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Methionine aminopeptidase 1
A methionine aminopeptidase 1 that is encoded in the genome of yeast. [OMA:Q01662, PRO:DNx]
Synonyms
MAP 1;
MetAP 1;
EC 3.4.11.18;
Peptidase M 1
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 15, Issue:3, 2005
Identification of potent type I MetAP inhibitors by simple bioisosteric replacement. Part 1: Synthesis and preliminary SAR studies of thiazole-4-carboxylic acid thiazol-2-ylamide derivatives.Bioorganic & medicinal chemistry letters, , Aug-15, Volume: 15, Issue:16, 2005
Identification of potent type I MetAPs inhibitors by simple bioisosteric replacement. Part 2: SAR studies of 5-heteroalkyl substituted TCAT derivatives.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 15, Issue:18, 2005
Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae.Journal of medicinal chemistry, , Jun-19, Volume: 46, Issue:13, 2003