Gamma-aminobutyric acid receptor subunit rho-1

A gamma-aminobutyric acid receptor subunit rho-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P24046]

Synonyms

GABA(A) receptor subunit rho-1;
GABA(C) receptor

Research

Bioassay Publications (8)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	3 (37.50)	29.6817
2010's	5 (62.50)	24.3611
2020's	0 (0.00)	2.80

Compounds (17)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
aminolevulinic acid	Homo sapiens (human)	IC50	12.9000	1	1
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid	Homo sapiens (human)	IC50	2.2200	2	2
cgp 36742	Homo sapiens (human)	IC50	62.0000	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gamma-aminobutyric acid	Homo sapiens (human)	EC50	0.5275	6	9
gamma-aminobutyric acid	Homo sapiens (human)	Kd	1.7000	1	1
isoguvacine	Homo sapiens (human)	EC50	38.9522	1	2
muscimol	Homo sapiens (human)	EC50	1.0806	4	6
muscimol	Homo sapiens (human)	Kd	2.3000	1	1
imidazoleacetic acid	Homo sapiens (human)	EC50	8.3903	2	3
4-aminocrotonic acid	Homo sapiens (human)	EC50	0.4800	3	3
4-aminocrotonic acid	Homo sapiens (human)	Kd	0.6000	1	1
n(4)-chloroacetylcytosine arabinoside	Homo sapiens (human)	EC50	74.0000	2	2

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-aminovaleric acid	Homo sapiens (human)	Kb	20.0000	2	2
gaboxadol	Homo sapiens (human)	Kb	32.0000	2	2
4-piperidinecarboxylic acid	Homo sapiens (human)	Kb	100.0000	1	1
piperidine-4-sulfonic acid	Homo sapiens (human)	Kb	81.0000	1	1
sk&f 97541	Homo sapiens (human)	Kb	0.8000	1	1
(1,2,5,6-tetrahydropyridin-4-yl)methylphosphinic acid	Homo sapiens (human)	Kb	2.1000	2	2
imidazoleacetic acid	Homo sapiens (human)	Kb	1.6000	2	2
3-aminopropylphosphonic acid	Homo sapiens (human)	Kb	10.0000	1	1
sr 95531	Homo sapiens (human)	Kb	35.0000	1	1
strychnine	Homo sapiens (human)	Kb	69.0000	1	1

Enables

This protein enables 7 target(s):

Target	Category	Definition
GABA-A receptor activity	molecular function	Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels. [PMID:8974333]
protein domain specific binding	molecular function	Binding to a specific domain of a protein. [GOC:go_curators]
GABA-gated chloride ion channel activity	molecular function	Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729]
identical protein binding	molecular function	Binding to an identical protein or proteins. [GOC:jl]
protein-containing complex binding	molecular function	Binding to a macromolecular complex. [GOC:jl]
ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	molecular function	Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451]
neurotransmitter receptor activity	molecular function	Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity. [GOC:jl, GOC:signaling]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
presynaptic membrane	cellular component	A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane. [GOC:jl, ISBN:0815316194]
postsynaptic membrane	cellular component	A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732]
glutamatergic synapse	cellular component	A synapse that uses glutamate as a neurotransmitter. [GOC:dos]
GABA-ergic synapse	cellular component	A synapse that uses GABA as a neurotransmitter. These synapses are typically inhibitory. [GOC:dos]

Active In

This protein is active in 3 target(s):

Target	Category	Definition
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
synapse	cellular component	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane. [GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110]

Part Of

This protein is part of 3 target(s):

Target	Category	Definition
chloride channel complex	cellular component	An ion channel complex through which chloride ions pass. [GOC:mah]
GABA-A receptor complex	cellular component	A protein complex which is capable of GABA-A receptor activity. In human, it is usually composed of either two alpha, two beta and one gamma chain of the GABA-A receptor subunits or 5 chains of the GABA-A receptor subunits rho1-3 (formally known as GABA-C receptor). [GO_REF:0000088, GOC:bhm, GOC:TermGenie, PMID:18790874]
transmembrane transporter complex	cellular component	A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. [GOC:bhm, GOC:TermGenie, PMID:18024586]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
gamma-aminobutyric acid signaling pathway	biological process	The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to its receptor on the surface of a target cell. [GOC:mah]
chemical synaptic transmission	biological process	The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435]
modulation of chemical synaptic transmission	biological process	Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai]
regulation of presynaptic membrane potential	biological process	Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef]
regulation of membrane potential	biological process	Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]
chloride transmembrane transport	biological process	The process in which chloride is transported across a membrane. [GOC:TermGenie, GOC:vw]