An inositol polyphosphate multikinase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8NFU5]
EC 2.7.1.140;
EC 2.7.1.151;
EC 2.7.1.153;
Inositol 1,3,4,6-tetrakisphosphate 5-kinase
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 3',4'-dihydroxyflavone | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 4',6-dihydroxyflavone | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| naringenin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| eriodictyol | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| quercetin | Homo sapiens (human) | IC50 | 2.3000 | 1 | 1 |
| acacetin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| apigenin | Homo sapiens (human) | IC50 | 29.0000 | 1 | 1 |
| luteolin | Homo sapiens (human) | IC50 | 5.5000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | IC50 | 4.4000 | 1 | 1 |
| diosmetin | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| genkwanin | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| 3-methylquercetin | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| rhamnetin | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| 4',7-dihydroxyflavone | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
This protein enables 12 target(s):
| Target | Category | Definition |
|---|---|---|
| inositol-1,4,5-trisphosphate 6-kinase activity | molecular function | Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + 2 ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + 2 ADP + 2 H+. [RHEA:32359] |
| inositol tetrakisphosphate 3-kinase activity | molecular function | Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate. [GOC:elh] |
| inositol tetrakisphosphate 6-kinase activity | molecular function | Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. [GOC:elh] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| inositol-1,4,5-trisphosphate 3-kinase activity | molecular function | Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + H+. [RHEA:11020] |
| metal ion binding | molecular function | Binding to a metal ion. [GOC:ai] |
| 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity | molecular function | Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate + ADP + 2 H+. [EC:2.7.1.153, RHEA:21292] |
| inositol tetrakisphosphate 5-kinase activity | molecular function | Catalysis of the reaction: 1D-myo-inositol 1,3,4,6-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP. [EC:2.7.1.140, MetaCyc:2.7.1.140-RXN] |
| flavonoid binding | molecular function | Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge. [GOC:sl, PMID:20599706] |
| myo-inositol-1,2,3,4,6-heptakisphosphate 5-kinase activity | molecular function | Catalysis of the reaction: 1L-myo-inositol 1,2,3,4,6-pentakisphosphate(10-) + ATP = H+ + myo-inositol hexakisphosphate(12-) + ADP. [EC:2.7.1.140, GOC:pz] |
| inositol tetrakisphosphate kinase activity | molecular function | Catalysis of the reaction: inositol tetrakisphosphate + ATP = inositol pentakisphosphate + ADP. [GOC:ai] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleoplasm | cellular component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| nucleus | cellular component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|---|---|
| inositol trisphosphate metabolic process | biological process | The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached. [GOC:mah] |
| inositol phosphate metabolic process | biological process | The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:jl] |
| phosphatidylinositol metabolic process | biological process | The chemical reactions and pathways involving phosphatidylinositol, any glycophospholipid in which a sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732] |
| necroptotic process | biological process | A programmed necrotic cell death process which begins when a cell receives a signal (e.g. a ligand binding to a death receptor or to a Toll-like receptor), and proceeds through a series of biochemical events (signaling pathways), characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3) and by critical dependence on mixed lineage kinase domain-like (MLKL), and which typically lead to common morphological features of necrotic cell death. The process ends when the cell has died. The process is divided into a signaling phase, and an execution phase, which is triggered by the former. [GOC:BHF, GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, PMID:18846107, PMID:20823910, PMID:21737330, PMID:21760595, PMID:21876153] |
| inositol phosphate biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached. [GOC:mah] |