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labetalol and Necrosis

labetalol has been researched along with Necrosis in 5 studies

Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.

Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.

Research Excerpts

ExcerptRelevanceReference
"Labetalol was found to be less effective in preventing tissue necrosis."5.28Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989)
" Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique."1.38Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012)
"This study used an animal model of acute pancreatitis induced by intravenous caeruleint (10 micrograms/kg/h for up to six hours), which does not entail either haemorrhage or significant necrosis of the pancreas."1.29Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis. ( Adler, G; Gress, TM; Lerch, MM; Pfaff, D; Turi, S; Weidenbach, H, 1995)
"Labetalol was found to be less effective in preventing tissue necrosis."1.28Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Li, P1
Robertson, TA1
Zhang, Q1
Fletcher, LM1
Crawford, DH1
Weiss, M1
Roberts, MS1
Long, RC1
Wofford, MR1
Harkins, KG1
Minor, DS1
Weidenbach, H1
Lerch, MM1
Gress, TM1
Pfaff, D1
Turi, S1
Adler, G1
Clark, JA1
Zimmerman, HJ1
Tanner, LA1
Aycock, BG1
Hawtof, DB1
Moody, SB1

Other Studies

5 other studies available for labetalol and Necrosis

ArticleYear
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
    Pharmaceutical research, 2012, Volume: 29, Issue:6

    Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti

2012
Hepatocellular necrosis associated with labetalol.
    Journal of clinical hypertension (Greenwich, Conn.), 2007, Volume: 9, Issue:4

    Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inj

2007
Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis.
    Gut, 1995, Volume: 37, Issue:3

    Topics: Acute Disease; Animals; Arginine; Bradykinin; Catecholamines; Ceruletide; Edema; Labetalol; Male; Mi

1995
Labetalol hepatotoxicity.
    Annals of internal medicine, 1990, Aug-01, Volume: 113, Issue:3

    Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Vir

1990
Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.
    Annals of plastic surgery, 1989, Volume: 23, Issue:1

    Topics: Animals; Epinephrine; Foot; Ischemia; Labetalol; Lidocaine; Models, Biological; Necrosis; Phentolami

1989