labetalol has been researched along with Necrosis in 5 studies
Labetalol: A salicylamide derivative that is a non-cardioselective blocker of BETA-ADRENERGIC RECEPTORS and ALPHA-1 ADRENERGIC RECEPTORS.
labetalol : A diastereoisomeric mixture of approximately equal amounts of all four possible stereoisomers ((R,S)-labetolol, (S,R)-labetolol, (S,S)-labetalol and (R,R)-labetalol). It is an adrenergic antagonist used to treat high blood pressure.
2-hydroxy-5-{1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl}benzamide : A member of the class of benzamides that is benzamide substituted by a hydroxy group at position 2 and by a 1-hydroxy-2-[(4-phenylbutan-2-yl)amino]ethyl group at position 5.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Labetalol was found to be less effective in preventing tissue necrosis." | 5.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
| " Hepatic pharmacokinetic modelling was performed with a two-phase physiologically-based organ pharmacokinetic model with the vascular space and dispersion evaluated with the MID technique." | 1.38 | Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage. ( Crawford, DH; Fletcher, LM; Li, P; Roberts, MS; Robertson, TA; Weiss, M; Zhang, Q, 2012) |
| "This study used an animal model of acute pancreatitis induced by intravenous caeruleint (10 micrograms/kg/h for up to six hours), which does not entail either haemorrhage or significant necrosis of the pancreas." | 1.29 | Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis. ( Adler, G; Gress, TM; Lerch, MM; Pfaff, D; Turi, S; Weidenbach, H, 1995) |
| "Labetalol was found to be less effective in preventing tissue necrosis." | 1.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Li, P | 1 |
| Robertson, TA | 1 |
| Zhang, Q | 1 |
| Fletcher, LM | 1 |
| Crawford, DH | 1 |
| Weiss, M | 1 |
| Roberts, MS | 1 |
| Long, RC | 1 |
| Wofford, MR | 1 |
| Harkins, KG | 1 |
| Minor, DS | 1 |
| Weidenbach, H | 1 |
| Lerch, MM | 1 |
| Gress, TM | 1 |
| Pfaff, D | 1 |
| Turi, S | 1 |
| Adler, G | 1 |
| Clark, JA | 1 |
| Zimmerman, HJ | 1 |
| Tanner, LA | 1 |
| Aycock, BG | 1 |
| Hawtof, DB | 1 |
| Moody, SB | 1 |
5 other studies available for labetalol and Necrosis
| Article | Year |
|---|---|
Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage.
Topics: Adrenergic Antagonists; Analysis of Variance; Animals; Anti-Inflammatory Agents, Non-Steroidal; Anti | 2012 |
Hepatocellular necrosis associated with labetalol.
Topics: Antihypertensive Agents; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liver Inj | 2007 |
Vasoactive mediators and the progression from oedematous to necrotising experimental acute pancreatitis.
Topics: Acute Disease; Animals; Arginine; Bradykinin; Catecholamines; Ceruletide; Edema; Labetalol; Male; Mi | 1995 |
Labetalol hepatotoxicity.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Diagnosis, Differential; Female; Hepatitis, Vir | 1990 |
Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.
Topics: Animals; Epinephrine; Foot; Ischemia; Labetalol; Lidocaine; Models, Biological; Necrosis; Phentolami | 1989 |