	1	1	0	0
4,4'-diisothiocyanostilbene-2,2'-disulfonic acid	3			1989	1993	32.3	low	0	1	2	0	0	0
coomassie brilliant blue	3			1981	2002	33.3	low	0	2	0	1	0	0
tetrodotoxin	23	azatetracycloalkane; oxatetracycloalkane; quinazoline alkaloid	animal metabolite; bacterial metabolite; marine metabolite; neurotoxin; voltage-gated sodium channel blocker	1985	2004	28.7	low	0	4	11	8	0	0
germanium	1	carbon group element atom; metalloid atom; nonmetal atom		2003	2003	21.0	low	0	0	0	1	0	0
selenium	5	chalcogen; nonmetal atom	micronutrient	1994	2019	16.2	low	0	0	1	2	2	0
tellurium	4	chalcogen; metalloid atom		2007	2019	8.8	low	0	0	0	1	3	0
trimethoxysilane	1			2001	2001	23.0	low	0	0	0	1	0	0
oxalates	1			1978	1978	46.0	low	0	1	0	0	0	0
1,1-diethyl-2-hydroxy-2-nitrosohydrazine	1	organic anion		2010	2010	14.0	low	0	0	0	1	0	0
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid	2	(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid		1995	2000	26.5	low	1	0	2	0	0	0
stains-all	35	cyanine dye; organic bromide salt	fluorochrome	1976	2018	30.7	high	0	15	11	6	3	0
3,3'-diethylthiatricarbocyanine	13			1980	2020	23.1	high	0	5	0	3	5	0
diacetylmonoxime	1			1999	1999	25.0	low	0	0	1	0	0	0
dizocilpine maleate	6	maleate salt; tetracyclic antidepressant	anaesthetic; anticonvulsant; neuroprotective agent; nicotinic antagonist; NMDA receptor antagonist	1997	2015	20.7	low	0	0	1	4	1	0
antimycin a	3	amidobenzoic acid		1978	2004	36.3	low	0	2	0	1	0	0
bongkrekic acid	3	ether; olefinic compound; tricarboxylic acid	apoptosis inhibitor; ATP/ADP translocase inhibitor; bacterial metabolite; EC 2.5.1.18 (glutathione transferase) inhibitor; toxin	2000	2005	21.3	low	0	0	1	2	0	0
1-palmitoyl-2-oleoylphosphatidylcholine	8			2005	2018	11.5	low	0	0	0	4	4	0
latrunculin b	2	cyclic hemiketal; macrolide; oxabicycloalkane; thiazolidinone	actin polymerisation inhibitor; metabolite; toxin	2000	2005	21.5	low	0	0	1	1	0	0
dehydroergosterol	3	3beta-hydroxy-Delta(5)-steroid; 3beta-sterol; ergostanoid; phytosterols	biomarker; metabolite	2004	2007	19.0	low	0	0	0	3	0	0
1,2-dioleoyloxy-3-(trimethylammonium)propane	2			2003	2012	16.5	low	0	0	0	1	1	0
dioleoyl phosphatidylethanolamine	1	phosphatidylethanolamine		2000	2000	24.0	low	0	0	1	0	0	0
1,1',3,3,3',3'-hexamethylindocarbocyanine iodide	7			1987	2009	30.1	high	0	3	2	2	0	0
1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidine)quinolinium, tetraiodide	6	cyanine dye; organic iodide salt	fluorochrome	1994	2016	16.3	low	0	0	1	3	2	0
1-(3-sulfonatopropyl)-4-(beta)(2-(di-n-butylamino)-6-naphthylvinyl)pyridinium betaine	1			1996	1996	28.0	low	0	0	1	0	0	0
bis(1,3-dibutylbarbiturate)trimethine oxonol	4			1995	2015	18.0	low	0	0	2	0	2	0
thiazole orange	13	cyanine dye	fluorochrome	2007	2017	11.5	low	0	0	0	2	11	0
oxonol v	2			1985	1987	38.0	low	0	2	0	0	0	0
cholesteryl oleyl ether	1			2004	2004	20.0	low	0	0	0	1	0	0
3-(n-phenylamino)-1,2-propanediol 1,2-dioleoyl ester	1			2006	2006	18.0	medium	0	0	0	1	0	0
cyanine dye 2	12			1996	2016	17.0	high	0	0	1	7	4	0
carbocyanine dye diic12(3)	45			1991	2017	20.1	high	0	0	14	25	6	0
ditetradecylindocarbocyanine	19			1987	2007	26.4	high	0	1	17	1	0	0
n,n'-bis(2-ethyl-1,3-dioxolane)kryptocyanine	5			1986	1990	36.4	high	0	4	1	0	0	0
1,2-bis(10(2',4'-hexadienoyloxy)decanoyl)-sn-glycero-3-phosphocholine	1			2000	2000	24.0	medium	0	0	1	0	0	0
1,1'-dipropyl-3,3,3',3'-tetramethylindocarbocyanine	21			1990	2012	28.5	high	0	0	19	1	1	0
1,1'-(4,4,7,7-tetramethyl-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-thiazole)-2-methylidene)quinolinium	3	cyanine dye; organic iodide salt	fluorochrome	1997	2004	22.7	low	0	0	1	2	0	0
yo-pro 1	2	cyanine dye; organic iodide salt; quaternary ammonium salt	fluorochrome	2011	2013	12.0	medium	0	0	0	0	2	0
bacteriochlorophylls	1			1987	1987	37.0	low	0	1	0	0	0	0
1,3'-diethyl-4,2'-quinolylthiacyanine iodide	26			1989	2021	12.1	high	0	1	3	3	16	3
1-oleoyl-2-palmitoylphosphatidylcholine	1			1998	1998	26.0	low	0	0	1	0	0	0
3,3'-dioctadecyloxacarbocyanine	43			1993	2021	19.0	high	0	0	14	21	7	1
asialo gm1 ganglioside	2			1996	2018	17.0	low	0	0	1	0	1	0
i(3)so3-galactosylceramide	1	galactosylceramide sulfate; N-acyl-beta-D-galactosylsphingosine		2018	2018	6.0	low	0	0	0	0	1	0
cellobionic acid	1	carbohydrate acid; disaccharide	metabolite	2020	2020	4.0	low	0	0	0	0	1	0
cyclosporin g	1			1986	1986	38.0	low	0	1	0	0	0	0
fm1 43	3	organic bromide salt; pyridinium salt; quaternary ammonium salt; tertiary amine	fluorochrome	2004	2013	16.3	low	0	0	0	2	1	0
beta-escin	1			2014	2014	10.0	low	0	0	0	0	1	0
lactacystin	1	lactam; S-substituted L-cysteine		2002	2002	22.0	low	0	0	0	1	0	0
gadolinium dtpa	3	gadolinium coordination entity	MRI contrast agent	2009	2020	10.3	low	0	0	0	1	2	0
sq-23377	8	cyclic ether; enol; polyunsaturated fatty acid; very long-chain fatty acid	calcium ionophore; metabolite	1986	2014	23.4	low	0	1	3	3	1	0
fumagillin	2	antibiotic antifungal drug; carboxylic ester; dicarboxylic acid monoester; meroterpenoid; organooxygen heterocyclic antibiotic; spiro-epoxide	angiogenesis inhibitor; antibacterial drug; antimicrobial agent; antiprotozoal drug; fungal metabolite; methionine aminopeptidase 2 inhibitor	2008	2008	16.0	low	0	0	0	2	0	0
enkephalin, leucine-2-alanine	1			2002	2002	22.0	low	0	0	0	1	0	0
xct790	1	cinnamamides		2010	2010	14.0	low	0	0	0	1	0	0
bromopyruvate	1	2-oxo monocarboxylic acid anion		2021	2021	3.0	low	0	0	0	0	0	1
epsilon-(gamma-glutamyl)-lysine	1	L-alpha-amino acid zwitterion; N(6)-acyl-L-lysine		2001	2001	23.0	low	0	0	0	1	0	0
staurosporine	4	ammonium ion derivative		1997	2015	15.0	low	0	0	1	0	3	0
2-amino-5,6,7-trimethyl-1,8-naphthyridine	1			2014	2014	10.0	low	0	0	0	0	1	0
grayanotoxin i	2	acetate ester; pentol; secondary alcohol; tertiary alcohol; tetracyclic diterpenoid	antihypertensive agent; metabolite; neuromuscular agent; phytotoxin	1990	1990	34.0	low	0	0	2	0	0	0
cholanic acid	1	cholanic acids		2012	2012	12.0	low	0	0	0	0	1	0
formazans	4			2005	2009	16.5	low	0	0	0	4	0	0
s-nitrosocysteine	1	L-cysteine derivative; nitrosothio compound	hematologic agent; platelet aggregation inhibitor; vasodilator agent	2003	2003	21.0	low	0	0	0	1	0	0
sr 142801	1			1999	1999	25.0	low	0	0	1	0	0	0
valyl-prolyl-proline	1	tripeptide	metabolite	2012	2012	12.0	low	0	0	0	0	1	0
bicyclol	1			2017	2017	7.0	low	0	0	0	0	1	0
jasplakinolide	1	cyclodepsipeptide; phenols	actin polymerisation inducer; animal metabolite; antifungal agent; antineoplastic agent; apoptosis inducer; marine metabolite; neuroprotective agent	2007	2007	17.0	low	0	0	0	1	0	0
Alexa Fluor 555	3	xanthenes	fluorochrome	2017	2021	5.3	medium	0	0	0	0	2	1
sincalide	4	oligopeptide		2002	2015	14.5	low	0	0	0	2	2	0
gambogic acid	1	pyranoxanthones	metabolite	2019	2019	5.0	low	0	0	0	0	1	0
flag peptide	3	peptide		2009	2020	10.0	low	0	0	0	1	2	0
kla peptide	1			2009	2009	15.0	low	0	0	0	1	0	0
mocetinostat	5	aminopyrimidine; benzamides; pyridines; secondary amino compound; secondary carboxamide; substituted aniline	antineoplastic agent; apoptosis inducer; autophagy inducer; cardioprotective agent; EC 3.5.1.98 (histone deacetylase) inhibitor; hepatotoxic agent	1981	2020	16.0	low	0	1	0	1	3	0
ginsenoside rg3	1	ginsenoside; glycoside; tetracyclic triterpenoid	angiogenesis modulating agent; antineoplastic agent; apoptosis inducer; plant metabolite	2005	2005	19.0	low	0	0	0	1	0	0
rucaparib	1	azepinoindole; caprolactams; organofluorine compound; secondary amino compound	antineoplastic agent; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	2020	2020	4.0	low	0	0	0	0	1	0
zeolites	5			2006	2018	11.6	low	0	0	0	2	3	0
isoleucyl-prolyl-proline	1	oligopeptide		2012	2012	12.0	low	0	0	0	0	1	0
tetramethylrhodamine	15	xanthene dye		1993	2020	18.1	low	0	0	4	6	5	0
g(m1) ganglioside	4	alpha-N-acetylneuraminosyl-(2->3)-[beta-D-galactosyl-(1->3)-N-acetyl-beta-D-galactosaminyl-(1->4)]-beta-D-galactosyl-(1->4)-beta-D-glucosyl-(1<->1')-N-acylsphingosine; sialotetraosylceramide		1996	2019	11.0	low	0	0	1	0	3	0
aluminum oxide	3			2010	2017	11.0	low	0	0	0	1	2	0
cereulide	1			2004	2004	20.0	low	0	0	0	1	0	0
phosphoramidite	3			2008	2013	13.0	low	0	0	0	1	2	0
cuprous sulfide	1	copper sulfide		2021	2021	3.0	low	0	0	0	0	0	1
struvite	1	hydrate; phosphate mineral	fertilizer	2018	2018	6.0	low	0	0	0	0	1	0
artenimol	1			2014	2014	10.0	low	0	0	0	0	1	0
epicocconone	1	organic heterotricyclic compound	fluorochrome	2017	2017	7.0	low	0	0	0	0	1	0
alpha-synuclein	6			2005	2012	15.2	low	0	0	0	5	1	0
7-aminoactinomycin d	3			2001	2004	21.7	low	0	0	0	3	0	0
ngr peptide	2			2014	2014	10.0	low	0	0	0	0	2	0
oxadiazoles	2			1988	1989	35.5	low	0	2	0	0	0	0
4,5-diaminofluorescein	1			2005	2005	19.0	low	0	0	0	1	0	0
cypate	1			2018	2018	6.0	low	0	0	0	0	1	0
ribose	1	D-ribose; ribopyranose		2001	2001	23.0	low	0	0	0	1	0	0
acebutolol	2	alpha-D-glucosyl-(1->4)-D-mannopyranose		1985	2008	27.5	low	0	1	0	1	0	0
rh 414	2			1995	2001	26.0	low	0	0	1	1	0	0
nystatin a1	3	nystatins		1981	2000	30.7	low	0	1	2	0	0	0
veratridine	6			1985	2001	35.0	low	0	4	1	1	0	0
crizotinib	1	3-[1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl)pyrazol-4-yl]pyridin-2-amine	antineoplastic agent; biomarker; EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor	2019	2019	5.0	low	0	0	0	0	1	0
ginsenoside rd	1	beta-D-glucoside; ginsenoside; tetracyclic triterpenoid	anti-inflammatory drug; apoptosis inducer; immunosuppressive agent; neuroprotective agent; plant metabolite; vulnerary	2013	2013	11.0	low	0	0	0	0	1	0
losartan potassium	3			2003	2012	16.7	low	0	0	0	2	1	0
guluronic acid	1	carbohydrate acid derivative		2009	2009	15.0	low	0	0	0	1	0	0
alpha-Neup5Ac-(2->3)-beta-D-Galp-(1->4)-[alpha-L-Fucp-(1->3)]-D-GlcpNAc	1	amino tetrasaccharide; glucosamine oligosaccharide	epitope	2007	2007	17.0	low	0	0	0	1	0	0
2-(n-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose	1			2014	2014	10.0	low	0	0	0	0	1	0
telomestatin	1			2017	2017	7.0	low	0	0	0	0	1	0
calcimycin	16	benzoxazole		1976	2003	37.7	low	0	14	1	1	0	0
sepharose	4			2005	2015	14.8	low	0	0	0	3	1	0
indocyanine green	18	1,1-diunsubstituted alkanesulfonate; benzoindole; cyanine dye		1979	2021	15.5	low	0	1	0	7	9	1
scopolamine hydrobromide	1			2012	2012	12.0	low	0	0	0	0	1	0
pituitrin	2			1995	2008	22.5	low	0	0	1	1	0	0
ethidium homodimer	1			2001	2001	23.0	low	0	0	0	1	0	0
vpm chloride	3			2017	2023	4.3	low	0	0	0	0	2	1
acid phosphatase	2			1978	2013	28.5	low	0	1	0	0	1	0
erythrosine	7			1990	2013	27.4	low	0	0	6	0	1	0
butaprost	1			2002	2002	22.0	low	0	0	0	1	0	0
jaw	1	indolecarboxamide		1999	1999	25.0	low	0	0	1	0	0	0
nad	9	organophosphate oxoanion	cofactor; human metabolite; hydrogen acceptor; Saccharomyces cerevisiae metabolite	1993	2021	16.2	low	0	0	2	3	3	1
cytochrome c-t	31			2003	2021	13.1	low	0	0	0	12	18	1
picogreen	1	benzothiazoles; cyanine dye; quinolines; tertiary amine	fluorescent dye	2006	2006	18.0	low	0	0	0	1	0	0
melitten	2			1986	1996	33.0	low	0	1	1	0	0	0
cholecystokinin	1			2007	2007	17.0	low	0	0	0	1	0	0
pleurocidin	1			2012	2012	12.0	low	0	0	0	0	1	0
alamethicin	1			2004	2004	20.0	low	0	0	0	1	0	0
gastrins	1			2005	2005	19.0	low	0	0	0	1	0	0
gramicidin a	22			1977	2013	31.8	low	0	11	4	6	1	0
neuropeptide y	14			1991	2016	25.1	low	0	0	12	1	1	0
lactoferricin b	1			2019	2019	5.0	low	0	0	0	0	1	0
oligonucleotides	75			2001	2020	13.9	low	0	0	0	39	36	0
tritrpticin	1			2006	2006	18.0	low	0	0	0	1	0	0
c-peptide	1			2016	2016	8.0	low	0	0	0	0	1	0
gastrin 17	1	gastrin	antineoplastic agent	2005	2005	19.0	low	0	0	0	1	0	0
cellulose	6	glycoside		1999	2013	14.7	low	0	0	1	1	4	0
3,3'-diethylthiacarbocyanine iodide	11	benzothiazoles; cyanine dye	fluorochrome	1991	2015	20.2	high	0	0	3	6	2	0
endothelin-1	4			2000	2008	22.0	low	0	0	3	1	0	0
phosphatidylcholines	53	1,2-diacyl-sn-glycero-3-phosphocholine		1975	2020	21.7	low	0	10	13	12	18	0
atto655	1			2014	2014	10.0	medium	0	0	0	0	1	0
4-aminobenzoyl-glycyl-prolyl-leucyl-alanine hydroxamic acid	1			2008	2008	16.0	low	0	0	0	1	0	0
atractyloside	1			2005	2005	19.0	low	0	0	0	1	0	0
nk 5	5	organic iodide salt; quinolines	fluorochrome	1990	2023	13.8	high	0	0	1	1	2	1
n-(7-(4-nitrobenzo-2-oxa-1,3-diazole))-6-aminocaproyl sphingosine	3	N-acylsphingosine	fluorescent probe	1992	2001	28.7	low	0	0	2	1	0	0
oxonol vi	2			1987	1990	35.5	low	0	1	1	0	0	0
chlorophyll a	5	chlorophyll; methyl ester	cofactor	1996	2021	13.2	low	0	0	1	1	2	1
tri-n-butylstannylmethacrylate	1			2007	2007	17.0	medium	0	0	0	1	0	0
tris-(8-hydroxyquinoline)aluminum	1			2013	2013	11.0	low	0	0	0	0	1	0
hoe 33342	25			1987	2017	22.9	low	0	4	8	6	7	0
ubiquinone	3			1994	2005	23.3	low	0	0	1	2	0	0
1-palmitoyl-2-(6-(n-(7-nitrobenz)-2-oxa-1,3-diazol-4-yl)aminocaproyl)phosphatidylcholine	1	1,2-diacyl-sn-glycero-3-phosphocholine(1+)	fluorescent probe	2008	2008	16.0	low	0	0	0	1	0	0
alpha-amanitin	1			2009	2009	15.0	low	0	0	0	1	0	0
calpain	2			2001	2015	16.0	low	0	0	0	1	1	0
n-azidoacetylmannosamine	4			2016	2017	7.5	medium	0	0	0	0	4	0
lucifer yellow	16	organic lithium salt	fluorochrome	1990	2009	27.5	low	0	0	14	2	0	0
biotinyltyramide	1			1998	1998	26.0	low	0	0	1	0	0	0
chitosan	31			2008	2021	9.8	low	0	0	0	7	21	3
iodouracil	1			2018	2018	6.0	low	0	0	0	0	1	0
tert-butyloxycarbonyl-phenylalanyl-leucyl-phenylalanyl-leucyl-phenylalanyl-oh	1			2001	2001	23.0	medium	0	0	0	1	0	0
bis(1,3-diethylthiobarbiturate)trimethineoxonol	4			1984	2004	29.0	low	0	1	1	2	0	0
2,6-bis(4-aminophenyl)-4-(4-(dimethylamino)phenyl)thiopyrylium	1			2004	2004	20.0	medium	0	0	0	1	0	0
lumin	1			2009	2009	15.0	low	0	0	0	1	0	0
mesna	1	organosulfonic acid		2008	2008	16.0	low	0	0	0	1	0	0
sodium bisulfite	1	inorganic sodium salt; sulfite salt	allergen; food antioxidant; food colour retention agent; mutagen; reducing agent	2002	2002	22.0	low	0	0	0	1	0	0
sodium nitrite	1	inorganic sodium salt; nitrite salt	antidote to cyanide poisoning; antihypertensive agent; antimicrobial food preservative; food antioxidant; poison	1999	1999	25.0	low	0	0	1	0	0	0
raltegravir potassium	1			2011	2011	13.0	low	0	0	0	0	1	0
sarkosyl	1			1983	1983	41.0	low	0	1	0	0	0	0
merocyanine dye	8			1987	2018	21.9	low	0	1	2	2	3	0
ro13-9904	1			2021	2021	3.0	low	0	0	0	0	0	1
nk 2761	1			1999	1999	25.0	low	0	0	1	0	0	0
olaparib	1	cyclopropanes; monofluorobenzenes; N-acylpiperazine; phthalazines	antineoplastic agent; apoptosis inducer; EC 2.4.2.30 (NAD(+) ADP-ribosyltransferase) inhibitor	2021	2021	3.0	low	0	0	0	0	0	1
s-adenosylmethionine	1	organic cation; sulfonium compound	coenzyme; cofactor; human metabolite; micronutrient; Mycoplasma genitalium metabolite; nutraceutical; Saccharomyces cerevisiae metabolite	2014	2014	10.0	low	0	0	0	0	1	0
gadofluorine m	2			2009	2009	15.0	low	0	0	0	2	0	0
picrotoxin	2			1987	2003	29.0	low	0	1	0	1	0	0
pci 32765	1	acrylamides; aromatic amine; aromatic ether; N-acylpiperidine; pyrazolopyrimidine; tertiary carboxamide	antineoplastic agent; EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor	2022	2022	2.0	low	0	0	0	0	0	1
ponatinib	1	(trifluoromethyl)benzenes; acetylenic compound; benzamides; imidazopyridazine; N-methylpiperazine	antineoplastic agent; tyrosine kinase inhibitor	2012	2012	12.0	low	0	0	0	0	1	0
4,4-difluoro-4-bora-3a,4a-diaza-s-indacene	24	BODIPY compound		1996	2023	14.9	low	0	0	6	5	12	1
ter 199	1			2019	2019	5.0	low	0	0	0	0	1	0
cardiovascular agents	2			2009	2009	15.0	low	0	0	0	2	0	0
neurotensin	2	peptide hormone	human metabolite; mitogen; neurotransmitter; vulnerary	1994	2004	25.0	low	0	0	1	1	0	0
nonaarginine	1			2016	2016	8.0	low	0	0	0	0	1	0
yoyo-3	1	cyanine dye; organic iodide salt	fluorochrome	2014	2014	10.0	medium	0	0	0	0	1	0
mannans	3			2014	2018	8.3	low	0	0	0	0	3	0
alexa fluor 546	3	organic heteropentacyclic compound	fluorochrome	2009	2018	10.7	low	0	0	0	1	2	0
acridine yellow	2	aminoacridines; hydrochloride	fluorochrome	1980	2017	25.5	low	0	1	0	0	1	0
mitotracker orange	3	organic chloride salt	fluorochrome	2000	2021	16.3	medium	0	0	1	1	0	1
to-pro-3	49	cyanine dye; organic iodide salt	fluorochrome	1996	2021	16.5	high	0	0	6	23	19	1
phosphinothricin	1	organic anion		2005	2005	19.0	low	0	0	0	1	0	0
4-hydroxy-5-nitrophenyl acetic acid	1	monocarboxylic acid anion		2014	2014	10.0	low	0	0	0	0	1	0
urushiol	1			1985	1985	39.0	low	0	1	0	0	0	0
glycolipids	6			1992	2017	21.2	low	0	0	1	4	1	0
piperidines	6			1999	2022	10.3	low	0	0	1	1	1	3
galactocerebroside	1			2003	2003	21.0	low	0	0	0	1	0	0
interleukin-8	4			2000	2016	15.5	low	0	0	1	1	2	0
bobo 3	14	cyanine dye; organic iodide salt	fluorochrome	1996	2017	14.9	high	0	0	1	8	5	0
colistin	1			2020	2020	4.0	low	0	0	0	0	1	0
uridine diphosphate n-acetylgalactosamine	1	nucleotide-sugar oxoanion	human metabolite	2017	2017	7.0	low	0	0	0	0	1	0
methylcellulose	1			2008	2008	16.0	low	0	0	0	1	0	0
isoquercitrin	1			2015	2015	9.0	low	0	0	0	0	1	0
1,2-dioleoyl-sn-glycero-3-phosphoglycerol	3	1,2-diacyl-sn-glycero-3-phospho-(1'-sn-glycerol)		1993	2018	15.0	low	0	0	1	0	2	0
6-ketocholestanol	1	cholestanoid		1998	1998	26.0	low	0	0	1	0	0	0
peptide a	1			2006	2006	18.0	low	0	0	0	1	0	0
vasoactive intestinal peptide	10			1991	2006	26.4	low	0	0	8	2	0	0
heme	1			2015	2015	9.0	low	0	0	0	0	1	0
chondroitin	1			1983	1983	41.0	low	0	1	0	0	0	0
heparitin sulfate	1			1999	1999	25.0	low	0	0	1	0	0	0
ascorbic acid	10	ascorbic acid; vitamin C	coenzyme; cofactor; flour treatment agent; food antioxidant; food colour retention agent; geroprotector; plant metabolite; skin lightening agent	1985	2019	16.6	low	0	1	1	4	4	0
chlortetracycline	6			1981	1998	36.0	low	0	4	2	0	0	0
oxytetracycline, anhydrous	1			1984	1984	40.0	low	0	1	0	0	0	0
salicylates	4	monohydroxybenzoate	plant metabolite	1993	2017	19.2	low	0	0	1	2	1	0
warfarin	15	benzenes; hydroxycoumarin; methyl ketone		2005	2022	9.6	low	0	0	0	3	11	1
antimycin	1			2004	2004	20.0	low	0	0	0	1	0	0
ascorbyl monolaurate	1			2013	2013	11.0	medium	0	0	0	0	1	0
nickel nitrilotriacetic acid	2			2008	2010	15.0	low	0	0	0	2	0	0
epidermal growth factor	17			1996	2022	17.1	low	0	0	4	8	4	1
gastrin-releasing peptide	1			1995	1995	29.0	low	0	0	1	0	0	0
clay	2			2006	2010	16.0	low	0	0	0	2	0	0
transforming growth factor beta	9			1997	2015	17.4	low	0	0	1	5	3	0
pacific blue succinimidyl ester	1	hydroxycoumarin; N-hydroxysuccinimide ester; organofluorine compound	fluorochrome	2011	2011	13.0	medium	0	0	0	0	1	0
okadaic acid	1	ketal		1994	1994	30.0	low	0	0	1	0	0	0
sybr green i	8	benzothiazolium ion; cyanine dye; quinolines; tertiary amine	fluorescent dye	1997	2019	20.8	low	0	0	4	3	1	0
bgp 15	1			2017	2017	7.0	low	0	0	0	0	1	0
kiss1 protein, human	1			2018	2018	6.0	low	0	0	0	0	1	0
platonin	1			2003	2003	21.0	low	0	0	0	1	0	0
hirudin	1			1985	1985	39.0	low	0	1	0	0	0	0
caseins	2			1986	2013	24.5	low	0	1	0	0	1	0
mitotracker green fm	5			1998	2008	21.6	low	0	0	2	3	0	0
ala-thr-trp-leu-pro-pro-arg	1			2018	2018	6.0	medium	0	0	0	0	1	0
oligomycins	15			1978	2017	26.1	low	0	5	2	6	2	0
crotamine	2			2004	2016	14.0	low	0	0	0	1	1	0
tetracarboxyphenylporphine	1			2014	2014	10.0	low	0	0	0	0	1	0
phthalocyanine	3	phthalocyanines; tetrapyrrole fundamental parent		2004	2013	15.7	low	0	0	0	2	1	0
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone	2			1999	2015	17.0	low	0	0	1	0	1	0
nitrophenols	2			2014	2016	9.0	low	0	0	0	0	2	0
bassianolide	1	cyclodepsipeptide; cyclooctadepsipeptide	antineoplastic agent; fungal metabolite; insecticide	2011	2011	13.0	low	0	0	0	0	1	0
lewis x antigen	3			2002	2004	21.3	low	0	0	0	3	0	0
snx 482	1			2013	2013	11.0	low	0	0	0	0	1	0
angiotensin i	1	angiotensin; peptide zwitterion	human metabolite; neurotransmitter agent	1995	1995	29.0	low	0	0	1	0	0	0
cobamamide	1			2018	2018	6.0	low	0	0	0	0	1	0
hyaluronoglucosaminidase	5			1977	1993	42.0	low	0	4	1	0	0	0
adrenomedullin	2			2005	2006	18.5	low	0	0	0	2	0	0
lipofectamine	4			2012	2019	10.0	low	0	0	0	0	4	0
vitamin b 12	2			2003	2018	13.5	low	0	0	0	1	1	0
oblimersen	1			2012	2012	12.0	low	0	0	0	0	1	0
as 1411	2			2014	2023	5.5	low	0	0	0	0	1	1
cyclosporine	16			1986	2020	19.9	low	0	1	4	8	3	0
cytochalasin d	8			1994	2013	23.4	low	0	0	5	2	1	0
lactoferrin	5			2000	2019	11.4	low	0	0	1	0	4	0
digitonin	3			1984	2008	31.3	low	0	2	0	1	0	0
thromboplastin	2			2005	2015	14.0	low	0	0	0	1	1	0
muramidase	15			1980	2020	17.5	low	0	3	0	4	8	0
amyloid beta-peptides	1			2000	2000	24.0	low	0	0	1	0	0	0
chondroitin sulfates	3			1983	2017	20.0	low	0	1	0	0	2	0
exendin 3	1			2015	2015	9.0	low	0	0	0	0	1	0
tetra(4-n-methylpyridyl)porphine	6			2007	2021	10.2	low	0	0	0	2	2	2
deoxyinosine	2	purine 2'-deoxyribonucleoside; purines 2'-deoxy-D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite	2012	2013	11.5	low	0	0	0	0	2	0
guanosine diphosphate	2	guanosine 5'-phosphate; purine ribonucleoside 5'-diphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor	2001	2005	21.0	low	0	0	0	2	0	0
guanosine triphosphate	5	guanosine 5'-phosphate; purine ribonucleoside 5'-triphosphate	Escherichia coli metabolite; mouse metabolite; uncoupling protein inhibitor	2001	2018	15.2	low	0	0	0	3	2	0
guanine	6	2-aminopurines; oxopurine; purine nucleobase	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	1996	2010	19.5	low	0	0	1	5	0	0
guanosine	2	guanosines; purines D-ribonucleoside	fundamental metabolite	2000	2004	22.0	low	0	0	1	1	0	0
inosine	2	inosines; purines D-ribonucleoside	Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite	2012	2013	11.5	low	0	0	0	0	2	0
folic acid	12	folic acids; N-acyl-amino acid	human metabolite; mouse metabolite; nutrient	2004	2021	8.5	low	0	0	0	1	10	1
3-methyladenine	1			2019	2019	5.0	low	0	0	0	0	1	0
rifampin	1	cyclic ketal; hydrazone; N-iminopiperazine; N-methylpiperazine; rifamycins; semisynthetic derivative; zwitterion	angiogenesis inhibitor; antiamoebic agent; antineoplastic agent; antitubercular agent; DNA synthesis inhibitor; EC 2.7.7.6 (RNA polymerase) inhibitor; Escherichia coli metabolite; geroprotector; leprostatic drug; neuroprotective agent; pregnane X receptor agonist; protein synthesis inhibitor	2015	2015	9.0	low	0	0	0	0	1	0
didanosine	1	purine 2',3'-dideoxyribonucleoside	antimetabolite; antiviral drug; EC 2.4.2.1 (purine-nucleoside phosphorylase) inhibitor; geroprotector; HIV-1 reverse transcriptase inhibitor	2001	2001	23.0	low	0	0	0	1	0	0
ganciclovir	1	2-aminopurines; oxopurine	antiinfective agent; antiviral drug	2012	2012	12.0	low	0	0	0	0	1	0
allopurinol	4	nucleobase analogue; organic heterobicyclic compound	antimetabolite; EC 1.17.3.2 (xanthine oxidase) inhibitor; gout suppressant; radical scavenger	1987	2000	28.2	low	0	1	3	0	0	0
tegaserod	1	carboxamidine; guanidines; hydrazines; indoles	gastrointestinal drug; serotonergic agonist	2004	2004	20.0	low	0	0	0	1	0	0
sildenafil citrate	1	citrate salt	EC 3.1.4.35 (3',5'-cyclic-GMP phosphodiesterase) inhibitor; vasodilator agent	2005	2005	19.0	low	0	0	0	1	0	0
trypan blue	4			2005	2019	13.5	low	0	0	0	2	2	0
arsenazo iii	1			1985	1985	39.0	low	0	1	0	0	0	0
coelenterazine	2			2019	2021	4.0	low	0	0	0	0	1	1
noc 9	1			2005	2005	19.0	low	0	0	0	1	0	0
dy-676	5	organic sodium salt	fluorochrome	2012	2015	10.2	high	0	0	0	0	5	0
cyanine dye 3	753			1994	2023	14.2	high	0	0	55	346	333	19
alcian blue	1			1983	1983	41.0	low	0	1	0	0	0	0
3,5-difluoro-4-hydroxybenzylidene imidazolinone	1			2016	2016	8.0	low	0	0	0	0	1	0
eye	9			1978	2009	27.1	low	0	1	5	3	0	0
mitotempo	1			2022	2022	2.0	low	0	0	0	0	0	1
oligomycin b	1			2003	2003	21.0	low	0	0	0	1	0	0
concanavalin a	8			1984	2003	32.0	low	0	4	3	1	0	0
chlorotoxin	7			2005	2011	15.1	low	0	0	0	6	1	0
trypsinogen	1			2005	2005	19.0	low	0	0	0	1	0	0
metallothionein	3			2000	2021	14.7	low	0	0	1	1	0	1
yo-pro 1	3			1997	2010	18.7	low	0	0	1	2	0	0
dinitrobenzenes	3			1995	2017	20.0	low	0	0	2	0	1	0
2',7'-bis-(2-carboxyethyl)-5(6)-carboxyfluorescein acetoxymethyl ester	1			2002	2002	22.0	low	0	0	0	1	0	0
2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein	2			1988	1997	31.5	low	0	1	1	0	0	0
phosphorus radioisotopes	1			2007	2007	17.0	low	0	0	0	1	0	0
thrombin aptamer	2			2011	2017	10.0	low	0	0	0	0	2	0
leptin	1			2004	2004	20.0	low	0	0	0	1	0	0
mitosox red	1			2020	2020	4.0	medium	0	0	0	0	1	0
pkh 26	5			1995	2006	23.0	low	0	0	1	4	0	0
pyrimidinones	7			1979	2012	28.7	low	0	2	2	2	1	0
filipin	3			1992	2001	26.3	low	0	0	2	1	0	0
phenanthrenes	2			2018	2019	5.5	low	0	0	0	0	2	0
sybr green ii	1			2019	2019	5.0	low	0	0	0	0	1	0

Condition	Studies	First Year	Last Year	Average Age	Relationship Strength	Trials	pre-1990	1990's	2000's	2010's	post-2020
2019 Novel Coronavirus Disease	4	2021	2022	2.8	low	0	0	0	0	0	4
22q11.2 Deletion Syndrome	1	1992	1992	32.0	low	0	0	1	0	0	0
47,XX,+21	1	2002	2002	22.0	low	0	0	0	1	0	0
Abdominal Cryptorchidism	1	2007	2007	17.0	low	0	0	0	1	0	0
Aberrant Tissue	3	1999	2003	23.3	low	0	0	2	1	0	0
Abnormalities, Autosome	2	2001	2005	21.0	low	0	0	0	2	0	0
Abnormalities, Congenital, Nervous System	3	2002	2007	18.7	low	0	0	0	3	0	0
Abnormalities, Sex Chromosome	1	2012	2012	12.0	low	0	0	0	0	1	0
Absence of Corpus Callosum	1	1999	1999	25.0	low	0	0	1	0	0	0
Ache	6	1993	2010	20.8	low	0	0	2	4	0	0
Acidosis	2	2012	2014	11.0	low	0	0	0	0	2	0
Acinetobacter Infections	1	2016	2016	8.0	low	0	0	0	0	1	0
Acquired Immune Deficiency Syndrome	1	1995	1995	29.0	low	0	0	1	0	0	0
Acquired Immunodeficiency Syndrome	1	1995	1995	29.0	low	0	0	1	0	0	0
Acquired-Immune Deficiency Syndrome Dementia Complex	1	2013	2013	11.0	low	0	0	0	0	1	0
Actinic Reticuloid Syndrome	1	2006	2006	18.0	low	0	0	0	1	0	0
Acute Brain Injuries	10	1996	2018	17.8	low	0	0	3	3	4	0
Acute Confusional Senile Dementia	24	1996	2021	15.0	low	0	0	5	8	9	2
Acute Disease	7	1995	2013	21.1	low	0	0	1	5	1	0
Acute Edematous Pancreatitis	1	2013	2013	11.0	low	0	0	0	0	1	0
Acute Hepatic Failure	2	2012	2014	11.0	low	0	0	0	0	2	0
Acute Kidney Failure	3	2005	2019	14.0	low	0	0	0	2	1	0
Acute Kidney Injury	3	2005	2019	14.0	low	0	0	0	2	1	0
Acute Liver Injury, Drug-Induced	3	2009	2020	10.0	low	0	0	0	1	2	0
Acute Lymphoid Leukemia	4	2004	2013	16.5	low	0	0	0	3	1	0
Acute Myelogenous Leukemia	7	2001	2019	14.7	low	0	0	0	4	3	0
Acute Promyelocytic Leukemia	1	2007	2007	17.0	low	0	0	0	1	0	0
Acute Relapsing Multiple Sclerosis	1	2009	2009	15.0	low	0	0	0	1	0	0
ADDH	1	2011	2011	13.0	low	0	0	0	0	1	0
Adenocarcinoma	17	1987	2018	15.5	low	0	1	1	6	9	0
Adenocarcinoma Of Kidney	1	2006	2006	18.0	low	0	0	0	1	0	0
Adenocarcinoma of Lung	1	2016	2016	8.0	low	0	0	0	0	1	0
Adenocarcinoma, Basal Cell	17	1987	2018	15.5	low	0	1	1	6	9	0
Adenoma	5	2003	2020	10.6	low	0	0	0	1	4	0
Adenoma, Basal Cell	5	2003	2020	10.6	low	0	0	0	1	4	0
Adenoma, Prostatic	1	2006	2006	18.0	low	0	0	0	1	0	0
Adenomatous Polyps	1	2020	2020	4.0	low	0	0	0	0	1	0
Adenovirus Infections, Human	1	1993	1993	31.0	low	0	0	1	0	0	0
Adiadochokinesis	1	2011	2011	13.0	low	0	0	0	0	1	0
Adipocere	1	2005	2005	19.0	low	0	0	0	1	0	0
Adjuvant Arthritis	10	1988	2021	16.8	low	0	1	0	6	2	1
ADPKD	1	2005	2005	19.0	low	0	0	0	1	0	0
Adult Periodontitis	1	2009	2009	15.0	low	0	0	0	1	0	0
Adult Spinal Muscular Atrophy	1	2002	2002	22.0	low	0	0	0	1	0	0
Adverse Drug Event	1	2011	2011	13.0	low	0	0	0	0	1	0
African Lymphoma	4	2012	2020	8.2	low	0	0	0	0	4	0
Age-Related Macular Degeneration	2	2005	2011	16.0	low	0	0	0	1	1	0
Age-Related Memory Disorders	1	2012	2012	12.0	low	0	0	0	0	1	0
Aging	55	1985	2017	25.3	low	0	1	33	18	3	0
AIDS Dementia Complex	1	2013	2013	11.0	low	0	0	0	0	1	0
AIDS-Related Complex	1	2017	2017	7.0	low	0	0	0	0	1	0
Airway Hyper-Responsiveness	1	2004	2004	20.0	low	0	0	0	1	0	0
Akinetic-Rigid Variant of Huntington Disease	1	2006	2006	18.0	low	0	0	0	1	0	0
Albinism	1	1993	1993	31.0	low	0	0	1	0	0	0
Albinism, Oculocutaneous	1	2002	2002	22.0	low	0	0	0	1	0	0
Albinism, Tyrosinase-Negative	1	2002	2002	22.0	low	0	0	0	1	0	0
Albuminuria	1	2003	2003	21.0	low	0	0	0	1	0	0
Alcohol Drinking	1	2019	2019	5.0	low	0	0	0	0	1	0
Allergic Cutaneous Angiitis	1	2013	2013	11.0	low	0	0	0	0	1	0
Allergic Encephalomyelitis	5	1992	2015	20.6	low	0	0	2	2	1	0
Allergic Reaction	3	2013	2018	9.0	low	0	0	0	0	3	0
Allodynia	2	2003	2013	16.0	low	0	0	0	1	1	0
Alloxan Diabetes	6	2001	2021	10.2	low	0	0	0	2	3	1
ALS - Amyotrophic Lateral Sclerosis	1	2011	2011	13.0	low	0	0	0	0	1	0
Alveolar Bone Atrophy	2	2009	2015	12.0	low	0	0	0	1	1	0
Alveolar Echinococcosis, Hepatic	1	2016	2016	8.0	low	0	0	0	0	1	0
Alveolitis, Fibrosing	2	2011	2018	9.5	low	0	0	0	0	2	0
Alzheimer Disease	24	1996	2021	15.0	low	0	0	5	8	9	2
Amaurosis	1	2003	2003	21.0	low	0	0	0	1	0	0
Ambiguous Genitalia	1	2008	2008	16.0	low	0	0	0	1	0	0
Amentia	1	1993	1993	31.0	low	0	0	1	0	0	0
American Trypanosomiasis	1	1990	1990	34.0	low	0	0	1	0	0	0
Amyloid Angiopathy, Cerebral	1	2016	2016	8.0	low	0	0	0	0	1	0
Amyloid Deposits	4	1998	2019	14.8	low	0	0	1	1	2	0
Amyotrophic Lateral Sclerosis	1	2011	2011	13.0	low	0	0	0	0	1	0
Anaplastic Astrocytoma	1	2012	2012	12.0	low	0	0	0	0	1	0
Anaplastic Oligodendroglioma	1	2012	2012	12.0	low	0	0	0	0	1	0
Anasarca	2	1988	2010	25.0	low	0	1	0	1	0	0
Anastomotic Leak	1	2018	2018	6.0	low	0	0	0	0	1	0
Anemia	1	1992	1992	32.0	low	0	0	1	0	0	0
Anemia, Aplastic	1	2014	2014	10.0	low	0	0	0	0	1	0
Anemia, Cooley's	1	2010	2010	14.0	low	0	0	0	1	0	0
Anemia, Fanconi	1	2015	2015	9.0	low	0	0	0	0	1	0
Anemia, Hypoplastic	1	2014	2014	10.0	low	0	0	0	0	1	0
Anemia, Sickle Cell	2	1986	1996	33.0	low	0	1	1	0	0	0
Anesthesia	2	1992	2016	20.0	low	0	0	1	0	1	0
Angiogenesis, Pathologic	22	1998	2020	12.7	low	0	0	1	8	13	0
Angioma	1	1993	1993	31.0	low	0	0	1	0	0	0
Animal Mammary Carcinoma	3	2019	2021	4.0	low	0	0	0	0	2	1
Anoxemia	19	1994	2021	15.5	low	0	0	5	6	5	3
Anoxia-Ischemia, Brain	4	2002	2012	16.0	low	0	0	0	3	1	0
Anoxia, Brain	1	2001	2001	23.0	low	0	0	0	1	0	0
Anterior Cerebral Circulation Infarction	2	2008	2010	15.0	low	0	0	0	2	0	0
Anterior Choroidal Artery Infarction	1	2010	2010	14.0	low	0	0	0	1	0	0
Anterior Circulation Transient Ischemic Attack	2	2010	2011	13.5	low	0	0	0	1	1	0
Anterior Ischemic Optic Neuropathy	1	2016	2016	8.0	low	0	0	0	0	1	0
Anthrax	1	2014	2014	10.0	low	0	0	0	0	1	0
Anti-GBM Disease	1	2001	2001	23.0	low	0	0	0	1	0	0
Anti-Glomerular Basement Membrane Disease	1	2001	2001	23.0	low	0	0	0	1	0	0
Anxiety	1	2012	2012	12.0	low	0	0	0	0	1	0
Aortic Diseases	2	2004	2017	13.5	low	0	0	0	1	1	0
Apolipoprotein B-100, Familial Defective	5	1995	2004	24.6	low	1	0	3	2	0	0
Apoplexy	2	2017	2022	4.5	low	0	0	0	0	1	1
Appendiceal Cancer	1	2004	2004	20.0	low	0	0	0	1	0	0
Appendiceal Neoplasms	1	2004	2004	20.0	low	0	0	0	1	0	0
Arachnoidal Cerebellar Sarcoma, Circumscribed	2	1994	2011	21.5	low	0	0	1	0	1	0
ARC	1	2017	2017	7.0	low	0	0	0	0	1	0
Arrhythmia	1	2016	2016	8.0	low	0	0	0	0	1	0
Arrhythmias, Cardiac	1	2016	2016	8.0	low	0	0	0	0	1	0
Arterial Obstructive Diseases	1	2004	2004	20.0	low	0	0	0	1	0	0
Arterial Occlusive Diseases	1	2004	2004	20.0	low	0	0	0	1	0	0
Arteriosclerosis	9	1985	2012	27.3	low	0	2	5	1	1	0
Arteriosclerosis, Coronary	2	2007	2008	16.5	low	0	0	0	2	0	0
Arterivirus Infections	1	1996	1996	28.0	low	0	0	1	0	0	0
Arthritis	4	1988	2015	16.5	low	0	1	0	0	3	0
Arthritis, Degenerative	3	2000	2014	15.7	low	0	0	1	0	2	0
Arthritis, Post-Infectious	1	2014	2014	10.0	low	0	0	0	0	1	0
Arthritis, Reactive	1	2014	2014	10.0	low	0	0	0	0	1	0
Arthritis, Rheumatoid	2	2008	2017	11.5	low	0	0	0	1	1	0
Arthus Phenomenon	1	2013	2013	11.0	low	0	0	0	0	1	0
Ascites	1	1997	1997	27.0	low	0	0	1	0	0	0
Asialia	1	1996	1996	28.0	low	0	0	1	0	0	0
Asphyxia Neonatorum	1	2002	2002	22.0	low	0	0	0	1	0	0
Astheno Teratozoospermia	1	2014	2014	10.0	low	0	0	0	0	1	0
Astrocytoma	1	2012	2012	12.0	low	0	0	0	0	1	0
Astrocytoma, Grade IV	25	1998	2022	9.4	low	0	0	1	4	17	3
Astrocytosis	4	1998	2007	21.0	low	0	0	1	3	0	0
Asystole	1	2017	2017	7.0	low	0	0	0	0	1	0
Ataxia	1	2004	2004	20.0	low	0	0	0	1	0	0
Atherogenesis	13	2007	2018	13.3	low	0	0	0	8	5	0
Atheroma	7	2011	2022	7.4	low	0	0	0	0	6	1
Atherosclerosis	13	2007	2018	13.3	low	0	0	0	8	5	0
Atresia, Pulmonary	1	2005	2005	19.0	low	0	0	0	1	0	0
Atrophy	1	2011	2011	13.0	low	0	0	0	0	1	0
Atrophy, Muscular, Peroneal	1	2002	2002	22.0	low	0	0	0	1	0	0
Attachment Loss, Periodontal	1	2009	2009	15.0	low	0	0	0	1	0	0
Attention Deficit Disorder with Hyperactivity	1	2011	2011	13.0	low	0	0	0	0	1	0
Aura	3	1997	2010	22.0	low	0	0	2	1	0	0
Autism	2	2009	2009	15.0	low	0	0	0	2	0	0
Autism-Dementia-Ataxia-Loss of Purposeful Hand Use Syndrome	3	2009	2017	11.3	low	0	0	0	1	2	0
Autistic Disorder	2	2009	2009	15.0	low	0	0	0	2	0	0
Autoimmune Diabetes	7	1988	2021	15.7	low	0	1	1	1	3	1
Autoimmune Disease	3	1992	2009	21.0	low	0	0	1	2	0	0
Autoimmune Diseases	3	1992	2009	21.0	low	0	0	1	2	0	0
Autolysis	2	2002	2021	12.5	low	0	0	0	1	0	1
Autosomal Dominant Juvenile Parkinson Disease	2	2003	2010	17.5	low	0	0	0	2	0	0
Autosomal Recessive Chronic Granulomatous Disease	3	1980	1990	40.3	low	0	2	1	0	0	0
Autosomal Recessive Emery-Dreifuss Muscular Dystrophy	1	2009	2009	15.0	low	0	0	0	1	0	0
Avian Flu	1	2012	2012	12.0	low	0	0	0	0	1	0
Axon Reaction	3	2001	2002	22.7	low	0	0	0	3	0	0
Azoospermia	1	2009	2009	15.0	low	0	0	0	1	0	0
B Virus Infection	2	2004	2023	10.5	low	0	0	0	1	0	1
B. burgdorferi Infection	2	2006	2006	18.0	low	0	0	0	2	0	0
B16 Melanoma	9	2004	2020	11.8	low	0	0	0	2	7	0
Bacillus anthracis Infection	1	2014	2014	10.0	low	0	0	0	0	1	0
Bacterial Disease	1	2021	2021	3.0	low	0	0	0	0	0	1
Bacterial Infections	1	2021	2021	3.0	low	0	0	0	0	0	1
Bacterial Infections, Gram-Positive	1	1998	1998	26.0	low	0	0	1	0	0	0
Bacteriuria	1	1978	1978	46.0	low	0	1	0	0	0	0
Bacteroidaceae Infections	1	2009	2009	15.0	low	0	0	0	1	0	0
Bacteroides Infections	1	2012	2012	12.0	low	0	0	0	0	1	0
Bang Disease	1	2004	2004	20.0	low	0	0	0	1	0	0
Bare Lymphocyte Syndrome	1	2002	2002	22.0	low	0	0	0	1	0	0
Barrett Epithelium	2	2018	2021	4.5	low	1	0	0	0	1	1
Barrett Esophagus	2	2018	2021	4.5	low	1	0	0	0	1	1
Becker Muscular Dystrophy	2	2004	2013	15.5	low	0	0	0	1	1	0
Benign Neoplasms	165	1976	2023	9.6	low	0	1	2	25	118	19
Benign Neoplasms, Brain	46	1990	2022	12.2	low	0	0	4	11	28	3
Benign Psychomotor Epilepsy, Childhood	1	2003	2003	21.0	low	0	0	0	1	0	0
Berger Disease	1	2020	2020	4.0	low	0	0	0	0	1	0
beta-Thalassemia	1	2010	2010	14.0	low	0	0	0	1	0	0
Bile Duct Cancer	1	2005	2005	19.0	low	0	0	0	1	0	0
Bile Duct Neoplasms	1	2005	2005	19.0	low	0	0	0	1	0	0
Bile Duct Obstruction, Extrahepatic	1	1981	1981	43.0	low	0	1	0	0	0	0
Bladder Cancer	9	1987	2022	15.7	low	0	2	0	3	3	1
Bladder Pain Syndrome	1	2008	2008	16.0	low	0	0	0	1	0	0
Blast Injuries	1	2012	2012	12.0	low	0	0	0	0	1	0
Blindness	1	2003	2003	21.0	low	0	0	0	1	0	0
Blood Clot	1	2005	2005	19.0	low	0	0	0	1	0	0
Blood Diseases	1	2001	2001	23.0	low	0	0	0	1	0	0
Blood Poisoning	1	2015	2015	9.0	low	0	0	0	0	1	0
Blood Pressure, High	2	2007	2012	14.5	low	0	0	0	1	1	0
Blunt Injuries	1	1999	1999	25.0	low	0	0	1	0	0	0
Body Weight	4	1992	2012	23.5	low	0	0	2	1	1	0
Bone Cancer	1	2012	2012	12.0	low	0	0	0	0	1	0
Bone Marrow Diseases	1	2014	2014	10.0	low	0	0	0	0	1	0
Bone Marrow Failure	1	2014	2014	10.0	low	0	0	0	0	1	0
Bone Marrow Failure Disorders	1	2014	2014	10.0	low	0	0	0	0	1	0
Bone Neoplasms	1	2012	2012	12.0	low	0	0	0	0	1	0
Brain Diseases	2	2000	2003	22.5	low	0	0	1	1	0	0
Brain Disorders	2	2000	2003	22.5	low	0	0	1	1	0	0
Brain Edema	1	2018	2018	6.0	low	0	0	0	0	1	0
Brain Hemorrhage, Cerebral	2	2016	2018	7.0	low	0	0	0	0	2	0
Brain Infarction	2	2008	2010	15.0	low	0	0	0	2	0	0
Brain Inflammation	1	2007	2007	17.0	low	0	0	0	1	0	0
Brain Injuries	10	1996	2018	17.8	low	0	0	3	3	4	0
Brain Injuries, Traumatic	3	2017	2020	5.7	low	0	0	0	0	3	0
Brain Ischemia	10	2002	2017	15.1	low	0	0	0	7	3	0
Brain Neoplasms	46	1990	2022	12.2	low	0	0	4	11	28	3
Brain Swelling	1	2018	2018	6.0	low	0	0	0	0	1	0
Breast Cancer	78	1978	2022	11.1	low	1	1	1	21	51	4
Breast Neoplasms	78	1978	2022	11.1	low	1	1	1	21	51	4
Bright Disease	1	2013	2013	11.0	low	0	0	0	0	1	0
Bullous Dermatoses	1	2009	2009	15.0	low	0	0	0	1	0	0
Burkitt Lymphoma	4	2012	2020	8.2	low	0	0	0	0	4	0
Burns	1	1985	1985	39.0	low	0	1	0	0	0	0
Cadaver	3	1991	2011	24.0	low	0	0	2	0	1	0
Calcification, Pathologic	2	2012	2015	10.5	low	0	0	0	0	2	0
Calcinosis	2	2012	2015	10.5	low	0	0	0	0	2	0
Cancer of Cervix	7	2000	2021	14.1	low	0	0	1	2	3	1
Cancer of Colon	26	1987	2019	15.6	low	0	2	4	4	16	0
Cancer of Endometrium	2	2012	2012	12.0	low	0	0	0	0	2	0
Cancer of Esophagus	3	2014	2019	7.0	low	0	0	0	0	3	0
Cancer of Gastrointestinal Tract	2	2000	2004	22.0	low	0	0	1	1	0	0
Cancer of Head	6	2000	2014	16.3	low	0	0	1	4	1	0
Cancer of Intestines	2	2003	2015	15.0	low	0	0	0	1	1	0
Cancer of Kidney	3	2006	2020	11.0	low	0	0	0	1	2	0
Cancer of Liver	30	1993	2022	12.7	low	0	0	3	8	17	2
Cancer of Lung	24	1990	2021	10.5	low	0	0	3	2	16	3
Cancer of Mouth	2	2012	2014	11.0	low	0	0	0	0	2	0
Cancer of Nasopharynx	2	2004	2008	18.0	low	0	0	0	2	0	0
Cancer of Ovary	13	1997	2021	12.3	low	0	0	1	3	8	1
Cancer of Pancreas	22	1997	2021	12.2	low	0	0	2	7	12	1
Cancer of Prostate	30	2005	2023	9.4	low	0	0	0	5	24	1
Cancer of Skin	5	1993	2023	11.0	low	0	0	1	0	3	1
Cancer of Stomach	12	2005	2022	10.7	low	0	0	0	4	6	2
Cancer of the Vulva	1	2005	2005	19.0	low	0	0	0	1	0	0
Candida Infection	1	2001	2001	23.0	low	0	0	0	1	0	0
Candidiasis	1	2001	2001	23.0	low	0	0	0	1	0	0
Carcinoma	7	1986	2014	20.6	low	0	1	2	2	2	0
Carcinoma, Anaplastic	7	1986	2014	20.6	low	0	1	2	2	2	0
Carcinoma, Ductal, Breast	1	2001	2001	23.0	low	0	0	0	1	0	0
Carcinoma, Ductal, Pancreatic	4	2004	2018	10.2	low	0	0	0	1	3	0
Carcinoma, Ehrlich Tumor	12	1978	2015	34.5	low	0	9	0	1	2	0
Carcinoma, Epidermoid	10	1994	2018	16.6	low	0	0	3	3	4	0
Carcinoma, Hepatocellular	18	1993	2022	12.6	low	0	0	2	5	9	2
Carcinoma, Lewis Lung	7	2003	2013	16.3	low	0	0	0	4	3	0
Carcinoma, Non-Small Cell Lung	7	2010	2021	7.6	low	0	0	0	1	5	1
Carcinoma, Non-Small-Cell Lung	7	2010	2021	7.6	low	0	0	0	1	5	1
Carcinoma, Pancreatic Ductal	4	2004	2018	10.2	low	0	0	0	1	3	0
Carcinoma, Renal Cell	1	2006	2006	18.0	low	0	0	0	1	0	0
Carcinoma, Squamous Cell	10	1994	2018	16.6	low	0	0	3	3	4	0
Carcinoma, Transitional Cell	4	2010	2022	8.2	low	0	0	0	1	2	1
Carcinosarcoma	1	2005	2005	19.0	low	0	0	0	1	0	0
Cardiac Failure	3	2008	2009	15.3	low	0	0	0	3	0	0
Cardiac Hypertrophy	1	2013	2013	11.0	low	0	0	0	0	1	0
Cardiac Remodeling, Ventricular	3	2008	2009	15.3	low	0	0	0	3	0	0
Cardiomegaly	1	2013	2013	11.0	low	0	0	0	0	1	0
Cardiovascular Stroke	14	2007	2020	12.1	low	0	0	0	8	6	0
Caries, Dental	2	1995	2013	20.0	low	0	0	1	0	1	0
Carotid Arteriopathies, Traumatic	3	1994	2009	22.7	low	0	0	1	2	0	0
Carotid Artery Narrowing	1	2004	2004	20.0	low	0	0	0	1	0	0
Carotid Stenosis	1	2004	2004	20.0	low	0	0	0	1	0	0
Cat Diseases	1	2001	2001	23.0	low	0	0	0	1	0	0
Cataract	2	1997	2019	16.0	low	0	0	1	0	1	0
Cataract, Membranous	2	1997	2019	16.0	low	0	0	1	0	1	0
Cell Transformation, Neoplastic	12	2009	2020	11.0	low	0	0	0	3	9	0
Cell Transformation, Viral	2	1992	1996	30.0	low	0	0	2	0	0	0
Cells, Neoplasm Circulating	10	2014	2019	7.4	low	0	0	0	0	10	0
Cerebellar Ataxia	1	2011	2011	13.0	low	0	0	0	0	1	0
Cerebral Amyloid Angiopathy	1	2016	2016	8.0	low	0	0	0	0	1	0
Cerebral Cortical Dysplasia	2	2014	2015	9.5	low	0	0	0	0	2	0
Cerebral Hemorrhage	2	2016	2018	7.0	low	0	0	0	0	2	0
Cerebral Infarction	1	2010	2010	14.0	low	0	0	0	1	0	0
Cerebral Infarction, Middle Cerebral Artery	3	2004	2011	15.7	low	0	0	0	2	1	0
Cerebral Ischemia	10	2002	2017	15.1	low	0	0	0	7	3	0
Cerebral Palsy	1	2013	2013	11.0	low	0	0	0	0	1	0
Cerebral Palsy, Athetoid	1	2013	2013	11.0	low	0	0	0	0	1	0
Cervical Spondylosis	1	2010	2010	14.0	low	0	0	0	1	0	0
Chagas Disease	1	1990	1990	34.0	low	0	0	1	0	0	0
Charcot-Marie-Tooth Disease	1	2002	2002	22.0	low	0	0	0	1	0	0
Chediak-Higashi Syndrome	1	1980	1980	44.0	low	0	1	0	0	0	0
Chemical and Drug Induced Liver Injury	3	2009	2020	10.0	low	0	0	0	1	2	0
Chlamydia Infections	1	2014	2014	10.0	low	0	0	0	0	1	0
Choroid Neoplasms	1	2002	2002	22.0	low	0	0	0	1	0	0
Choroid Neovascularization	1	2011	2011	13.0	low	0	0	0	0	1	0
Chromosomal Translocation	1	2007	2007	17.0	low	0	0	0	1	0	0
Chromosome Deletion	1	2012	2012	12.0	low	0	0	0	0	1	0
Chronic Disease	4	1997	2019	13.0	low	0	0	1	0	3	0
Chronic Hepatitis B	2	2001	2011	18.0	low	0	0	0	1	1	0
Chronic Illness	4	1997	2019	13.0	low	0	0	1	0	3	0
Chronic Progressive Multiple Sclerosis	1	2009	2009	15.0	low	0	0	0	1	0	0
Cicatrix	2	1999	2012	18.5	low	0	0	1	0	1	0
Cicatrization	2	1999	2012	18.5	low	0	0	1	0	1	0
Cirrhosis	3	2009	2014	13.3	low	0	0	0	2	1	0
Classic Globoid Cell Leukodystrophy	1	2007	2007	17.0	low	0	0	0	1	0	0
Cleft Spine	1	2003	2003	21.0	low	0	0	0	1	0	0
Clinically Isolated CNS Demyelinating Syndrome	4	1996	2014	18.0	low	0	0	1	1	2	0
Cognition Disorders	1	2010	2010	14.0	low	0	0	0	1	0	0
Colitis	2	2007	2013	14.0	low	0	0	0	1	1	0
Colitis Gravis	2	2004	2006	19.0	low	0	0	0	2	0	0
Colitis, Granulomatous	2	2006	2016	13.0	low	0	0	0	1	1	0
Colitis, Mucous	1	2013	2013	11.0	low	0	0	0	0	1	0
Colitis, Ulcerative	2	2004	2006	19.0	low	0	0	0	2	0	0
Colonic Neoplasms	26	1987	2019	15.6	low	0	2	4	4	16	0
Colonic Polyps	2	2003	2020	12.5	low	0	0	0	1	1	0
Colorectal Cancer	11	2005	2022	9.8	low	0	0	0	2	8	1
Colorectal Neoplasms	11	2005	2022	9.8	low	0	0	0	2	8	1
Concomitant Strabismus	1	1995	1995	29.0	low	0	0	1	0	0	0
Condition, Preneoplastic	2	2004	2018	13.0	low	0	0	0	1	1	0
Congenital Myotonic Dystrophy	1	2016	2016	8.0	low	0	0	0	0	1	0
Contact Dermatitis	1	2014	2014	10.0	low	0	0	0	0	1	0
Cornea Injuries	1	1991	1991	33.0	low	0	0	1	0	0	0
Corneal Angiogenesis	1	2009	2009	15.0	low	0	0	0	1	0	0
Corneal Endothelial Cell Damage	1	2017	2017	7.0	low	0	0	0	0	1	0
Corneal Injuries	1	1991	1991	33.0	low	0	0	1	0	0	0
Corneal Neovascularization	1	2009	2009	15.0	low	0	0	0	1	0	0
Coronary Artery Disease	2	2007	2008	16.5	low	0	0	0	2	0	0
Coronary Disease	1	2020	2020	4.0	low	0	0	0	0	1	0
Coronary Heart Disease	1	2020	2020	4.0	low	0	0	0	0	1	0
Cot Death	1	2001	2001	23.0	low	0	0	0	1	0	0
Cranial Nerve II Diseases	4	2003	2018	15.2	low	0	0	0	3	1	0
Cranial Nerve II Injuries	8	2001	2012	19.1	low	0	0	0	7	1	0
Cranial Nerve VII Injuries	3	1999	2014	17.0	low	0	0	1	1	1	0
Crohn Disease	2	2006	2016	13.0	low	0	0	0	1	1	0
Cryptogenic Fibrosing Alveolitis	2	2019	2021	4.0	low	0	0	0	0	1	1
Cystic Echinococcosis	1	2016	2016	8.0	low	0	0	0	0	1	0
Cystic Fibrosis	1	2004	2004	20.0	low	0	0	0	1	0	0
Cystic Fibrosis of Pancreas	1	2004	2004	20.0	low	0	0	0	1	0	0
Cystitis, Interstitial	1	2008	2008	16.0	low	0	0	0	1	0	0
Deaf Mutism	1	2007	2007	17.0	low	0	0	0	1	0	0
Deafness	1	2007	2007	17.0	low	0	0	0	1	0	0
Deep Vein Thrombosis	1	2007	2007	17.0	low	0	0	0	1	0	0
Degenerative Diseases, Central Nervous System	3	2011	2017	11.0	low	0	0	0	0	3	0
Delayed Effects, Prenatal Exposure	3	2003	2007	19.0	low	0	0	0	3	0	0
Dementia	1	1993	1993	31.0	low	0	0	1	0	0	0
Dementia Praecox	3	2005	2021	11.7	low	0	0	0	1	1	1
Dementias, Transmissible	1	2010	2010	14.0	low	0	0	0	1	0	0
Demyelinating Diseases	4	1996	2014	18.0	low	0	0	1	1	2	0
Dental Caries	2	1995	2013	20.0	low	0	0	1	0	1	0
Dental Plaque	1	2004	2004	20.0	low	0	0	0	1	0	0
Dentin, Secondary	1	1995	1995	29.0	low	0	0	1	0	0	0
Depression	1	2022	2022	2.0	low	0	0	0	0	0	1
Dermatitis	1	2017	2017	7.0	low	0	0	0	0	1	0
Dermatitis Herpetiformis	1	2009	2009	15.0	low	0	0	0	1	0	0
Dermatitis, Atopic	1	2012	2012	12.0	low	0	0	0	0	1	0
Dermatitis, Contact	1	2014	2014	10.0	low	0	0	0	0	1	0
Dermatitis, Irritant	1	2018	2018	6.0	low	0	0	0	0	1	0
Dermatoses	1	2021	2021	3.0	low	0	0	0	0	0	1
Devic Disease	1	2013	2013	11.0	low	0	0	0	0	1	0
Diabetes Mellitus	4	1997	2018	12.5	low	0	0	1	0	3	0
Diabetes Mellitus, Adult-Onset	4	1988	2019	18.5	low	0	1	0	2	1	0
Diabetes Mellitus, Type 1	7	1988	2021	15.7	low	0	1	1	1	3	1
Diabetes Mellitus, Type 2	4	1988	2019	18.5	low	0	1	0	2	1	0
Diabetic Glomerulosclerosis	1	2001	2001	23.0	low	0	0	0	1	0	0
Diabetic Nephropathies	1	2001	2001	23.0	low	0	0	0	1	0	0
Diabetic Retinopathy	1	2007	2007	17.0	low	0	0	0	1	0	0
Diffuse Large B-Cell Lymphoma	2	1996	2022	15.0	low	0	0	1	0	0	1
Diffuse Mixed Small and Large Cell Lymphoma	2	2014	2017	8.5	low	0	0	0	0	2	0
DiGeorge Syndrome	1	1992	1992	32.0	low	0	0	1	0	0	0
Disbacteriosis	1	2017	2017	7.0	low	0	0	0	0	1	0
Disease Exacerbation	6	2006	2018	12.0	low	0	0	0	2	4	0
Disease Models, Animal	120	1992	2022	11.9	low	0	0	3	40	71	6
Disorders of Sex Development	1	2008	2008	16.0	low	0	0	0	1	0	0
Down Syndrome	1	2002	2002	22.0	low	0	0	0	1	0	0
Drug-Related Side Effects and Adverse Reactions	1	2011	2011	13.0	low	0	0	0	0	1	0
Duhring Disease	1	2009	2009	15.0	low	0	0	0	1	0	0
Dysentery, Bacillary	1	2018	2018	6.0	low	0	0	0	0	1	0
Dysentery, Shiga bacillus	1	2018	2018	6.0	low	0	0	0	0	1	0
Dyskinesia Syndromes	2	2001	2012	17.5	low	0	0	0	1	1	0
Dysmyelopoietic Syndromes	1	2014	2014	10.0	low	0	0	0	0	1	0
E coli Infections	3	2002	2013	15.0	low	0	0	0	1	2	0
Eczema, Atopic	1	2012	2012	12.0	low	0	0	0	0	1	0
Edema	2	1988	2010	25.0	low	0	1	0	1	0	0
Edema, Pulmonary	1	2004	2004	20.0	low	0	0	0	1	0	0
EHS Tumor	3	1994	2008	24.0	low	0	0	2	1	0	0
Elaeophoriasis	2	1947	1948	76.5	low	0	2	0	0	0	0
Electrolytes	11	1983	2014	17.8	low	0	1	0	8	2	0
Electron Transport Chain Deficiencies, Mitochondrial	6	2005	2018	11.8	low	0	0	0	3	3	0
Elevated Cholesterol	6	1993	2005	26.7	low	0	0	5	1	0	0
Embolism, Pulmonary	1	2007	2007	17.0	low	0	0	0	1	0	0
Encephalitis	1	2007	2007	17.0	low	0	0	0	1	0	0
Encephalitis, Venezuelan Equine	1	2006	2006	18.0	low	0	0	0	1	0	0
Encephalopathy, Hepatic	1	2001	2001	23.0	low	0	0	0	1	0	0
Encephalopathy, Toxic	1	2006	2006	18.0	low	0	0	0	1	0	0
Encephalopathy, Traumatic	3	2017	2020	5.7	low	0	0	0	0	3	0
Endometrial Neoplasms	2	2012	2012	12.0	low	0	0	0	0	2	0
Endometrioma	1	1999	1999	25.0	low	0	0	1	0	0	0
Endometriosis	1	1999	1999	25.0	low	0	0	1	0	0	0
Endomyocardial Fibrosis	1	2008	2008	16.0	low	0	0	0	1	0	0
Endotoxin Shock	1	2014	2014	10.0	low	0	0	0	0	1	0
Epilepsy	3	1997	2010	22.0	low	0	0	2	1	0	0
Epilepsy, Temporal Lobe	1	2003	2003	21.0	low	0	0	0	1	0	0
Epiretinal Membrane	1	2015	2015	9.0	low	0	0	0	0	1	0
Epithelial Neoplasms	1	2012	2012	12.0	low	0	0	0	0	1	0
ER-Negative PR-Negative HER2-Negative Breast Cancer	5	2015	2021	5.2	low	0	0	0	0	4	1
Escherichia coli Infections	3	2002	2013	15.0	low	0	0	0	1	2	0
Esophageal Neoplasms	3	2014	2019	7.0	low	0	0	0	0	3	0
Experimental Hepatoma	2	2004	2021	11.5	low	0	0	0	1	0	1
Experimental Lung Inflammation	5	2008	2018	13.0	low	0	0	0	3	2	0
Experimental Mammary Neoplasms	20	1997	2021	10.6	low	0	0	1	4	13	2
Experimental Neoplasms	49	1978	2022	13.1	low	0	5	3	7	27	7
Extravasation of Contrast Media	2	1997	2011	20.0	low	0	0	1	0	1	0
Extravascular Hemolysis	14	1986	2021	13.2	low	0	1	1	2	9	1
Eye Injuries, Penetrating	1	2005	2005	19.0	low	0	0	0	1	0	0
Facial Pain, Referred	1	2010	2010	14.0	low	0	0	0	1	0	0
Failure to Thrive	1	1994	1994	30.0	low	0	0	1	0	0	0
Fallot's Tetralogy	1	2005	2005	19.0	low	0	0	0	1	0	0
Fanconi Anemia	1	2015	2015	9.0	low	0	0	0	0	1	0
Fasciculation	1	2003	2003	21.0	low	0	0	0	1	0	0
Fasting Hypoglycemia	2	2005	2017	13.0	low	0	0	0	1	1	0
Fatty Liver	1	1981	1981	43.0	low	0	1	0	0	0	0
Fibroid	1	1993	1993	31.0	low	0	0	1	0	0	0
Fibroma, Shope	1	1993	1993	31.0	low	0	0	1	0	0	0
Fibrosarcoma	8	1994	2020	18.8	low	0	0	2	5	1	0
Fibrosis	3	2009	2014	13.3	low	0	0	0	2	1	0
Filariasis	2	1947	1948	76.5	low	0	2	0	0	0	0
FMR1-Related Primary Ovarian Insufficiency	1	2019	2019	5.0	low	0	0	0	0	1	0
Focal Segmental Glomerulosclerosis	2	1999	2009	20.0	low	0	0	1	1	0	0
Gastric Ulcer	1	2005	2005	19.0	low	0	0	0	1	0	0
Gastritis	1	2004	2004	20.0	low	0	0	0	1	0	0
Gastrointestinal Stromal Neoplasm	1	2004	2004	20.0	low	0	0	0	1	0	0
Gastrointestinal Stromal Tumors	1	2004	2004	20.0	low	0	0	0	1	0	0
Genetic Predisposition	1	2016	2016	8.0	low	0	0	0	0	1	0
Germinoblastoma	6	2003	2017	15.2	low	0	0	0	4	2	0
Gingival Hemorrhage	1	2009	2009	15.0	low	0	0	0	1	0	0
Gingivitis	1	1995	1995	29.0	low	0	0	1	0	0	0
Glaucoma	5	1996	2018	18.0	low	0	0	1	3	1	0
Glaucoma, Suspect	1	2017	2017	7.0	low	0	0	0	0	1	0
Glial Cell Tumors	25	1981	2021	15.3	low	0	1	3	8	12	1
Glioblastoma	25	1998	2022	9.4	low	0	0	1	4	17	3
Glioblastoma with Sarcomatous Component	6	1995	2015	19.7	low	0	0	1	4	1	0
Glioma	25	1981	2021	15.3	low	0	1	3	8	12	1
Gliosarcoma	6	1995	2015	19.7	low	0	0	1	4	1	0
Glomerulonephritis	1	2013	2013	11.0	low	0	0	0	0	1	0
Glomerulonephritis, IGA	1	2020	2020	4.0	low	0	0	0	0	1	0
Glomerulosclerosis, Focal Segmental	2	1999	2009	20.0	low	0	0	1	1	0	0
Graft vs Host Disease	1	2011	2011	13.0	low	0	0	0	0	1	0
Graft-Versus-Host Disease	1	2011	2011	13.0	low	0	0	0	0	1	0
Gram-Positive Bacterial Infections	1	1998	1998	26.0	low	0	0	1	0	0	0
Granulocytic Leukemia	9	1991	2006	25.3	low	0	0	4	5	0	0
Granulocytic Leukemia, Chronic	1	2007	2007	17.0	low	0	0	0	1	0	0
Granulomatous Disease, Chronic	3	1980	1990	40.3	low	0	2	1	0	0	0
Grippe	2	2013	2019	8.0	low	0	0	0	0	2	0
HbS Disease	2	1986	1996	33.0	low	0	1	1	0	0	0
Head and Neck Neoplasms	6	2000	2014	16.3	low	0	0	1	4	1	0
Heart Arrest	1	2017	2017	7.0	low	0	0	0	0	1	0
Heart Disease, Ischemic	1	2012	2012	12.0	low	0	0	0	0	1	0
Heart Failure	3	2008	2009	15.3	low	0	0	0	3	0	0
Heart Valve Diseases	1	2012	2012	12.0	low	0	0	0	0	1	0
Heat Stroke	1	2018	2018	6.0	low	0	0	0	0	1	0
Heatstroke	1	2018	2018	6.0	low	0	0	0	0	1	0
Helicobacter Infections	1	2004	2004	20.0	low	0	0	0	1	0	0
Hemangioma	1	1993	1993	31.0	low	0	0	1	0	0	0
Hematologic Diseases	1	2001	2001	23.0	low	0	0	0	1	0	0
Hemoglobinuria, Paroxysmal	1	2014	2014	10.0	low	0	0	0	0	1	0
Hemolysis	14	1986	2021	13.2	low	0	1	1	2	9	1
Hemorrhage, Gingival	1	2009	2009	15.0	low	0	0	0	1	0	0
Hemorrhagic Shock	1	2015	2015	9.0	low	0	0	0	0	1	0
Hepatic Encephalopathy	1	2001	2001	23.0	low	0	0	0	1	0	0
Hepatitis B	2	2011	2014	11.5	low	0	0	0	0	2	0
Hepatitis B Virus Infection	2	2011	2014	11.5	low	0	0	0	0	2	0
Hepatitis B, Chronic	2	2001	2011	18.0	low	0	0	0	1	1	0
Hepatoblastoma	1	2002	2002	22.0	low	0	0	0	1	0	0
Hepatocellular Carcinoma	18	1993	2022	12.6	low	0	0	2	5	9	2
Hereditary Optic Neuroretinopathy	1	2005	2005	19.0	low	0	0	0	1	0	0
Herpes Simplex	3	2009	2023	9.3	low	0	0	0	1	1	1
Herpes Simplex Virus Infection	3	2009	2023	9.3	low	0	0	0	1	1	1
HIV	2	2007	2018	11.5	low	0	0	0	1	1	0
HIV Coinfection	1	2013	2013	11.0	low	0	0	0	0	1	0
HIV Infections	1	2013	2013	11.0	low	0	0	0	0	1	0
HPV Infection	2	2006	2016	13.0	low	0	0	0	1	1	0
Human Adenovirus Infections	1	1993	1993	31.0	low	0	0	1	0	0	0
Huntington Disease	1	2006	2006	18.0	low	0	0	0	1	0	0
Hypercapnia	1	2011	2011	13.0	low	0	0	0	0	1	0
Hypercholesterolemia	6	1993	2005	26.7	low	0	0	5	1	0	0
Hypergonadotropic Hypogonadism	1	1992	1992	32.0	low	0	0	1	0	0	0
Hyperlipoproteinemia Type II	5	1995	2004	24.6	low	1	0	3	2	0	0
Hypermyotonia	1	2012	2012	12.0	low	0	0	0	0	1	0
Hyperoxia	1	2008	2008	16.0	low	0	0	0	1	0	0
Hypersensitivity	3	2013	2018	9.0	low	0	0	0	0	3	0
Hypertension	2	2007	2012	14.5	low	0	0	0	1	1	0
Hypertension, Pulmonary	2	2013	2017	9.0	low	0	0	0	0	2	0
Hypertrophy, Right Ventricular	1	2017	2017	7.0	low	0	0	0	0	1	0
Hypoglycemia	2	2005	2017	13.0	low	0	0	0	1	1	0
Hypogonadism	1	1992	1992	32.0	low	0	0	1	0	0	0
Hypospermatogenesis	1	2014	2014	10.0	low	0	0	0	0	1	0
Hypoxia	19	1994	2021	15.5	low	0	0	5	6	5	3
Hypoxia-Ischemia, Brain	4	2002	2012	16.0	low	0	0	0	3	1	0
Idiopathic Inflammatory Myopathies	1	2020	2020	4.0	low	0	0	0	0	1	0
Idiopathic Parkinson Disease	3	1998	2018	18.7	low	0	0	2	0	1	0
Idiopathic Pulmonary Fibrosis	2	2019	2021	4.0	low	0	0	0	0	1	1
Inadequate Sleep	1	2007	2007	17.0	low	0	0	0	1	0	0
Infarction, Middle Cerebral Artery	3	2004	2011	15.7	low	0	0	0	2	1	0
Infection	2	2004	2005	19.5	low	0	0	0	2	0	0
Infection, Postoperative Wound	1	2020	2020	4.0	low	0	0	0	0	1	0
Infections	2	2004	2005	19.5	low	0	0	0	2	0	0
Infections, Chlamydia	1	2014	2014	10.0	low	0	0	0	0	1	0
Infections, Helicobacter	1	2004	2004	20.0	low	0	0	0	1	0	0
Infections, Klebsiella	2	2015	2018	7.5	low	0	0	0	0	2	0
Infections, Orthomyxoviridae	1	2005	2005	19.0	low	0	0	0	1	0	0
Infections, Plasmodium	1	2012	2012	12.0	low	0	0	0	0	1	0
Infections, Poxviridae	1	2006	2006	18.0	low	0	0	0	1	0	0
Infections, Staphylococcal	2	2012	2015	10.5	low	0	0	0	0	2	0
Infections, Trichomonas	1	2015	2015	9.0	low	0	0	0	0	1	0
Infertility, Male	5	2003	2016	14.6	low	0	0	0	2	3	0
Inflammation	30	1985	2021	13.7	low	0	1	2	10	16	1
Inflammatory Response Syndrome, Systemic	1	2019	2019	5.0	low	0	0	0	0	1	0
Influenza in Birds	1	2012	2012	12.0	low	0	0	0	0	1	0
Influenza, Human	2	2013	2019	8.0	low	0	0	0	0	2	0
Injuries	1	2019	2019	5.0	low	0	0	0	0	1	0
Injuries, Prenatal	1	1995	1995	29.0	low	0	0	1	0	0	0
Injuries, Radiation	1	2005	2005	19.0	low	0	0	0	1	0	0
Injuries, Spinal Cord	12	1993	2014	20.6	low	0	0	3	7	2	0
Injuries, Tendon	1	2003	2003	21.0	low	0	0	0	1	0	0
Injury, Ischemia-Reperfusion	10	2003	2019	12.9	low	0	0	0	4	6	0
Injury, Myocardial Reperfusion	3	2000	2013	19.3	low	0	0	1	1	1	0
Innate Inflammatory Response	30	1985	2021	13.7	low	0	1	2	10	16	1
Intestinal Diseases	1	2021	2021	3.0	low	0	0	0	0	0	1
Intestinal Neoplasms	2	2003	2015	15.0	low	0	0	0	1	1	0
Intraocular Pressure	4	2003	2018	12.8	low	0	0	0	2	2	0
Invasiveness, Neoplasm	8	1995	2019	14.5	low	0	0	2	1	5	0
Iris Diseases	1	1983	1983	41.0	low	0	1	0	0	0	0
Irritable Bowel Syndrome	1	2013	2013	11.0	low	0	0	0	0	1	0
Ischemia	4	2003	2012	15.8	low	0	0	0	3	1	0
Ischemic Attack, Transient	2	2010	2011	13.5	low	0	0	0	1	1	0
Kahler Disease	3	2004	2021	10.0	low	0	0	0	1	1	1
Kaposi Sarcoma	1	2004	2004	20.0	low	0	0	0	1	0	0
Kidney Diseases	1	2019	2019	5.0	low	0	0	0	0	1	0
Kidney Neoplasms	3	2006	2020	11.0	low	0	0	0	1	2	0
Klebsiella Infections	2	2015	2018	7.5	low	0	0	0	0	2	0
Koch's Disease	1	2010	2010	14.0	low	0	0	0	1	0	0
Leiomyoma	1	1993	1993	31.0	low	0	0	1	0	0	0
Leiomyosarcoma	1	2005	2005	19.0	low	0	0	0	1	0	0
Leiomyosarcoma, Epithelioid	1	2005	2005	19.0	low	0	0	0	1	0	0
Leishmaniasis, American	1	2014	2014	10.0	low	0	0	0	0	1	0
Leishmaniasis, Cutaneous	1	2014	2014	10.0	low	0	0	0	0	1	0
Lesion of Sciatic Nerve	3	2004	2014	16.3	low	0	0	0	2	1	0
Leucocythaemia	5	2000	2013	18.6	low	0	0	1	3	1	0
Leukemia	5	2000	2013	18.6	low	0	0	1	3	1	0
Leukemia L 1210	2	1984	1996	34.0	low	0	1	1	0	0	0
Leukemia, Acute Monocytic	1	1998	1998	26.0	low	0	0	1	0	0	0
Leukemia, Monocytic, Acute	1	1998	1998	26.0	low	0	0	1	0	0	0
Leukemia, Myelogenous, Chronic, BCR-ABL Positive	1	2007	2007	17.0	low	0	0	0	1	0	0
Leukemia, Myeloid	9	1991	2006	25.3	low	0	0	4	5	0	0
Leukemia, Myeloid, Acute	7	2001	2019	14.7	low	0	0	0	4	3	0
Leukemia, Myeloid, Acute, M4	1	1995	1995	29.0	low	0	0	1	0	0	0
Leukemia, Myelomonocytic, Acute	1	1995	1995	29.0	low	0	0	1	0	0	0
Leukemia, Pre-B-Cell	1	2013	2013	11.0	low	0	0	0	0	1	0
Leukemia, Promyelocytic, Acute	1	2007	2007	17.0	low	0	0	0	1	0	0
Leukodystrophy, Globoid Cell	1	2007	2007	17.0	low	0	0	0	1	0	0
Libman-Sacks Disease	1	2015	2015	9.0	low	0	0	0	0	1	0
Lichen Planus	1	2009	2009	15.0	low	0	0	0	1	0	0
Lichen Ruber Planus	1	2009	2009	15.0	low	0	0	0	1	0	0
Lingual Nerve Contusion	1	2007	2007	17.0	low	0	0	0	1	0	0
Liver Diseases	2	2015	2021	6.0	low	0	0	0	0	1	1
Liver Dysfunction	2	2015	2021	6.0	low	0	0	0	0	1	1
Liver Failure, Acute	2	2012	2014	11.0	low	0	0	0	0	2	0
Liver Neoplasms	30	1993	2022	12.7	low	0	0	3	8	17	2
Liver Steatosis	1	1981	1981	43.0	low	0	1	0	0	0	0
Low Back Ache	1	2003	2003	21.0	low	0	0	0	1	0	0
Low Back Pain	1	2003	2003	21.0	low	0	0	0	1	0	0
Luft Disease	1	2004	2004	20.0	low	0	0	0	1	0	0
Lung Adenocarcinoma	1	2016	2016	8.0	low	0	0	0	0	1	0
Lung Neoplasms	24	1990	2021	10.5	low	0	0	3	2	16	3
Lupus Erythematosus, Systemic	1	2015	2015	9.0	low	0	0	0	0	1	0
Lyme Disease	2	2006	2006	18.0	low	0	0	0	2	0	0
Lymph Node Metastasis	6	2005	2019	10.7	low	0	0	0	1	5	0
Lymphoma	6	2003	2017	15.2	low	0	0	0	4	2	0
Lymphoma, Large B-Cell, Diffuse	2	1996	2022	15.0	low	0	0	1	0	0	1
Lymphoma, Non-Hodgkin	2	2014	2017	8.5	low	0	0	0	0	2	0
Macular Degeneration	2	2005	2011	16.0	low	0	0	0	1	1	0
Macular Holes	1	2004	2004	20.0	low	0	0	0	1	0	0
Malaria	1	2012	2012	12.0	low	0	0	0	0	1	0
Malaria, Falciparum	2	2014	2019	7.5	low	0	0	0	0	2	0
Malaria, Vivax	1	2013	2013	11.0	low	0	0	0	0	1	0
Malignant Melanoma	11	1994	2021	18.2	low	0	0	3	5	2	1
Marchiafava-Micheli Syndrome	1	2014	2014	10.0	low	0	0	0	0	1	0
Margins of Excision	1	2018	2018	6.0	low	0	0	0	0	1	0
Medulloblastoma	2	1994	2011	21.5	low	0	0	1	0	1	0
Melanoma	11	1994	2021	18.2	low	0	0	3	5	2	1
Melanoma, Amelanotic	1	2009	2009	15.0	low	0	0	0	1	0	0
Memory Disorders	1	2012	2012	12.0	low	0	0	0	0	1	0
Metabolic Acidosis	2	2012	2014	11.0	low	0	0	0	0	2	0
Metastase	17	2005	2021	10.9	low	0	0	0	5	11	1
Microphthalmia	1	1994	1994	30.0	low	0	0	1	0	0	0
Mitochondrial Diseases	6	2005	2018	11.8	low	0	0	0	3	3	0
Mitochondrial Myopathies	1	2004	2004	20.0	low	0	0	0	1	0	0
Mouth Neoplasms	2	2012	2014	11.0	low	0	0	0	0	2	0
Movement Disorders	2	2001	2012	17.5	low	0	0	0	1	1	0
MS (Multiple Sclerosis)	4	1990	2019	16.5	low	0	0	1	1	2	0
Multiple Myeloma	3	2004	2021	10.0	low	0	0	0	1	1	1
Multiple Sclerosis	4	1990	2019	16.5	low	0	0	1	1	2	0
Multiple Sclerosis, Chronic Progressive	1	2009	2009	15.0	low	0	0	0	1	0	0
Multiple Sclerosis, Relapsing-Remitting	1	2009	2009	15.0	low	0	0	0	1	0	0
Muscle Contraction	8	1994	2012	23.4	low	0	0	5	2	1	0
Muscle Weakness	1	2004	2004	20.0	low	0	0	0	1	0	0
Muscular Atrophy, Spinal	1	2002	2002	22.0	low	0	0	0	1	0	0
Muscular Dystrophies	1	1989	1989	35.0	low	0	1	0	0	0	0
Muscular Dystrophy	1	1989	1989	35.0	low	0	1	0	0	0	0
Muscular Dystrophy, Duchenne	2	2004	2013	15.5	low	0	0	0	1	1	0
Muscular Weakness	1	2004	2004	20.0	low	0	0	0	1	0	0
Myelodysplastic Syndromes	1	2014	2014	10.0	low	0	0	0	0	1	0
Myocardial Infarction	14	2007	2020	12.1	low	0	0	0	8	6	0
Myocardial Ischemia	1	2012	2012	12.0	low	0	0	0	0	1	0
Myopia	1	2007	2007	17.0	low	0	0	0	1	0	0
Myositis	1	2020	2020	4.0	low	0	0	0	0	1	0
Myotonic Dystrophy	1	2016	2016	8.0	low	0	0	0	0	1	0
Nasopharyngeal Neoplasms	2	2004	2008	18.0	low	0	0	0	2	0	0
Nearsightedness	1	2007	2007	17.0	low	0	0	0	1	0	0
Necrosis	20	1994	2016	16.8	low	0	0	2	12	6	0
Neoplasm Metastasis	17	2005	2021	10.9	low	0	0	0	5	11	1
Neoplasm Regression, Spontaneous	1	2004	2004	20.0	low	0	0	0	1	0	0
Neoplasms	165	1976	2023	9.6	low	0	1	2	25	118	19
Neovascularization, Optic Disc	1	2017	2017	7.0	low	0	0	0	0	1	0
Nephritis	1	2010	2010	14.0	low	0	0	0	1	0	0
Nephrotic Syndrome	1	2009	2009	15.0	low	0	0	0	1	0	0
Nerve Degeneration	13	1991	2009	22.5	low	0	0	3	10	0	0
Nerve Pain	1	2015	2015	9.0	low	0	0	0	0	1	0
Nerve Root Avulsion	2	2008	2010	15.0	low	0	0	0	2	0	0
Neuralgia	1	2015	2015	9.0	low	0	0	0	0	1	0
Neuroblastoma	15	1981	2017	24.0	low	0	3	2	9	1	0
Neurodegenerative Diseases	3	2011	2017	11.0	low	0	0	0	0	3	0
Neuroendocrine Tumors	1	2021	2021	3.0	low	0	0	0	0	0	1
Neuromuscular Junction Diseases	1	2014	2014	10.0	low	0	0	0	0	1	0
Neuromyelitis Optica	1	2013	2013	11.0	low	0	0	0	0	1	0
Neurovisceral Storage Disease with Vertical Supranuclear Ophthalmoplegia	1	2007	2007	17.0	low	0	0	0	1	0	0
Niemann-Pick Disease, Type C	1	2007	2007	17.0	low	0	0	0	1	0	0
Obesity	1	2008	2008	16.0	low	0	0	0	1	0	0
Ocular Hypertension	1	2017	2017	7.0	low	0	0	0	0	1	0
Odontalgia	1	2013	2013	11.0	low	0	0	0	0	1	0
Oligodendroglioma	1	2012	2012	12.0	low	0	0	0	0	1	0
Optic Atrophy, Hereditary, Leber	1	2005	2005	19.0	low	0	0	0	1	0	0
Optic Nerve Diseases	4	2003	2018	15.2	low	0	0	0	3	1	0
Optic Neuropathy, Ischemic	1	2016	2016	8.0	low	0	0	0	0	1	0
Orchitis	1	1995	1995	29.0	low	0	0	1	0	0	0
Orthomyxoviridae Infections	1	2005	2005	19.0	low	0	0	0	1	0	0
Osteoarthritis	3	2000	2014	15.7	low	0	0	1	0	2	0
Osteoarthritis of Knee	1	2015	2015	9.0	low	0	0	0	0	1	0
Osteoarthritis, Knee	1	2015	2015	9.0	low	0	0	0	0	1	0
Osteogenic Sarcoma	4	1999	2018	15.8	low	0	0	1	1	2	0
Osteosarcoma	4	1999	2018	15.8	low	0	0	1	1	2	0
Ovarian Neoplasms	13	1997	2021	12.3	low	0	0	1	3	8	1
Pain	6	1993	2010	20.8	low	0	0	2	4	0	0
Pancreatic Neoplasms	22	1997	2021	12.2	low	0	0	2	7	12	1
Pancreatitis	1	2013	2013	11.0	low	0	0	0	0	1	0
Papillomavirus Infections	2	2006	2016	13.0	low	0	0	0	1	1	0
Parkinson Disease	3	1998	2018	18.7	low	0	0	2	0	1	0
Parkinsonian Disorders	2	2003	2010	17.5	low	0	0	0	2	0	0
Pemphigoid	1	2009	2009	15.0	low	0	0	0	1	0	0
Pemphigoid, Bullous	1	2009	2009	15.0	low	0	0	0	1	0	0
Pericementitis	1	2015	2015	9.0	low	0	0	0	0	1	0
Periodontal Pocket	1	2009	2009	15.0	low	0	0	0	1	0	0
Periodontitis	1	2015	2015	9.0	low	0	0	0	0	1	0
Peripheral Nerve Diseases	1	2003	2003	21.0	low	0	0	0	1	0	0
Peripheral Nerve Injuries	3	2004	2019	11.0	low	0	0	0	1	2	0
Peripheral Nerve Injury	3	2004	2019	11.0	low	0	0	0	1	2	0
Peripheral Nervous System Diseases	1	2003	2003	21.0	low	0	0	0	1	0	0
Peritoneal Carcinomatosis	1	2012	2012	12.0	low	0	0	0	0	1	0
Peritoneal Neoplasms	1	2012	2012	12.0	low	0	0	0	0	1	0
Peritonitis	1	2010	2010	14.0	low	0	0	0	1	0	0
Pigmentary Retinopathy	3	2004	2013	14.7	low	0	0	0	1	2	0
Plasmodium falciparum Malaria	2	2014	2019	7.5	low	0	0	0	0	2	0
Plasmodium vivax Malaria	1	2013	2013	11.0	low	0	0	0	0	1	0
Pleural Effusion	1	2018	2018	6.0	low	0	0	0	0	1	0
Pneumonia	5	2008	2018	13.0	low	0	0	0	3	2	0
Pocket, Periodontal	1	2009	2009	15.0	low	0	0	0	1	0	0
Polyarthritis	4	1988	2015	16.5	low	0	1	0	0	3	0
Polycystic Kidney, Autosomal Dominant	1	2005	2005	19.0	low	0	0	0	1	0	0
Polycystic Ovarian Syndrome	2	2007	2021	10.0	low	0	0	0	1	0	1
Polycystic Ovary Syndrome	2	2007	2021	10.0	low	0	0	0	1	0	1
Polyneuropathies	1	2006	2006	18.0	low	0	0	0	1	0	0
Polyneuropathy, Acquired	1	2006	2006	18.0	low	0	0	0	1	0	0
Polyploid	2	2009	2009	15.0	low	0	0	0	2	0	0
Polyps	1	2015	2015	9.0	low	0	0	0	0	1	0
Precancerous Conditions	2	2004	2018	13.0	low	0	0	0	1	1	0
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1	2013	2013	11.0	low	0	0	0	0	1	0
Precursor Cell Lymphoblastic Leukemia-Lymphoma	4	2004	2013	16.5	low	0	0	0	3	1	0
Pregnancy	94	1978	2019	24.4	low	0	3	52	32	7	0
Primary Ovarian Insufficiency	1	2019	2019	5.0	low	0	0	0	0	1	0
Primary Peritonitis	1	2010	2010	14.0	low	0	0	0	1	0	0
Prostatic Hyperplasia	1	2006	2006	18.0	low	0	0	0	1	0	0
Prostatic Neoplasms	30	2005	2023	9.4	low	0	0	0	5	24	1
Proteinuria	1	2013	2013	11.0	low	0	0	0	0	1	0
Pulmonary Consumption	1	2004	2004	20.0	low	0	0	0	1	0	0
Pulmonary Edema	1	2004	2004	20.0	low	0	0	0	1	0	0
Pulmonary Embolism	1	2007	2007	17.0	low	0	0	0	1	0	0
Pulmonary Fibrosis	2	2011	2018	9.5	low	0	0	0	0	2	0
Pulmonary Hypertension	2	2013	2017	9.0	low	0	0	0	0	2	0
Radiculopathy	2	2008	2010	15.0	low	0	0	0	2	0	0
Reperfusion Injury	10	2003	2019	12.9	low	0	0	0	4	6	0
Retinal Degeneration	3	1996	2007	21.0	low	0	0	1	2	0	0
Retinal Detachment	1	2004	2004	20.0	low	0	0	0	1	0	0
Retinal Diseases	5	2003	2015	15.6	low	0	0	0	4	1	0
Retinal Neovascularization	1	2017	2017	7.0	low	0	0	0	0	1	0
Retinal Perforations	1	2004	2004	20.0	low	0	0	0	1	0	0
Retinal Pigment Epithelial Detachment	1	2004	2004	20.0	low	0	0	0	1	0	0
Retinitis Pigmentosa	3	2004	2013	14.7	low	0	0	0	1	2	0
Retinopathy of Prematurity	1	2017	2017	7.0	low	0	0	0	0	1	0
Retrolental Fibroplasia	1	2017	2017	7.0	low	0	0	0	0	1	0
Rett Syndrome	3	2009	2017	11.3	low	0	0	0	1	2	0
Rheumatoid Arthritis	2	2008	2017	11.5	low	0	0	0	1	1	0
Rida	1	2013	2013	11.0	low	0	0	0	0	1	0
Sarcoma	1	2004	2004	20.0	low	0	0	0	1	0	0
Sarcoma, Epithelioid	1	2004	2004	20.0	low	0	0	0	1	0	0
Sarcoma, Kaposi	1	2004	2004	20.0	low	0	0	0	1	0	0
Schizophrenia	3	2005	2021	11.7	low	0	0	0	1	1	1
Sensitivity and Specificity	160	1995	2022	17.0	low	0	0	21	96	42	1
Sepsis	1	2015	2015	9.0	low	0	0	0	0	1	0
Severe Combined Immunodeficiency	1	2002	2002	22.0	low	0	0	0	1	0	0
Sex Chromosome Disorders of Sex Development	1	2012	2012	12.0	low	0	0	0	0	1	0
Sex Chromosome DSD	1	2012	2012	12.0	low	0	0	0	0	1	0
Shock, Septic	1	2014	2014	10.0	low	0	0	0	0	1	0
Skin Diseases	1	2021	2021	3.0	low	0	0	0	0	0	1
Skin Neoplasms	5	1993	2023	11.0	low	0	0	1	0	3	1
Spermatic Cord Torsion	1	2006	2006	18.0	low	0	0	0	1	0	0
Spinal Cord Injuries	12	1993	2014	20.6	low	0	0	3	7	2	0
Spondylosis	1	2010	2010	14.0	low	0	0	0	1	0	0
Staphylococcal Infections	2	2012	2015	10.5	low	0	0	0	0	2	0
Sterility, Male	5	2003	2016	14.6	low	0	0	0	2	3	0
Stomach Neoplasms	12	2005	2022	10.7	low	0	0	0	4	6	2
Stomach Ulcer	1	2005	2005	19.0	low	0	0	0	1	0	0
Strabismus	1	1995	1995	29.0	low	0	0	1	0	0	0
Stroke	2	2017	2022	4.5	low	0	0	0	0	1	1
Systemic Inflammatory Response Syndrome	1	2019	2019	5.0	low	0	0	0	0	1	0
Tauopathies	3	2005	2011	15.3	low	0	0	0	2	1	0
Teratocarcinoma	4	1995	2008	22.5	low	0	0	2	2	0	0
Tetralogy of Fallot	1	2005	2005	19.0	low	0	0	0	1	0	0
Thalassemia	1	2010	2010	14.0	low	0	0	0	1	0	0
Thalassemias	1	2010	2010	14.0	low	0	0	0	1	0	0
Thrombocytopenia	2	2002	2005	20.5	low	0	0	0	2	0	0
Thrombopenia	2	2002	2005	20.5	low	0	0	0	2	0	0
Thrombosis	1	2005	2005	19.0	low	0	0	0	1	0	0
Tooth Mobility	1	2009	2009	15.0	low	0	0	0	1	0	0
Toothache	1	2013	2013	11.0	low	0	0	0	0	1	0
Trichomonas Infections	1	2015	2015	9.0	low	0	0	0	0	1	0
Triple Negative Breast Neoplasms	5	2015	2021	5.2	low	0	0	0	0	4	1
Tuberculosis	1	2010	2010	14.0	low	0	0	0	1	0	0
Tuberculosis, Pulmonary	1	2004	2004	20.0	low	0	0	0	1	0	0
Urinary Bladder Neoplasms	9	1987	2022	15.7	low	0	2	0	3	3	1
Uterine Cervical Neoplasms	7	2000	2021	14.1	low	0	0	1	2	3	1
Vascular Calcification	1	2012	2012	12.0	low	0	0	0	0	1	0
Venous Thrombosis	1	2007	2007	17.0	low	0	0	0	1	0	0
Viral Diseases	1	1985	1985	39.0	low	0	1	0	0	0	0
Virus Diseases	1	1985	1985	39.0	low	0	1	0	0	0	0
Vulvar Neoplasms	1	2005	2005	19.0	low	0	0	0	1	0	0
Wallerian Degeneration	1	2005	2005	19.0	low	0	0	0	1	0	0
Weight Loss	1	2011	2011	13.0	low	0	0	0	0	1	0
Weight Reduction	1	2011	2011	13.0	low	0	0	0	0	1	0
Wounds and Injuries	1	2019	2019	5.0	low	0	0	0	0	1	0
Xerostomia	1	1996	1996	28.0	low	0	0	1	0	0	0

Safety/Toxicity (46)

Article	Year
Conjugation of Palbociclib with MHI-148 Has an Increased Cytotoxic Effect for Breast Cancer Cells and an Altered Mechanism of Action. Molecules (Basel, Switzerland), , Jan-27, Volume: 27, Issue:3	2022
Real-time imaging of polymersome nanoparticles in zebrafish embryos engrafted with melanoma cancer cells: Localization, toxicity and treatment analysis. EBioMedicine, , Volume: 58	2020
Real-time monitoring and accurate diagnosis of drug-induced hepatotoxicity in vivo by ratio-fluorescence and photoacoustic imaging of peroxynitrite. Nanoscale, , May-14, Volume: 12, Issue:18	2020
Microfluidic-Based Holonomic Constraints of siRNA in the Kernel of Lipid/Polymer Hybrid Nanoassemblies for Improving Stable and Safe In Vivo Delivery. ACS applied materials & interfaces, , Apr-01, Volume: 12, Issue:13	2020
Synthesis, optical properties and cytotoxicity of meso-heteroatom substituted IR-786 analogs. Bioorganic & medicinal chemistry letters, , 02-01, Volume: 28, Issue:3	2018
Actinomycin D synergistically enhances the cytotoxicity of CDDP on KB cells by activating P53 via decreasing P53-MDM2 complex. Journal of Asian natural products research, , Volume: 19, Issue:6	2017
The Potential of Poly[N-(2-hydroxypropyl)methacrylamide] via Reversible Addition-Fragmentation Chain Transfer Polymerization as Safe Nanocarrier. Journal of nanoscience and nanotechnology, , Volume: 16, Issue:6	2016
Near-infrared fluorescent peptide probes for imaging of tumor in vivo and their biotoxicity evaluation. Journal of biomedical materials research. Part A, , Volume: 104, Issue:4	2016
Surface modification of PLGA nanoparticles with biotinylated chitosan for the sustained in vitro release and the enhanced cytotoxicity of epirubicin. Colloids and surfaces. B, Biointerfaces, , Feb-01, Volume: 138	2016
Photocytotoxicity of a cyanine dye with two chromophores toward melanoma and normal cells. Biochimica et biophysica acta, , Volume: 1850, Issue:6	2015
Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and surfaces. B, Biointerfaces, , May-01, Volume: 117	2014
Cytotoxicity of lidocaine to human corneal endothelial cells in vitro. Basic & clinical pharmacology & toxicology, , Volume: 114, Issue:4	2014
Polycationic adamantane-based dendrons of different generations display high cellular uptake without triggering cytotoxicity. Journal of the American Chemical Society, , Jan-15, Volume: 136, Issue:2	2014
NMO sera down-regulate AQP4 in human astrocyte and induce cytotoxicity independent of complement. Journal of the neurological sciences, , Aug-15, Volume: 331, Issue:1-2	2013
In vitro evidence for mycophenolic acid dose-related cytotoxicity in human retinal cells. Retina (Philadelphia, Pa.), , Volume: 33, Issue:10
DiI labeling of human adipose-derived stem cells: evaluation of DNA damage, toxicity and functional impairment. Cells, tissues, organs, , Volume: 197, Issue:5	2013
1H and 13C NMR assignments for the cyanine dyes SYBR Safe and thiazole orange. The Journal of organic chemistry, , Dec-07, Volume: 77, Issue:23	2012
Synthetic liposomes are protective from bleomycin-induced lung toxicity. American journal of physiology. Lung cellular and molecular physiology, , Volume: 301, Issue:2	2011
Protection of cortical neurons from excitotoxicity by conjugated linoleic acid. Journal of neurochemistry, , Volume: 115, Issue:1	2010
Long-term efficacy and safety of human umbilical cord mesenchymal stromal cells in rotenone-induced hemiparkinsonian rats. Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, , Volume: 16, Issue:11	2010
Protective effects of memantine and epicatechin on catechol-induced toxicity on Müller cells in vitro. Toxicology, , May-27, Volume: 271, Issue:3	2010
New approach to hydrophobic cyanine-type photosensitizer delivery using polymeric oil-cored nanocarriers: hemolytic activity, in vitro cytotoxicity and localization in cancer cells. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, , Mar-18, Volume: 39, Issue:5	2010
Determination of glutathione, mitochondrial transmembrane potential, and cytotoxicity in H9c2 cardiomyoblasts exposed to reactive oxygen and nitrogen species. Methods in molecular biology (Clifton, N.J.), , Volume: 610	2010
Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging. Toxicology and applied pharmacology, , Aug-15, Volume: 239, Issue:1	2009
Evaluation of human mast cell-mediated cytotoxicity by DIOC18 target cell labeling in flow cytometry. Journal of immunological methods, , Jan-30, Volume: 319, Issue:1-2	2007
Evaluation of a proposed in vitro test strategy using neuronal and non-neuronal cell systems for detecting neurotoxicity. Toxicology in vitro : an international journal published in association with BIBRA, , Volume: 20, Issue:8	2006
Localization of glutamate receptors in developing cortical neurons in culture and relationship to susceptibility to excitotoxicity. The Journal of comparative neurology, , Sep-10, Volume: 498, Issue:2	2006
Oligodendrocyte excitotoxicity determined by local glutamate accumulation and mitochondrial function. Journal of neurochemistry, , Volume: 98, Issue:1	2006
Differential contributions of Caenorhabditis elegans histone deacetylases to huntingtin polyglutamine toxicity. The Journal of neuroscience : the official journal of the Society for Neuroscience, , Mar-08, Volume: 26, Issue:10	2006
Heat shock proteins reduce toxicity of 1-methyl-4-phenylpyridinium ion in SK-N-SH cells. Journal of neuroscience research, , Nov-15, Volume: 82, Issue:4	2005
Uptake and phototoxicity of tricarbocyanine indolenine dye covalently bound with glucose (TICS) under acidification of tumor cells environment. Experimental oncology, , Volume: 26, Issue:3	2004
Comparison of the dark and light-induced toxicity of thio and seleno analogues of the thiopyrylium dye AA1. Bioorganic & medicinal chemistry, , May-15, Volume: 12, Issue:10	2004
Toxicity and cell cycle effects of synthetic 8-prenylnaringenin and derivatives in human cells. Pharmacology, , Volume: 71, Issue:1	2004
Long-term lithium treatment prevents neurotoxic effects of beta-bungarotoxin in primary cultured neurons. Journal of neuroscience research, , Sep-01, Volume: 69, Issue:5	2002
A flow-cytometry based cytotoxicity assay using stained effector cells in combination with native target cells. Journal of immunological methods, , Sep-15, Volume: 267, Issue:2	2002
Allopregnanolone attenuates N-methyl-D-aspartate-induced excitotoxicity and apoptosis in the human NT2 cell line in culture. Neuroscience letters, , Aug-02, Volume: 328, Issue:1	2002
Distinct subsets of nucleus basalis neurons exhibit similar sensitivity to excitotoxicity. Neuroreport, , May-07, Volume: 13, Issue:6	2002
Antibody-dependent cell-mediated cytotoxicity: a flow cytometry-based assay using fluorophores. Journal of immunological methods, , Dec-01, Volume: 258, Issue:1-2	2001
Direct analysis of mitochondrial toxicity of antiretroviral drugs. AIDS (London, England), , Sep-07, Volume: 15, Issue:13	2001
Development of a novel flow cytometric cell-mediated cytotoxicity assay using the fluorophores PKH-26 and TO-PRO-3 iodide. Journal of immunological methods, , Jun-01, Volume: 252, Issue:1-2	2001
Toxicity and genotoxicity of antimalarial alkaloid rich extracts derived from Mitragyna inermis O. Kuntze and Nauclea latifolia. Phytotherapy research : PTR, , Volume: 14, Issue:8	2000
Cytotoxic effect of thiacarbocyanine dyes on human colon carcinoma cells and inhibition of bovine heart mitochondrial NADH-ubiquinone reductase activity via a rotenone-type mechanism by two of the dyes. Biochemical pharmacology, , Feb-09, Volume: 45, Issue:3	1993
Phototoxicity mechanism of a kryptocyanine dye in human red cell membranes and isolated murine mitochondria. Cancer research, , Dec-01, Volume: 48, Issue:23	1988
Toxicity in vital fluorescence microscopy: effect of dimethylsulfoxide, rhodamine-123, and DiI-low density lipoprotein on fibroblast growth in vitro. In vitro cellular & developmental biology : journal of the Tissue Culture Association, , Volume: 27A, Issue:8	1991
Toxicity of "DiI" for embryonic rat motoneurons and sensory neurons in vitro. Life sciences, , Volume: 49, Issue:26	1991
Direct visualisation and quantification of cellular cytotoxicity using two colour flourescence. Journal of immunological methods, , Nov-25, Volume: 156, Issue:1	1992

Long-term Use (1)

Article	Year
Small Mitochondria-Targeting Fluorophore with Multifunctional Therapeutic Activities against Prostate Cancer via the HIF1α/OATPs Pathway. Molecular pharmaceutics, , Dec-04, Volume: 20, Issue:12	2023

Pharmacokinetics (19)

Article	Year
Hydrogel-Assisted 3D Volumetric Hotspot for Sensitive Detection by Surface-Enhanced Raman Spectroscopy. International journal of molecular sciences, , Jan-17, Volume: 23, Issue:2	2022
Tracers for Fluorescence-Guided Surgery: How Elongation of the Polymethine Chain in Cyanine Dyes Alters the Pharmacokinetics of a Dual-Modality c[RGDyK] Tracer. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, , Volume: 59, Issue:6	2018
Nano Endoscopy with Plasmon-Enhanced Fluorescence for Sensitive Sensing Inside Ultrasmall Volume Samples. Analytical chemistry, , 01-17, Volume: 89, Issue:2	2017
Investigation of injection dose and camera integration time on quantifying pharmacokinetics of a Cy5.5-GX1 probe with dynamic fluorescence imaging in vivo. Journal of biomedical optics, , 08-01, Volume: 21, Issue:8	2016
Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter. Nanoscale, , Feb-21, Volume: 8, Issue:7	2016
Tumor Targeting and Pharmacokinetics of a Near-Infrared Fluorescent-Labeled δ-Opioid Receptor Antagonist Agent, Dmt-Tic-Cy5. Molecular pharmaceutics, , Feb-01, Volume: 13, Issue:2	2016
Impact of C4'-O-Alkyl Linker on in Vivo Pharmacokinetics of Near-Infrared Cyanine/Monoclonal Antibody Conjugates. Molecular pharmaceutics, , Sep-08, Volume: 12, Issue:9	2015
Reduced Fluorescence versus Forward Scatter Time-of-Flight and Increased Peak versus Integral Fluorescence Ratios Indicate Receptor Clustering in Flow Cytometry. Journal of immunology (Baltimore, Md. : 1950), , Jul-01, Volume: 195, Issue:1	2015
In vivo biodistribution and clearance of peptide amphiphile micelles. Nanomedicine : nanotechnology, biology, and medicine, , Volume: 11, Issue:2	2015
Enhanced single molecule fluorescence and reduced observation volumes on nanoporous gold (NPG) films. Chemical communications (Cambridge, England), , Nov-28, Volume: 49, Issue:92	2013
Pharmacokinetics and biodistribution of human serum albumin-TIMP-2 fusion protein using near-infrared optical imaging. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques, , Volume: 14, Issue:3	2011
Cyanine dyes as contrast agents for near-infrared imaging in vivo: acute tolerance, pharmacokinetics, and fluorescence imaging. Journal of biomedical optics, , Volume: 16, Issue:6	2011
Rapid pharmacokinetic and biodistribution studies using cholorotoxin-conjugated iron oxide nanoparticles: a novel non-radioactive method. PloS one, , Mar-04, Volume: 5, Issue:3	2010
Semiautomatic landmark-based two-dimensional-three-dimensional image fusion in living mice: correlation of near-infrared fluorescence imaging of Cy5.5-labeled antibodies with flat-panel volume computed tomography. Molecular imaging, , Volume: 8, Issue:1
Quantification of sodium dodecyl sulfate in microliter-volume biochemical samples by visible light spectroscopy. Analytical biochemistry, , Aug-01, Volume: 295, Issue:1	2001
The LightCycler: a microvolume multisample fluorimeter with rapid temperature control. BioTechniques, , Volume: 22, Issue:1	1997
Nanogram-level micro-volume DNA assay based on the monomeric cyanine dye PO-PRO-3 iodide. BioTechniques, , Volume: 18, Issue:1	1995
Delayed increase of cell volume of single pyramidal cells in live rat hippocampal slices upon kainate application. Neuroscience letters, , May-19, Volume: 191, Issue:1-2	1995
Membrane depolarization of human B cells follows stimulation by either anti-mu or B-cell growth factor, but only anti-mu causes cell volume changes. Human immunology, , Volume: 21, Issue:3	1988

Bioavailability (11)

Article	Year
Renal-clearable ultrasmall covalent organic framework nanodots as photodynamic agents for effective cancer therapy. Biomaterials, , Volume: 223	2019
The Potential of Exosomes From Cow Milk for Oral Delivery. Journal of pharmaceutical sciences, , Volume: 108, Issue:4	2019
Cyanine derivative as a suitable marker for thermosensitive in situ gelling delivery systems: In vitro and in vivo validation of a sustained buccal drug delivery. International journal of pharmaceutics, , Dec-20, Volume: 534, Issue:1-2	2017
Improving Therapeutic Potential of Farnesylthiosalicylic Acid: Tumor Specific Delivery via Conjugation with Heptamethine Cyanine Dye. Molecular pharmaceutics, , 01-03, Volume: 14, Issue:1	2017
Optimizing the bioavailability of small molecular optical imaging probes by conjugation to an albumin affinity tag. Journal of controlled release : official journal of the Controlled Release Society, , Jul-28, Volume: 186	2014
In vivo temperature controlled ultrasound-mediated intracellular delivery of cell-impermeable compounds. Journal of controlled release : official journal of the Controlled Release Society, , Jul-10, Volume: 161, Issue:1	2012
Image-guided breast tumor therapy using a small interfering RNA nanodrug. Cancer research, , Oct-01, Volume: 70, Issue:19	2010
Synthesis of the Cyanine 7 labeled neutrophil-specific agents for noninvasive near infrared fluorescence imaging. Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 20, Issue:12	2010
Development and application of a dual-purpose nanoparticle platform for delivery and imaging of siRNA in tumors. Methods in molecular biology (Clifton, N.J.), , Volume: 555	2009
[Development of near-infrared fluorescent probes for in-vivo imaging]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, , Volume: 128, Issue:11	2008
Action of diclofenac on kidney mitochondria and cells. Biochemical and biophysical research communications, , Sep-22, Volume: 348, Issue:2	2006

Dosage (26)

Article	Year
Laser-Activated Drug Implant for Controlled Release to the Posterior Segment of the Eye. ACS applied bio materials, , 02-15, Volume: 4, Issue:2	2021
A Renal-Clearable Macromolecular Reporter for Near-Infrared Fluorescence Imaging of Bladder Cancer. Angewandte Chemie (International ed. in English), , 03-09, Volume: 59, Issue:11	2020
Closed-loop control of targeted ultrasound drug delivery across the blood-brain/tumor barriers in a rat glioma model. Proceedings of the National Academy of Sciences of the United States of America, , 11-28, Volume: 114, Issue:48	2017
Microscale Symmetrical Electroporator Array as a Versatile Molecular Delivery System. Scientific reports, , 03-20, Volume: 7	2017
Individual aggregates of amyloid beta induce temporary calcium influx through the cell membrane of neuronal cells. Scientific reports, , 08-24, Volume: 6	2016
Rapid determination of IL-6 specific activity by flow cytometry. Journal of immunological methods, , Dec-15, Volume: 415	2014
Optimizing the bioavailability of small molecular optical imaging probes by conjugation to an albumin affinity tag. Journal of controlled release : official journal of the Controlled Release Society, , Jul-28, Volume: 186	2014
Surface-mediated nucleic acid delivery by lipoplexes prepared in microwell arrays. Small (Weinheim an der Bergstrasse, Germany), , Jul-08, Volume: 9, Issue:13	2013
Near infrared imaging of EGFR of oral squamous cell carcinoma in mice administered arsenic trioxide. PloS one, , Volume: 7, Issue:9	2012
Optical imaging to trace near infrared fluorescent zinc oxide nanoparticles following oral exposure. International journal of nanomedicine, , Volume: 7	2012
The antiproliferative cytostatic effects of a self-activating viridin prodrug. Molecular cancer therapeutics, , Volume: 8, Issue:6	2009
Inhibition of tau polymerization with a cyanine dye in two distinct model systems. The Journal of biological chemistry, , Jul-31, Volume: 284, Issue:31	2009
Technical demonstration of whole genome array comparative genomic hybridization. Journal of visualized experiments : JoVE, , Aug-05, Issue:18	2008
Alcohol exposure during the first two trimesters-equivalent alters the development of corpus callosum projection neurons in the rat. Alcohol (Fayetteville, N.Y.), , Volume: 42, Issue:4	2008
Towards a FRET-based immunosensor for continuous carbohydrate monitoring. Journal of immunological methods, , Apr-20, Volume: 333, Issue:1-2	2008
A fluorescent photoprobe for the imaging of endothelin receptors. Bioconjugate chemistry, , Volume: 18, Issue:3
A high-throughput cell-based toxicity analysis of drug metabolites using flow cytometry. Cell biology and toxicology, , Volume: 23, Issue:5	2007
Optical pretargeting of tumor with fluorescent MORF oligomers. Molecular imaging and biology, , Volume: 9, Issue:1
In vivo imaging of integrin alpha v beta 3 expression using fluorescence-mediated tomography. European journal of nuclear medicine and molecular imaging, , Volume: 34, Issue:5	2007
rAAV2 traffics through both the late and the recycling endosomes in a dose-dependent fashion. Molecular therapy : the journal of the American Society of Gene Therapy, , Volume: 13, Issue:4	2006
Suitability of LLC-PK1 pig kidney cells for the study of drug action on renal cell cholesterol uptake: identification and characterization of low-density lipoprotein receptors. Journal of pharmacological and toxicological methods, , Volume: 51, Issue:2
Electrokinetically driven microfluidic chips with surface-modified chambers for heterogeneous immunoassays. Analytical chemistry, , Jul-15, Volume: 73, Issue:14	2001
Impaired erythrocyte transmembrane potential in diabetes mellitus and its possible improvement by resorcylidene aminoguanidine. Bioelectrochemistry (Amsterdam, Netherlands), , Volume: 52, Issue:2	2000
Leishmania infantum promastigotes: flow cytometry as a possible tool for assessing the effects of drugs on cellular functions. Experimental parasitology, , Volume: 87, Issue:1	1997
Flow cytometry as a quantitative and sensitive method to evaluate low dose radiation induced apoptosis in vitro in human peripheral blood lymphocytes. International journal of radiation biology, , Volume: 71, Issue:4	1997
Nonuniform alteration of dendritic development in the cerebral cortex following prenatal cocaine exposure. Cerebral cortex (New York, N.Y. : 1991), , Volume: 6, Issue:3

Interactions (6)

Article	Year
Biological effects in photodynamic treatment combined with electropermeabilization in wild and drug resistant breast cancer cells. Bioelectrochemistry (Amsterdam, Netherlands), , Volume: 123	2018
Platelet poor plasma gel combined with amnion improves the therapeutic effects of human umbilical cord‑derived mesenchymal stem cells on wound healing in rats. Molecular medicine reports, , Volume: 16, Issue:3	2017
Identification of potential serum markers for nasopharyngeal carcinoma from a xenografted mouse model using Cy-dye labeling combined with three-dimensional fractionation. Proteomics, , Volume: 8, Issue:17	2008
Discriminating in vitro cell fusion from cell aggregation by flow cytometry combined with fluorescence resonance energy transfer. Journal of virological methods, , Volume: 138, Issue:1-2	2006
Investigation of quadruplex oligonucleotide-drug interactions by electrospray ionization mass spectrometry. Analytical chemistry, , May-01, Volume: 74, Issue:9	2002
DiI tracing in combination with immunocytochemistry for analysis of connectivities and chemoarchitectonics of specific neural systems in a teleost, the Atlantic salmon. Journal of neuroscience methods, , Volume: 42, Issue:1-2	1992

Natural Sources (1)

Article	Year
Curcumin-cyclodextrin encapsulated chitosan nanoconjugates with enhanced solubility and cell cytotoxicity. Colloids and surfaces. B, Biointerfaces, , May-01, Volume: 117	2014