Cysteinyl leukotriene receptor 1

A cysteinyl leukotriene receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9Y271]

Synonyms

CysLTR1;
Cysteinyl leukotriene D4 receptor;
LTD4 receptor;
G-protein coupled receptor HG55;
HMTMF81

Research

Bioassay Publications (16)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (43.75)	18.2507
2000's	0 (0.00)	29.6817
2010's	8 (50.00)	24.3611
2020's	1 (6.25)	2.80

Compounds (28)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
clotrimazole	Homo sapiens (human)	IC50	33.1720	1	0
clotrimazole	Homo sapiens (human)	Ki	16.5860	1	0
ly 171883	Homo sapiens (human)	Ki	0.6000	1	1
ono 1078	Homo sapiens (human)	IC50	0.0030	5	5
pf 5901	Homo sapiens (human)	IC50	1.1000	2	2
pf 5901	Homo sapiens (human)	Ki	0.7000	1	1
ici 204,219	Homo sapiens (human)	IC50	0.0039	5	4
ici 204,219	Homo sapiens (human)	Ki	0.0006	2	1
ablukast	Homo sapiens (human)	IC50	4.0000	1	1
zileuton	Homo sapiens (human)	IC50	0.4200	1	1
wy 48252	Homo sapiens (human)	Ki	0.0350	1	1
pobilukast	Homo sapiens (human)	Ki	0.0050	1	1
fpl 55712	Homo sapiens (human)	IC50	2.2550	2	2
l 648051	Homo sapiens (human)	Ki	6.2000	1	1
sr 2640	Homo sapiens (human)	IC50	0.0230	1	1
rg 12525	Homo sapiens (human)	Ki	0.0030	1	1
diethylstilbestrol	Homo sapiens (human)	IC50	17.7450	1	0
diethylstilbestrol	Homo sapiens (human)	Ki	8.8720	1	0
leukotriene d4	Homo sapiens (human)	IC50	0.0038	2	2
leukotriene d4	Homo sapiens (human)	Ki	0.0004	2	2
montelukast	Homo sapiens (human)	IC50	0.0015	4	3
montelukast	Homo sapiens (human)	Ki	0.0011	1	0
l 735821	Homo sapiens (human)	IC50	1.5000	1	1
bay u9773	Homo sapiens (human)	IC50	0.4400	1	1
l 365260	Homo sapiens (human)	IC50	5.0000	1	1
sulindac sulfide	Homo sapiens (human)	IC50	29.3680	1	0
sulindac sulfide	Homo sapiens (human)	Ki	14.6840	1	0
gw 1929	Homo sapiens (human)	IC50	10.9100	1	0
gw 1929	Homo sapiens (human)	Ki	5.4550	1	0
cp 105696	Homo sapiens (human)	IC50	0.0084	1	1
l 365260	Homo sapiens (human)	IC50	10.0000	1	1
mk 0571	Homo sapiens (human)	Ki	0.0002	1	1
montelukast sodium	Homo sapiens (human)	IC50	0.1562	2	2
3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acid	Homo sapiens (human)	IC50	2.5000	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ici 204,219	Homo sapiens (human)	Kd	0.0000	1	1
leukotriene c4	Homo sapiens (human)	EC50	0.0430	1	1
leukotriene d4	Homo sapiens (human)	EC50	0.0009	1	1
leukotriene e4	Homo sapiens (human)	EC50	0.1040	1	1
montelukast	Homo sapiens (human)	EC50	0.0720	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
leukotriene receptor activity	molecular function	Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]
cysteinyl leukotriene receptor activity	molecular function	Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732]
G protein-coupled peptide receptor activity	molecular function	Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 14 target(s):

Target	Category	Definition
inflammatory response to antigenic stimulus	biological process	An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes. [GOC:add, ISBN:0781735149]
calcium ion transport	biological process	The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai]
chemotaxis	biological process	The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [ISBN:0198506732]
defense response	biological process	Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack. [GOC:go_curators]
cell surface receptor signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
positive regulation of cytosolic calcium ion concentration	biological process	Any process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
respiratory gaseous exchange by respiratory system	biological process	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. [ISBN:0198506732]
positive regulation of angiogenesis	biological process	Any process that activates or increases angiogenesis. [GOC:go_curators]
positive regulation of vasoconstriction	biological process	Any process that activates or increases the frequency, rate or extent of vasoconstriction. [GOC:go_curators]
establishment of localization in cell	biological process	Any process, occuring in a cell, that localizes a substance or cellular component. This may occur via movement, tethering or selective degradation. [GOC:ai, GOC:dos, GOC:dph, GOC:tb]
positive regulation of glial cell proliferation	biological process	Any process that activates or increases the rate or extent of glial cell proliferation. [GOC:dph, GOC:sl, GOC:tb]
leukotriene signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, PMID:21771892]
cellular response to hypoxia	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. [GOC:mah]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]

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