Proteins > Polyunsaturated fatty acid 5-lipoxygenase
Page last updated: 2024-08-07 15:49:58
Polyunsaturated fatty acid 5-lipoxygenase
A polyunsaturated fatty acid 5-lipoxygenase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P09917]
Synonyms
EC 1.13.11.-;
Arachidonate 5-lipoxygenase;
5-LO;
5-lipoxygenase;
1.13.11.34
Research
Bioassay Publications (144)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 7 (4.86) | 18.7374 |
| 1990's | 25 (17.36) | 18.2507 |
| 2000's | 28 (19.44) | 29.6817 |
| 2010's | 73 (50.69) | 24.3611 |
| 2020's | 11 (7.64) | 2.80 |
Compounds (161)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aa 861 | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| acetazolamide | Homo sapiens (human) | Ki | 0.0025 | 1 | 1 |
| anthralin | Homo sapiens (human) | IC50 | 7.0000 | 1 | 1 |
| celecoxib | Homo sapiens (human) | IC50 | 4.2950 | 2 | 2 |
| chloroxine | Homo sapiens (human) | IC50 | 3.6000 | 1 | 1 |
| embelin | Homo sapiens (human) | IC50 | 1.2240 | 5 | 5 |
| 2,5-dihydroxybenzoic acid | Homo sapiens (human) | IC50 | 75.0000 | 1 | 1 |
| hexylresorcinol | Homo sapiens (human) | IC50 | 3.7000 | 2 | 2 |
| idebenone | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| indirubin-3'-monoxime | Homo sapiens (human) | IC50 | 11.4333 | 3 | 3 |
| ketotifen | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ly 171883 | Homo sapiens (human) | IC50 | 18.9000 | 1 | 1 |
| meclofenamic acid(1-) | Homo sapiens (human) | IC50 | 5.6400 | 1 | 1 |
| masoprocol | Homo sapiens (human) | IC50 | 3.1839 | 12 | 12 |
| n-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| pd 158780 | Homo sapiens (human) | IC50 | 0.0150 | 1 | 1 |
| pf 5901 | Homo sapiens (human) | IC50 | 1.6500 | 2 | 2 |
| rofecoxib | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| triclosan | Homo sapiens (human) | IC50 | 0.5850 | 2 | 2 |
| zonisamide | Homo sapiens (human) | Ki | 0.1170 | 1 | 1 |
| thymidine | Homo sapiens (human) | Ki | 27.0000 | 1 | 1 |
| cycloheximide | Homo sapiens (human) | Ki | 24.2000 | 1 | 2 |
| phenidone | Homo sapiens (human) | IC50 | 5.2500 | 2 | 2 |
| 1,3-ditolylguanidine | Homo sapiens (human) | Ki | 0.0890 | 1 | 2 |
| glycyrrhetinic acid | Homo sapiens (human) | IC50 | 24.8000 | 1 | 1 |
| osthol | Homo sapiens (human) | IC50 | 36.2000 | 1 | 1 |
| allyl sulfide | Homo sapiens (human) | IC50 | 83.0000 | 1 | 1 |
| bw-755c | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| zileuton | Homo sapiens (human) | IC50 | 4.4044 | 74 | 75 |
| tebufelone | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| mk 0591 | Homo sapiens (human) | IC50 | 5.0003 | 6 | 6 |
| 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| ursolic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| medicagenic acid | Homo sapiens (human) | IC50 | 30.4000 | 1 | 1 |
| dioxadrol | Homo sapiens (human) | Ki | 0.0350 | 1 | 2 |
| isoscopoletin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| prifelone | Homo sapiens (human) | IC50 | 12.4000 | 2 | 2 |
| ubenimex | Homo sapiens (human) | Ki | 0.0103 | 2 | 2 |
| honokiol | Homo sapiens (human) | IC50 | 4.2000 | 1 | 1 |
| puupehenone | Homo sapiens (human) | IC50 | 0.6800 | 1 | 1 |
| beta-amyrin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| alpha-amyrin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| hederagenin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| tryptanthrine | Homo sapiens (human) | IC50 | 133.3833 | 3 | 3 |
| arjunolic acid | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| maslinic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| 3,4-dihydroxyphenylethanol | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| primin | Homo sapiens (human) | IC50 | 1.3700 | 1 | 1 |
| uvaol | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| 8-mercaptoquinoline | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| rapanone | Homo sapiens (human) | IC50 | 2.4733 | 3 | 3 |
| erythrodiol | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| fulvestrant | Homo sapiens (human) | Ki | 0.0024 | 2 | 4 |
| ici 164384 | Homo sapiens (human) | Ki | 0.0046 | 1 | 1 |
| asiatic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| pd 142893 | Homo sapiens (human) | IC50 | 4.4000 | 1 | 2 |
| benzyl 2-naphthyl ether | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| bay x 1005 | Homo sapiens (human) | IC50 | 0.0600 | 1 | 1 |
| tetrahydrocurcumin | Homo sapiens (human) | IC50 | 3.2000 | 1 | 1 |
| l 656224 | Homo sapiens (human) | IC50 | 0.2055 | 2 | 2 |
| rg 6866 | Homo sapiens (human) | IC50 | 0.2500 | 2 | 2 |
| bwa 137c | Homo sapiens (human) | IC50 | 0.7700 | 1 | 1 |
| eth 615 | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
| ici d2138 | Homo sapiens (human) | IC50 | 0.3300 | 1 | 1 |
| zm 230487 | Homo sapiens (human) | IC50 | 0.0800 | 3 | 3 |
| ml-3000 | Homo sapiens (human) | IC50 | 0.3017 | 6 | 6 |
| 3',4'-dihydroxyflavone | Homo sapiens (human) | IC50 | 1.7000 | 1 | 1 |
| perifosine | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| 4-methoxyhonokiol | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| moracin c | Homo sapiens (human) | IC50 | 2.3500 | 1 | 1 |
| atractylenolide iii | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| n-benzyl-n-hydroxy-5-phenylpentamide | Homo sapiens (human) | IC50 | 0.1500 | 1 | 1 |
| acrovestone | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| ici 211965 | Homo sapiens (human) | IC50 | 0.1250 | 2 | 2 |
| boswellic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| miconidin | Homo sapiens (human) | IC50 | 0.9400 | 1 | 1 |
| 5-o-methylembelin | Homo sapiens (human) | IC50 | 1.9267 | 3 | 3 |
| elarofiban | Homo sapiens (human) | IC50 | 0.0001 | 1 | 1 |
| amastatin | Homo sapiens (human) | Ki | 0.0300 | 1 | 1 |
| alpha bitter acid | Homo sapiens (human) | IC50 | 9.6500 | 2 | 2 |
| e 3040 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| phenylalanine arginine beta-naphthylamide | Homo sapiens (human) | IC50 | 730.0000 | 1 | 2 |
| resveratrol | Homo sapiens (human) | IC50 | 4.9000 | 1 | 1 |
| diethylstilbestrol | Homo sapiens (human) | Ki | 0.0001 | 1 | 1 |
| 6-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 2.0333 | 6 | 6 |
| 8-prenylnaringenin | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| boswellic acid | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| cinnamaldehyde | Homo sapiens (human) | IC50 | 35.0000 | 1 | 1 |
| piperine | Homo sapiens (human) | IC50 | 54.0000 | 1 | 1 |
| propolin c | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| xanthohumol | Homo sapiens (human) | IC50 | 2.5000 | 2 | 2 |
| 3,3',4,5'-tetrahydroxystilbene | Homo sapiens (human) | IC50 | 0.6700 | 2 | 2 |
| caffeic acid | Homo sapiens (human) | IC50 | 15.0500 | 4 | 4 |
| 2-methoxy-6-[[(1-methyl-2-benzimidazolyl)amino]methyl]phenol | Homo sapiens (human) | IC50 | 7.6000 | 1 | 1 |
| 4-(4-(4-chloro-phenyl)thiazol-2-ylamino)phenol | Homo sapiens (human) | IC50 | 0.2550 | 3 | 3 |
| curcumin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| capsaicin | Homo sapiens (human) | IC50 | 56.0000 | 1 | 1 |
| tamoxifen | Homo sapiens (human) | Ki | 0.0844 | 2 | 2 |
| atractylon | Homo sapiens (human) | IC50 | 25.1000 | 1 | 1 |
| via 2291 | Homo sapiens (human) | IC50 | 0.0900 | 1 | 1 |
| l 663536 | Homo sapiens (human) | IC50 | 0.4900 | 7 | 7 |
| 1-phenyl-2-[[4-(trifluoromethyl)phenyl]methylthio]imidazole | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 3-hydroxy-2-methyl-4h-pyran-4-thione | Homo sapiens (human) | IC50 | 11.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 6.9580 | 5 | 5 |
| leukotriene a4 | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 1.6000 | 1 | 1 |
| scopoletin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 15-keto-5,8,11,13-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 5-hydroxy-6,8,11,14-eicosatetraenoic acid | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 2.7000 | 1 | 1 |
| baicalein | Homo sapiens (human) | IC50 | 50.4250 | 1 | 2 |
| morusin | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| trans-2,3',4,5'-tetrahydroxystilbene | Homo sapiens (human) | IC50 | 18.4900 | 1 | 1 |
| pterostilbene | Homo sapiens (human) | IC50 | 4.5867 | 3 | 3 |
| caffeic acid phenethyl ester | Homo sapiens (human) | IC50 | 0.9700 | 1 | 1 |
| shogaol | Homo sapiens (human) | IC50 | 7.4000 | 1 | 1 |
| wedelolactone | Homo sapiens (human) | IC50 | 2.5000 | 1 | 1 |
| topiramate | Homo sapiens (human) | Ki | 0.0009 | 1 | 1 |
| 6,7,4'-trihydroxyisoflavone | Homo sapiens (human) | IC50 | 70.0000 | 1 | 2 |
| atractylenolide i | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| 3',4',7-trihydroxyflavone | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| 4,3',5'-tri-o-methylpiceatannol | Homo sapiens (human) | IC50 | 5.4850 | 2 | 2 |
| 3,4',5-trimethoxystilbene | Homo sapiens (human) | IC50 | 2.1900 | 2 | 2 |
| 4',7,8-trihydroxyisoflavone | Homo sapiens (human) | IC50 | 0.9000 | 1 | 1 |
| eupomatenoid 6 | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| al 3264 | Homo sapiens (human) | IC50 | 4.8600 | 1 | 1 |
| bwa 4c | Homo sapiens (human) | IC50 | 0.1976 | 34 | 34 |
| kme 4 | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| enofelast | Homo sapiens (human) | IC50 | 0.1200 | 1 | 1 |
| 13-oxo-9,11-octadecadienoic acid | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| hylin | Homo sapiens (human) | IC50 | 3.0000 | 2 | 2 |
| corosolic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| 11-keto-boswellic acid | Homo sapiens (human) | IC50 | 15.6500 | 2 | 2 |
| em 800 | Homo sapiens (human) | Ki | 0.0047 | 1 | 1 |
| 3'-hydroxypterostilbene | Homo sapiens (human) | IC50 | 0.1850 | 2 | 2 |
| jaspaquinol | Homo sapiens (human) | IC50 | 0.4500 | 1 | 1 |
| xanthohumol c | Homo sapiens (human) | IC50 | 10.0000 | 2 | 2 |
| trans-delta-tocotrienoloic acid | Homo sapiens (human) | IC50 | 0.2030 | 4 | 4 |
| myxochelin b | Homo sapiens (human) | IC50 | 1.4000 | 1 | 1 |
| conocarpan | Homo sapiens (human) | IC50 | 18.4000 | 1 | 1 |
| acetyl-11-ketoboswellic acid | Homo sapiens (human) | IC50 | 19.1500 | 2 | 2 |
| 3-o-acetyl-beta-boswellic acid | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| 11-deoxy glycyrrhetinic acid | Homo sapiens (human) | IC50 | 42.0000 | 1 | 1 |
| atractylenolide ii | Homo sapiens (human) | IC50 | 200.0000 | 1 | 1 |
| myxochelin a | Homo sapiens (human) | IC50 | 1.8075 | 2 | 2 |
| ys 121 | Homo sapiens (human) | IC50 | 4.5400 | 5 | 5 |
| N-[(5-bromo-8-hydroxy-7-quinolinyl)-thiophen-2-ylmethyl]acetamide | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| myrtucommulone a | Homo sapiens (human) | IC50 | 6.2500 | 4 | 4 |
| ML355 | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| 7-bromoindirubin-3'-oxime | Homo sapiens (human) | IC50 | 3.7000 | 3 | 3 |
| isaindigotone | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| hydrazinocurcumin | Homo sapiens (human) | IC50 | 0.1618 | 5 | 5 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| bw-755c | Homo sapiens (human) | EC50 | 6.8000 | 1 | 1 |
| tepoxalin | Homo sapiens (human) | EC50 | 0.0700 | 1 | 1 |
| zileuton | Homo sapiens (human) | EC50 | 0.4700 | 1 | 1 |
| pd 156707 | Homo sapiens (human) | Kd | 0.0251 | 1 | 1 |
| ys 121 | Homo sapiens (human) | EC50 | 4.1000 | 1 | 1 |
Drugs with Other Measurements
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Bioassay-guided identification of an anti-inflammatory prenylated acylphloroglucinol from Melicope ptelefolia and molecular insights into its interaction with 5-lipoxygenase.Bioorganic & medicinal chemistry, , Nov-01, Volume: 19, Issue:21, 2011
Design, synthesis and biological evaluation of benzo[1.3.2]dithiazolium ylide 1,1-dioxide derivatives as potential dual cyclooxygenase-2/5-lipoxygenase inhibitors.Bioorganic & medicinal chemistry, , Nov-01, Volume: 19, Issue:21, 2011
Design, synthesis, and biological evaluation of prenylated chalcones as 5-LOX inhibitors.Bioorganic & medicinal chemistry, , Aug-15, Volume: 18, Issue:16, 2010
Using enzyme assays to evaluate the structure and bioactivity of sponge-derived meroterpenes.Journal of natural products, , Volume: 72, Issue:10, 2009
Characterization of novel furan compounds on the basis of their radical scavenging activity and cytoprotective effects against glutamate- and lipopolysaccharide-induced insults.Bioorganic & medicinal chemistry, , Dec-15, Volume: 16, Issue:24, 2008
Synthesis and biological evaluation of 1-(benzenesulfonamido)-2-[5-(N-hydroxypyridin-2(1H)-one)]acetylene regioisomers: a novel class of 5-lipoxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Jul-15, Volume: 18, Issue:14, 2008
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.Journal of natural products, , Volume: 70, Issue:5, 2007
5-Lipoxygenase and cyclooxygenase-1 inhibitory active compounds from Atractylodes lancea.Journal of natural products, , Volume: 61, Issue:3, 1998
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Indole naphthyridinones as inhibitors of bacterial enoyl-ACP reductases FabI and FabK.Journal of medicinal chemistry, , Apr-24, Volume: 46, Issue:9, 2003
1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI).Bioorganic & medicinal chemistry letters, , Aug-20, Volume: 11, Issue:16, 2001
A facile synthesis of 1-ethoxy-4-cyano-5-ethoxycarbonyl-3H-azuleno[1,2-c]pyran-3-one, a selective 15-lipoxygenase inhibitor.Bioorganic & medicinal chemistry letters, , Jan-05, Volume: 14, Issue:1, 2004
5-Lipoxygenase inhibitors: synthesis and structure-activity relationships of a series of 1-aryl-2H,4H-tetrahydro-1,2,4-triazin-3-ones.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Synthesis and structure-activity relationships of a novel class of 5-lipoxygenase inhibitors. 2-(Phenylmethyl)-4-hydroxy-3,5-dialkylbenzofurans: the development of L-656,224.Journal of medicinal chemistry, , Volume: 32, Issue:6, 1989
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Structure-Activity Relationship Studies of New Sinapic Acid Phenethyl Ester Analogues Targeting the Biosynthesis of 5-Lipoxygenase Products: The Role of Phenolic Moiety, Ester Function, and Bioisosterism.Journal of natural products, , 01-28, Volume: 85, Issue:1, 2022
Tuning melatonin receptor subtype selectivity in oxadiazolone-based analogues: Discovery of QR2 ligands and NRF2 activators with neurogenic properties.European journal of medicinal chemistry, , Mar-15, Volume: 190, 2020
Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents.European journal of medicinal chemistry, , Jan-15, Volume: 186, 2020
Synthesis, inhibitory activity and in silico docking of dual COX/5-LOX inhibitors with quinone and resorcinol core.European journal of medicinal chemistry, , Oct-15, Volume: 204, 2020
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Immobilized Metal Affinity Chromatography as a Drug Discovery Platform for Metalloenzyme Inhibitors.Journal of medicinal chemistry, , 10-22, Volume: 63, Issue:20, 2020
Chalcone-Thiazole Hybrids: Rational Design, Synthesis, and Lead Identification against 5-Lipoxygenase.ACS medicinal chemistry letters, , Oct-10, Volume: 10, Issue:10, 2019
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.Journal of natural products, , 12-27, Volume: 82, Issue:12, 2019
Myxochelin- and Pseudochelin-Derived Lipoxygenase Inhibitors from a Genetically Engineered Journal of natural products, , 09-27, Volume: 82, Issue:9, 2019
Discovery of a novel 2,5-dihydroxycinnamic acid-based 5-lipoxygenase inhibitor that induces apoptosis and may impair autophagic flux in RCC4 renal cancer cells.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.Bioorganic & medicinal chemistry, , 02-15, Volume: 27, Issue:4, 2019
Role of sulphur-heterocycles in medicinal chemistry: An update.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Prenylated Stilbenoids Affect Inflammation by Inhibiting the NF-κB/AP-1 Signaling Pathway and Cyclooxygenases and Lipoxygenase.Journal of natural products, , 07-26, Volume: 82, Issue:7, 2019
Design, synthesis and identification of novel substituted 2-amino thiazole analogues as potential anti-inflammatory agents targeting 5-lipoxygenase.European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Neurogenic and neuroprotective donepezil-flavonoid hybrids with sigma-1 affinity and inhibition of key enzymes in Alzheimer's disease.European journal of medicinal chemistry, , Aug-05, Volume: 156, 2018
Evaluation of Dual 5-Lipoxygenase/Microsomal Prostaglandin E2 Synthase-1 Inhibitory Effect of Natural and Synthetic Acronychia-Type Isoprenylated Acetophenones.Journal of natural products, , 03-24, Volume: 80, Issue:3, 2017
[no title available]Journal of natural products, , 03-24, Volume: 80, Issue:3, 2017
Recent synthetic and medicinal perspectives of tryptanthrin.Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
Anti-inflammatory Activity of Natural Geranylated Flavonoids: Cyclooxygenase and Lipoxygenase Inhibitory Properties and Proteomic Analysis.Journal of natural products, , 04-28, Volume: 80, Issue:4, 2017
4,5-Diarylisoxazol-3-carboxylic acids: A new class of leukotriene biosynthesis inhibitors potentially targeting 5-lipoxygenase-activating protein (FLAP).European journal of medicinal chemistry, , May-04, Volume: 113, 2016
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Novel series of benzoquinones with high potency against 5-lipoxygenase in human polymorphonuclear leukocytes.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Benzo[d]isothiazole 1,1-dioxide derivatives as dual functional inhibitors of 5-lipoxygenase and microsomal prostaglandin E(2) synthase-1.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 24, Issue:12, 2014
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
Development of 3,5-dinitrobenzoate-based 5-lipoxygenase inhibitors.Bioorganic & medicinal chemistry, , Apr-15, Volume: 22, Issue:8, 2014
One-step semisynthesis of oleacein and the determination as a 5-lipoxygenase inhibitor.Journal of natural products, , Mar-28, Volume: 77, Issue:3, 2014
Further studies on ethyl 5-hydroxy-indole-3-carboxylate scaffold: design, synthesis and evaluation of 2-phenylthiomethyl-indole derivatives as efficient inhibitors of human 5-lipoxygenase.European journal of medicinal chemistry, , Jun-23, Volume: 81, 2014
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
Identification of 1, 4-Dihydrothieno [3', 2':5, 6]thiopyrano[4, 3-c] pyrazole derivatives as human 5-Lipo-oxygenase inhibitors.Chemical biology & drug design, , Volume: 84, Issue:6, 2014
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.European journal of medicinal chemistry, , Volume: 67, 2013
Investigating the selectivity of metalloenzyme inhibitors.Journal of medicinal chemistry, , Oct-24, Volume: 56, Issue:20, 2013
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.Chemical biology & drug design, , Volume: 80, Issue:1, 2012
Anacardic acid derived salicylates are inhibitors or activators of lipoxygenases.Bioorganic & medicinal chemistry, , Aug-15, Volume: 20, Issue:16, 2012
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 22, Issue:5, 2012
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.Journal of medicinal chemistry, , Mar-22, Volume: 55, Issue:6, 2012
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 20, Issue:11, 2012
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.Journal of natural products, , Aug-26, Volume: 74, Issue:8, 2011
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.Bioorganic & medicinal chemistry, , Apr-01, Volume: 18, Issue:7, 2010
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Structural optimization and biological evaluation of 2-substituted 5-hydroxyindole-3-carboxylates as potent inhibitors of human 5-lipoxygenase.Journal of medicinal chemistry, , Jun-11, Volume: 52, Issue:11, 2009
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
5-Lipoxygenase inhibition by N-hydroxycarbamates in dual-function compounds.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 15, Issue:4, 2005
Synthesis and activity of a new methoxytetrahydropyran derivative as dual cyclooxygenase-2/5-lipoxygenase inhibitor.Bioorganic & medicinal chemistry letters, , Mar-11, Volume: 12, Issue:5, 2002
Heteroarylmethoxyphenylalkoxyiminoalkylcarboxylic acids as leukotriene biosynthesis inhibitors.Journal of medicinal chemistry, , Feb-24, Volume: 43, Issue:4, 2000
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.Journal of medicinal chemistry, , Aug-29, Volume: 40, Issue:18, 1997
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Synthesis, structure-activity relationships, and pharmacological evaluation of pyrrolo[3,2,1-ij]quinoline derivatives: potent histamine and platelet activating factor antagonism and 5-lipoxygenase inhibitory properties. Potential therapeutic application iJournal of medicinal chemistry, , Feb-17, Volume: 38, Issue:4, 1995
Derivatives of 2-[[N-(Aminocarbonyl)-N-hydroxyamino]methyl]-1,4- benzodioxan as orally active 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Jan-06, Volume: 38, Issue:1, 1995
Thiopyrano[2,3,4-cd]indoles as 5-lipoxygenase inhibitors: synthesis, biological profile, and resolution of 2-[2-[1-(4-chlorobenzyl)-4-methyl-6-[(5-phenylpyridin-2-yl)methoxy]-4,5 -dihydro-1H-thiopyrano[2,3,4-cd]indol-2-yl]ethoxy]butanoic acid.Journal of medicinal chemistry, , Apr-15, Volume: 37, Issue:8, 1994
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Substituted chromenes as potent, orally active 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Benzothiazole hydroxy ureas as inhibitors of 5-lipoxygenase: use of the hydroxyurea moiety as a replacement for hydroxamic acid.Journal of medicinal chemistry, , Aug-21, Volume: 35, Issue:17, 1992
New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.Journal of medicinal chemistry, , Aug-27, Volume: 41, Issue:18, 1998
New cyclooxygenase-2/5-lipoxygenase inhibitors. 1. 7-tert-buty1-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: discovery and variation of the 5-keto substituent.Journal of medicinal chemistry, , Mar-26, Volume: 41, Issue:7, 1998
Lead modification: amino acid appended indoles as highly effective 5-LOX inhibitors.Bioorganic & medicinal chemistry, , Mar-01, Volume: 22, Issue:5, 2014
N-1, C-3 substituted indoles as 5-LOX inhibitors--in vitro enzyme immunoaasay, mass spectral and molecular docking investigations.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 23, Issue:5, 2013
Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors; synthesis, biological profile, and pharmacokinetics of L-739,010.Journal of medicinal chemistry, , Aug-29, Volume: 40, Issue:18, 1997
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.Journal of medicinal chemistry, , Sep-27, Volume: 39, Issue:20, 1996
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.Journal of medicinal chemistry, , Oct-27, Volume: 38, Issue:22, 1995
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
Designed multiple ligands. An emerging drug discovery paradigm.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
Effect of structure on potency and selectivity in 2,6-disubstituted 4-(2-arylethenyl)phenol lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:7, 1990
The most potent organophosphorus inhibitors of leucine aminopeptidase. Structure-based design, chemistry, and activity.Journal of medicinal chemistry, , Jun-19, Volume: 46, Issue:13, 2003
Synthesis of sulfur-containing analogues of bestatin. Inhibition of aminopeptidases by alpha-thiolbestatin analogues.Journal of medicinal chemistry, , Volume: 31, Issue:11, 1988
Recent synthetic and medicinal perspectives of tryptanthrin.Bioorganic & medicinal chemistry, , 09-01, Volume: 25, Issue:17, 2017
Synthesis of benzo-annulated tryptanthrins and their biological properties.Bioorganic & medicinal chemistry, , Aug-15, Volume: 20, Issue:16, 2012
Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors.European journal of medicinal chemistry, , Mar-01, Volume: 189, 2020
Inhibition of the enzymes in the leukotriene and prostaglandin pathways in inflammation by 3-aryl isocoumarins.European journal of medicinal chemistry, , Nov-29, Volume: 124, 2016
Novel di-tertiary-butyl phenylhydrazones as dual cyclooxygenase-2/5-lipoxygenase inhibitors: synthesis, COX/LOX inhibition, molecular modeling, and insights into their cytotoxicities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 24, Issue:1, 2014
Dynamic modeling of human 5-lipoxygenase-inhibitor interactions helps to discover novel inhibitors.Journal of medicinal chemistry, , Mar-22, Volume: 55, Issue:6, 2012
Designed multiple ligands. An emerging drug discovery paradigm.Journal of medicinal chemistry, , Oct-20, Volume: 48, Issue:21, 2005
(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.Journal of medicinal chemistry, , Jun-10, Volume: 37, Issue:12, 1994
Naphthalenic lignan lactones as selective, nonredox 5-lipoxygenase inhibitors. Synthesis and biological activity of (methoxyalkyl)thiazole and methoxytetrahydropyran hybrids.Journal of medicinal chemistry, , Feb-18, Volume: 37, Issue:4, 1994
(Methoxyalkyl)thiazoles: a new series of potent, selective, and orally active 5-lipoxygenase inhibitors displaying high enantioselectivity.Journal of medicinal chemistry, , Volume: 34, Issue:7, 1991
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
Indirubin core structure of glycogen synthase kinase-3 inhibitors as novel chemotype for intervention with 5-lipoxygenase.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
Design, synthesis and evaluation of semi-synthetic triazole-containing caffeic acid analogues as 5-lipoxygenase inhibitors.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Synthesis and 5-lipoxygenase inhibitory activity of new cinnamoyl and caffeoyl clusters.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 19, Issue:4, 2009
Acrylamide derivatives as antiallergic agents. 2. Synthesis and structure-activity relationships of N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(3-pyridyl)acryl amides.Journal of medicinal chemistry, , Volume: 32, Issue:3, 1989
Multi-dimensional target profiling of N,4-diaryl-1,3-thiazole-2-amines as potent inhibitors of eicosanoid metabolism.European journal of medicinal chemistry, , Sep-12, Volume: 84, 2014
Synthesis and biological evaluation of N-aryl-4-aryl-1,3-thiazole-2-amine derivatives as direct 5-lipoxygenase inhibitors.Chemical biology & drug design, , Volume: 80, Issue:1, 2012
Flexible estrogen receptor modulators: design, synthesis, and antagonistic effects in human MCF-7 breast cancer cells.Journal of medicinal chemistry, , Mar-29, Volume: 44, Issue:7, 2001
(S)-(+)-4-[7-(2,2-dimethyl-1-oxopropoxy)-4-methyl-2-[4-[2-(1-piperidinyl)-ethoxy]phenyl]-2H-1-benzopyran-3-yl]-phenyl 2,2-dimethylpropanoate (EM-800): a highly potent, specific, and orally active nonsteroidal antiestrogen.Journal of medicinal chemistry, , Jul-04, Volume: 40, Issue:14, 1997
Identification of multi-target inhibitors of leukotriene and prostaglandin EEuropean journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Thiopyranol[2,3,4-c,d]indoles as inhibitors of 5-lipoxygenase, 5-lipoxygenase-activating protein, and leukotriene C4 synthase.Journal of medicinal chemistry, , Oct-27, Volume: 38, Issue:22, 1995
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
5-Lipoxygenase as a drug target: A review on trends in inhibitors structural design, SAR and mechanism based approach.Bioorganic & medicinal chemistry, , 09-01, Volume: 27, Issue:17, 2019
Structure-activity relationship and synthetic methodologies of α-santonin derivatives with diverse bioactivities: A mini-review.European journal of medicinal chemistry, , Aug-01, Volume: 175, 2019
Inhibition of LOX by flavonoids: a structure-activity relationship study.European journal of medicinal chemistry, , Jan-24, Volume: 72, 2014
Identification of natural-product-derived inhibitors of 5-lipoxygenase activity by ligand-based virtual screening.Journal of medicinal chemistry, , May-31, Volume: 50, Issue:11, 2007
Lipoxygenase inhibitory constituents of the fruits of noni (Morinda citrifolia) collected in Tahiti.Journal of natural products, , Volume: 70, Issue:5, 2007
Protective effect of piceatannol and bioactive stilbene derivatives against hypoxia-induced toxicity in H9c2 cardiomyocytes and structural elucidation as 5-LOX inhibitors.European journal of medicinal chemistry, , Oct-15, Volume: 180, 2019
Design, synthesis and identification of novel coumaperine derivatives for inhibition of human 5-LOX: Antioxidant, pseudoperoxidase and docking studies.Bioorganic & medicinal chemistry, , 02-15, Volume: 27, Issue:4, 2019
Novel potent benzimidazole-based microsomal prostaglandin EEuropean journal of medicinal chemistry, , Mar-05, Volume: 231, 2022
Identification of multi-target inhibitors of leukotriene and prostaglandin EEuropean journal of medicinal chemistry, , Apr-25, Volume: 150, 2018
SAR studies on curcumin's pro-inflammatory targets: discovery of prenylated pyrazolocurcuminoids as potent and selective novel inhibitors of 5-lipoxygenase.Journal of medicinal chemistry, , Jul-10, Volume: 57, Issue:13, 2014
Discovery and biological evaluation of novel 1,4-benzoquinone and related resorcinol derivatives that inhibit 5-lipoxygenase.European journal of medicinal chemistry, , Volume: 67, 2013
Modified acidic nonsteroidal anti-inflammatory drugs as dual inhibitors of mPGES-1 and 5-LOX.Journal of medicinal chemistry, , Oct-25, Volume: 55, Issue:20, 2012
SAR-study on a new class of imidazo[1,2-a]pyridine-based inhibitors of 5-lipoxygenase.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 22, Issue:5, 2012
Synthesis and biological evaluation of a class of 5-benzylidene-2-phenyl-thiazolinones as potent 5-lipoxygenase inhibitors.Bioorganic & medicinal chemistry, , Jun-01, Volume: 20, Issue:11, 2012
Discovery and biological evaluation of a novel class of dual microsomal prostaglandin E2 synthase-1/5-lipoxygenase inhibitors based on 2-[(4,6-diphenethoxypyrimidin-2-yl)thio]hexanoic acid.Journal of medicinal chemistry, , Jul-14, Volume: 54, Issue:13, 2011
Identification of 2-mercaptohexanoic acids as dual inhibitors of 5-lipoxygenase and microsomal prostaglandin E₂ synthase-1.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
A novel class of dual mPGES-1/5-LO inhibitors based on the α-naphthyl pirinixic acid scaffold.Bioorganic & medicinal chemistry letters, , Mar-01, Volume: 21, Issue:5, 2011
Pharmacophore modeling and virtual screening for novel acidic inhibitors of microsomal prostaglandin E₂ synthase-1 (mPGES-1).Journal of medicinal chemistry, , May-12, Volume: 54, Issue:9, 2011
A class of 5-benzylidene-2-phenylthiazolinones with high potency as direct 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 54, Issue:6, 2011
Pyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils.European journal of medicinal chemistry, , Volume: 46, Issue:10, 2011
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.Journal of medicinal chemistry, , Sep-11, Volume: 51, Issue:17, 2008
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Design and synthesis of novel 2-amino-5-hydroxyindole derivatives that inhibit human 5-lipoxygenase.Journal of medicinal chemistry, , Jul-13, Volume: 49, Issue:14, 2006
5-lipoxygenase: properties, pharmacology, and the quinolinyl(bridged)aryl class of inhibitors.Journal of medicinal chemistry, , Jul-10, Volume: 35, Issue:14, 1992
Acetohydroxamic acids as potent, selective, orally active 5-lipoxygenase inhibitors.Journal of medicinal chemistry, , Volume: 31, Issue:3, 1988
Exploration of Long-Chain Vitamin E Metabolites for the Discovery of a Highly Potent, Orally Effective, and Metabolically Stable 5-LOX Inhibitor that Limits Inflammation.Journal of medicinal chemistry, , 08-12, Volume: 64, Issue:15, 2021
Structure-based design, semi-synthesis and anti-inflammatory activity of tocotrienolic amides as 5-lipoxygenase inhibitors.European journal of medicinal chemistry, , Sep-15, Volume: 202, 2020
Aminothiazole-featured pirinixic acid derivatives as dual 5-lipoxygenase and microsomal prostaglandin E2 synthase-1 inhibitors with improved potency and efficiency in vivo.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Novel and potent inhibitors of 5-lipoxygenase product synthesis based on the structure of pirinixic acid.Journal of medicinal chemistry, , Sep-11, Volume: 51, Issue:17, 2008
Pirinixic acid derivatives as novel dual inhibitors of microsomal prostaglandin E2 synthase-1 and 5-lipoxygenase.Journal of medicinal chemistry, , Dec-25, Volume: 51, Issue:24, 2008
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| arachidonate 5-lipoxygenase activity | molecular function | Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate. [EC:1.13.11.34, RHEA:32307] |
| arachidonate 12(S)-lipoxygenase activity | molecular function | Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate. [EC:1.13.11.31, RHEA:10428] |
| iron ion binding | molecular function | Binding to an iron (Fe) ion. [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| hydrolase activity | molecular function | Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. [ISBN:0198506732] |
| arachidonate 8(S)-lipoxygenase activity | molecular function | Catalysis of the reaction: arachidonate + O2 = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate. [GOC:lb, PMID:10625675, RHEA:38675] |
Located In
This protein is located in 11 target(s):
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| extracellular space | cellular component | That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684] |
| nuclear envelope | cellular component | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684] |
| nuclear envelope lumen | cellular component | The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide. [GOC:ai] |
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| nuclear matrix | cellular component | The dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089] |
| nuclear membrane | cellular component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
| secretory granule lumen | cellular component | The volume enclosed by the membrane of a secretory granule. [GOC:rph] |
| perinuclear region of cytoplasm | cellular component | Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| nuclear envelope | cellular component | The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space). [ISBN:0198547684] |
Involved In
This protein is involved in 30 target(s):
| Target | Category | Definition |
|---|
| negative regulation of endothelial cell proliferation | biological process | Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation. [GOC:add] |
| leukocyte chemotaxis involved in inflammatory response | biological process | The movement of an immune cell in response to an external stimulus contributing to an inflammatory response. [GOC:add, ISBN:0781735149] |
| leukocyte migration involved in inflammatory response | biological process | The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response. [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] |
| leukotriene production involved in inflammatory response | biological process | The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels. [GOC:add, ISBN:0781735149] |
| leukotriene metabolic process | biological process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma] |
| humoral immune response | biological process | An immune response mediated through a body fluid. [GOC:hb, ISBN:0198506732] |
| negative regulation of angiogenesis | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators] |
| leukotriene biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:go_curators] |
| lipoxygenase pathway | biological process | The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase. [GOC:mah, PMID:17163881] |
| positive regulation of bone mineralization | biological process | Any process that activates or increases the frequency, rate or extent of bone mineralization. [GOC:go_curators] |
| dendritic cell migration | biological process | The movement of a dendritic cell within or between different tissues and organs of the body. [CL:0000451, GOC:nhn, PMID:19339990] |
| glucose homeostasis | biological process | Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators] |
| long-chain fatty acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a long-chain fatty acid. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. [PMID:18390550] |
| regulation of fat cell differentiation | biological process | Any process that modulates the frequency, rate or extent of adipocyte differentiation. [GOC:go_curators] |
| regulation of inflammatory response | biological process | Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. [GOC:ai] |
| negative regulation of inflammatory response | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| regulation of insulin secretion | biological process | Any process that modulates the frequency, rate or extent of the regulated release of insulin. [GOC:ai] |
| negative regulation of vascular wound healing | biological process | Any process that decreases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature. [GOC:BHF, GOC:dph] |
| negative regulation of wound healing | biological process | Any process that decreases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph] |
| regulation of inflammatory response to wounding | biological process | Any process that modulates the frequency, rate or extent of the inflammatory response to wounding. [GOC:BHF, GOC:BHF_miRNA, GOC:rph, PMID:26022821] |
| regulation of cytokine production involved in inflammatory response | biological process | Any process that modulates the frequency, rate or extent of cytokine production involved in inflammatory response. [GOC:TermGenie] |
| regulation of cellular response to oxidative stress | biological process | Any process that modulates the frequency, rate or extent of cellular response to oxidative stress. [GOC:mah, GOC:TermGenie] |
| leukotriene A4 biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of leukotriene A4. [GOC:TermGenie, GOC:yaf, PMID:23242647] |
| regulation of reactive oxygen species biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of reactive oxygen species biosynthetic process. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:24252804] |
| negative regulation of response to endoplasmic reticulum stress | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of a response to endoplasmic reticulum stress. [GO_REF:0000058, GOC:bf, GOC:PARL, GOC:TermGenie, PMID:11381086] |
| negative regulation of sprouting angiogenesis | biological process | Any process that stops, prevents or reduces the frequency, rate or extent of sprouting angiogenesis. [GO_REF:0000058, GOC:TermGenie, PMID:16756958] |
| positive regulation of leukocyte adhesion to arterial endothelial cell | biological process | Any process that activates or increases the frequency, rate or extent of leukocyte adhesion to arterial endothelial cell. [GO_REF:0000058, GOC:bc, GOC:BHF, GOC:BHF_miRNA, GOC:TermGenie, PMID:22267480] |
| lipoxin biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of a lipoxin. A lipoxin is a non-classic eicosanoid and signaling molecule that has four conjugated double bonds and is derived from arachidonic acid. [GOC:mw] |
| arachidonic acid metabolic process | biological process | The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer. [ISBN:0198506732] |
| lipid oxidation | biological process | The removal of one or more electrons from a lipid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen. [GOC:BHF, GOC:mah] |