Page last updated: 2024-11-12

dehydroeburicoic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

dehydroeburicoic acid: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID15250826
CHEMBL ID1744446
CHEBI ID80817
SCHEMBL ID18195826
MeSH IDM0543706

Synonyms (17)

Synonym
dehydroeburicoic acid
C16950
dehydroeburicoicacid
chebi:80817 ,
CHEMBL1744446
AC-34636
6879-05-6
dehydrotrametenolicacid
SCHEMBL18195826
AKOS037514512
HY-N2490
Q27149860
(2r)-2-[(3s,5r,10s,13r,14r,17r)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1h-cyclopenta[a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
(2r)-2-[(3s,5r,10s,13r,14r,17r)-3-hydroxy-4,4,10,13,14-pentamethyl-2,3,5,6,12,15,16,17-octahydro-1h-cyclopenta [a]phenanthren-17-yl]-6-methyl-5-methylideneheptanoic acid
CS-0022761
MS-28661
DTXSID501346470

Research Excerpts

Overview

Dehydroeburicoic acid (DeEA) is a triterpene purified from medicinal fungi such as Antrodia camphorate. It is known to exert cytotoxic effects against several types of cancer cells.

ExcerptReferenceRelevance
"Dehydroeburicoic acid (DeEA) is a triterpene purified from medicinal fungi such as Antrodia camphorate, the crude extract of which is known to exert cytotoxic effects against several types of cancer cells. "( Dehydroeburicoic acid induces calcium- and calpain-dependent necrosis in human U87MG glioblastomas.
Chen, SJ; Deng, JY; Hsueh, CW; Jeng, CJ; Jow, GM, 2009
)
3.24
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
bile acidAny member of a group of hydroxy-5beta-cholanic acids occuring in bile, where they are present as the sodium salts of their amides with glycine or taurine. In mammals bile acids almost invariably have 5beta-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (16)

Assay IDTitleYearJournalArticle
AID288566Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 1000 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID1546666Cytotoxicity against human U251 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID1546668Cytotoxicity against human SW480 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID1427863Antiproliferative activity against human CCRF-CEM cells after 72 hrs by MTT assay2016Journal of natural products, 11-23, Volume: 79, Issue:11
Cytotoxic Lanostanoids from Poria cocos.
AID288570Cell viability of Raji cells2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288568Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 100 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID1546669Cytotoxicity against human L02 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID289114Inhibition of fMLP-induced superoxide production in human neutrophils2007Journal of natural products, Jun, Volume: 70, Issue:6
Anti-inflammatory benzenoids from Antrodia camphorata.
AID288569Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 10 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID288567Inhibition of TPA-induced Epstein-Barr virus early antigen activation in Raji cells at 500 mol ratio/32 pmol TPA relative to control2007Journal of natural products, Jun, Volume: 70, Issue:6
Triterpene acids from Poria cocos and their anti-tumor-promoting effects.
AID1546667Cytotoxicity against human MCF7 cells incubated for 24 hrs by MTT assay2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID1427865Antiproliferative activity against human K562 cells after 72 hrs by MTT assay2016Journal of natural products, 11-23, Volume: 79, Issue:11
Cytotoxic Lanostanoids from Poria cocos.
AID1064288Cytotoxicity against human HS68 cells at 25 to 200 uM after 48 hrs by SRB assay2014Journal of natural products, Jan-24, Volume: 77, Issue:1
Antcamphins A-L, ergostanoids from Antrodia camphorata.
AID1427862Antiproliferative activity against human MOLT4 cells after 72 hrs by MTT assay2016Journal of natural products, 11-23, Volume: 79, Issue:11
Cytotoxic Lanostanoids from Poria cocos.
AID1546670Induction of ROS scavenging activity in HUVEC assessed as reduction in high glucose-induced intracellular ROS level at 20 uM incubated for 6 hrs by DCFH-DA/Hoechst 33342 staining based assay relative to control2020Journal of natural products, 01-24, Volume: 83, Issue:1
Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from
AID1427864Antiproliferative activity against human HL60 cells after 72 hrs by MTT assay2016Journal of natural products, 11-23, Volume: 79, Issue:11
Cytotoxic Lanostanoids from Poria cocos.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (18.75)29.6817
2010's10 (62.50)24.3611
2020's3 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 19.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index19.86 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.06 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (19.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]