Page last updated: 2024-12-10

arborinine

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

arborinine: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID5281832
CHEMBL ID349609
CHEBI ID2804
SCHEMBL ID1663913
MeSH IDM0079370

Synonyms (40)

Synonym
bdbm50049390
1-hydroxy-2,3-dimethoxy-n-methylacridone
1-hydroxy-2,3-dimethoxy-10-methyl-10h-acridin-9-one
1-hydroxy-2,3-dimethoxy-10-methyl-9-acridone
16xg8ue639 ,
nsc 94650
unii-16xg8ue639
9-acridanone, 1-hydroxy-2,3-dimethoxy-10-methyl-
9(10h)-acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl-
nsc 681020
1-hydroxy-2,3-dimethoxy-10-methyl-9(10h)-acridinone
nsc681020
1-hydroxy-2,3-dimethoxy-10-methyl-acridin-9-one
9(10h)-acridinone,3-dimethoxy-10-methyl-
9-acridanone,3-dimethoxy-10-methyl-
nsc-94650
nsc94650
arborinin
arbornine
5489-57-6
arborinine
nsc-681020
chebi:2804 ,
CHEMBL349609 ,
1-hydroxy-2,3-dimethoxy-10-methylacridin-9-one
SCHEMBL1663913
1-hydroxy-2,3-dimethoxy-10-methylacridan-9-one
1-hydroxy-2,3-dimethoxy-10-methylacridone
1-hydroxy-2,3-dimethoxy-10-methylacridin-9(10h)-one
ATBZZQPALSPNMF-UHFFFAOYSA-N
DTXSID60203378
1-hydroxy-2,3-dimethoxy-10-methyl-9,10-dihydroacridin-9-one
9(10h)-acridinone, 1-hydroxy-2,3-dimethoxy-10-methyl- (9ci)
1-hydroxy-2,3-dimethoxy-10-methyl-9-acridanone
9-acridanone, 1-hydroxy-2,3-dimethoxy-10-methyl- (8ci)
Q27105822
XA163699
AKOS040761369
CS-0102112
HY-128912

Research Excerpts

Effects

ExcerptReferenceRelevance
"Arborinine has been known as a broad-spectrum anti-tumor agent due to it possesses a potent cytotoxic effect on various cancer cells."( Arborinine suppresses ovarian cancer development through inhibition of LSD1.
Li, N; Yang, L; Zuo, H, 2022
)
2.89

Treatment

ExcerptReferenceRelevance
"Arborinine treatment dose-dependently reduced LSD1 expression, resulting in increased H3K4m1 expression."( Arborinine suppresses ovarian cancer development through inhibition of LSD1.
Li, N; Yang, L; Zuo, H, 2022
)
2.89
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
acridines
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (21)

Assay IDTitleYearJournalArticle
AID333231Cytotoxicity against human Raji cells at 32 nM after 48 hrs by trypan blue staining method2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID479389Cytotoxicity against human A549 cells after 48 hrs by resazurin reduction assay2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.
AID360825Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum HB3 after 48 hrs by LDH reporter activity2002Journal of natural products, Jul, Volume: 65, Issue:7
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.
AID33936Affinity at Adenosine A2A receptor in rat striatal membranes by [3H]- CGS 21680 displacement.1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
Interactions of flavonoids and other phytochemicals with adenosine receptors.
AID360826Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by LDH activity2002Journal of natural products, Jul, Volume: 65, Issue:7
Isolation and in vitro antiplasmodial activities of alkaloids from Teclea trichocarpa: in vivo antimalarial activity and X-ray crystal structure of normelicopicine.
AID333234Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 3.2 nM after 48 hrs relative to control2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID605705Binding affinity to heme assessed as equilibrium binding constant by UV-visible spectrophotometry2011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation.
AID333230Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 32 nM after 48 hrs relative to control2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID605707Inhibition of heme-mediated bovine serum albumin oxidation assessed as protein carbonyl formation after 1 hr in presence of H2O2 at pH 7.42011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation.
AID333236Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 0.32 nM after 48 hrs relative to control2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID605706Inhibition of heme-mediated bovine serum albumin degradation at 100 uM after 1 hr by gel electrophoresis in presence of H2O2 at pH 7.42011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Synthesis of novel heme-interacting acridone derivatives to prevent free heme-mediated protein oxidation and degradation.
AID479391Cytotoxicity against human WS1 cells after 48 hrs by resazurin reduction assay2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.
AID333232Inhibition of TPA-induced EBV-early antigen activation in human Raji cells at 16 nM after 48 hrs relative to control2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333233Cytotoxicity against human Raji cells at 16 nM after 48 hrs by trypan blue staining method2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID34263Displacement of specific [125I]AB-MECA binding from human Adenosine A3 receptor expressed in HEK293 cells1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
Interactions of flavonoids and other phytochemicals with adenosine receptors.
AID479390Cytotoxicity against human DLD1 cells after 48 hrs by resazurin reduction assay2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
In vitro cytotoxic activity of isolated acridones alkaloids from Zanthoxylum leprieurii Guill. et Perr.
AID32357Displacement of specific [3H]PIA binding from adenosine A1 receptor in rat brain membranes.1996Journal of medicinal chemistry, Feb-02, Volume: 39, Issue:3
Interactions of flavonoids and other phytochemicals with adenosine receptors.
AID333235Cytotoxicity against human Raji cells at 3.2 nM after 48 hrs by trypan blue staining method2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID333237Cytotoxicity against human Raji cells at 0.32 nM after 48 hrs by trypan blue staining method2004Journal of natural products, Sep, Volume: 67, Issue:9
Chemical constituents of Glycosmis arborea: three new carbazole alkaloids and their biological activity.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (6.25)18.7374
1990's1 (6.25)18.2507
2000's6 (37.50)29.6817
2010's5 (31.25)24.3611
2020's3 (18.75)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.70

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.70 (24.57)
Research Supply Index2.83 (2.92)
Research Growth Index5.24 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.70)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other16 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]