Lysosomal Pro-X carboxypeptidase

A lysosomal Pro-X carboxypeptidase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42785]

Synonyms

EC 3.4.16.2;
Angiotensinase C;
Lysosomal carboxypeptidase C;
Proline carboxypeptidase;
Prolylcarboxypeptidase;
PRCP

Research

Bioassay Publications (4)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	1 (25.00)	18.7374
1990's	2 (50.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (11)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
phencyclidine	Homo sapiens (human)	IC50	0.0910	1	1
2-methyl-1,2,3,4-tetrahydroisoquinoline	Homo sapiens (human)	IC50	30.0000	1	1
tenocyclidine	Homo sapiens (human)	IC50	0.0200	1	1
1,2,3,4-tetrahydro-1-(phenylmethyl)isoquinoline	Homo sapiens (human)	IC50	1.0000	1	1
1,2,3,4-tetrahydro-1-phenylisoquinoline	Homo sapiens (human)	IC50	1.9000	1	1
metaphit	Homo sapiens (human)	Ki	0.0160	1	1
1-(1-(2-benzo(b)thienyl)cyclohexyl)piperidine	Homo sapiens (human)	Ki	10.0000	1	1
jtp 4819	Homo sapiens (human)	IC50	100.0000	1	1
dizocilpine	Homo sapiens (human)	IC50	0.0053	1	1
cocaine	Homo sapiens (human)	Ki	10.0000	1	1
4-phenyl-1,2,3,4-tetrahydroisoquinoline	Homo sapiens (human)	IC50	30.0000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
serine-type carboxypeptidase activity	molecular function	Catalysis of the hydrolysis of a single C-terminal amino acid residue from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [https://www.ebi.ac.uk/merops/about/glossary.shtml#CARBOXYPEPTIDASE]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
dipeptidyl-peptidase activity	molecular function	Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain. [GOC:mb, https://www.ebi.ac.uk/merops/about/glossary.shtml#DIPEPTIDYL-PEPTIDASE]

Located In

This protein is located in 6 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
azurophil granule membrane	cellular component	The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid. [GOC:bf, PMID:17152095]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
basal part of cell	cellular component	The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue. [GOC:mah, ISBN:0815316194]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]
ficolin-1-rich granule membrane	cellular component	The lipid bilayer surrounding a ficolin-1-rich granule. [GOC:mec, PMID:23650620]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
regulation of thyroid hormone mediated signaling pathway	biological process	Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway. [GOC:hjd]
plasma kallikrein-kinin cascade	biological process	A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability. [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
glucose homeostasis	biological process	Any process involved in the maintenance of an internal steady state of glucose within an organism or cell. [GOC:go_curators]
energy homeostasis	biological process	Any process involved in the balance between food intake (energy input) and energy expenditure. [GOC:yaf, PMID:15919751]
regulation of reactive oxygen species metabolic process	biological process	Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process. [GOC:mah]
angiogenesis involved in wound healing	biological process	Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to a damaged tissue, following an injury. [GOC:dph, PMID:15039218]
negative regulation of systemic arterial blood pressure	biological process	The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]
regulation of blood vessel endothelial cell migration	biological process	Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels. [GOC:go_curators]