Tyrosine-protein kinase Blk

A tyrosine-protein kinase BLK that is encoded in the genome of human. [PRO:DNx, UniProtKB:P51451]

Synonyms

EC 2.7.10.2;
B lymphocyte kinase;
p55-Blk

Research

Bioassay Publications (25)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (28.00)	29.6817
2010's	14 (56.00)	24.3611
2020's	4 (16.00)	2.80

Compounds (84)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
pd168393	Homo sapiens (human)	IC50	7.7350	2	2
imatinib	Homo sapiens (human)	GI50	7.0500	2	2
staurosporine	Homo sapiens (human)	IC50	0.0011	2	2
canertinib	Homo sapiens (human)	IC50	0.0395	2	2
birb 796	Homo sapiens (human)	IC50	15.5000	2	2
s 1033	Homo sapiens (human)	GI50	1.3000	1	1
dasatinib	Homo sapiens (human)	GI50	0.0050	1	1
sulfuretin	Homo sapiens (human)	IC50	2.8800	1	1
a 419259	Homo sapiens (human)	IC50	0.2080	1	2
tofacitinib	Homo sapiens (human)	IC50	0.0815	1	8
amg 458	Homo sapiens (human)	IC50	0.5190	1	1
bms 777607	Homo sapiens (human)	IC50	0.5000	1	1
pci 32765	Homo sapiens (human)	IC50	0.0004	7	7
acp-196	Homo sapiens (human)	IC50	1.0000	1	1
bmx-in-1	Homo sapiens (human)	IC50	0.3770	1	1
9-(1-methyl-4-pyrazolyl)-1-[1-(1-oxoprop-2-enyl)-2,3-dihydroindol-6-yl]-2-benzo[h][1,6]naphthyridinone	Homo sapiens (human)	IC50	0.3660	1	1

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
sb 202190	Homo sapiens (human)	Kd	10.0000	1	1
imatinib	Homo sapiens (human)	Kd	0.5200	2	2
staurosporine	Homo sapiens (human)	Kd	0.0150	2	2
gefitinib	Homo sapiens (human)	Kd	1.2000	2	2
lestaurtinib	Homo sapiens (human)	Kd	0.1600	2	2
vatalanib	Homo sapiens (human)	Kd	10.0000	2	2
ruboxistaurin	Homo sapiens (human)	Kd	10.0000	2	2
canertinib	Homo sapiens (human)	Kd	0.0450	2	2
birb 796	Homo sapiens (human)	Kd	0.6800	2	2
cyc 202	Homo sapiens (human)	Kd	10.0000	1	1
sb 203580	Homo sapiens (human)	Kd	10.0000	2	2
enzastaurin	Homo sapiens (human)	Kd	10.0000	1	1
erlotinib	Homo sapiens (human)	Kd	0.1900	2	2
lapatinib	Homo sapiens (human)	Kd	10.0000	2	2
sorafenib	Homo sapiens (human)	Kd	10.0000	3	3
pd 173955	Homo sapiens (human)	Kd	0.0015	1	1
s 1033	Homo sapiens (human)	Kd	0.5000	1	1
bms 387032	Homo sapiens (human)	Kd	10.0000	2	2
tandutinib	Homo sapiens (human)	Kd	10.0000	3	3
vx-745	Homo sapiens (human)	Kd	3.1000	2	2
dasatinib	Homo sapiens (human)	Kd	0.0002	2	2
zd 6474	Homo sapiens (human)	Kd	0.0660	2	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1h-imidazol-2-yl)benzamide	Homo sapiens (human)	Kd	10.0000	1	1
alvocidib	Homo sapiens (human)	Kd	10.0000	2	2
bosutinib	Homo sapiens (human)	Kd	0.0033	1	1
su 11248	Homo sapiens (human)	Kd	0.0650	3	3
jnj-7706621	Homo sapiens (human)	Kd	10.0000	1	1
vx680	Homo sapiens (human)	Kd	2.2000	2	2
ekb 569	Homo sapiens (human)	Kd	0.0780	1	1
axitinib	Homo sapiens (human)	Kd	3.1000	1	1
pd 184352	Homo sapiens (human)	Kd	10.0000	1	1
bms345541	Homo sapiens (human)	Kd	10.0000	1	1
midostaurin	Homo sapiens (human)	Kd	0.5000	3	3
ki 20227	Homo sapiens (human)	Kd	0.1200	1	1
cp 724714	Homo sapiens (human)	Kd	10.0000	1	1
pi103	Homo sapiens (human)	Kd	10.0000	2	2
hki 272	Homo sapiens (human)	Kd	0.0850	1	1
tofacitinib	Homo sapiens (human)	Kd	10.0000	2	2
n-(6-chloro-7-methoxy-9h-beta-carbolin-8-yl)-2-methylnicotinamide	Homo sapiens (human)	Kd	10.0000	1	1
cediranib	Homo sapiens (human)	Kd	0.1200	1	1
masitinib	Homo sapiens (human)	Kd	0.1500	1	1
pazopanib	Homo sapiens (human)	Kd	2.6000	2	2
azd 6244	Homo sapiens (human)	Kd	10.0000	1	1
su 14813	Homo sapiens (human)	Kd	0.7500	2	2
bibw 2992	Homo sapiens (human)	Kd	0.2200	1	1
tg100-115	Homo sapiens (human)	Kd	10.0000	1	1
pha 665752	Homo sapiens (human)	Kd	1.9000	1	1
6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)-4-pyrimidinyl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one	Homo sapiens (human)	Kd	0.0250	1	1
brivanib	Homo sapiens (human)	Kd	2.0000	1	1
at 7519	Homo sapiens (human)	Kd	10.0000	1	1
bi 2536	Homo sapiens (human)	Kd	10.0000	1	1
nvp-ast487	Homo sapiens (human)	Kd	0.0300	2	2
kw 2449	Homo sapiens (human)	Kd	3.5000	1	1
abt 869	Homo sapiens (human)	Kd	10.0000	2	2
gw 2580	Homo sapiens (human)	Kd	10.0000	2	2
crizotinib	Homo sapiens (human)	Kd	0.1100	1	1
chir-265	Homo sapiens (human)	Kd	8.9500	2	2
motesanib	Homo sapiens (human)	Kd	2.2000	2	2
mln8054	Homo sapiens (human)	Kd	0.0680	3	3
GDC-0879	Homo sapiens (human)	Kd	10.0000	1	1
gsk 461364	Homo sapiens (human)	Kd	10.0000	1	1
azd 1152-hqpa	Homo sapiens (human)	Kd	1.5000	2	2
nvp-tae684	Homo sapiens (human)	Kd	0.1300	1	1
fedratinib	Homo sapiens (human)	Kd	0.6500	1	1
gsk690693	Homo sapiens (human)	Kd	10.0000	1	1
gdc 0941	Homo sapiens (human)	Kd	10.0000	1	1
plx 4720	Homo sapiens (human)	Kd	1.1000	1	1
sgx 523	Homo sapiens (human)	Kd	10.0000	1	1
pci 32765	Homo sapiens (human)	Kd	0.0006	1	1
quizartinib	Homo sapiens (human)	Kd	10.0000	2	2
incb-018424	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1838705a	Homo sapiens (human)	Kd	10.0000	1	1
gsk 1363089	Homo sapiens (human)	Kd	0.0054	1	1
acp-196	Homo sapiens (human)	Kd	0.0180	1	1
chir 258	Homo sapiens (human)	Kd	0.1900	2	2
nintedanib	Homo sapiens (human)	Kd	0.3800	1	1
pp242	Homo sapiens (human)	Kd	0.2400	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
protein tyrosine kinase activity	molecular function	Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate. [RHEA:10596]
non-membrane spanning protein tyrosine kinase activity	molecular function	Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein. [EC:2.7.10.2]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
peptidyl-tyrosine phosphorylation	biological process	The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine. [RESID:AA0039]
positive regulation of insulin secretion	biological process	Any process that activates or increases the frequency, rate or extent of the regulated release of insulin. [GOC:mah]
positive regulation of protein binding	biological process	Any process that activates or increases the frequency, rate or extent of protein binding. [GOC:mah]
intracellular signal transduction	biological process	The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell. [GOC:bf, GOC:jl, GOC:signaling, ISBN:3527303782]
B cell receptor signaling pathway	biological process	The series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell. [GOC:add]
innate immune response	biological process	Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu]
protein phosphorylation	biological process	The process of introducing a phosphate group on to a protein. [GOC:hb]
cell differentiation	biological process	The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state. [ISBN:0198506732]
cell surface receptor protein tyrosine kinase signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb, GOC:signaling]

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