An alpha-ketoglutarate-dependent dioxygenase FTO that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9C0B1]
Fat mass and obesity-associated protein;
U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO;
1.14.11.-;
U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO;
1.14.11.-;
mRNA (2'-O-methyladenosine-N(6)-)-demethylase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| citric acid, anhydrous | Homo sapiens (human) | IC50 | 300.0000 | 1 | 1 |
| malic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| pyruvic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| 2,4-pyridinedicarboxylic acid | Homo sapiens (human) | IC50 | 8.3000 | 1 | 1 |
| d-glutamate | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| d-lactic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| d-2-hydroxyglutarate | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| alpha-hydroxyglutarate, (l)-isomer | Homo sapiens (human) | IC50 | 320.0000 | 1 | 1 |
| fumaric acid | Homo sapiens (human) | IC50 | 150.0000 | 1 | 1 |
| 5-carboxy-8-hydroxyquinoline | Homo sapiens (human) | IC50 | 3.3000 | 1 | 1 |
| aconitic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
| oxalylglycine | Homo sapiens (human) | IC50 | 44.0000 | 1 | 1 |
| entacapone | Homo sapiens (human) | IC50 | 3.0000 | 1 | 0 |
| fg-4592 | Homo sapiens (human) | IC50 | 9.8000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| ferrous iron binding | molecular function | Binding to a ferrous iron ion, Fe(II). [GOC:ai] |
| transferase activity | molecular function | Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. [ISBN:0198506732] |
| oxidative RNA demethylase activity | molecular function | Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms. [PMID:12594517, PMID:16482161, PMID:18775698] |
| broad specificity oxidative DNA demethylase activity | molecular function | Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O2 = a nucleobase within DNA + formaldehyde + succinate + CO2. Catalyzes oxidative demethylation of the DNA base lesions N1- methyladenine, N3-methylcytosine, N1-methylguanine, and N3- methylthymine. Can also act of RNA. [PMID:12594517, PMID:16482161, PMID:18775698, PMID:19786499, RHEA:30299] |
| mRNA N6-methyladenosine dioxygenase activity | molecular function | Catalysis of the oxidative demethylation of N6-methyladenosine RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N6-methyladenosine as formaldehyde. [PMID:22002720, PMID:26458103] |
| tRNA demethylase activity | molecular function | Catalysis of the removal of a methyl group from one or more positions within a tRNA molecule. [PMID:27745969] |
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| nuclear speck | cellular component | A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy. [http://www.cellnucleus.com/] |
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is involved in 11 target(s):
| Target | Category | Definition |
|---|---|---|
| temperature homeostasis | biological process | A homeostatic process in which an organism modulates its internal body temperature. [GOC:jl] |
| DNA alkylation repair | biological process | The repair of alkylation damage in DNA, e.g. the removal of a non-physiological alkyl group from a nucleobase. This is usually mediated by DNA alkyltransferases. [PMID:10946226, PMID:35543797] |
| regulation of lipid storage | biological process | Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development. [GOC:BHF, GOC:dph, GOC:tb] |
| snRNA processing | biological process | Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule. The primary function of snRNAs is processing pre-messenger RNA in the nucleus. They have also been shown to aid in the regulation of transcription factors (7SK RNA) or RNA polymerase II (B2 RNA), and maintaining the telomeres. [PMID:15196465, PMID:31815536] |
| regulation of multicellular organism growth | biological process | Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size. [GOC:dph, GOC:ems, GOC:tb] |
| RNA repair | biological process | Any process that results in the repair of damaged RNA. [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692] |
| regulation of respiratory system process | biological process | Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system. [GOC:jl] |
| adipose tissue development | biological process | The process whose specific outcome is the progression of adipose tissue over time, from its formation to the mature structure. Adipose tissue is specialized tissue that is used to store fat. [GOC:dph] |
| mRNA destabilization | biological process | Any process that decreases the stability of an mRNA molecule, making it more vulnerable to degradative processes. Messenger RNA is the intermediate molecule between DNA and protein. It includes UTR and coding sequences. It does not contain introns. [GOC:dph, GOC:jh] |
| regulation of white fat cell proliferation | biological process | Any process that modulates the frequency, rate or extent of white fat cell proliferation. [GOC:mah, GOC:sl] |
| regulation of brown fat cell differentiation | biological process | Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [GOC:tb] |