5-hydroxytryptamine receptor 1B

A 5-hydroxytryptamine receptor 1B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P28222]

Synonyms

5-HT-1B;
5-HT1B;
S12;
Serotonin 1D beta receptor;
5-HT-1D-beta;
Serotonin receptor 1B

Research

Bioassay Publications (72)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (1.39)	18.7374
1990's	22 (30.56)	18.2507
2000's	33 (45.83)	29.6817
2010's	11 (15.28)	24.3611
2020's	5 (6.94)	2.80

Compounds (66)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptamine	Homo sapiens (human)	Ki	0.0360	1	1
8-hydroxy-2-(di-n-propylamino)tetralin	Homo sapiens (human)	Ki	0.5985	2	2
1-(1-naphthyl)piperazine	Homo sapiens (human)	Ki	0.0104	2	2
5-(nonyloxy)tryptamine	Homo sapiens (human)	Ki	0.0012	1	1
5-carboxamidotryptamine	Homo sapiens (human)	Ki	0.0013	1	1
methylbufotenin	Homo sapiens (human)	IC50	0.5500	1	1
5-methoxytryptamine	Homo sapiens (human)	Ki	0.0035	1	1
alpha-methylserotonin	Homo sapiens (human)	Ki	0.2500	1	1
ketanserin	Homo sapiens (human)	IC50	8.2500	2	2
naratriptan	Homo sapiens (human)	Ki	0.0033	1	1
oxymetazoline	Homo sapiens (human)	Ki	0.0003	1	1
4-iodoclonidine	Homo sapiens (human)	Ki	1.9800	1	1
pindolol	Homo sapiens (human)	Ki	6.3000	1	2
prazosin	Homo sapiens (human)	Ki	7.7000	1	1
propranolol	Homo sapiens (human)	IC50	5.0119	1	1
propranolol	Homo sapiens (human)	Ki	10.0000	1	1
rizatriptan	Homo sapiens (human)	IC50	0.0410	1	1
rizatriptan	Homo sapiens (human)	Ki	0.0101	1	1
sumatriptan	Homo sapiens (human)	IC50	0.0131	7	7
sumatriptan	Homo sapiens (human)	Ki	0.0188	13	13
tolazoline	Homo sapiens (human)	Ki	10.0000	2	2
n-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-n-(2-pyridinyl)cyclohexanecarboxamide	Homo sapiens (human)	Ki	0.0240	1	1
xylometazoline	Homo sapiens (human)	Ki	0.0135	2	2
ergotamine	Homo sapiens (human)	Ki	0.0027	2	3
indopan	Homo sapiens (human)	Ki	0.5301	1	2
sertindole	Homo sapiens (human)	Ki	0.0560	1	1
zolmitriptan	Homo sapiens (human)	IC50	0.0062	1	1
zolmitriptan	Homo sapiens (human)	Ki	0.0042	1	1
frovatriptan	Homo sapiens (human)	Ki	0.0103	1	1
xylonidine	Homo sapiens (human)	Ki	30.0000	1	1
gr 127935	Homo sapiens (human)	Ki	0.0018	3	3
pramipexole	Homo sapiens (human)	Ki	3.5080	1	1
gr 55562	Homo sapiens (human)	Ki	0.0130	2	2
cp 122288	Homo sapiens (human)	IC50	0.0144	1	1
harmalan	Homo sapiens (human)	Ki	10.0000	1	1
8-(di-n-propylamino)-6,7,8,9-tetrahydro-3h-benz(e)indole-1-carbaldehyde	Homo sapiens (human)	Ki	0.3640	1	1
nantenine, (+-)-isomer	Homo sapiens (human)	Ki	0.1000	2	2
rs 127445	Homo sapiens (human)	Ki	0.0003	1	1
1-methyl-6-methoxy-dihydro-beta-carboline	Homo sapiens (human)	Ki	10.0000	1	1
sb-224289	Homo sapiens (human)	Ki	0.0082	2	2
harmine	Homo sapiens (human)	Ki	10.0000	1	1
ly 344864	Homo sapiens (human)	Ki	0.5000	1	1
l 745870	Homo sapiens (human)	Ki	10.0000	1	1
ly 334370	Homo sapiens (human)	Ki	0.1877	3	3
sb 258719	Homo sapiens (human)	Ki	5.0119	1	1
sb 271046	Homo sapiens (human)	Ki	0.7943	1	1
gr 46611	Homo sapiens (human)	Ki	0.0002	1	1
1-(3-(5-(1,2,4-triazol-4-yl)-1h-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	Homo sapiens (human)	IC50	0.0735	4	4
sb 269970	Homo sapiens (human)	Ki	5.5000	2	2
ms-245	Homo sapiens (human)	Ki	5.7050	2	2
n-(2,5-dibromo-3-fluorophenyl)-4-methoxy-3-piperazin-1-ylbenzenesulfonamide	Homo sapiens (human)	Ki	3.9811	1	1
l 772405	Homo sapiens (human)	IC50	0.1675	2	2
sb258741	Homo sapiens (human)	Ki	1.5849	1	1
5-chloro-2,3-dihydro-6-(4-methylpiperazin-1-yl)-1-(4-(pyridin-4-yl)naphth-1-ylaminocarbonyl)-1h-indole	Homo sapiens (human)	Ki	0.0060	2	2
pnu 109291	Homo sapiens (human)	Ki	5.7750	1	1
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chloride	Homo sapiens (human)	Ki	1.0000	1	1
sb-656104-a	Homo sapiens (human)	Ki	0.6310	1	1
5-chloro-2-methyl-3-(1,2,3,6-tetrahydro-4-pyridinyl)-1h-indole	Homo sapiens (human)	IC50	0.1100	1	1
sb-649915	Homo sapiens (human)	Ki	0.0100	5	5
sb 328437	Homo sapiens (human)	IC50	0.0070	1	1
naphyrone	Homo sapiens (human)	IC50	10.0000	1	1
col-144	Homo sapiens (human)	Ki	0.5910	1	1
a 803467	Homo sapiens (human)	IC50	10.0000	1	1
sp 203	Homo sapiens (human)	Ki	10.0000	1	1
n,n-diallyl-5-methoxytryptamine	Homo sapiens (human)	Ki	0.3330	2	3

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
8-hydroxy-2-(di-n-propylamino)tetralin	Homo sapiens (human)	EC50	0.2600	1	1
1-(1-naphthyl)piperazine	Homo sapiens (human)	EC50	5.5000	2	2
methylbufotenin	Homo sapiens (human)	Kd	0.0794	1	1
propranolol	Homo sapiens (human)	EC50	5.0119	1	1
sumatriptan	Homo sapiens (human)	EC50	0.0576	2	2
zolmitriptan	Homo sapiens (human)	EC50	0.0157	1	1
eletriptan	Homo sapiens (human)	EC50	0.0116	1	1
1-(3-(5-(1,2,4-triazol-4-yl)-1h-indol-3-yl)propyl)-4-(2-(3-fluorophenyl)ethyl)piperazine	Homo sapiens (human)	EC50	0.4300	1	1
vilazodone	Homo sapiens (human)	EC50	30.0000	1	1
methylhistaprodifen	Homo sapiens (human)	Kd	8.1283	1	1
histaprodifen	Homo sapiens (human)	Kd	14.1254	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
metergoline	Homo sapiens (human)	Activity	0.0280	1	1
sb 269970	Homo sapiens (human)	Kb	0.0010	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
G protein-coupled serotonin receptor activity	molecular function	Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates. [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
serotonin binding	molecular function	Binding to serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties. [GOC:ai]
voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levels	molecular function	Regulation of presynaptic cytosolic calcium ion concentrations via the action of voltage-gated calcium ion channels. [GOC:dos, PMID:15548655]
neurotransmitter receptor activity	molecular function	Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
presynaptic membrane	cellular component	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
calyx of Held	cellular component	The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system. [NIF_Subcellular:sao1684283879, PMID:11823805]
serotonergic synapse	cellular component	A synapse that uses serotonin as a neurotransmitter. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
G protein-coupled serotonin receptor complex	cellular component	A protein complex that is capable of G protein-coupled serotonin receptor activity. [GO_REF:0000088, GOC:bhm, GOC:TermGenie]

Involved In

This protein is involved in 25 target(s):

Target	Category	Definition
G protein-coupled receptor internalization	biological process	The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle. [PMID:8396717]
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
adenylate cyclase-inhibiting serotonin receptor signaling pathway	biological process	An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by serotonin binding to its receptor, and ending with the regulation of a downstream cellular process. [GOC:dph, GOC:mah, GOC:signaling, GOC:tb]
protein kinase C-activating G protein-coupled receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG). [GOC:mah, GOC:signaling]
negative regulation of gamma-aminobutyric acid secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid. [GOC:ef]
regulation of dopamine secretion	biological process	Any process that modulates the frequency, rate or extent of the regulated release of dopamine. [GOC:ef]
negative regulation of serotonin secretion	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin. [GOC:ef]
negative regulation of synaptic transmission, GABAergic	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA). [GOC:mah]
response to cocaine	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl]
vasoconstriction	biological process	A decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. [GOC:pr, ISBN:0192800752]
drinking behavior	biological process	The specific behavior of an organism relating to the intake of liquids, especially water. [GOC:curators, GOC:pr]
response to ethanol	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethanol stimulus. [GOC:go_curators]
bone remodeling	biological process	The continuous turnover of bone matrix and mineral that involves first, an increase in resorption (osteoclastic activity) and later, reactive bone formation (osteoblastic activity). The process of bone remodeling takes place in the adult skeleton at discrete foci. The process ensures the mechanical integrity of the skeleton throughout life and plays an important role in calcium homeostasis. An imbalance in the regulation of bone resorption and bone formation results in many of the metabolic bone diseases, such as osteoporosis. [GOC:curators]
regulation of behavior	biological process	Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli. [GOC:go_curators, GOC:pr]
response to mineralocorticoid	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mineralocorticoid stimulus. Mineralocorticoids are hormonal C21 corticosteroids synthesized from cholesterol and characterized by their similarity to aldosterone. Mineralocorticoids act primarily on water and electrolyte balance. [GOC:ai, PMID:9884123]
negative regulation of synaptic transmission, glutamatergic	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of glutamatergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter glutamate. [GOC:ai]
cellular response to alkaloid	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active. [GOC:mah]
cellular response to xenobiotic stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:krc, GOC:mah]
cellular response to temperature stimulus	biological process	Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus. [GOC:mah]
presynaptic modulation of chemical synaptic transmission	biological process	Any process, acting in the presynapse that results in modulation of chemical synaptic transmission. [GOC:dos]
regulation of presynaptic cytosolic calcium ion concentration	biological process	Any process that regulates the concentration of calcium in the presynaptic cytosol. [GOC:dos]
positive regulation of vascular associated smooth muscle cell proliferation	biological process	Any process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
regulation of synaptic vesicle exocytosis	biological process	Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis. [GOC:obol]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	biological process	A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194]