Page last updated: 2024-11-01

omeprazole and Necrosis

omeprazole has been researched along with Necrosis in 17 studies

Omeprazole: A 4-methoxy-3,5-dimethylpyridyl, 5-methoxybenzimidazole derivative of timoprazole that is used in the therapy of STOMACH ULCERS and ZOLLINGER-ELLISON SYNDROME. The drug inhibits an H(+)-K(+)-EXCHANGING ATPASE which is found in GASTRIC PARIETAL CELLS.
omeprazole : A racemate comprising equimolar amounts of (R)- and (S)-omeprazole.
5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole : A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a [4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl group at position 2 and a methoxy group at position 5.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue."7.91Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats. ( Goyal, SN; Mahajan, UB; Ojha, S; Patil, AS; Patil, CR; Singh, AD, 2019)
"We investigated the effect of omeprazole (OPZ) and lansoprazole (LPZ) on the pathophysiology of myocardial necrosis in rats by inspecting a series of indicators like hemodynamic parameters, biochemical estimations and histopathological changes in the myocardial tissue."3.91Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats. ( Goyal, SN; Mahajan, UB; Ojha, S; Patil, AS; Patil, CR; Singh, AD, 2019)
"Percentage of flap necrosis was found to be less in all omeprazole received groups."3.85The Effect of Omeprazole Usage on the Viability of Random Pattern Skin Flaps in Rats. ( Çitil, R; Işik, VM; Koçer, U; Korkmaz, M; Oruç, M; Sadiç, M; Sayar, H; Şen, H, 2017)
"Omeprazole has a lethal effect over some cancer cells, and cell death is a key process in kidney disease."1.56Molecular pathways driving omeprazole nephrotoxicity. ( Cardenas-Villacres, D; Carrasco, S; Fontecha-Barriuso, M; Martín-Sanchez, D; Martinez-Moreno, JM; Ortiz, A; Ruiz-Ortega, M; Sanchez-Niño, MD; Sanz, AB, 2020)
"Pretreatment with lansoprazole 90 micromol/kg, given intraduodenally as single dose or once daily by intragastric route for 8 days, significantly prevented ethanol-HCl-induced gastric damage."1.32Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds. ( Blandizzi, C; Colucci, R; Del Tacca, M; Fornai, M; Lazzeri, G; Lubrano, V; Natale, G; Vassalle, C, 2004)
"Omeprazole was administered intraperitoneally, twice daily, for 3 days to male Wistar rats in two doses: 0."1.31Hepatic lysosomal enzymes activity and liver morphology after short-time omeprazole administration. ( Burdan, F; Maciejewski, R; Madej, B; Radzikowska, E; Siezieniewska, Z; Wojtowicz, Z, 2002)
"Pretreatment with naloxone almost completely blocked both fluid pooling effect and mucosal protective effect of loperamide."1.30Subcutaneous loperamide prevents gastric lesions induced by necrotizing agents in rats. ( Hatakeyama, Y; Ohtsuka, M; Shimomura, K; Tomoi, M, 1997)
"Timoprazole was an active antisecretory agent when given subcutaneously (ED50 10 mg/kg), but was not cytoprotective when given by this route."1.27Timoprazole is a unique cytoprotective agent in the rat. ( Davis, JP; Lancaster, C; Nezamis, JE; Nichols, NM; Ochoa, R; Rush, BD; Ruwart, MJ, 1984)

Research

Studies (17)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.88)18.7374
1990's3 (17.65)18.2507
2000's7 (41.18)29.6817
2010's4 (23.53)24.3611
2020's2 (11.76)2.80

Authors

AuthorsStudies
Roa Colomo, A1
García Robles, A1
Ruiz Escolano, E1
Fontecha-Barriuso, M1
Martín-Sanchez, D1
Martinez-Moreno, JM1
Cardenas-Villacres, D1
Carrasco, S1
Sanchez-Niño, MD1
Ruiz-Ortega, M1
Ortiz, A1
Sanz, AB1
Deliwala, SS1
Gurvits, GE1
Ozer, K1
Çolak, Ö1
Patil, AS1
Singh, AD1
Mahajan, UB1
Patil, CR1
Ojha, S1
Goyal, SN1
Şen, H1
Oruç, M1
Işik, VM1
Sadiç, M1
Sayar, H1
Çitil, R1
Korkmaz, M1
Koçer, U1
Castelluccio, MS1
Hermida, R1
Ayunta, H1
Manzotti, L1
Cháves, E1
Romo, R1
Perelstein, G1
Hussain, A1
Mahmood, H1
Ansari, T1
El-Hasani, S1
Natale, G2
Lazzeri, G1
Lubrano, V1
Colucci, R1
Vassalle, C1
Fornai, M1
Blandizzi, C2
Del Tacca, M2
Ruwart, MJ1
Nezamis, JE1
Rush, BD1
Lancaster, C1
Davis, JP1
Nichols, NM1
Ochoa, R1
Gherardi, G1
Marveggio, C1
Carignani, D1
Hatakeyama, Y1
Tomoi, M1
Ohtsuka, M1
Shimomura, K1
Benoit, R1
Grobost, O1
Reichart, M1
Busch, OR1
Bruno, MJ1
Van Lanschot, JJ1
Katsinelos, P1
Christodoulou, K1
Pilpilidis, I1
Papagiannis, A1
Xiarchos, P1
Tsolkas, P1
Vasiliadis, I1
Eugenidis, N1
Martínez-Chamorro, C1
Martínez, E1
Gil-Fernández, JJ1
Escudero, A1
Acevedo, A1
Fernández-Rañada, JM1
Burdan, F1
Siezieniewska, Z1
Maciejewski, R1
Madej, B1
Radzikowska, E1
Wojtowicz, Z1

Reviews

3 reviews available for omeprazole and Necrosis

ArticleYear
[Black esophagus related to acute esophageal necrosis: a new case].
    Presse medicale (Paris, France : 1983), 1999, Sep-25, Volume: 28, Issue:28

    Topics: Acute Disease; Anti-Ulcer Agents; Combined Modality Therapy; Duodenal Ulcer; Esophagoscopy; Esophagu

1999
Black esophagus: an unusual finding during routine endoscopy.
    Endoscopy, 2001, Volume: 33, Issue:10

    Topics: Aged; Anti-Ulcer Agents; Biopsy; Esophagoscopy; Esophagus; Humans; Male; Mucous Membrane; Necrosis;

2001
Acute necrotizing gastritis by Escherichia coli in a severely neutropenic patient.
    Haematologica, 2002, Volume: 87, Issue:1

    Topics: Acute Disease; Amikacin; Anemia, Aplastic; Antilymphocyte Serum; Combined Modality Therapy; Cyclospo

2002

Other Studies

14 other studies available for omeprazole and Necrosis

ArticleYear
Black esophagus, is it as bad as it seems?
    Gastroenterologia y hepatologia, 2019, Volume: 42, Issue:10

    Topics: Alcoholism; Colonic Pseudo-Obstruction; Esophagitis; Esophagoscopy; Food, Formulated; Gastrointestin

2019
Molecular pathways driving omeprazole nephrotoxicity.
    Redox biology, 2020, Volume: 32

    Topics: Animals; Apoptosis; Cell Death; Humans; Kidney; Mice; Necrosis; Omeprazole; Oxidative Stress

2020
Acute Esophageal Necrosis in a Patient With COVID-19.
    The American journal of gastroenterology, 2021, 10-01, Volume: 116, Issue:10

    Topics: Acute Disease; COVID-19; Drug Therapy, Combination; Endoscopy, Digestive System; Esophagus; Humans;

2021
Discussion on the Effect of Omeprazole Usage on the Viability of Random Pattern Skin Flaps in Rats.
    Annals of plastic surgery, 2018, Volume: 80, Issue:1

    Topics: Animals; Graft Survival; Necrosis; Omeprazole; Rats; Rats, Sprague-Dawley; Rats, Wistar; Skin; Surgi

2018
Protective effect of omeprazole and lansoprazole on β-receptor stimulated myocardial infarction in Wistar rats.
    Molecular and cellular biochemistry, 2019, Volume: 456, Issue:1-2

    Topics: Animals; Electrocardiography; Lansoprazole; Male; Malondialdehyde; Myocardial Infarction; Myocardium

2019
The Effect of Omeprazole Usage on the Viability of Random Pattern Skin Flaps in Rats.
    Annals of plastic surgery, 2017, Volume: 78, Issue:6

    Topics: Animals; Female; Graft Survival; Image Interpretation, Computer-Assisted; Necrosis; Omeprazole; Post

2017
[Upper gastrointestinal bleeding of infrequent cause].
    Acta gastroenterologica Latinoamericana, 2008, Volume: 38, Issue:2

    Topics: Acute Disease; Aged, 80 and over; Ampicillin; Anti-Ulcer Agents; Esophagitis; Fatal Outcome; Gastroi

2008
Pneumomediastinum, stomach wall and hepatic portal vein gas secondary to partial necrosis of the stomach wall.
    Singapore medical journal, 2009, Volume: 50, Issue:5

    Topics: Aged; Amoxicillin-Potassium Clavulanate Combination; Anti-Bacterial Agents; Anti-Infective Agents; A

2009
Mechanisms of gastroprotection by lansoprazole pretreatment against experimentally induced injury in rats: role of mucosal oxidative damage and sulfhydryl compounds.
    Toxicology and applied pharmacology, 2004, Feb-15, Volume: 195, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Animals; Anti-Ulcer Agents; Cyclooxygenase 1; Cyclooxygenas

2004
Timoprazole is a unique cytoprotective agent in the rat.
    Digestion, 1984, Volume: 30, Issue:1

    Topics: 2-Pyridinylmethylsulfinylbenzimidazoles; Adenosine Triphosphatases; Animals; Benzimidazoles; Ethanol

1984
Mechanisms of protection by omeprazole against experimental gastric mucosal damage in rats.
    Digestion, 1995, Volume: 56, Issue:3

    Topics: Animals; Ethanol; Gastric Acid; Gastric Mucosa; Gastritis; Hydrochloric Acid; Male; Misoprostol; Muc

1995
Subcutaneous loperamide prevents gastric lesions induced by necrotizing agents in rats.
    Digestive diseases and sciences, 1997, Volume: 42, Issue:12

    Topics: Animals; Ethanol; Gastric Mucosa; Hydrochloric Acid; Injections, Subcutaneous; Irritants; Loperamide

1997
Black esophagus: a view in the dark.
    Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus, 2000, Volume: 13, Issue:4

    Topics: Acute Disease; Aged; Anti-Ulcer Agents; Esophageal Diseases; Esophagus; Gastric Outlet Obstruction;

2000
Hepatic lysosomal enzymes activity and liver morphology after short-time omeprazole administration.
    Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie, 2002, Volume: 53, Issue:6

    Topics: Animals; Animals, Outbred Strains; beta-Galactosidase; Dose-Response Relationship, Drug; Enzyme Inhi

2002