Proteins > Echinoderm microtubule-associated protein-like 4
Page last updated: 2024-08-07 21:21:07
Echinoderm microtubule-associated protein-like 4
An echinoderm microtubule-associated protein-like 4 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HC35]
Synonyms
EMAP-4;
Restrictedly overexpressed proliferation-associated protein;
Ropp 120
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 6 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (10)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| crizotinib | Homo sapiens (human) | IC50 | 0.6542 | 15 | 15 |
| nvp-tae684 | Homo sapiens (human) | IC50 | 0.0300 | 2 | 2 |
| entrectinib | Homo sapiens (human) | IC50 | 0.3307 | 3 | 3 |
| gilteritinib | Homo sapiens (human) | IC50 | 0.0036 | 2 | 0 |
| alectinib | Homo sapiens (human) | IC50 | 0.0682 | 7 | 7 |
| ceritinib | Homo sapiens (human) | IC50 | 0.5935 | 6 | 6 |
| ap26113 | Homo sapiens (human) | IC50 | 0.3965 | 6 | 6 |
| pf-06463922 | Homo sapiens (human) | IC50 | 0.0186 | 9 | 9 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| thiopental sodium | Homo sapiens (human) | EC50 | 6.2580 | 1 | 1 |
| ceritinib | Homo sapiens (human) | EC50 | 1.5520 | 3 | 3 |
| osimertinib | Homo sapiens (human) | EC50 | 1.7480 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ceritinib | Homo sapiens (human) | CC50 | 0.0380 | 1 | 1 |
[no title available]Journal of medicinal chemistry, , 12-26, Volume: 62, Issue:24, 2019
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Discovery of a potent dual ALK and EGFR T790M inhibitor.European journal of medicinal chemistry, , Aug-18, Volume: 136, 2017
Novel 2,4-diaminopyrimidines bearing tetrahydronaphthalenyl moiety against anaplastic lymphoma kinase (ALK): Synthesis, in vitro, ex vivo, and in vivo efficacy studies.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 26, Issue:7, 2016
Discovery of Inhibitors That Overcome the G1202R Anaplastic Lymphoma Kinase Resistance Mutation.Journal of medicinal chemistry, , Dec-10, Volume: 58, Issue:23, 2015
Enables
This protein enables 5 target(s):
| Target | Category | Definition |
|---|
| molecular_function | molecular function | A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. [GOC:pdt] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| alpha-tubulin binding | molecular function | Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl] |
| beta-tubulin binding | molecular function | Binding to the microtubule constituent protein beta-tubulin. [GOC:krc] |
| microtubule binding | molecular function | Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc] |
Located In
This protein is located in 8 target(s):
| Target | Category | Definition |
|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
| microtubule organizing center | cellular component | An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides. [GOC:vw, ISBN:0815316194, PMID:17072892, PMID:17245416, Wikipedia:Microtubule_organizing_center] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| microtubule | cellular component | Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568] |
| microtubule cytoskeleton | cellular component | The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins. [GOC:jl, ISBN:0395825172] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| midbody | cellular component | A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis. [ISBN:0815316194] |
| mitotic spindle | cellular component | A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178] |
Involved In
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|
| mitotic cell cycle | biological process | Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278] |
| microtubule-based process | biological process | Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins. [GOC:mah] |
| mitotic metaphase chromosome alignment | biological process | A chromosome localization process whereby chromosomes are positioned in a specific order and orientation at the metaphase plate (spindle equator), during mitotic chromosome segregation. This alignment ensures that each daughter cell will receive the correct number of chromosomes during cell division. [ISBN:0815316194] |
| attachment of spindle microtubules to kinetochore | biological process | The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex. [GOC:vw, PMID:10322137] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| microtubule cytoskeleton organization | biological process | A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah] |