| Assay ID | Title | Year | Journal | Article |
|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
| Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4
| A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID36377 | In vitro binding affinity towards alpha-2B adrenergic receptor of rat neonatal lung in radioligand binding assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID60508 | Percent response towards alpha 1A adrenergic receptor in canine prostate using phenylephrine as control agonist | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID234297 | Selectivity is the ratio of binding affinities of alpha 1A adrenergic receptor to alpha 1b adrenergic receptor | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID234283 | Selectivity is ratio of pKi (binding affinity) of Alpha-1D to that of alpha1A | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID234282 | Selectivity is ratio of pKi (binding affinity) of alpha-1B receptor to that of alpha-1A receptor. | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID37499 | Efficacy relative to phenylephrine (PE) constriction of rat spleen containing alpha-1B adrenergic receptor | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID235160 | Selectivity ratio as the ratio of Ki value towards Alpha1D receptor to that of Alpha1A receptor. | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID36764 | Efficacy relative to phenylephrine (PE) to constrict tissue containing the alpha-1A adrenergic receptor in rabbit urethra | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID37044 | Binding affinity towards Alpha-1A adrenergic receptor in rat submaxillary glands | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID35742 | In vitro binding affinity towards alpha-1D adrenergic receptor of rat clone in radioligand binding assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID36463 | Binding affinity towards bovine clonal Alpha-1A adrenergic receptor | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID36421 | Effective concentration in vitro against rabbit urethra Alpha-1 adrenergic receptor | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID37188 | In vitro binding affinity towards alpha-1B adrenergic receptor of hamster clone in radioligand binding assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID37046 | In vitro binding affinity towards alpha-1A adrenergic receptor of rat submaxillary gland in radioligand binding assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID180025 | Percent response towards alpha 1A adrenergic receptor in rat vas deferens using phenylephrine as control agonist | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID37497 | Effective concentration in vitro against rat spleen Alpha-1B adrenergic receptor indicates EC50 < 15% at a concentration of 10 uM | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID234280 | Relative affinities for alpha2B and alpha1A receptors | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID36151 | Binding affinity towards rat submaxillary gland Alpha-1 adrenergic receptor; value ranges from (0.009 - 0.015) | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID36078 | In vitro binding affinity towards alpha-2A adrenergic receptor of human clone in radioligand binding assay | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID41728 | Dose corresponding to a 5 mmHg increase in Intraurethral pressure (IUP) was determined in vivo in isoflurane anesthetized female beagles | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID180028 | Percent response towards alpha 1D adrenergic receptor in rat aorta using phenylephrine as control agonist | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID234277 | Selectivity is ratio of efficacy of alpha-1B to that of alpha1A adrenoceptor | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID233243 | Functional selectivity ratio as the ratio of EC50 value towards Alpha1B receptor to that of Alpha1A receptor. | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID41727 | Dose corresponding to a 20 mmHg increase in mean arterial pressure (MAP) was determined in vivo in isoflurane anesthetized female beagles | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID233244 | Functional selectivity ratio as the ratio of EC50 value towards Alpha1D receptor to that of Alpha1A receptor. | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID234278 | Selectivity is ratio of efficacy of Alpha-1D to that of alpha-1A adrenoceptor | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID234298 | Selectivity is the ratio of binding affinities of alpha 1A adrenergic receptor to alpha 1d adrenergic receptor | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID35739 | Binding affinity towards rat clonal Alpha-1D adrenergic receptor | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID235159 | Selectivity ratio as the ratio of Ki value towards Alpha1B receptor to that of Alpha1A receptor. | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID35157 | Functional agonism of the compounds to constrict tissue containing the alpha-1B adrenergic receptor in rat spleen | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID37185 | Binding affinity towards hamster clonal Alpha-1B adrenergic receptor | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID36096 | Functional agonism of the compounds to constrict tissue containing the alpha-2A adrenergic receptor in rat prostatic vas deferens; NT = not tested | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID35160 | In vitro agonist potency towards Alpha-1B adrenergic receptor in rat spleen | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID59114 | Uroselectivity was determined by measuring effective dose required for 20 mmHg increase of mean arterial pressure (MAP) in vivo in dog | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID229761 | Ratio of IUP ED delta5 to that of MAP ED delta20 | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID36470 | In vitro agonist potency towards Alpha-1A adrenergic receptor in canine prostate | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID36766 | Functional agonism of the compounds to constrict tissue containing the alpha-1A adrenergic receptor in rabbit urethra | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID37036 | In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferens | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID35618 | In vitro agonist potency towards Alpha-1D adrenergic receptor in rat aorta | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID196269 | In vitro percent efficacy of compound was tested in rat spleen | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID35617 | Functional agonism of the compounds to constrict tissue containing the alpha-1D adrenergic receptor in rat aorta | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID224497 | In vitro percent efficacy of compound was tested in rabbit urethra | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID37070 | Binding affinity towards hamster cloned Alpha-1B adrenergic receptor; value ranges from (2.0 -4.4) | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID234281 | Relative affinities for alpha-2a and alpha-1A receptors | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID35589 | Efficacy relative to phenylephrine (PE) constrict tissue containing the alpha-1D adrenergic receptor in rat aorta | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID195188 | In vitro percent efficacy of compound was tested in rat aorta | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID35598 | Binding affinity towards rat cloned Alpha-1D adrenergic receptor; value ranges from (1.3 -1.6) | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID180026 | Percent response towards alpha 1B adrenergic receptor in rat spleen using phenylephrine as control agonist | 1996 | Journal of medicinal chemistry, Sep-27, Volume: 39, Issue:20
| Synthesis and in vitro characterization of N-[5-(4,5-dihydro-1H-imidazol-2-yl)-2-hydroxy-5,6,7,8- tetrahydronaphthalen-1-yl]methanesulfonamide and its enantiomers: a novel selective alpha 1A receptor agonist. |
| AID234457 | Uroselectivity as the ratio of MAP ED20 to that of IUP ED5. | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID59116 | Uroselectivity was determined by measuring effective dose required for 5 mmHg increase of intraurethral pressure (IUP) in vivo in dog | 2004 | Journal of medicinal chemistry, Jun-03, Volume: 47, Issue:12
| Synthesis and structure-activity studies on N-[5-(1H-imidazol-4-yl)-5,6,7,8-tetrahydro-1-naphthalenyl]methanesulfonamide, an imidazole-containing alpha(1A)-adrenoceptor agonist. |
| AID35586 | Effective concentration in vitro against rat aorta Alpha-1D adrenergic receptor;* indicates EC50 < 15% at a concentration of 10 uM | 2002 | Journal of medicinal chemistry, Sep-26, Volume: 45, Issue:20
| N-[3-(1H-imidazol-4-ylmethyl)phenyl]ethanesulfonamide (ABT-866, 1),(1) a novel alpha(1)-adrenoceptor ligand with an enhanced in vitro and in vivo profile relative to phenylpropanolamine and midodrine. |
| AID1345908 | Human alpha1A-adrenoceptor (Adrenoceptors) | 1997 | British journal of pharmacology, Jul, Volume: 121, Issue:6
| Pharmacological pleiotropism of the human recombinant alpha1A-adrenoceptor: implications for alpha1-adrenoceptor classification. |
| AID1345908 | Human alpha1A-adrenoceptor (Adrenoceptors) | 1995 | The Journal of pharmacology and experimental therapeutics, Jul, Volume: 274, Issue:1
| A-61603, a potent alpha 1-adrenergic receptor agonist, selective for the alpha 1A receptor subtype. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] |