Histamine N-methyltransferase

A histamine N-methyltransferase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P50135]

HMT;
EC 2.1.1.8

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
s-adenosylhomocysteine	Homo sapiens (human)	Ki	14.3000	1	2
amodiaquine hydrochloride	Homo sapiens (human)	Ki	0.0190	1	1

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	Activity	0.0100	1	1
diphenhydramine	Homo sapiens (human)	Activity	0.0100	1	1
metoprine	Homo sapiens (human)	Activity	0.0100	1	1
amodiaquine hydrochloride	Homo sapiens (human)	Activity	0.0100	1	1

This protein enables 1 target(s):

Target	Category	Definition
histamine N-methyltransferase activity	molecular function	Catalysis of the reaction: S-adenosyl-L-methionine(1+) + histamine = N(tau)-methylhistamine + S-adenosyl-L-homocysteine + H+. [EC:2.1.1.8, RHEA:19301]

This protein is located in 5 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
centrosome	cellular component	A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 5 target(s):

Target	Category	Definition
histamine metabolic process	biological process	The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]
histamine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. [GOC:jl, ISBN:0395825172]
histidine catabolic process	biological process	The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid. [GOC:go_curators]
respiratory gaseous exchange by respiratory system	biological process	The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms. [ISBN:0198506732]
methylation	biological process	The process in which a methyl group is covalently attached to a molecule. [GOC:mah]