Potassium voltage-gated channel subfamily KQT member 2

A voltage-gated potassium channel subunit KCNQ2 that is encoded in the genome of human. []

KQT-like 2;
Neuroblastoma-specific potassium channel subunit alpha KvLQT2;
Voltage-gated potassium channel subunit Kv7.2

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
N-(2-aminoethyl)-5-chloro-1-naphthalenesulfonamide	Homo sapiens (human)	IC50	54,954,100,000.0000	1	1
xe 991, anthracenone	Homo sapiens (human)	IC50	0.0550	1	1
10,10-bis((2-fluoro-4-pyridinyl)methyl)-9(10h)-anthracenone	Homo sapiens (human)	IC50	0.0480	1	1
a 803467	Homo sapiens (human)	IC50	10.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
flupirtine	Homo sapiens (human)	EC50	0.5600	1	1
ezogabine	Homo sapiens (human)	EC50	2.6220	10	10
bms204352	Homo sapiens (human)	EC50	2.4000	1	1
N-(2,4,6-trimethylphenyl)-3-bicyclo[2.2.1]heptanecarboxamide	Homo sapiens (human)	EC50	0.0400	1	1
n-(6-chloropyridin-3-yl)-4-fluorobenzamide	Homo sapiens (human)	EC50	0.9800	1	1
ica 27243	Homo sapiens (human)	EC50	0.4200	2	2
(r)-n-(4-(4-methoxyphenyl)thiazol-2-yl)-1-tosylpiperidine-2-carboxamide	Homo sapiens (human)	EC50	30.0000	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
flupirtine	Homo sapiens (human)	EC2	2.0000	1	1
ezogabine	Homo sapiens (human)	Activity	0.3200	1	1
ezogabine	Homo sapiens (human)	EC2	0.3300	1	1
N-(2,4,6-trimethylphenyl)-3-bicyclo[2.2.1]heptanecarboxamide	Homo sapiens (human)	Activity	0.0400	1	1
ica 27243	Homo sapiens (human)	Activity	0.4600	1	1

This protein enables 4 target(s):

Target	Category	Definition
voltage-gated potassium channel activity	molecular function	Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. [GOC:mtg_transport, ISBN:0815340729]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
calmodulin binding	molecular function	Binding to calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states. [GOC:krc]
ankyrin binding	molecular function	Binding to ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins. [GOC:mah, ISBN:0198506732]

This protein is located in 4 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
node of Ranvier	cellular component	An axon part that is a gap in the myelin where voltage-gated sodium channels cluster and saltatory conduction is executed. [GOC:mh]
axon initial segment	cellular component	Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment. [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

This protein is active in 1 target(s):

Target	Category	Definition
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is part of 1 target(s):

Target	Category	Definition
voltage-gated potassium channel complex	cellular component	A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential. [GOC:mah]

This protein is involved in 4 target(s):

Target	Category	Definition
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
nervous system development	biological process	The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
potassium ion transmembrane transport	biological process	A process in which a potassium ion is transported from one side of a membrane to the other. [GOC:mah]
action potential	biological process	A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities. [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8]