A free fatty acid receptor 3 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O14843]
G-protein coupled receptor 41
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| acetic acid | Homo sapiens (human) | EC50 | 12.0000 | 1 | 1 |
| butyric acid | Homo sapiens (human) | EC50 | 12.0000 | 1 | 1 |
| propionic acid | Homo sapiens (human) | EC50 | 11.4881 | 3 | 3 |
| sodium butyrate | Homo sapiens (human) | EC50 | 10.1000 | 1 | 1 |
| gw9508 | Homo sapiens (human) | EC50 | 50.1187 | 1 | 1 |
This protein enables 3 target(s):
| Target | Category | Definition |
|---|---|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| lipid binding | molecular function | Binding to a lipid. [GOC:ai] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
This protein is involved in 13 target(s):
| Target | Category | Definition |
|---|---|---|
| mucosal immune response | biological process | An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract. [GO_REF:0000022, GOC:jal, ISBN:0781735149] |
| positive regulation of cytokine production involved in immune response | biological process | Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response. [GOC:add] |
| positive regulation of acute inflammatory response to non-antigenic stimulus | biological process | Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus. [GOC:add] |
| inflammatory response | biological process | The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages. [GO_REF:0000022, ISBN:0198506732] |
| G protein-coupled receptor signaling pathway | biological process | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] |
| adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the inhibition of adenylyl cyclase activity and a subsequent decrease in the intracellular concentration of cyclic AMP (cAMP). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| regulation of norepinephrine secretion | biological process | Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine. [GOC:ef] |
| positive regulation of chemokine production | biological process | Any process that activates or increases the frequency, rate, or extent of chemokine production. [GOC:mah] |
| negative regulation of blood pressure | biological process | Any process in which the force of blood traveling through the circulatory system is decreased. [GOC:go_curators, GOC:mtg_cardio] |
| regulation of insulin receptor signaling pathway | biological process | Any process that modulates the frequency, rate or extent of insulin receptor signaling. [GOC:bf] |
| regulation of hormone biosynthetic process | biological process | Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones. [GOC:ai] |
| cellular response to fatty acid | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus. [GOC:mah] |
| regulation of peptide hormone secretion | biological process | Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules. [GOC:tb] |