ifosfamide has been researched along with Necrosis in 16 studies
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Flow cytometric analyses by means of annexin-V and propidium iodide double staining and immunofluorescence staining of active caspase-3 revealed that cells subjected to a lethal dose of chloroacetaldehyde displayed features characteristic of necrosis and that caspase-3 was not activated in response to chloroacetaldehyde." | 7.74 | Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. ( Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H, 2007) |
| "The efficacy of zoledronic acid (ZOL), with or without the anticancer drug ifosfamide (IFO), was tested on primary bone tumor growth using a rat-transplantable model of osteosarcoma." | 7.73 | Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma. ( Blanchard, F; Charrier, C; Coipeau, P; Couillaud, S; Gouin, F; Heymann, D; Heymann, MF; Ory, B; Redini, F; Thiery, JP, 2005) |
| "To improve the accuracy of magnetic resonance imaging (MRI) in evaluating the response of osteosarcomas to preoperative chemotherapy, the authors developed a technique of mapping tumor necrosis and viability by quantitating slope values of gadolinium-DTPA (Gd-DTPA) uptake on dynamic fast low-angle shot (FLASH) images." | 7.68 | Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping. ( Fairclough, DL; Fletcher, BD; Hanna, SL; Le, AH; Meyer, WH; Parham, DM, 1992) |
| " Flow cytometric analyses by means of annexin-V and propidium iodide double staining and immunofluorescence staining of active caspase-3 revealed that cells subjected to a lethal dose of chloroacetaldehyde displayed features characteristic of necrosis and that caspase-3 was not activated in response to chloroacetaldehyde." | 3.74 | Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde. ( Fujimoto, Y; Sakurai, K; Takahashi, K; Tanaka, H, 2007) |
| "The efficacy of zoledronic acid (ZOL), with or without the anticancer drug ifosfamide (IFO), was tested on primary bone tumor growth using a rat-transplantable model of osteosarcoma." | 3.73 | Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma. ( Blanchard, F; Charrier, C; Coipeau, P; Couillaud, S; Gouin, F; Heymann, D; Heymann, MF; Ory, B; Redini, F; Thiery, JP, 2005) |
| "To improve the accuracy of magnetic resonance imaging (MRI) in evaluating the response of osteosarcomas to preoperative chemotherapy, the authors developed a technique of mapping tumor necrosis and viability by quantitating slope values of gadolinium-DTPA (Gd-DTPA) uptake on dynamic fast low-angle shot (FLASH) images." | 3.68 | Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping. ( Fairclough, DL; Fletcher, BD; Hanna, SL; Le, AH; Meyer, WH; Parham, DM, 1992) |
| "The resulting treatment-induced necrosis rates are predictive of subsequent metastatic risk, and this information may provide an opportunity to guide postoperative systemic therapies." | 1.36 | Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy. ( Connell, PP; Haydon, RC; Luu, HH; MacDermed, DM; Miller, LL; Montag, AG; Peabody, TD; Simon, MA; Undevia, SD, 2010) |
| "Chloroacetaldehyde (CAA) is a metabolite of the alkylating agent ifosfamide (IFO) and putatively responsible for renal damage following anti-tumor therapy with IFO." | 1.33 | Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy. ( Benesic, A; Freudinger, R; Gekle, M; Groezinger, F; Kirchhoff, A; Mildenberger, S; Schwerdt, G; Wollny, B, 2006) |
| "Necrosis was found in 22 (38%) of 57 patients, mature teratoma with or without necrosis was found in nine (16%) of 57 patients, and viable cancer with or without additional necrosis or mature teratoma was found in 26 (46%) of 57 patients." | 1.32 | Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer. ( Beyer, J; Bokemeyer, C; Braun, T; Hartmann, JT; Hartmann, M; Pottek, T; Rachud, B; Rick, O; Schirren, J; Siegert, W; Weinknecht, S; Weissbach, L, 2004) |
| " Ifosfamide, although itself the effective antineoplastic drug useful in situations which have proved refractory to cyclophosphamide therapy, has the side-effect toxicities caused by its metabolities that pose clinically a very real problem." | 1.30 | Influence of mesna on urotoxic effects of selected bromosubstituted analogs of ifosfamide. ( Konarski, L; Kowalski, P; Kuśnierczyk, H; Radzikowski, C, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (37.50) | 18.2507 |
| 2000's | 7 (43.75) | 29.6817 |
| 2010's | 3 (18.75) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Opydo-Chanek, M | 1 |
| Mazur, L | 1 |
| Stojak, M | 1 |
| MacDermed, DM | 1 |
| Miller, LL | 1 |
| Peabody, TD | 1 |
| Simon, MA | 1 |
| Luu, HH | 1 |
| Haydon, RC | 1 |
| Montag, AG | 1 |
| Undevia, SD | 1 |
| Connell, PP | 1 |
| Cui, Q | 1 |
| Jiang, W | 1 |
| Guo, J | 1 |
| Liu, C | 1 |
| Li, D | 1 |
| Wang, X | 1 |
| Zeng, Y | 1 |
| Rick, O | 1 |
| Bokemeyer, C | 1 |
| Weinknecht, S | 1 |
| Schirren, J | 1 |
| Pottek, T | 1 |
| Hartmann, JT | 1 |
| Braun, T | 1 |
| Rachud, B | 1 |
| Weissbach, L | 1 |
| Hartmann, M | 1 |
| Siegert, W | 1 |
| Beyer, J | 1 |
| Heymann, D | 1 |
| Ory, B | 1 |
| Blanchard, F | 1 |
| Heymann, MF | 1 |
| Coipeau, P | 1 |
| Charrier, C | 1 |
| Couillaud, S | 1 |
| Thiery, JP | 1 |
| Gouin, F | 1 |
| Redini, F | 1 |
| Ford, CD | 1 |
| Gabor, F | 1 |
| Morgan, R | 1 |
| Dabbas, B | 1 |
| Benesic, A | 1 |
| Schwerdt, G | 1 |
| Freudinger, R | 1 |
| Mildenberger, S | 1 |
| Groezinger, F | 1 |
| Wollny, B | 1 |
| Kirchhoff, A | 1 |
| Gekle, M | 1 |
| Takahashi, K | 2 |
| Sakurai, K | 1 |
| Tanaka, H | 1 |
| Fujimoto, Y | 1 |
| Miser, JS | 1 |
| Pritchard, DJ | 1 |
| Rock, MG | 1 |
| Shives, TC | 1 |
| Gilchrist, GS | 1 |
| Smithson, WA | 1 |
| Arndt, CA | 1 |
| Edmonson, JH | 1 |
| Schaid, DJ | 1 |
| Kuśnierczyk, H | 1 |
| Konarski, L | 1 |
| Kowalski, P | 1 |
| Radzikowski, C | 1 |
| Lindner, NJ | 1 |
| Scarborough, MT | 1 |
| Spanier, SS | 1 |
| Enneking, WF | 1 |
| Ganjoo, KN | 1 |
| Chan, RJ | 1 |
| Sharma, M | 1 |
| Einhorn, LH | 1 |
| Philip, T | 1 |
| Iliescu, C | 1 |
| Demaille, MC | 1 |
| Pacquement, H | 1 |
| Gentet, JC | 1 |
| Krakowski, I | 1 |
| Soler-Michel, P | 1 |
| Thiesse, P | 1 |
| Chauvin, F | 1 |
| Blay, JY | 1 |
| Brunat-Mentigny, M | 1 |
| Karle, P | 1 |
| Renner, M | 1 |
| Salmons, B | 1 |
| Günzburg, WH | 1 |
| Eilber, FC | 1 |
| Rosen, G | 1 |
| Eckardt, J | 1 |
| Forscher, C | 1 |
| Nelson, SD | 1 |
| Selch, M | 1 |
| Dorey, F | 1 |
| Eilber, FR | 1 |
| Hanna, SL | 1 |
| Parham, DM | 1 |
| Fairclough, DL | 1 |
| Meyer, WH | 1 |
| Le, AH | 1 |
| Fletcher, BD | 1 |
1 review available for ifosfamide and Necrosis
| Article | Year |
|---|---|
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child | 1993 |
3 trials available for ifosfamide and Necrosis
| Article | Year |
|---|---|
Osteosarcoma in adolescents and young adults: new developments and controversies. The Mayo Clinic studies.
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; Child | 1993 |
Local host response in osteosarcoma after chemotherapy referred to radiographs, CT, tumour necrosis and patient survival.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Child, Pre | 1998 |
High-dose methotrexate and HELP [Holoxan (ifosfamide), eldesine (vindesine), platinum]--doxorubicin in non-metastatic osteosarcoma of the extremity: a French multicentre pilot study. Fédération Nationale des Centres de Lutte contre le Cancer and Société F
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; | 1999 |
13 other studies available for ifosfamide and Necrosis
| Article | Year |
|---|---|
In vitro cytotoxicity testing of new generation oxazaphosphorines against human histiocytic lymphoma cells.
Topics: Antineoplastic Agents, Alkylating; Apoptosis; Cell Proliferation; Cyclophosphamide; Flow Cytometry; | 2013 |
Primary tumor necrosis predicts distant control in locally advanced soft-tissue sarcomas after preoperative concurrent chemoradiotherapy.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Doxo | 2010 |
Relationship between hypermethylated MGMT gene and osteosarcoma necrosis rate after chemotherapy.
Topics: Adolescent; Adult; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Child; Cisplatin; | 2011 |
Residual tumor resection after high-dose chemotherapy in patients with relapsed or refractory germ cell cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cohort Studies; Disease-Free Survival; Et | 2004 |
Enhanced tumor regression and tissue repair when zoledronic acid is combined with ifosfamide in rat osteosarcoma.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Bone Remodeling; Caspases; Cell Line, Tumor | 2005 |
False-positive restaging PET scans involving the spleen in two patients with aggressive non-Hodgkin lymphoma.
Topics: Antibodies, Monoclonal; Antibodies, Monoclonal, Murine-Derived; Antineoplastic Combined Chemotherapy | 2006 |
Chloroacetaldehyde as a sulfhydryl reagent: the role of critical thiol groups in ifosfamide nephropathy.
Topics: Acetaldehyde; Antineoplastic Agents, Alkylating; Biomarkers; Caspase 3; Caspase 8; Cathepsin B; Cell | 2006 |
Necrotic pathway in human osteosarcoma Saos-2 cell death induced by chloroacetaldehyde.
Topics: Acetaldehyde; Adenosine Triphosphate; Annexin A5; Antineoplastic Agents, Alkylating; Blotting, Weste | 2007 |
Influence of mesna on urotoxic effects of selected bromosubstituted analogs of ifosfamide.
Topics: Administration, Oral; Animals; Cystitis; Edema; Female; Hemorrhage; Ifosfamide; Injections, Intraper | 1997 |
Positron emission tomography scans in the evaluation of postchemotherapy residual masses in patients with seminoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Humans; Ifosfamide; Male; Me | 1999 |
Necrotic, rather than apoptotic, cell death caused by cytochrome P450-activated ifosfamide.
Topics: Adenocarcinoma; Animals; Antineoplastic Agents, Alkylating; Apoptosis; Cats; Cell Line; Cells, Cultu | 2001 |
Treatment-induced pathologic necrosis: a predictor of local recurrence and survival in patients receiving neoadjuvant therapy for high-grade extremity soft tissue sarcomas.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Child; C | 2001 |
Assessment of osteosarcoma response to preoperative chemotherapy using dynamic FLASH gadolinium-DTPA-enhanced magnetic resonance mapping.
Topics: Adolescent; Antineoplastic Combined Chemotherapy Protocols; Bone Neoplasms; Chemotherapy, Adjuvant; | 1992 |