An MHC class I histocompatibility antigen A alpha chain that is encoded in the genome of human. [PRO:DAN]
| Target | Category | Definition |
|---|
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| signaling receptor binding | molecular function | Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| beta-2-microglobulin binding | molecular function | Binding to beta-2-microglobulin. [GOC:mah] |
| peptide antigen binding | molecular function | Binding to an antigen peptide. [GOC:add, GOC:jl, GOC:rv] |
| T cell receptor binding | molecular function | Binding to a T cell receptor, the antigen-recognizing receptor on the surface of T cells. [GOC:jl] |
| CD8 receptor binding | molecular function | Binding to a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes. [GOC:jl, MSH:D016827] |
| TAP binding | molecular function | Binding to TAP protein, transporter associated with antigen processing protein. TAP protein is a heterodimeric peptide transporter consisting of the subunits TAP1 and TAP2. [PMID:11133832] |
| TAP complex binding | molecular function | Binding to a TAP complex. [PMID:17947644] |
| Target | Category | Definition |
|---|
| Golgi membrane | cellular component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| Golgi apparatus | cellular component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| Golgi medial cisterna | cellular component | The middle Golgi cisterna (or cisternae). [ISBN:0815316194] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| ER to Golgi transport vesicle membrane | cellular component | The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| phagocytic vesicle membrane | cellular component | The lipid bilayer surrounding a phagocytic vesicle. [GOC:mah] |
| early endosome membrane | cellular component | The lipid bilayer surrounding an early endosome. [GOC:pz] |
| recycling endosome membrane | cellular component | The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| endoplasmic reticulum exit site | cellular component | An endoplasmic reticulum part at which COPII-coated vesicles are produced. [NIF_Subcellular:sao124393998, PMID:15623529, PMID:16957052] |
| lumenal side of endoplasmic reticulum membrane | cellular component | The side (leaflet) of the plasma membrane that faces the lumen. [GOC:ab, GOC:dos] |
| Target | Category | Definition |
|---|
| T cell mediated cytotoxicity | biological process | The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] |
| positive regulation of T cell mediated cytotoxicity | biological process | Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity. [GOC:add, ISBN:0781735149] |
| T cell mediated cytotoxicity directed against tumor cell target | biological process | The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors. [GOC:add, ISBN:0781735149, PMID:16730260] |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] |
| antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules. [GOC:add, PMID:14647477, PMID:15771591] |
| peptide antigen assembly with MHC class I protein complex | biological process | The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591] |
| positive regulation of T cell cytokine production | biological process | Any process that activates or increases the frequency, rate, or extent of T cell cytokine production. [GOC:add] |
| immune response | biological process | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add] |
| detection of bacterium | biological process | The series of events in which a stimulus from a bacterium is received and converted into a molecular signal. [GOC:hb] |
| antibacterial humoral response | biological process | An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster. [GOC:go_curators, GOC:mtg_sensu] |
| antigen processing and presentation of endogenous peptide antigen via MHC class I | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591] |
| positive regulation of type II interferon production | biological process | Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383] |
| CD8-positive, alpha-beta T cell activation | biological process | The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific. [CL:0000625, GOC:yaf] |
| protection from natural killer cell mediated cytotoxicity | biological process | The process of protecting a cell from natural killer cell mediated cytotoxicity. [GOC:add, ISBN:0781735149] |
| antigen processing and presentation of exogenous peptide antigen via MHC class I | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules. [GOC:add, ISBN:0781735149, PMID:15771591] |
| innate immune response | biological process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |
| defense response to Gram-positive bacterium | biological process | Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism. [GOC:ai] |
| T cell receptor signaling pathway | biological process | The series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add] |
| positive regulation of CD8-positive, alpha-beta T cell proliferation | biological process | Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation. [GOC:obol] |
| positive regulation of memory T cell activation | biological process | Any process that activates or increases the frequency, rate or extent of memory T cell activation. [GOC:obol] |
| positive regulation of CD8-positive, alpha-beta T cell activation | biological process | Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell activation. [GOC:obol] |
| antigen processing and presentation of endogenous peptide antigen via MHC class Ib | biological process | The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family. [GOC:add, PMID:15928678] |