Page last updated: 2024-08-07 23:18:40
Acyl-CoA desaturase 1
An acyl-CoA desaturase 1 that is encoded in the genome of mouse. [PRO:DNx, UniProtKB:P13516]
Synonyms
EC 1.14.19.1;
Delta(9)-desaturase 1;
Delta-9 desaturase 1;
Fatty acid desaturase 1;
Stearoyl-CoA desaturase 1
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| staurosporine | Mus musculus (house mouse) | IC50 | 3.4000 | 1 | 1 |
| zanamivir | Mus musculus (house mouse) | IC50 | 0.0010 | 1 | 1 |
| oseltamivir | Mus musculus (house mouse) | IC50 | 0.0080 | 1 | 1 |
| mk 8245 | Mus musculus (house mouse) | IC50 | 0.0030 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| mbx-8025 | Mus musculus (house mouse) | EC50 | 1.0000 | 1 | 1 |
Discovery of potent and liver-targeted stearoyl-CoA desaturase (SCD) inhibitors in a bispyrrolidine series.Bioorganic & medicinal chemistry letters, , Jan-15, Volume: 22, Issue:2, 2012
Development of a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor (MK-8245) to establish a therapeutic window for the treatment of diabetes and dyslipidemia.Journal of medicinal chemistry, , Jul-28, Volume: 54, Issue:14, 2011