Thyroid hormone receptor alpha

A thyroid hormone receptor alpha that is encoded in the genome of human. [PRO:HJD, UniProtKB:P10827]

Synonyms

Nuclear receptor subfamily 1 group A member 1;
V-erbA-related protein 7;
EAR-7;
c-erbA-1;
c-erbA-alpha

Research

Bioassay Publications (29)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (3.45)	18.2507
2000's	18 (62.07)	29.6817
2010's	7 (24.14)	24.3611
2020's	3 (10.34)	2.80

Compounds (17)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
amiodarone	Homo sapiens (human)	IC50	0.6500	1	1
3,3',5-triiodothyroacetic acid	Homo sapiens (human)	IC50	0.0001	3	3
3,3',5-triiodothyropropionic acid	Homo sapiens (human)	IC50	0.0000	3	3
triiodothyronine	Homo sapiens (human)	IC50	0.0006	7	8
triiodothyronine	Homo sapiens (human)	Ki	0.0013	4	4
mifepristone	Homo sapiens (human)	Ki	1.2500	1	1
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	IC50	100.0000	1	1
gc 1 compound	Homo sapiens (human)	Ki	0.0011	1	1
kb 141	Homo sapiens (human)	IC50	0.0224	8	9
kb 141	Homo sapiens (human)	Ki	0.0074	3	3
kb 130015	Homo sapiens (human)	IC50	3.7333	3	3
cgs 23425	Homo sapiens (human)	Ki	0.0005	1	1
3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid	Homo sapiens (human)	IC50	0.0012	6	7
kb 2115	Homo sapiens (human)	Ki	0.0096	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
thyroxine	Homo sapiens (human)	EC50	0.0190	1	1
triiodothyronine	Homo sapiens (human)	EC50	0.0069	13	15
triiodothyronine	Homo sapiens (human)	Kd	0.0001	6	8
tetraiodothyroacetic acid	Homo sapiens (human)	EC50	0.0200	1	1
3,5-dimethyl-3'-isopropyl-l-thyronine	Homo sapiens (human)	Kd	0.0093	2	3
pregna-4,17-diene-3,16-dione	Homo sapiens (human)	EC50	100.0000	1	1
gc 1 compound	Homo sapiens (human)	EC50	0.0240	2	2
gc 1 compound	Homo sapiens (human)	Kd	0.0011	4	5
kb 141	Homo sapiens (human)	EC50	0.0068	3	3
3,5-dibromo-4-(4-hydroxy-3-isopropylphenoxy)phenylacetic acid	Homo sapiens (human)	EC50	0.0004	1	1
fg-4592	Homo sapiens (human)	EC50	0.0327	1	1
mgl-3196	Homo sapiens (human)	EC50	3.2375	2	2

Enables

This protein enables 12 target(s):

Target	Category	Definition
transcription cis-regulatory region binding	molecular function	Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH]
DNA-binding transcription factor activity, RNA polymerase II-specific	molecular function	A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018]
DNA-binding transcription factor activity	molecular function	A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. [GOC:txnOH-2018]
nuclear receptor activity	molecular function	A DNA-binding transcription factor activity regulated by binding to a ligand that modulates the transcription of specific gene sets transcribed by RNA polymerase II. Nuclear receptor ligands are usually lipid-based (such as a steroid hormone) and the binding of the ligand to its receptor often occurs in the cytosol, which leads to its translocation to the nucleus. [GOC:txnOH-2018, PMID:23457262]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
zinc ion binding	molecular function	Binding to a zinc ion (Zn). [GOC:ai]
TBP-class protein binding	molecular function	Binding to a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs). [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
chromatin DNA binding	molecular function	Binding to DNA that is assembled into chromatin. [GOC:mah]
thyroid hormone binding	molecular function	Binding to thyroxine (T4) or triiodothyronine (T3), tyrosine-based hormones produced by the thyroid gland. [GOC:rph]
general transcription initiation factor binding	molecular function	Binding to a general transcription initiation factor, a protein that contributes to transcription start site selection and transcription initiation. [GOC:txnOH-2018]
RNA polymerase II cis-regulatory region sequence-specific DNA binding	molecular function	Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018]

Located In

This protein is located in 3 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
RNA polymerase II transcription regulator complex	cellular component	A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II. [GOC:tb]

Involved In

This protein is involved in 25 target(s):

Target	Category	Definition
cartilage condensation	biological process	The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes. [ISBN:0878932437]
ossification	biological process	The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance. [GOC:mtg_mpo, PMID:17572649]
regulation of thyroid hormone mediated signaling pathway	biological process	Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway. [GOC:hjd]
regulation of transcription by RNA polymerase II	biological process	Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
transcription by RNA polymerase II	biological process	The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs). [GOC:jl, GOC:txnOH, ISBN:0321000382]
learning or memory	biological process	The acquisition and processing of information and/or the storage and retrieval of this information over time. [GOC:jid, PMID:8938125]
regulation of heart contraction	biological process	Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body. [GOC:dph, GOC:go_curators, GOC:tb]
female courtship behavior	biological process	The behavior of a female, for the purpose of attracting a sexual partner. [GOC:bf, GOC:pr]
response to cold	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr]
hormone-mediated signaling pathway	biological process	The series of molecular signals mediated by the detection of a hormone. [GOC:sm]
negative regulation of RNA polymerase II transcription preinitiation complex assembly	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly. [GOC:go_curators]
erythrocyte differentiation	biological process	The process in which a myeloid precursor cell acquires specializes features of an erythrocyte. [GOC:mah]
thyroid gland development	biological process	The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone. [GOC:dgh]
regulation of myeloid cell apoptotic process	biological process	Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process. [GOC:add, GOC:mtg_apoptosis]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
positive regulation of female receptivity	biological process	Any process that activates or increases the receptiveness of a female to male advances. [GOC:go_curators]
regulation of lipid catabolic process	biological process	Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]
type I pneumocyte differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a type I pneumocyte. A type I pneumocyte is a flattened cell with greatly attenuated cytoplasm and a paucity of organelles. [GOC:dph, GOC:mtg_lung, ISBN:0721662544]
positive regulation of cold-induced thermogenesis	biological process	Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809]
negative regulation of DNA-templated transcription initiation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation. [GOC:mah, GOC:txnOH]
thyroid hormone mediated signaling pathway	biological process	The series of molecular signals mediated by the detection of a thyroid hormone. [GOC:hjd]
negative regulation of transcription by RNA polymerase II	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
positive regulation of transcription by RNA polymerase II	biological process	Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH]
retinoic acid receptor signaling pathway	biological process	The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands. [GOC:dgh]

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