Proteins > Protein polybromo-1
Page last updated: 2024-08-08 00:01:27

Protein polybromo-1

A protein polybromo-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q86U86]

Synonyms

hPB1;
BRG1-associated factor 180;
BAF180;
Polybromo-1D

Research

Bioassay Publications (7)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's5 (71.43)24.3611
2020's2 (28.57)2.80

Compounds (7)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
lobenzaritHomo sapiens (human)IC50250.000011
i-bet726Homo sapiens (human)IC5016.126922

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
3-acetylindoleHomo sapiens (human)Kd1,195.000011
2,4-Di(3-pyridyl)-1,3-thiazoleHomo sapiens (human)Kd1,387.000011
5-Methyl-6-(2-thienyl)-2,3,4,5-tetrahydropyridazin-3-oneHomo sapiens (human)Kd1,210.000011
luteolinHomo sapiens (human)Kd12.900011
pf-06687252Homo sapiens (human)EC501.000010
pf-06687252Homo sapiens (human)Kd1.011565

Enables

This protein enables 3 target(s):

TargetCategoryDefinition
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nuclear chromosomecellular componentA chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact. [GOC:dph, GOC:mah]
kinetochorecellular componentA multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules. [GOC:elh]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
nuclear matrixcellular componentThe dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089]

Part Of

This protein is part of 3 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
RSC-type complexcellular componentA SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining. [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]
SWI/SNF complexcellular componentA SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof. [GOC:bhm, PMID:12672490]

Involved In

This protein is involved in 13 target(s):

TargetCategoryDefinition
mitotic cell cyclebiological processProgression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
chromatin remodelingbiological processA dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
regulation of transcription by RNA polymerase IIbiological processAny process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
negative regulation of cell population proliferationbiological processAny process that stops, prevents or reduces the rate or extent of cell proliferation. [GOC:go_curators]
regulation of mitotic metaphase/anaphase transitionbiological processAny process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin. [GOC:mah]
positive regulation of T cell differentiationbiological processAny process that activates or increases the frequency, rate or extent of T cell differentiation. [GOC:go_curators]
positive regulation of cell differentiationbiological processAny process that activates or increases the frequency, rate or extent of cell differentiation. [GOC:go_curators]
positive regulation of myoblast differentiationbiological processAny process that activates or increases the frequency, rate or extent of myoblast differentiation. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers. [CL:0000056, GOC:go_curators, GOC:mtg_muscle]
regulation of G0 to G1 transitionbiological processA cell cycle process that modulates the rate or extent of the transition from the G0 quiescent state to the G1 phase. [GOC:mah]
regulation of G1/S transition of mitotic cell cyclebiological processAny signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle. [GOC:mtg_cell_cycle]
positive regulation of double-strand break repairbiological processAny process that activates or increases the frequency, rate or extent of double-strand break repair. [GOC:BHF]
regulation of nucleotide-excision repairbiological processAny process that modulates the frequency, rate or extent of nucleotide-excision repair. [GOC:jp, PMID:18836076]
transcription elongation by RNA polymerase IIbiological processThe extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II. [GOC:mah, GOC:txnOH]