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gallic acid and Necrosis

gallic acid has been researched along with Necrosis in 19 studies

gallate : A trihydroxybenzoate that is the conjugate base of gallic acid.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis."7.85Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017)
"These results provide evidence for the first time that GA causes selective HSC death through a Ca(2+)/calpain I-mediated necrosis cascade, suggesting that GA may represent a potential therapeutic agent to combat liver fibrosis."7.80Gallic acid selectively induces the necrosis of activated hepatic stellate cells via a calcium-dependent calpain I activation pathway. ( Hsieh, SC; Hsu, SL; Hsueh, CM; Liu, MC; Wu, CC; Wu, CH; Yen, JH, 2014)
" The present study was intended to appraise the nutraceutical inherent of HPLC standardized Spinacia oleracea methanolic leaf extract (SoLE) in isoproterenol (ISO) induced male albino Wistar rats via activation of pro-inflammatory signaling pathway that drives myocardial necrosis."3.85Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation. ( Jolapuram, U; Kodidhela, LD; Vutharadhi, S, 2017)
"These results provide evidence for the first time that GA causes selective HSC death through a Ca(2+)/calpain I-mediated necrosis cascade, suggesting that GA may represent a potential therapeutic agent to combat liver fibrosis."3.80Gallic acid selectively induces the necrosis of activated hepatic stellate cells via a calcium-dependent calpain I activation pathway. ( Hsieh, SC; Hsu, SL; Hsueh, CM; Liu, MC; Wu, CC; Wu, CH; Yen, JH, 2014)
"In this study, we investigated the hepatoprotective effects of four compounds from Galla Rhois [gallic acid methyl ester, gallic acid, an equilibrium mixture of 3-galloyl-gallic acid and 4-galloyl-gallic acid isomers, and 1,2,3,4,6-penta- O-galloyl- beta- D-glucose (PGG)] in primary rat hepatocytes undergoing necrosis or apoptosis."3.741,2,3,4,6-penta-O-galloyl-beta-D-glucose from Galla Rhois protects primary rat hepatocytes from necrosis and apoptosis. ( An, RB; Kim, YC; Park, EJ; Sohn, DH; Zhao, YZ, 2008)
"Acetaminophen is a commonly used drug for the treatment of patients with common cold and influenza."1.35Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1. ( Chan, AK; Chan, AS; Cheng, CH; Cheng, GY; Chui, CH; Fong, DW; Gambari, R; Hau, DK; Kan, CW; Kok, SH; Lai, PB; Lau, FY; Leung, AK; Tang, JC; Tong, CS; Wong, RS; Wong, WY; Yuen, MC; Zhu, GY, 2009)
"Pre-treatment with gallic acid significantly rendered K562 cells more susceptible to NK cell-mediated necrosis, while pre-treatment with rutin significantly rendered K562 cells more susceptible to apoptosis."1.33Effect of phenols on natural killer (NK) cell-mediated death in the K562 human leukemic cell line. ( Andrikopoulos, NK; Dedoussis, GV; Kaliora, AC, 2005)

Research

Studies (19)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (10.53)18.2507
2000's6 (31.58)29.6817
2010's10 (52.63)24.3611
2020's1 (5.26)2.80

Authors

AuthorsStudies
Gomes, INF1
Silva, AG1
Frazao Lima, GF1
Longatti, TR1
Do Carmo, LF1
Villar, JAFP1
Araujo, AADC1
Tome, RG1
Santos, HBD1
Azambuja Ribeiro, RIM1
Zhou, Y1
Jin, H1
Wu, Y1
Chen, L1
Bao, X1
Lu, C1
Hsieh, SC2
Wu, CH1
Wu, CC2
Yen, JH2
Liu, MC1
Hsueh, CM1
Hsu, SL3
Sun, DP1
Li, XX1
Liu, XL1
Zhao, D1
Qiu, FQ1
Li, Y1
Ma, P1
Tam, J1
Beilhartz, GL1
Auger, A1
Gupta, P1
Therien, AG1
Melnyk, RA1
Chang, YJ1
Liu, YT1
Lin, YH1
Lin, MH1
Huang, SJ1
Ho, JA1
Wu, LC1
Sachdeva, M1
Chadha, R1
Kumar, A1
Karan, M1
Singh, T1
Dhingra, S1
Vutharadhi, S1
Jolapuram, U1
Kodidhela, LD1
Park, EJ1
Zhao, YZ1
An, RB1
Kim, YC1
Sohn, DH1
Hau, DK1
Gambari, R1
Wong, RS1
Yuen, MC1
Cheng, GY1
Tong, CS1
Zhu, GY1
Leung, AK1
Lai, PB1
Lau, FY1
Chan, AK1
Wong, WY1
Kok, SH1
Cheng, CH1
Kan, CW1
Chan, AS1
Chui, CH1
Tang, JC1
Fong, DW1
You, BR1
Moon, HJ1
Han, YH1
Park, WH1
Mahadeswaraswamy, YH1
Kumar, MS1
Gowtham, YJ1
Nagaraju, S1
Girish, KS1
Kemparaju, K1
Dedoussis, GV1
Kaliora, AC1
Andrikopoulos, NK1
Łabieniec, M1
Gabryelak, T2
Labieniec, M1
Chiou, GC1
Hong, SJ2
Zhu, J1
Filippich, LJ1
Ng, J1
Hwang, JH1

Other Studies

19 other studies available for gallic acid and Necrosis

ArticleYear
Alkaloid and phenolic compounds of Xylopia aromatica inhibits tumor growth by down-regulating matrix metalloproteinase-2 (MMP-2) expression.
    Pakistan journal of pharmaceutical sciences, 2021, Volume: 34, Issue:2

    Topics: Alkaloids; Animals; Aporphines; Carcinoma, Ehrlich Tumor; Catechin; Cell Line, Tumor; Cell Prolifera

2021
Gallic acid protects against ethanol-induced hepatocyte necroptosis via an NRF2-dependent mechanism.
    Toxicology in vitro : an international journal published in association with BIBRA, 2019, Volume: 57

    Topics: Apoptosis; Cell Line; Ethanol; Gallic Acid; Hepatocytes; Humans; Necrosis; NF-E2-Related Factor 2; N

2019
Gallic acid selectively induces the necrosis of activated hepatic stellate cells via a calcium-dependent calpain I activation pathway.
    Life sciences, 2014, Apr-25, Volume: 102, Issue:1

    Topics: Animals; Antioxidants; Calcium; Calpain; Dose-Response Relationship, Drug; Gallic Acid; Hepatic Stel

2014
Gypenosides induce apoptosis by ca2+ overload mediated by endoplasmic-reticulum and store-operated ca2+ channels in human hepatoma cells.
    Cancer biotherapy & radiopharmaceuticals, 2013, Volume: 28, Issue:4

    Topics: Antineoplastic Agents; Apoptosis; Boron Compounds; Calcium; Calcium Channel Blockers; Calcium Channe

2013
Small molecule inhibitors of Clostridium difficile toxin B-induced cellular damage.
    Chemistry & biology, 2015, Feb-19, Volume: 22, Issue:2

    Topics: Animals; Bacterial Proteins; Bacterial Toxins; Biflavonoids; Catechin; Cell Line; Cell Survival; Chl

2015
Gallic acid induces necroptosis via TNF-α signaling pathway in activated hepatic stellate cells.
    PloS one, 2015, Volume: 10, Issue:3

    Topics: Animals; Apoptosis; Blotting, Western; Caspases; Cell Cycle; Cell Proliferation; Cells, Cultured; Ch

2015
Hepatoprotective effect of trimethylgallic acid esters against carbon tetrachloride-induced liver injury in rats.
    Indian journal of experimental biology, 2015, Volume: 53, Issue:12

    Topics: Animals; Anti-Inflammatory Agents; Antioxidants; Biomarkers; Carbon Tetrachloride; Chemical and Drug

2015
Molecular mechanisms of gallic acid-induced growth inhibition, apoptosis, and necrosis in hypertrophic scar fibroblasts.
    Life sciences, 2017, Jun-15, Volume: 179

    Topics: Apoptosis; Calcium; Calpain; Cell Cycle; Cells, Cultured; Cicatrix, Hypertrophic; Dose-Response Rela

2017
Nutraceutical inherent of Spinacia oleracea Linn. methanolic leaf extract ameliorates isoproterenol induced myocardial necrosis in male albino Wistar rats via mitigating inflammation.
    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017, Volume: 85

    Topics: Animals; Anti-Inflammatory Agents; Apoptosis; Cardiomyopathies; Chromatography, High Pressure Liquid

2017
1,2,3,4,6-penta-O-galloyl-beta-D-glucose from Galla Rhois protects primary rat hepatocytes from necrosis and apoptosis.
    Planta medica, 2008, Volume: 74, Issue:11

    Topics: Animals; Aphids; Apoptosis; Cells, Cultured; Gallic Acid; Hepatocytes; Hydrolyzable Tannins; Necrosi

2008
Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1.
    Phytomedicine : international journal of phytotherapy and phytopharmacology, 2009, Volume: 16, Issue:8

    Topics: Acetaminophen; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP2E1 Inhibitors;

2009
Gallic acid inhibits the growth of HeLa cervical cancer cells via apoptosis and/or necrosis.
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2010, Volume: 48, Issue:5

    Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Cell Survival; Drug Screening Assays, Antitumor; E

2010
The polyphenol 3, 4, 5 - tri-hydroxy benzoic acid inhibits indian daboia russelli venom and its hemorrhagic complex induced local toxicity.
    Current topics in medicinal chemistry, 2011, Volume: 11, Issue:20

    Topics: Animals; Antivenins; Circular Dichroism; Daboia; Edema; Erythrocytes; Extracellular Matrix Proteins;

2011
Effect of phenols on natural killer (NK) cell-mediated death in the K562 human leukemic cell line.
    Cell biology international, 2005, Volume: 29, Issue:11

    Topics: Annexin A5; Annexins; Apoptosis; Cell Death; Cell Line, Tumor; Cell Separation; Coculture Techniques

2005
Oxidatively modified proteins and DNA in digestive gland cells of the fresh-water mussel Unio tumidus in the presence of tannic acid and its derivatives.
    Mutation research, 2006, Jan-31, Volume: 603, Issue:1

    Topics: Animals; Apoptosis; Bivalvia; Comet Assay; Cross-Linking Reagents; DNA Damage; Dose-Response Relatio

2006
Study of interactions between phenolic compounds and H2O2 or Cu(II) ions in B14 Chinese hamster cells.
    Cell biology international, 2006, Volume: 30, Issue:10

    Topics: Animals; Antioxidants; Apoptosis; Cell Line; Cell Survival; Copper; Cricetinae; Cricetulus; Dose-Res

2006
Prevention and reduction of neural damage in ischemic strokes by w-(N,N'-diethylamino)-n-alkyl-3,4,5-trimethoxybenzoate compounds.
    The Journal of pharmacology and experimental therapeutics, 1995, Volume: 275, Issue:1

    Topics: Animals; Aorta; Brain Ischemia; Calcium; Calcium Channel Blockers; Cells, Cultured; Cerebral Cortex;

1995
Rumen involvement in sheep tannic acid metabolism.
    Veterinary and human toxicology, 1995, Volume: 37, Issue:5

    Topics: Abomasum; Administration, Oral; Animals; Chromatography, High Pressure Liquid; Ellagic Acid; Gallic

1995
Reduction of neuronal damage in ischemic stroke using a combination therapy of TMB-8 with L-arginine.
    The Kaohsiung journal of medical sciences, 2000, Volume: 16, Issue:4

    Topics: Animals; Arginine; Brain Ischemia; Calcium; Calcium Channel Blockers; Drug Therapy, Combination; Gal

2000