Proteins > Matrix metalloproteinase-9
Page last updated: 2024-08-07 15:59:27

Matrix metalloproteinase-9

A matrix metalloproteinase-9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P14780]

Synonyms

MMP-9;
EC 3.4.24.35;
92 kDa gelatinase;
92 kDa type IV collagenase;
Gelatinase B;
GELB

Research

Bioassay Publications (91)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (8.79)18.2507
2000's44 (48.35)29.6817
2010's32 (35.16)24.3611
2020's7 (7.69)2.80

Compounds (66)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
catecholHomo sapiens (human)IC5023.367010
busulfanHomo sapiens (human)IC505.215010
econazoleHomo sapiens (human)IC506.997010
way 151693Homo sapiens (human)IC500.005757
nafamostatHomo sapiens (human)IC50420.000011
prazosinHomo sapiens (human)IC506.963010
secobarbitalHomo sapiens (human)IC502.643010
clodronic acidHomo sapiens (human)IC50320.000011
tiludronic acidHomo sapiens (human)IC50100.000011
5,5'-methylenedisalicylic acidHomo sapiens (human)IC5043.400011
zoledronic acidHomo sapiens (human)IC5052.000011
piloty's acidHomo sapiens (human)Ki56.3100310
aminoquinurideHomo sapiens (human)IC50100.000011
marimastatHomo sapiens (human)IC501.08181010
marimastatHomo sapiens (human)Ki0.007733
n-(2-isobutyl-3-(n'-hydroxycarbonylamido)propanoyl)-o-methyltyrosinemethylamideHomo sapiens (human)Ki0.001011
ilomastatHomo sapiens (human)IC500.00341212
ilomastatHomo sapiens (human)Ki0.000422
procyanidin C1Homo sapiens (human)IC5053.200011
3-((benzyl)(methylaminocarbonyl)methylaminocarbonyl)n-hydroxy-5-methylhexanamideHomo sapiens (human)IC500.000411
2-(4-aminophenyl)benzothiazoleHomo sapiens (human)IC5079.000011
taxifolinHomo sapiens (human)IC5032.020011
cgs 27023aHomo sapiens (human)IC500.019157
cgs 27023aHomo sapiens (human)Ki0.021125
prinomastatHomo sapiens (human)IC500.000766
isoliquiritigeninHomo sapiens (human)IC500.010011
2-[(4-phenylphenyl)sulfonylamino]pentanedioic acidHomo sapiens (human)IC5014.000011
caffeic acidHomo sapiens (human)IC500.015622
rs-130830Homo sapiens (human)IC500.046368
rs-130830Homo sapiens (human)Ki0.091449
quercetinHomo sapiens (human)IC500.891922
luteolinHomo sapiens (human)IC505.620011
pulmicortHomo sapiens (human)IC501.989010
amentoflavoneHomo sapiens (human)IC502.580011
mangiferinHomo sapiens (human)IC500.250011
robustaflavoneHomo sapiens (human)IC5011.850011
tmi-1Homo sapiens (human)IC500.013016
benzyloxycarbonyl-phe-ala-fluormethylketoneHomo sapiens (human)IC50100.000011
bilobetinHomo sapiens (human)IC5010.330011
batimastatHomo sapiens (human)IC500.006644
isoacteosideHomo sapiens (human)IC5014.280011
Methyl rosmarinateHomo sapiens (human)IC500.610011
ik 682Homo sapiens (human)IC5010.340011
ik 682Homo sapiens (human)Ki10.340022
bay 12-9566Homo sapiens (human)IC500.301011
bay 12-9566Homo sapiens (human)Ki0.301011
chlorhexidineHomo sapiens (human)IC507.630011
(11c)cgs 25966Homo sapiens (human)IC500.008011
(11c)cgs 25966Homo sapiens (human)Ki0.024655
bb-78485Homo sapiens (human)IC500.097211
ro 32-3555Homo sapiens (human)IC500.030435
ro 32-3555Homo sapiens (human)Ki0.029822
ro 28-2653Homo sapiens (human)IC500.007011
abt-770Homo sapiens (human)IC500.120033
sb 3ct compoundHomo sapiens (human)Ki0.533366
pd 166793Homo sapiens (human)IC507.921622
sc 78080Homo sapiens (human)IC500.000222
ro 31-9790Homo sapiens (human)IC500.012022
ro 31-9790Homo sapiens (human)Ki0.002011
n-((2s)-2-mercapto-1-oxo-4-(3,4,4- trimethyl-2,5-dioxo-1-imidazolidinyl)butyl)-l-leucyl-n,3- dimethyl-l-valinamideHomo sapiens (human)IC500.025011
arp-100Homo sapiens (human)IC500.200066
kb r8301Homo sapiens (human)IC500.000311
s 3304Homo sapiens (human)IC500.016322
N(2)-([biphenyl]-4-ylsulfonyl)-N-hydroxy-N(2)-isopropoxy-D-valinamideHomo sapiens (human)IC500.006733
bms-566394Homo sapiens (human)Ki6.064022
ks370gHomo sapiens (human)IC500.007311
incb3619Homo sapiens (human)IC500.366022
tosedostatHomo sapiens (human)IC501.500011
grassystatin aHomo sapiens (human)IC505.000011
minocyclineHomo sapiens (human)IC50180.000011
dacarbazineHomo sapiens (human)IC500.556010
2-[(4-chlorophenyl)methylthio]-1,5,6,7-tetrahydrocyclopenta[d]pyrimidin-4-oneHomo sapiens (human)IC50100.000011
2-[(4-methoxyphenyl)methylthio]-6-methyl-1H-pyrimidin-4-oneHomo sapiens (human)IC50100.000011
hydrazinocurcuminHomo sapiens (human)IC5019.400011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
amentoflavoneHomo sapiens (human)Kd2.180011
MMP-9-IN-1Homo sapiens (human)Kd2.100011

Enables

This protein enables 9 target(s):

TargetCategoryDefinition
endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]
metalloendopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE, https://www.ebi.ac.uk/merops/about/glossary.shtml#ENDOPEPTIDASE]
serine-type endopeptidase activitymolecular functionCatalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
collagen bindingmolecular functionBinding to collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%). [GOC:ai, ISBN:0198506732]
peptidase activitymolecular functionCatalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181]
metallopeptidase activitymolecular functionCatalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
zinc ion bindingmolecular functionBinding to a zinc ion (Zn). [GOC:ai]
identical protein bindingmolecular functionBinding to an identical protein or proteins. [GOC:jl]

Located In

This protein is located in 6 target(s):

TargetCategoryDefinition
extracellular regioncellular componentThe space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]
collagen-containing extracellular matrixcellular componentAn extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]
extracellular exosomecellular componentA vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
tertiary granule lumencellular componentAny membrane-enclosed lumen that is part of a tertiary granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]
ficolin-1-rich granule lumencellular componentAny membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
extracellular spacecellular componentThat part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 30 target(s):

TargetCategoryDefinition
skeletal system developmentbiological processThe process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb]
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
proteolysisbiological processThe hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
apoptotic processbiological processA programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died. [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263]
embryo implantationbiological processAttachment of the blastocyst to the uterine lining. [GOC:isa_complete, http://www.medterms.com]
cell migrationbiological processThe controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, Wikipedia:Cell_migration]
extracellular matrix disassemblybiological processA process that results in the breakdown of the extracellular matrix. [GOC:jid]
macrophage differentiationbiological processThe process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage. [GOC:add, ISBN:0781735149]
collagen catabolic processbiological processThe proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells. [GOC:mah, ISBN:0815316194]
cellular response to reactive oxygen speciesbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals. [GOC:mah]
endodermal cell differentiationbiological processThe process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo. [CL:0000223, GOC:yaf, PMID:17624332]
positive regulation of apoptotic processbiological processAny process that activates or increases the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of DNA bindingbiological processAny process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb]
positive regulation of epidermal growth factor receptor signaling pathwaybiological processAny process that activates or increases the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity. [GOC:go_curators]
ephrin receptor signaling pathwaybiological processThe series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
positive regulation of keratinocyte migrationbiological processAny process that activates or increases the frequency, rate or extent of keratinocyte migration. [GOC:ai]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
cellular response to cadmium ionbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus. [GOC:mah]
cellular response to UV-Abiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-A radiation stimulus. UV-A radiation (UV-A light) spans the wavelengths 315 to 400 nm. [GOC:mah]
positive regulation of release of cytochrome c from mitochondriabiological processAny process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation. [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:tb]
regulation of neuroinflammatory responsebiological processAny process that modulates the frequency, rate or extent of neuroinflammatory response. [GOC:aruk, GOC:bc, PMID:10981966, PMID:11099416, PMID:18164423]
positive regulation of receptor bindingbiological processAny process that activates or increases the frequency, rate or extent of a protein or other molecule binding to a receptor. [GOC:signaling, GOC:TermGenie]
response to amyloid-betabiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824]
positive regulation of vascular associated smooth muscle cell proliferationbiological processAny process that activates or increases the frequency, rate or extent of vascular smooth muscle cell proliferation. [GO_REF:0000058, GOC:TermGenie, PMID:23246467]
negative regulation of epithelial cell differentiation involved in kidney developmentbiological processAny process that stops, prevents or reduces the frequency, rate or extent of epithelial cell differentiation involved in kidney development. [GOC:mtg_kidney_jan10, GOC:yaf]
negative regulation of intrinsic apoptotic signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of intrinsic apoptotic signaling pathway. [GOC:mtg_apoptosis]
negative regulation of cation channel activitybiological processAny process that stops, prevents or reduces the frequency, rate or extent of cation channel activity. [GOC:BHF]
negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of cysteine-type endopeptidase activity involved in apoptotic signaling pathway. [GOC:mtg_apoptosis]
extracellular matrix organizationbiological processA process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix. [GOC:mah]
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