A protein-S-isoprenylcysteine O-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:O60725]
EC 2.1.1.100;
Isoprenylcysteine carboxylmethyltransferase;
Prenylated protein carboxyl methyltransferase;
PPMT;
Prenylcysteine carboxyl methyltransferase;
pcCMT
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (16.67) | 29.6817 |
| 2010's | 5 (83.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| s-trans,trans-farnesylthiosalicylic acid | Homo sapiens (human) | IC50 | 25.5000 | 1 | 1 |
| cysmethynil | Homo sapiens (human) | IC50 | 2.0579 | 5 | 5 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| protein C-terminal carboxyl O-methyltransferase activity | molecular function | Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein. [PMID:8428937] |
| protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity | molecular function | Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester. [EC:2.1.1.100] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum | cellular component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| C-terminal protein methylation | biological process | The methylation of the C-terminal amino acid of a protein. [GOC:ai] |
| protein targeting to membrane | biological process | The process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:curators] |
| protein modification process | biological process | The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). [GOC:bf, GOC:jl] |
| S-adenosylhomocysteine metabolic process | biological process | The chemical reactions and pathways involving S-adenosylhomocysteine; the L-enantiomer is formed from S-adenosylmethionine and is a strong inhibitor of S-adenosylmethionine-mediated methylation reactions. It can be cleaved to form adenosine and homocysteine. [ISBN:0198506732] |
| S-adenosylmethioninamine metabolic process | biological process | The chemical reactions and pathways involving S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt. [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] |