Page last updated: 2024-08-07 15:23:05
Mitogen-activated protein kinase 13
A mitogen-activated protein kinase 13 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15264]
Synonyms
MAP kinase 13;
MAPK 13;
EC 2.7.11.24;
Mitogen-activated protein kinase p38 delta;
MAP kinase p38 delta;
Stress-activated protein kinase 4
Research
Bioassay Publications (57)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (8.77) | 18.2507 |
| 2000's | 35 (61.40) | 29.6817 |
| 2010's | 16 (28.07) | 24.3611 |
| 2020's | 1 (1.75) | 2.80 |
Compounds (98)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1-anilino-8-naphthalenesulfonate | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| kynurenic acid | Homo sapiens (human) | Ki | 1,300.0000 | 1 | 1 |
| pd 153035 | Homo sapiens (human) | IC50 | 6.3000 | 1 | 1 |
| sb 220025 | Homo sapiens (human) | IC50 | 0.0190 | 1 | 1 |
| sb 239063 | Homo sapiens (human) | IC50 | 50.0220 | 2 | 2 |
| sb 202190 | Homo sapiens (human) | IC50 | 0.0800 | 1 | 1 |
| sb 216995 | Homo sapiens (human) | IC50 | 0.0570 | 2 | 2 |
| sk&f 86002 | Homo sapiens (human) | IC50 | 3.8000 | 2 | 3 |
| imatinib | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | IC50 | 0.4137 | 3 | 3 |
| 3,4-dihydro-2(1h)-quinolinone | Homo sapiens (human) | IC50 | 0.0007 | 1 | 1 |
| cephalotaxine | Homo sapiens (human) | IC50 | 0.2000 | 1 | 1 |
| birb 796 | Homo sapiens (human) | IC50 | 0.1057 | 3 | 3 |
| sb 203580 | Homo sapiens (human) | IC50 | 0.2329 | 21 | 22 |
| repsox | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| vx-745 | Homo sapiens (human) | IC50 | 0.0577 | 4 | 4 |
| vx-745 | Homo sapiens (human) | Ki | 0.0008 | 1 | 1 |
| dasatinib | Homo sapiens (human) | IC50 | 0.1000 | 3 | 3 |
| kn 93 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 2-tert-butyl-9-fluoro-3,6-dihydro-7h-benz(h)imidazo(4,5-f)isoquinoline-7-one | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| ml 3403 | Homo sapiens (human) | IC50 | 0.8538 | 5 | 5 |
| a 770041 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| vk 19911 | Homo sapiens (human) | IC50 | 0.1216 | 5 | 5 |
| [4-(2-amino-4-bromoanilino)-2-chlorophenyl]-(2-methylphenyl)methanone | Homo sapiens (human) | IC50 | 0.0260 | 5 | 5 |
| rwj 68354 | Homo sapiens (human) | IC50 | 0.0066 | 2 | 2 |
| sb 210313 | Homo sapiens (human) | IC50 | 0.7100 | 2 | 2 |
| ct52923 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| tak-715 | Homo sapiens (human) | IC50 | 5.1200 | 2 | 2 |
| ly2090314 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| gw 2580 | Homo sapiens (human) | IC50 | 16.0000 | 1 | 1 |
| 4-(3-cyclohexyl-5-(4-fluoro-phenyl)-3h-imidazol-4-yl)pyrimidin-2-ylamine | Homo sapiens (human) | IC50 | 0.0392 | 1 | 1 |
| 2-({2-[(3-hydroxyphenyl)amino]pyrimidin-4-yl}amino)benzamide | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| al8697 | Homo sapiens (human) | IC50 | 0.0062 | 1 | 1 |
| ly3009120 | Homo sapiens (human) | IC50 | 0.0610 | 1 | 1 |
| as1940477 | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| imatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| staurosporine | Homo sapiens (human) | Kd | 0.2400 | 1 | 1 |
| gefitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| lestaurtinib | Homo sapiens (human) | Kd | 3.5000 | 2 | 2 |
| vatalanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| ruboxistaurin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| canertinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| birb 796 | Homo sapiens (human) | EC50 | 0.0180 | 1 | 1 |
| birb 796 | Homo sapiens (human) | Kd | 0.0261 | 2 | 3 |
| sb 203580 | Homo sapiens (human) | EC50 | 0.0600 | 1 | 1 |
| sb 203580 | Homo sapiens (human) | Kd | 5.0050 | 2 | 2 |
| enzastaurin | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| erlotinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| lapatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sorafenib | Homo sapiens (human) | Kd | 6.6000 | 2 | 2 |
| 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea | Homo sapiens (human) | EC50 | 5.9000 | 1 | 1 |
| 1-(3-tert-butyl-1-methylpyrazol-5-yl)-3-(4-chlorophenyl)urea | Homo sapiens (human) | Kd | 0.3500 | 2 | 2 |
| pd 173955 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| s 1033 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bms 387032 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tandutinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| vx-745 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| dasatinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| zd 6474 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| alvocidib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bosutinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 11248 | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| vx680 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| trk 820 | Homo sapiens (human) | EC50 | 0.0052 | 1 | 1 |
| axitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pd 184352 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| vk 19911 | Homo sapiens (human) | Kd | 0.0150 | 1 | 1 |
| bms345541 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| midostaurin | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| ki 20227 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pi103 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| hki 272 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tofacitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| cediranib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| masitinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pazopanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| azd 6244 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| su 14813 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bibw 2992 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| tg100-115 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pha 665752 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| 6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one | Homo sapiens (human) | Kd | 0.6900 | 1 | 1 |
| brivanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| at 7519 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| bi 2536 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| nvp-ast487 | Homo sapiens (human) | Kd | 0.0130 | 1 | 1 |
| kw 2449 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| abt 869 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gw 2580 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| crizotinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| chir-265 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| motesanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| mln8054 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| GDC-0879 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 461364 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| azd 1152-hqpa | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| nvp-tae684 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| fedratinib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk690693 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gdc 0941 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| plx 4720 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| sgx 523 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| quizartinib | Homo sapiens (human) | Kd | 10.0000 | 2 | 2 |
| incb-018424 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 1838705a | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| gsk 1363089 | Homo sapiens (human) | Kd | 0.0540 | 1 | 1 |
| chir 258 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| nintedanib | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| pp242 | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| protein serine/threonine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. [GOC:bf, MetaCyc:PROTEIN-KINASE-RXN, PMID:2956925] |
| MAP kinase activity | molecular function | Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli. [GOC:ma, ISBN:0198547684] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| protein serine kinase activity | molecular function | Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate. [RHEA:17989] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
Involved In
This protein is involved in 12 target(s):
| Target | Category | Definition |
|---|---|---|
| response to osmotic stress | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell. [GOC:jl] |
| peptidyl-serine phosphorylation | biological process | The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037] |
| positive regulation of interleukin-6 production | biological process | Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah] |
| cellular response to UV | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:mah] |
| positive regulation of inflammatory response | biological process | Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| stress-activated MAPK cascade | biological process | A MAPK cascade that starts with the activation of a stress-activated MAP kinase cascade. [GOC:ai, PMID:15936270] |
| cellular response to hydrogen peroxide | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus. [CHEBI:16240, GOC:mah] |
| cellular response to interleukin-1 | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-1 stimulus. [GOC:mah] |
| cellular response to sorbitol | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sorbitol stimulus. [GOC:mah] |
| cellular response to anisomycin | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anisomycin stimulus. [GOC:mah] |
| cellular response to sodium arsenite | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium arsenite stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:18674524] |
| intracellular signal transduction | biological process | The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782] |