An epoxide hydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07099]
EC 3.3.2.9;
Epoxide hydratase;
Microsomal epoxide hydrolase;
mEH
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 1 (33.33) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| dodecylamine | Homo sapiens (human) | IC50 | 12.9000 | 1 | 1 |
| 1,3-diphenyl-2-aminopropane | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| ketoconazole | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| 3-oxetanone | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| epoxide hydrolase activity | molecular function | Catalysis of the reaction: an epoxide + H2O = an ethanediol. [EC:3.3.2.10] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| oxysterol binding | molecular function | Binding to oxysterol, an oxidized form of cholesterol. [GOC:curators] |
| cis-stilbene-oxide hydrolase activity | molecular function | Catalysis of the reaction: cis-stilbene oxide + H2O = (+)-(1R,2R)-1,2-diphenylethane-1,2-diol. [EC:3.3.2.9] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| response to toxic substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus. [GOC:lr] |
| response to organic cyclic compound | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism. [ISBN:0198547684] |
| epoxide metabolic process | biological process | The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers. [GOC:rs, PMID:15822179] |