Proteins > Endothelin receptor type B
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Endothelin receptor type B

An endothelin receptor type B that is encoded in the genome of human. [PRO:WCB, UniProtKB:P24530]

Synonyms

ET-B;
ET-BR;
Endothelin receptor non-selective type

Research

Bioassay Publications (34)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's14 (41.18)18.2507
2000's13 (38.24)29.6817
2010's7 (20.59)24.3611
2020's0 (0.00)2.80

Compounds (41)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
cyproheptadineHomo sapiens (human)Ki0.050122
mianserinHomo sapiens (human)Ki0.063122
ritanserinHomo sapiens (human)Ki0.015822
spiperoneHomo sapiens (human)Ki0.020022
2-bromolysergic acid diethylamideHomo sapiens (human)Ki0.010022
metergolineHomo sapiens (human)Ki0.006322
butaclamolHomo sapiens (human)Ki0.063111
butaclamolHomo sapiens (human)Ki0.063111
mesulergineHomo sapiens (human)Ki0.007922
bosentan anhydrousHomo sapiens (human)IC500.304477
bosentan anhydrousHomo sapiens (human)Ki0.210022
1h-indene-2-carboxylic acid, 1-(1,3-benzodioxol-5-yl)-3-(2- (carboxymethoxy)-4-methoxyphenyl)-2,3-dihydro-5-propoxy-, (1s,2r,3s)-Homo sapiens (human)Ki0.015833
ro 46-2005Homo sapiens (human)IC501.100011
pd 142893Homo sapiens (human)IC504.400011
5-(dimethylamino)-n-(3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamideHomo sapiens (human)Ki50.000022
endothelin (16-21)Homo sapiens (human)IC5050.000011
tezosentanHomo sapiens (human)IC500.021011
atrasentanHomo sapiens (human)IC500.222133
lu 135252Homo sapiens (human)IC500.016011
lu 135252Homo sapiens (human)Ki0.371011
enrasentanHomo sapiens (human)Ki0.110522
tbc-11251Homo sapiens (human)IC504.904922
bq 123Homo sapiens (human)IC501.000011
a 192621Homo sapiens (human)IC500.005162
a 192621Homo sapiens (human)Ki0.008810
irl 2500Homo sapiens (human)IC500.001311
irl 2500Homo sapiens (human)Ki0.001011
ro 46-8443Homo sapiens (human)IC500.069011
clazosentanHomo sapiens (human)IC500.175011
clazosentanHomo sapiens (human)Ki0.175011
lu 224332Homo sapiens (human)Ki0.007211
1-methyl-d-lysergic acid butanolamideHomo sapiens (human)Ki0.012622
lu 208075Homo sapiens (human)IC500.692522
bms 193884Homo sapiens (human)Ki18.700044
sb258741Homo sapiens (human)Ki0.003211
ci 1020Homo sapiens (human)IC500.492055
ci 1020Homo sapiens (human)Ki0.139011
lu 302872Homo sapiens (human)Ki0.004822
zibotentanHomo sapiens (human)IC500.100011
avosentanHomo sapiens (human)IC500.900022
naluzotanHomo sapiens (human)Ki2.000011
macitentanHomo sapiens (human)IC500.589733
pd 156707Homo sapiens (human)IC500.417011
pd 156707Homo sapiens (human)Ki0.139011
act-132577Homo sapiens (human)IC500.987022
endothelinsHomo sapiens (human)IC500.000222
endothelinsHomo sapiens (human)Ki0.000111
nitd 609Homo sapiens (human)IC5030.000011
clozapineHomo sapiens (human)Ki0.012622

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
bosentan anhydrousHomo sapiens (human)Kd0.072411
a 192621Homo sapiens (human)EC5010.000010

Enables

This protein enables 4 target(s):

TargetCategoryDefinition
endothelin receptor activitymolecular functionCombining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
peptide hormone bindingmolecular functionBinding to a peptide with hormonal activity in animals. [GOC:jl, ISBN:0198506732]
type 1 angiotensin receptor bindingmolecular functionBinding to a type 1 angiotensin receptor. [GOC:mah, GOC:nln]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
nuclear membranecellular componentEither of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 52 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
neural crest cell migrationbiological processThe characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo. [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437]
positive regulation of protein phosphorylationbiological processAny process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein. [GOC:hjd]
renin secretion into blood streambiological processThe regulated release of renin into the blood stream by juxtoglomerular cells. [ISBN:0721643949]
regulation of heart ratebiological processAny process that modulates the frequency or rate of heart contraction. [GOC:dph, GOC:tb, PMID:10358008]
regulation of pHbiological processAny process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. [GOC:dph, GOC:go_curators, GOC:tb]
cell surface receptor signaling pathwaybiological processThe series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling]
negative regulation of adenylate cyclase activitybiological processAny process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity. [GOC:go_curators]
phospholipase C-activating G protein-coupled receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194]
positive regulation of cytosolic calcium ion concentrationbiological processAny process that increases the concentration of calcium ions in the cytosol. [GOC:ai]
nervous system developmentbiological processThe process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state. [GOC:dgh]
peripheral nervous system developmentbiological processThe process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands. [GOC:go_curators, UBERON:0000010]
posterior midgut developmentbiological processThe process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure. [GOC:go_curators]
positive regulation of cell population proliferationbiological processAny process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators]
gene expressionbiological processThe process in which a gene's sequence is converted into a mature gene product (protein or RNA). This includes the production of an RNA transcript and its processing, as well as translation and maturation for protein-coding genes. [GOC:txnOH-2018, PMID:25934543, PMID:31580950]
negative regulation of neuron maturationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation. [GOC:ef]
response to organic cyclic compoundbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:ef]
vein smooth muscle contractionbiological processA process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds. [GOC:mtg_muscle, MA:0000715, MSH:D014680]
calcium-mediated signalingbiological processAny intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling]
cGMP-mediated signalingbiological processAn intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]
heparin metabolic processbiological processThe chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues. [GOC:mah, ISBN:0198506732]
melanocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a melanocyte. [GOC:mah]
regulation of fever generationbiological processAny process that modulates the rate or extent of fever generation. [GOC:add, GOC:dph, GOC:tb]
aldosterone metabolic processbiological processThe chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. [PMID:16527843]
enteric smooth muscle cell differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine. [CL:0002504, GOC:BHF]
positive regulation of urine volumebiological processAny process that increases the amount of urine excreted from the body over a unit of time. [GOC:mtg_25march11, GOC:yaf]
renal sodium excretionbiological processThe elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. [GOC:mtg_25march11, GOC:yaf, PMID:25287933]
epithelial fluid transportbiological processThe directed movement of fluid across epithelia. [GOC:jl, PMID:11390830]
vasoconstrictionbiological processA decrease in the diameter of blood vessels, especially arteries, due to constriction of smooth muscle cells that line the vessels, and usually causing an increase in blood pressure. [GOC:pr, ISBN:0192800752]
vasodilationbiological processAn increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. [GOC:pr, ISBN:0192800981]
negative regulation of apoptotic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
positive regulation of canonical NF-kappaB signal transductionbiological processAny process that activates or increases the frequency, rate or extent of a canonical NF-kappaB signaling cascade. [GOC:jl]
macrophage chemotaxisbiological processThe movement of a macrophage in response to an external stimulus. [GOC:jid]
response to painbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pain stimulus. Pain stimuli cause activation of nociceptors, peripheral receptors for pain, include receptors which are sensitive to painful mechanical stimuli, extreme heat or cold, and chemical stimuli. [GOC:jid, PMID:10203867, PMID:12723742, PMID:12843304, Wikipedia:Pain]
enteric nervous system developmentbiological processThe process whose specific outcome is the progression of the enteric nervous system over time, from its formation to the mature structure. The enteric nervous system is composed of two ganglionated neural plexuses in the gut wall which form one of the three major divisions of the autonomic nervous system. The enteric nervous system innervates the gastrointestinal tract, the pancreas, and the gallbladder. It contains sensory neurons, interneurons, and motor neurons. Thus the circuitry can autonomously sense the tension and the chemical environment in the gut and regulate blood vessel tone, motility, secretions, and fluid transport. The system is itself governed by the central nervous system and receives both parasympathetic and sympathetic innervation. [FMA:66070, GOC:jid, GOC:sr]
regulation of epithelial cell proliferationbiological processAny process that modulates the frequency, rate or extent of epithelial cell proliferation. [GOC:ai]
negative regulation of protein metabolic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein. [GOC:ai]
canonical Wnt signaling pathwaybiological processA type of Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the by propagation of the molecular signals via beta-catenin, and end with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. [PMID:11532397, PMID:19619488]
positive regulation of penile erectionbiological processAny process that increases the rate, frequency or extent of penile erection. Penile erection is the hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow. [GOC:dph, GOC:tb]
establishment of endothelial barrierbiological processThe establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]
renal sodium ion absorptionbiological processA renal system process in which sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures. [GOC:dph, GOC:mah]
calcium ion transmembrane transportbiological processA process in which a calcium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. [GOC:mah]
cellular response to lipopolysaccharidebiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:mah]
protein transmembrane transportbiological processThe process in which a protein is transported across a membrane. [GOC:mah, GOC:vw]
podocyte differentiationbiological processThe process in which a relatively unspecialized cell acquires specialized features of a glomerular visceral epithelial cell. A glomerular visceral epithelial cell is a specialized epithelial cell that contains 'feet' that interdigitate with the 'feet' of other glomerular epithelial cells. [GOC:mtg_kidney_jan10]
endothelin receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:bf, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, PMID:10977869]
renal albumin absorptionbiological processA renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. [GOC:yaf, PMID:18431508]
neuroblast migrationbiological processThe orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron. [CL:0000031, GOC:jc, PMID:15543145]
chordate pharynx developmentbiological processThe process whose specific outcome is the progression of cordate pharynx over time, from its formation to the mature structure. [PMID:23020903]
response to sodium phosphatebiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24625659]
response to endothelinbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3). [PMID:16365184]
developmental pigmentationbiological processThe developmental process that results in the deposition of coloring matter in an organism, tissue or cell. [ISBN:0582227089]