An M-phase inducer phosphatase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P30304]
EC 3.1.3.48;
Dual specificity phosphatase Cdc25A
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (12.50) | 18.2507 |
| 2000's | 8 (50.00) | 29.6817 |
| 2010's | 6 (37.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-(2-hydroxyethylsulfanyl)-3-methyl-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 4.5300 | 2 | 2 |
| 2,3-dimethoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 8.9000 | 1 | 1 |
| miltefosine | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| 1-(2-naphthalenyl)-3-[(phenylmethyl)-propan-2-ylamino]-1-propanone | Homo sapiens (human) | IC50 | 18.0000 | 1 | 1 |
| lapachol | Homo sapiens (human) | IC50 | 33.2000 | 1 | 1 |
| beta-lapachone | Homo sapiens (human) | IC50 | 1.8000 | 1 | 1 |
| vitamin k 3 | Homo sapiens (human) | IC50 | 4.5500 | 2 | 2 |
| yohimbine | Homo sapiens (human) | IC50 | 22.3000 | 1 | 1 |
| plumbagin | Homo sapiens (human) | IC50 | 0.7000 | 1 | 1 |
| 2-methoxy-1,4-naphthoquinone | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| nsc 95397 | Homo sapiens (human) | IC50 | 2.2445 | 6 | 6 |
| nsc 663284 | Homo sapiens (human) | IC50 | 33.2325 | 4 | 4 |
| nsc 663284 | Homo sapiens (human) | Ki | 0.0290 | 1 | 1 |
| nsc668394 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| shikonin | Homo sapiens (human) | IC50 | 0.2200 | 1 | 1 |
| ag-213 | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| 2-[[5-(3-chlorophenyl)-4-prop-2-enyl-1,2,4-triazol-3-yl]thio]-1-(3,4-dihydroxyphenyl)ethanone | Homo sapiens (human) | IC50 | 3.2800 | 1 | 1 |
| rottlerin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| gw-5074 | Homo sapiens (human) | IC50 | 15.0000 | 1 | 1 |
| dysidiolide | Homo sapiens (human) | IC50 | 13.6667 | 6 | 6 |
This protein enables 5 target(s):
| Target | Category | Definition |
|---|---|---|
| phosphoprotein phosphatase activity | molecular function | Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cellular proteins and thereby provide an important mechanism for regulating cellular activity. [ISBN:0198547684] |
| protein tyrosine phosphatase activity | molecular function | Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. [EC:3.1.3.48] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| protein-folding chaperone binding | molecular function | Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. [PMID:10585443] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| regulation of cyclin-dependent protein serine/threonine kinase activity | biological process | Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr] |
| G1/S transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated. [GOC:mtg_cell_cycle] |
| G2/M transition of mitotic cell cycle | biological process | The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex. [GOC:mtg_cell_cycle] |
| cell population proliferation | biological process | The multiplication or reproduction of cells, resulting in the expansion of a cell population. [GOC:mah, GOC:mb] |
| response to radiation | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation. [GOC:jl, Wikipedia:Electromagnetic_radiation] |
| positive regulation of G2/M transition of mitotic cell cycle | biological process | Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle. [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] |
| cellular response to UV | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers. [GOC:mah] |
| positive regulation of DNA replication | biological process | Any process that activates or increases the frequency, rate or extent of DNA replication. [GOC:go_curators] |
| cell division | biological process | The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr] |
| positive regulation of G2/MI transition of meiotic cell cycle | biological process | Any signaling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to MI phase of the meiotic cell cycle. [GOC:vw, PMID:25492408] |