A Toll-like receptor 8 that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q9NR97]
[no title available]Journal of medicinal chemistry, , 06-10, Volume: 64, Issue:11, 2021
Optimization of 8-oxoadenines with toll-like-receptor 7 and 8 activity.Bioorganic & medicinal chemistry letters, , 03-15, Volume: 30, Issue:6, 2020
Further exploration of the structure-activity relationship of imidazoquinolines; identification of potent C7-substituted imidazoquinolines.Bioorganic & medicinal chemistry letters, , 01-15, Volume: 30, Issue:2, 2020
Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.Bioorganic & medicinal chemistry letters, , 10-15, Volume: 28, Issue:19, 2018
Design and Synthesis of N1-Modified Imidazoquinoline Agonists for Selective Activation of Toll-like Receptors 7 and 8.ACS medicinal chemistry letters, , Nov-09, Volume: 8, Issue:11, 2017
Incorporation of Phosphonate into Benzonaphthyridine Toll-like Receptor 7 Agonists for Adsorption to Aluminum Hydroxide.Journal of medicinal chemistry, , 06-23, Volume: 59, Issue:12, 2016
Structure-activity relationship analysis of imidazoquinolines with Toll-like receptors 7 and 8 selectivity and enhanced cytokine induction.Journal of medicinal chemistry, , Jan-23, Volume: 57, Issue:2, 2014
Discovery of Imidazoquinolines with Toll-Like Receptor 7/8 Independent Cytokine Induction.ACS medicinal chemistry letters, , Jun-14, Volume: 3, Issue:6, 2012
| Target | Category | Definition |
|---|
| DNA binding | molecular function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| RNA binding | molecular function | Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah] |
| double-stranded RNA binding | molecular function | Binding to double-stranded RNA. [GOC:jl] |
| single-stranded RNA binding | molecular function | Binding to single-stranded RNA. [GOC:jl] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
| pattern recognition receptor activity | molecular function | Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response. [GOC:ar, GOC:bf] |
| Target | Category | Definition |
|---|
| regulation of protein phosphorylation | biological process | Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein. [GOC:hjd] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| response to virus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus. [GOC:hb] |
| immunoglobulin mediated immune response | biological process | An immune response mediated by immunoglobulins, whether cell-bound or in solution. [GO_REF:0000022, GOC:add, ISBN:0781735149] |
| negative regulation of interleukin-12 production | biological process | Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production. [GOC:mah] |
| positive regulation of interferon-alpha production | biological process | Any process that activates or increases the frequency, rate, or extent of interferon-alpha production. [GOC:mah, PMID:15546383] |
| positive regulation of interferon-beta production | biological process | Any process that activates or increases the frequency, rate, or extent of interferon-beta production. [GOC:mah, PMID:15546383] |
| positive regulation of type II interferon production | biological process | Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383] |
| positive regulation of interleukin-1 beta production | biological process | Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production. [GOC:mah] |
| positive regulation of interleukin-6 production | biological process | Any process that activates or increases the frequency, rate, or extent of interleukin-6 production. [GOC:mah] |
| positive regulation of interleukin-8 production | biological process | Any process that activates or increases the frequency, rate, or extent of interleukin-8 production. [GOC:mah] |
| toll-like receptor 8 signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to the endolysosomal toll-like receptor 8. [GOC:add, PMID:16551253, PMID:17328678] |
| positive regulation of canonical NF-kappaB signal transduction | biological process | Any process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl] |
| innate immune response | biological process | Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_sensu] |
| positive regulation of innate immune response | biological process | Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection. [GOC:ebc] |
| defense response to virus | biological process | Reactions triggered in response to the presence of a virus that act to protect the cell or organism. [GOC:ai] |
| cellular response to mechanical stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus. [GOC:mah] |
| toll-like receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to a toll-like receptor of a target cell. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response. [GO_REF:0000022, GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] |
| canonical NF-kappaB signal transduction | biological process | An intracellular signaling cassette characterized by the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB, also known as the canonical NF-kappaB signaling cascade. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription. The canonical NF-kappaB pathway is mainly stimulated by proinflammatory cytokines such as IL-1beta, tumor necrosis factor (TNF)-alpha, antigen ligands, and toll-like receptors (TLRs). [GOC:bf, PMID:12773372, PMID:34659217] |