Page last updated: 2024-09-25

ru-28362

Description

11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one: glucocorticoid receptor agonist; RN given refers to (11beta,17beta)-isomer [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID123790
SCHEMBL ID10599789
MeSH IDM0140985

Synonyms (22)

Synonym
ru28362
(8s,9s,10r,11s,13s,14s,17s)-11,17-dihydroxy-6,10,13-trimethyl-17-prop-1-ynyl-9,11,12,14,15,16-hexahydro-8h-cyclopenta[a]phenanthren-3-one
74915-64-3
androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11beta,17beta)-
ru 28362
unii-vh397cn9sv
ru 362
ru-28362
ru-362
11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-triene-3-one
vh397cn9sv ,
gtpl3445
SCHEMBL10599789
Q7277962
DTXSID101027141
ru28362-6
androsta-1,4,6-trien-3-one, 11,17-dihydroxy-6-methyl-17-(1-propynyl)-, (11.beta.,17.beta.)-
(11.beta.,17.beta.)-11,17-dihydroxy-6-methyl-17-(1-propynyl)androsta-1,4,6-trien-3-one
ru362
AKOS040749370
CS-0083558
HY-121859

Research

Studies (168)

TimeframeStudies, This Drug (%)All Drugs %
pre-199038 (22.62)18.7374
1990's102 (60.71)18.2507
2000's22 (13.10)29.6817
2010's5 (2.98)24.3611
2020's1 (0.60)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (0.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other174 (99.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Long-term Use (4)

ArticleYear
Role of adrenal steroid mineralocorticoid and glucocorticoid receptors in long-term potentiation in the CA1 field of hippocampal slices.
Brain research, Nov-04, Volume: 738, Issue: 2
1996
Acute, chronic, and interactive effects of type I and II corticosteroid receptor stimulation on feeding and weight gain.
Physiology & behavior, Volume: 47, Issue: 6
1990
Cannabinoid interactions with glucocorticoid receptors in rat hippocampus.
Brain research, Nov-26, Volume: 534, Issue: 1-2
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (11)

ArticleYear
Limited brain diffusion of the glucocorticoid receptor agonist RU28362 following i.c.v. administration: implications for i.c.v. drug delivery and glucocorticoid negative feedback in the hypothalamic-pituitary-adrenal axis.
Neuroscience, Sep-01, Volume: 141, Issue: 3
2006
Acute glucocorticoid pretreatment suppresses stress-induced hypothalamic-pituitary-adrenal axis hormone secretion and expression of corticotropin-releasing hormone hnRNA but does not affect c-fos mRNA or fos protein expression in the paraventricular nucle
Journal of neuroendocrinology, Volume: 15, Issue: 11
2003
Glucocorticoid receptor activation in the rat nucleus of the solitary tract facilitates memory consolidation: involvement of the basolateral amygdala.
The European journal of neuroscience, Volume: 11, Issue: 4
1999
Specificity and mechanism of biphasic action of glucocorticoids on alpha-lactalbumin production by rat mammary gland explants.
Endocrinology, Volume: 118, Issue: 3
1986
Binding and action of glucocorticoids and mineralocorticoids in rabbit mammary gland. Exclusive participation of glucocorticoid type II receptors for stimulation of casein synthesis.
Molecular and cellular endocrinology, Volume: 52, Issue: 3
1987
Steroid receptors, and the generation of closely coupled/biphasic dose-response curves.
Journal of steroid biochemistry, Volume: 30, Issue: 1-6
1988
Suppression of growth of PHA-stimulated human lymphocytes by a novel steroid (RU 28 362) lacking the 21-OH group.
International journal of immunopharmacology, Volume: 9, Issue: 8
1987
Corticosterone's dual metabolic actions.
Life sciences, Volume: 45, Issue: 15
1989
Quantification of type I and II adrenal steroid receptors in neuronal, lymphoid and pituitary tissues.
Brain research, Dec-04, Volume: 503, Issue: 2
1989
Receptor specificity of a glucocorticoid- and stress-induced hippocampal protein.
The Journal of neuroscience : the official journal of the Society for Neuroscience, Volume: 9, Issue: 4
1989
Steroid interactions affecting metabolic activities of a T-lymphocyte line.
International journal of immunopharmacology, Volume: 14, Issue: 8
1992
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]