Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

An oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:P36551]

COX;
Coprogen oxidase;
Coproporphyrinogenase;
EC 1.3.3.3

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
coproporphyrinogen iii	Homo sapiens (human)	Km	680.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
coproporphyrinogen oxidase activity	molecular function	Catalysis of the reaction: coproporphyrinogen III + 2 H+ + O2 = 2 CO2 + 2 H2O + protoporphyrinogen IX. [EC:1.3.3.3, RHEA:18257]
structural constituent of eye lens	molecular function	The action of a molecule that contributes to the structural integrity of the lens of an eye. [GOC:mah]
protein homodimerization activity	molecular function	Binding to an identical protein to form a homodimer. [GOC:jl]

This protein is located in 4 target(s):

Target	Category	Definition
mitochondrion	cellular component	A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial intermembrane space	cellular component	The region between the inner and outer lipid bilayers of the mitochondrial envelope. [GOC:mah]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 5 target(s):

Target	Category	Definition
protoporphyrinogen IX biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX. [GOC:go_curators]
heme biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. [GOC:jl, PMID:11788607]
heme A biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme A, a derivative of heme found in cytochrome aa3. [GOC:ai, PMID:11788607]
heme B biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme B, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes. [GOC:yaf, PMID:29414780]
heme O biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of heme O, a derivative of heme containing a 17-carbon hydroxyethylfarnesyl side chain at position 8 of the tetrapyrrole macrocycle. [GOC:jid]