Page last updated: 2024-09-24

l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide

Cross-References

ID SourceID
PubMed CID107823
SCHEMBL ID194686
MeSH IDM0090501

Synonyms (15)

Synonym
rx-77368
rx 77368
l-pyroglutamyl-l-histidyl-3,3-dimethylprolinamide
l-prolinamide, 5-oxo-l-prolyl-l-histidyl-3,3-dimethyl-
76820-40-1
pyr-his-dmp-nh2
rx77368
pyaiku1m4k ,
5-oxo-l-prolyl-l-histidyl-3,3-dimethyl-l-prolinamide
unii-pyaiku1m4k
SCHEMBL194686
l-pyroglutamyl-l-histidyl-l-3,3-dimethylprolinamide
pglu-his-(3,3'-dimethyl)-pro-nh2
DTXSID10998141
5-hydroxy-n-[1-{2-[hydroxy(imino)methyl]-3,3-dimethylpyrrolidin-1-yl}-3-(1h-imidazol-5-yl)-1-oxopropan-2-yl]-3,4-dihydro-2h-pyrrole-2-carboximidic acid

Research

Studies (132)

TimeframeStudies, This Drug (%)All Drugs %
pre-199045 (34.09)18.7374
1990's63 (47.73)18.2507
2000's20 (15.15)29.6817
2010's4 (3.03)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials7 (5.07%)5.53%
Reviews1 (0.72%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other130 (94.20%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (1)

ArticleYear
Comparative efficacy and safety of intravenous and oral administration of a TRH analogue (RX77368) in motor neuron disease.
Journal of neurology, neurosurgery, and psychiatry, Volume: 53, Issue: 11
1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (1)

ArticleYear
Thyrotropin-releasing hormone (TRH) analogues show enhanced CNS selectivity because of increased biological stability.
Regulatory peptides, Volume: 2, Issue: 5
1981
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (3)

ArticleYear
The ability of RX 77368 - a stabilised analogue of TRH - to provoke the secretion of prolactin and TSH in vivo.
Neuropeptides, Volume: 3, Issue: 1
1982
Is thyrotropin releasing hormone an endogenous ergotropic substance in the brain?
Lancet (London, England), Mar-14, Volume: 1, Issue: 8220 Pt 1
1981
Serotonin depletion potentiates gastric secretory and motor responses to vagal but not peripheral gastric stimulants.
The Journal of pharmacology and experimental therapeutics, Volume: 251, Issue: 2
1989
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]