Proteins > Nuclear receptor corepressor 2
Page last updated: 2024-08-07 18:54:10

Nuclear receptor corepressor 2

A nuclear receptor corepressor 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9Y618]

Synonyms

N-CoR2;
CTG repeat protein 26;
SMAP270;
Silencing mediator of retinoic acid and thyroid hormone receptor;
SMRT;
T3 receptor-associating factor;
TRAC;
Thyroid-, retinoic-acid-receptor-associated corepressor

Research

Bioassay Publications (60)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (1.67)29.6817
2010's42 (70.00)24.3611
2020's17 (28.33)2.80

Compounds (28)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ci 994Homo sapiens (human)IC500.190011
entinostatHomo sapiens (human)IC501.185066
entinostatHomo sapiens (human)Ki0.822544
scriptaidHomo sapiens (human)IC500.188422
fenofibrateHomo sapiens (human)IC5075.000011
fenofibrateHomo sapiens (human)Ki75.000011
vorinostatHomo sapiens (human)IC500.09053131
vorinostatHomo sapiens (human)Ki0.002011
benzohydroxamic acidHomo sapiens (human)IC5071.572011
n-hydroxy-2,2-diphenylacetamideHomo sapiens (human)IC5050.000011
trichostatin aHomo sapiens (human)IC500.013877
trichostatin aHomo sapiens (human)Ki0.000622
romidepsinHomo sapiens (human)IC501.058588
romidepsinHomo sapiens (human)Ki0.024911
psammaplin aHomo sapiens (human)IC500.012411
tubacinHomo sapiens (human)IC501.270022
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)IC500.019333
(3S,6S,9S,12R)-3-[(2S)-Butan-2-yl]-6-[(1-methoxyindol-3-yl)methyl]-9-(6-oxooctyl)-1,4,7,10-tetrazabicyclo[10.4.0]hexadecane-2,5,8,11-tetroneHomo sapiens (human)Ki0.001511
panobinostatHomo sapiens (human)IC500.002066
n1-(2-aminophenyl)-n7-phenylheptanediamideHomo sapiens (human)IC500.069011
givinostatHomo sapiens (human)IC500.136011
mocetinostatHomo sapiens (human)IC500.045011
quisinostatHomo sapiens (human)IC500.004933
abexinostatHomo sapiens (human)IC500.148011
chidamideHomo sapiens (human)IC500.330011
pci 34051Homo sapiens (human)IC5030.065233
largazoleHomo sapiens (human)IC502.002011
tubastatin aHomo sapiens (human)IC5010.320488
pracinostatHomo sapiens (human)IC500.070011
acy-1215Homo sapiens (human)IC500.046333
cudc-907Homo sapiens (human)IC500.002522
rgfp966Homo sapiens (human)IC500.200022
rg2833Homo sapiens (human)IC500.063011
rg2833Homo sapiens (human)Ki0.005011
santacruzamate aHomo sapiens (human)IC505.000011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
DNA bindingmolecular functionAny molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw]
chromatin bindingmolecular functionBinding to chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase. [GOC:jl, ISBN:0198506732, PMID:20404130]
transcription corepressor activitymolecular functionA transcription coregulator activity that represses or decreases the transcription of specific gene sets via binding to a DNA-bound DNA-binding transcription factor, either on its own or as part of a complex. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription corepressors modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. [GOC:txnOH-2018, PMID:10213677, PMID:16858867]
Notch bindingmolecular functionBinding to a Notch (N) protein, a surface receptor. [GOC:ceb]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
nuclear glucocorticoid receptor bindingmolecular functionBinding to a nuclear glucocorticoid receptor. [GOC:bf]
histone deacetylase bindingmolecular functionBinding to histone deacetylase. [GOC:jl]
nuclear retinoid X receptor bindingmolecular functionBinding to a nuclear retinoid X receptor. [GOC:ai]

Located In

This protein is located in 5 target(s):

TargetCategoryDefinition
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasmcellular componentThat part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
nuclear matrixcellular componentThe dense fibrillar network lying on the inner side of the nuclear membrane. [ISBN:0582227089]
nuclear bodycellular componentExtra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins. [GOC:ma, PMID:10330182]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
chromatincellular componentThe ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]
transcription repressor complexcellular componentA protein complex that possesses activity that prevents or downregulates transcription. [GOC:mah]

Involved In

This protein is involved in 10 target(s):

TargetCategoryDefinition
negative regulation of transcription by RNA polymerase IIbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH]
lactationbiological processThe regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young. [ISBN:0198506732]
response to organonitrogen compoundbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond. [PMID:9869419]
regulation of cellular ketone metabolic processbiological processAny process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups. [GOC:dph, GOC:tb]
cerebellum developmentbiological processThe process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
response to estradiolbiological processAny process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123]
estrous cyclebiological processA type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur. [GOC:jl, Wikipedia:Estrous_cycle]
negative regulation of DNA-templated transcriptionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
negative regulation of androgen receptor signaling pathwaybiological processAny process that decreases the rate, frequency, or extent of the androgen receptor signaling pathway. [GOC:dph]
negative regulation of miRNA transcriptionbiological processAny process that stops, prevents or reduces the frequency, rate or extent of microRNA (miRNA) gene transcription. [GO_REF:0000058, GOC:dph, GOC:kmv, GOC:TermGenie, PMID:24699545]