Proteins > Guanylate cyclase soluble subunit beta-1
Page last updated: 2024-08-07 13:29:25
Guanylate cyclase soluble subunit beta-1
A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02153]
Synonyms
GCS-beta-1;
EC 4.6.1.2;
Guanylate cyclase soluble subunit beta-3;
GCS-beta-3;
Soluble guanylate cyclase small subunit
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| gemfibrozil | Homo sapiens (human) | EC50 | 624.0000 | 1 | 1 |
| benzydamine | Homo sapiens (human) | EC50 | 1.0200 | 1 | 1 |
Drugs with Other Measurements
Enables
This protein enables 10 target(s):
| Target | Category | Definition |
|---|
| adenylate cyclase activity | molecular function | Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate. [EC:4.6.1.1] |
| guanylate cyclase activity | molecular function | Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate. [EC:4.6.1.2] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| GTP binding | molecular function | Binding to GTP, guanosine triphosphate. [GOC:ai] |
| heme binding | molecular function | Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai] |
| signaling receptor activity | molecular function | Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response. [GOC:bf, GOC:signaling] |
| protein-containing complex binding | molecular function | Binding to a macromolecular complex. [GOC:jl] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| cytidylate cyclase activity | molecular function | Catalysis of the reaction: CTP = 3',5'-cyclic CMP + diphosphate + H+. [EC:4.6.1.6, RHEA:14737] |
| Hsp90 protein binding | molecular function | Binding to Hsp90 proteins, any of a group of heat shock proteins around 90kDa in size. [GOC:ai] |
Located In
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| presynaptic active zone cytoplasmic component | cellular component | A specialized region below the presynaptic membrane, characterized by electron-dense material, a specialized cytoskeletal matrix and accumulated (associated) synaptic vesicles. [GOC:dos] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| guanylate cyclase complex, soluble | cellular component | Complex that possesses guanylate cyclase activity and is not bound to a membrane. [GOC:mah] |
Involved In
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|
| cGMP biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732] |
| nitric oxide mediated signal transduction | biological process | An intracellular signaling cassette that starts with production of nitric oxide, detection by receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and ends with the activation of downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms. [GOC:jl, PMID:21549190] |
| blood circulation | biological process | The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825] |
| nitric oxide-cGMP-mediated signaling | biological process | An intracellular signaling cassette in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP. [GOC:signaling, PMID:21549190, PMID:22019632] |
| cellular response to nitric oxide | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitric oxide stimulus. [GOC:mah, GOC:yaf] |
| trans-synaptic signaling by nitric oxide, modulating synaptic transmission | biological process | Cell-cell signaling between presynapse and postsynapse, via the release and reception of nitric oxide molecules, that modulates the synaptic transmission properties of the synapse. [GOC:dos] |
| cGMP-mediated signaling | biological process | An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling] |
| response to oxygen levels | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of oxygen. [GOC:BHF, GOC:mah] |